WO1997012527A3 - Verwendung von threonin zur behandlung der phenylketonurie - Google Patents

Verwendung von threonin zur behandlung der phenylketonurie Download PDF

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Publication number
WO1997012527A3
WO1997012527A3 PCT/EP1996/004093 EP9604093W WO9712527A3 WO 1997012527 A3 WO1997012527 A3 WO 1997012527A3 EP 9604093 W EP9604093 W EP 9604093W WO 9712527 A3 WO9712527 A3 WO 9712527A3
Authority
WO
WIPO (PCT)
Prior art keywords
threonine
phenylketonuria
treatment
composition
foods
Prior art date
Application number
PCT/EP1996/004093
Other languages
English (en)
French (fr)
Other versions
WO1997012527A2 (de
Inventor
Gilda Georgi
Guenther Sawatzki
Original Assignee
Milupa Gmbh & Co Kg
Gilda Georgi
Guenther Sawatzki
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Milupa Gmbh & Co Kg, Gilda Georgi, Guenther Sawatzki filed Critical Milupa Gmbh & Co Kg
Priority to DE59608276T priority Critical patent/DE59608276D1/de
Priority to DK96932564T priority patent/DK0852469T3/da
Priority to EP96932564A priority patent/EP0852469B1/de
Priority to AT96932564T priority patent/ATE209005T1/de
Priority to JP9513925A priority patent/JP2000502323A/ja
Publication of WO1997012527A2 publication Critical patent/WO1997012527A2/de
Publication of WO1997012527A3 publication Critical patent/WO1997012527A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Die Erfindung betrifft die Verwendung von Threonin zur Behandlung der Phenylketonurie. Der Erfindung liegt die überraschende Erkenntnis zugrunde, daß durch zusätzliche Gaben von Threonin die Konzentration von Phenylalanin im Plasma von PKU-Patienten gesenkt werden kann. Gegenstand der Erfindung ist somit auch ein Mittel zur diätetischen oder pharmazeutischen Verwendung bei der Phenylketonurie, welches mindestens 8 g Threonin pro 100 g Aminosäuren enthält. Bei diesem Mittel kann es sich um Nahrungen, insbesondere Formelnahrungen und PKU-Diätetika handeln.
PCT/EP1996/004093 1995-09-18 1996-09-18 Verwendung von threonin zur behandlung der phenylketonurie WO1997012527A2 (de)

Priority Applications (5)

Application Number Priority Date Filing Date Title
DE59608276T DE59608276D1 (de) 1995-09-18 1996-09-18 Verwendung von threonin zur behandlung der phenylketonurie
DK96932564T DK0852469T3 (da) 1995-09-18 1996-09-18 Anvendelse af threonin til behandling af phenylketonuri
EP96932564A EP0852469B1 (de) 1995-09-18 1996-09-18 Verwendung von threonin zur behandlung der phenylketonurie
AT96932564T ATE209005T1 (de) 1995-09-18 1996-09-18 Verwendung von threonin zur behandlung der phenylketonurie
JP9513925A JP2000502323A (ja) 1995-09-18 1996-09-18 フェニルケトン尿症の処置を目的とするトレオニンの使用

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19534602.5 1995-09-18
DE19534602A DE19534602C2 (de) 1995-09-18 1995-09-18 Verwendung von Threonin zur Behandlung der Phenylketonurie

Publications (2)

Publication Number Publication Date
WO1997012527A2 WO1997012527A2 (de) 1997-04-10
WO1997012527A3 true WO1997012527A3 (de) 1997-05-01

Family

ID=7772491

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1996/004093 WO1997012527A2 (de) 1995-09-18 1996-09-18 Verwendung von threonin zur behandlung der phenylketonurie

Country Status (10)

Country Link
US (1) US20010011070A1 (de)
EP (1) EP0852469B1 (de)
JP (1) JP2000502323A (de)
AT (1) ATE209005T1 (de)
CA (1) CA2232134A1 (de)
DE (2) DE19534602C2 (de)
DK (1) DK0852469T3 (de)
ES (1) ES2168508T3 (de)
PT (1) PT852469E (de)
WO (1) WO1997012527A2 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1708690T3 (pl) 2003-11-17 2017-01-31 Biomarin Pharmaceutical Inc. Leczenie fenyloketonurii za pomocą BH4
US20100317562A1 (en) * 2007-03-23 2010-12-16 Lynn Paolella Dietary Compositions
EP2008656A1 (de) 2007-06-28 2008-12-31 Bergen Teknologioverforing AS Zusammensetzungen zur Behandlung von Hyperphenylalaninämie
FR3002831B1 (fr) * 2013-03-11 2015-07-17 Lactalis Nutrition Sante Produit alimentaire pret a consommer pour patients atteints d'une maladie du metabolisme d'un ou de plusieurs acides amines

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2654820A1 (de) * 1976-12-03 1978-06-08 Maizena Gmbh Aminosaeuregemisch
JPS595111A (ja) * 1982-07-02 1984-01-12 Meiji Milk Prod Co Ltd フエニ−ルケトン尿症乳幼児用栄養調製物
DD294865A5 (de) * 1990-06-07 1991-10-17 Veb Berlin-Chemie,De Phenylalaninfreies aminosaeuregemisch mit organoleptisch guten eigenschaften zur ernaehrung von phenylketonurie-patienten
EP0488078A1 (de) * 1990-11-24 1992-06-03 MILUPA GmbH & Co. KG Phenylalaninfreies Diätetikum für juvenile und adulte Personen mit Phenylketonurie
EP0492183A1 (de) * 1990-12-28 1992-07-01 MILUPA GmbH & Co. KG Phenylalaninfreie Säuglings- und Kleinkindnahrungsgrundlage

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1122508A (en) * 1965-07-16 1968-08-07 Kyowa Hakko Kogyo Kk Process for producing l-threonine
FR2505144B1 (fr) * 1981-05-11 1985-10-25 Fabre Sa Pierre Association edulcorante exempte de sucre et son procede de preparation
IT1212792B (it) * 1983-11-30 1989-11-30 Egidio Aldo Moja Supplemento dietetico e alimento preconfezionato che lo contiene procedimento di preparazione e metodo di somministrazione
DD226775A1 (de) * 1984-08-29 1985-09-04 Berlin Chemie Veb Verfahren zur herstellung eines diaetetischen praeparats
ES2087027B1 (es) * 1994-08-03 1997-02-01 Univ Illes Balears Suplementos nutricionales termogeneticos, alimentos que los contienen y aplicaciones.

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2654820A1 (de) * 1976-12-03 1978-06-08 Maizena Gmbh Aminosaeuregemisch
JPS595111A (ja) * 1982-07-02 1984-01-12 Meiji Milk Prod Co Ltd フエニ−ルケトン尿症乳幼児用栄養調製物
DD294865A5 (de) * 1990-06-07 1991-10-17 Veb Berlin-Chemie,De Phenylalaninfreies aminosaeuregemisch mit organoleptisch guten eigenschaften zur ernaehrung von phenylketonurie-patienten
EP0488078A1 (de) * 1990-11-24 1992-06-03 MILUPA GmbH & Co. KG Phenylalaninfreies Diätetikum für juvenile und adulte Personen mit Phenylketonurie
EP0492183A1 (de) * 1990-12-28 1992-07-01 MILUPA GmbH & Co. KG Phenylalaninfreie Säuglings- und Kleinkindnahrungsgrundlage

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Section Ch Week 8408, Derwent World Patents Index; Class BO5, AN 84-045209 *
PATENT ABSTRACTS OF JAPAN vol. 008, no. 085 (C - 219) 18 April 1984 (1984-04-18) *

Also Published As

Publication number Publication date
DE19534602A1 (de) 1997-04-10
DE59608276D1 (de) 2002-01-03
ATE209005T1 (de) 2001-12-15
WO1997012527A2 (de) 1997-04-10
EP0852469A2 (de) 1998-07-15
EP0852469B1 (de) 2001-11-21
ES2168508T3 (es) 2002-06-16
DK0852469T3 (da) 2002-05-13
JP2000502323A (ja) 2000-02-29
US20010011070A1 (en) 2001-08-02
CA2232134A1 (en) 1997-04-10
DE19534602C2 (de) 1999-09-09
PT852469E (pt) 2002-03-28

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