WO1997010211A1 - Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant - Google Patents

Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant Download PDF

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Publication number
WO1997010211A1
WO1997010211A1 PCT/FR1996/001416 FR9601416W WO9710211A1 WO 1997010211 A1 WO1997010211 A1 WO 1997010211A1 FR 9601416 W FR9601416 W FR 9601416W WO 9710211 A1 WO9710211 A1 WO 9710211A1
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WIPO (PCT)
Prior art keywords
group
alkyl
hydrogen
substituted
unsubstituted
Prior art date
Application number
PCT/FR1996/001416
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English (en)
French (fr)
Inventor
Daniel Bichon
Xavier Edmonds-Alt
Patrick Gueule
Vincenzo Proietto
Didier Van Broeck
Original Assignee
Sanofi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi filed Critical Sanofi
Priority to AT96931126T priority Critical patent/ATE254104T1/de
Priority to JP9511718A priority patent/JPH11514983A/ja
Priority to AU69925/96A priority patent/AU6992596A/en
Priority to MX9801890A priority patent/MX9801890A/es
Priority to DE69630717T priority patent/DE69630717T2/de
Priority to EP96931126A priority patent/EP1019373B1/fr
Priority to US09/043,247 priority patent/US6028082A/en
Priority to BR9610081A priority patent/BR9610081A/pt
Publication of WO1997010211A1 publication Critical patent/WO1997010211A1/fr

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
PCT/FR1996/001416 1995-09-14 1996-09-13 Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant WO1997010211A1 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
AT96931126T ATE254104T1 (de) 1995-09-14 1996-09-13 1-acyl-3-phenyl-3-(3-piperidinopropyl)piperidin derivate als für den menschlichen nk3-rezeptor selektive antagonisten
JP9511718A JPH11514983A (ja) 1995-09-14 1996-09-13 新規なヒトｎｋ▲下３▼受容体選択的拮抗性化合物、これらを得るための方法、及びこれらを含有する薬学的組成物
AU69925/96A AU6992596A (en) 1995-09-14 1996-09-13 Novel human nk3 receptor-selective antagonist compounds, method for obtaining them and pharmaceutical compositions containing them
MX9801890A MX9801890A (es) 1995-09-14 1996-09-13 Nuevos compuestos antagonistas selectivos del receptor nk3 humano, procedimiento para su obtencion y composiciones farmaceuticas que los contienen.
DE69630717T DE69630717T2 (de) 1995-09-14 1996-09-13 1-acyl-3-phenyl-3-(3-piperidinopropyl)piperidinderivate als für den menschlichen nk3-rezeptor selektive antagonisten
EP96931126A EP1019373B1 (fr) 1995-09-14 1996-09-13 Derives de 1-acyl-3-phenyl-3-(3-piperidinopropyl)piperidine comme antagonistes selectifs du recepteur nk3 humain
US09/043,247 US6028082A (en) 1995-09-14 1996-09-13 Human NK3 receptor-selective antagonist compounds, method for obtaining them and pharmaceutical compositions containing them
BR9610081A BR9610081A (pt) 1995-09-14 1996-09-13 Composto solvatos processo para preparação de um composto enantiômero e composição farmacêutica

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9510776A FR2738819B1 (fr) 1995-09-14 1995-09-14 Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant
FR95/10776 1995-09-14

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09/043,247 A-371-Of-International US6028082A (en) 1995-09-14 1996-09-13 Human NK3 receptor-selective antagonist compounds, method for obtaining them and pharmaceutical compositions containing them
US09/437,203 Division US6291672B1 (en) 1995-09-14 1999-11-09 Human NK3 receptor-selective antagonist compounds, method for obtaining them and pharmaceutical compositions containing them

Publications (1)

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WO1997010211A1 true WO1997010211A1 (fr) 1997-03-20

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PCT/FR1996/001416 WO1997010211A1 (fr) 1995-09-14 1996-09-13 Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant

Country Status (11)

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US (4) US6028082A (US06291672-20010918-C00094.png)
EP (2) EP1019373B1 (US06291672-20010918-C00094.png)
JP (2) JPH11514983A (US06291672-20010918-C00094.png)
AT (1) ATE254104T1 (US06291672-20010918-C00094.png)
AU (1) AU6992596A (US06291672-20010918-C00094.png)
BR (1) BR9610081A (US06291672-20010918-C00094.png)
CA (1) CA2232007A1 (US06291672-20010918-C00094.png)
DE (1) DE69630717T2 (US06291672-20010918-C00094.png)
FR (1) FR2738819B1 (US06291672-20010918-C00094.png)
MX (1) MX9801890A (US06291672-20010918-C00094.png)
WO (1) WO1997010211A1 (US06291672-20010918-C00094.png)

Cited By (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998011090A2 (en) * 1996-09-16 1998-03-19 Warner-Lambert Company 3-alkyl-3-phenyl-piperidines
WO1998031364A1 (en) * 1997-01-21 1998-07-23 Merck & Co., Inc. 3,3-disubstituted piperidines as modulators of chemokine receptor activity
WO1999038514A1 (en) * 1998-02-02 1999-08-05 Merck & Co., Inc. Cyclic amine modulators of chemokine receptor activity
US6040316A (en) * 1996-09-16 2000-03-21 Warner-Lambert Company 3-alkyl-3-phenyl-piperidines
EP0992493A1 (en) * 1998-10-08 2000-04-12 Pfizer Inc. Substituted benzoylpiperidine derivatives and their use as Neurokinin antagonists
WO2000021931A1 (fr) * 1998-10-09 2000-04-20 Sanofi-Synthelabo Derives d'ureidopiperidine comme antagonistes selectifs des recepteurs nk3 humains
WO2000035879A1 (fr) * 1998-12-15 2000-06-22 Sanofi-Synthelabo Derives de 3-phenyl-2, 6-dioxopiperidin-3-yl propionamide et leur procede de preparation
WO2000039126A1 (fr) * 1998-12-23 2000-07-06 Sanofi-Synthelabo Procede de preparation du (r)- (+)-3-{1-[2- (4-benzoyl-2- (3,4-difluorophenyl)morpholin-2- yl)ethyl]-4-phenylpiperidin-4- yl}-1,1- dimethyluree, de ses sels, solvats et/ou hydrates
US6124319A (en) * 1997-01-21 2000-09-26 Merck & Co., Inc. 3,3-disubstituted piperidines as modulators of chemokine receptor activity
WO2000061125A2 (fr) * 1999-04-13 2000-10-19 Sanofi-Synthelabo L'osanetant dans le traitement des troubles de l'humeur
US6140349A (en) * 1998-02-02 2000-10-31 Merck & Co., Inc. Cyclic amine modulators of chemokine receptor activity
FR2824828A1 (fr) * 2001-05-21 2002-11-22 Sanofi Synthelabo Nouveaux derives de piperidinecarboxamide, un procede pour leur preparation et les compositions pharmaceutiques les contenant
WO2005016884A1 (en) 2003-08-15 2005-02-24 H. Lundbeck A/S Cyclopropyl derivatives as nk3 receptor antagonists
EA009477B1 (ru) * 2003-08-15 2008-02-28 Х. Лундбекк А/С Производные циклопропила в качестве антагонистов рецептора nk3

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2738819B1 (fr) * 1995-09-14 1997-12-05 Sanofi Sa Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant
US20020099076A1 (en) * 2000-05-25 2002-07-25 Richard Scheyer D. Use of (+)-a-(2,3-dimethoxyphenyl)-1-[2-(4-fluorophenyl) ethyl]-4-piperidinemethanol or its prodrug in the treatment of symptoms of dementia and dopamine induced psychosis
FR2873373B1 (fr) * 2004-07-23 2006-09-08 Sanofi Synthelabo Derives de 4-arylmorpholin-3-one, leur preparation et leur application en therapeutique
KR20080098070A (ko) * 2006-02-22 2008-11-06 버텍스 파마슈티칼스 인코포레이티드 무스카린성 수용체의 조절제로서의 스피로 축합된 피페리딘
WO2010008446A2 (en) * 2008-06-25 2010-01-21 Ip Dynamics, Llc Moisture resistant solar panel and method of making same
EP2391615B1 (en) * 2009-01-30 2013-01-16 F. Hoffmann-La Roche AG Piperidine derivatives as nk3 receptor antagonists
WO2021030335A1 (en) * 2019-08-12 2021-02-18 Millendo Therapeutics, Inc. A stereoisomerically pure nk-3 receptor antagonist and crystalline forms thereof

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EP0428434A2 (fr) * 1989-11-06 1991-05-22 Sanofi Composés aromatiques aminés et leurs énantiomères, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0474561A1 (fr) * 1990-09-05 1992-03-11 Sanofi Arylalkylamines, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0512901A1 (fr) * 1991-05-03 1992-11-11 Sanofi Composés polycycliques aminés et leurs énantiomères, procédé pour leur préparation et compositions pharmaceutiques en contenant
EP0515240A1 (fr) * 1991-05-03 1992-11-25 Sanofi Nouveaux composés N-alkylènepipéridino et leurs énantiomères, procédé pour leur préparation et compositions pharmaceutiques les contenant
WO1993018002A1 (fr) * 1992-03-03 1993-09-16 Elf Sanofi Sels quaternaires de piperidines 4-substitues, leur preparation et compositions pharmaceutiques les contenant
EP0625509A1 (en) * 1993-05-17 1994-11-23 Zeneca Limited N-alkyl substituted piperidine-derivatives with neurokinin receptor antagonist activity
WO1994026735A1 (en) * 1993-05-06 1994-11-24 Merrell Dow Pharmaceuticals Inc. Substituted pyrrolidin-3-yl-alkyl-piperidines useful as tachykinin antagonists
EP0673928A1 (fr) * 1994-03-18 1995-09-27 Sanofi Nouveaux dérivés de la N-(3,4-dichlorophényl-propyl)-pipéridine comme antagonistes sélectifs du récepteur NK3 humain

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Publication number Priority date Publication date Assignee Title
US5563133A (en) * 1995-02-21 1996-10-08 Eli Lilly And Company Hexamethyleneiminyl tachykinin receptor antagonists
FR2738819B1 (fr) * 1995-09-14 1997-12-05 Sanofi Sa Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0428434A2 (fr) * 1989-11-06 1991-05-22 Sanofi Composés aromatiques aminés et leurs énantiomères, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0474561A1 (fr) * 1990-09-05 1992-03-11 Sanofi Arylalkylamines, procédé pour leur préparation et compositions pharmaceutiques les contenant
EP0512901A1 (fr) * 1991-05-03 1992-11-11 Sanofi Composés polycycliques aminés et leurs énantiomères, procédé pour leur préparation et compositions pharmaceutiques en contenant
EP0515240A1 (fr) * 1991-05-03 1992-11-25 Sanofi Nouveaux composés N-alkylènepipéridino et leurs énantiomères, procédé pour leur préparation et compositions pharmaceutiques les contenant
WO1993018002A1 (fr) * 1992-03-03 1993-09-16 Elf Sanofi Sels quaternaires de piperidines 4-substitues, leur preparation et compositions pharmaceutiques les contenant
WO1994026735A1 (en) * 1993-05-06 1994-11-24 Merrell Dow Pharmaceuticals Inc. Substituted pyrrolidin-3-yl-alkyl-piperidines useful as tachykinin antagonists
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WO1998011090A3 (en) * 1996-09-16 1998-05-22 Warner Lambert Co 3-alkyl-3-phenyl-piperidines
US6040316A (en) * 1996-09-16 2000-03-21 Warner-Lambert Company 3-alkyl-3-phenyl-piperidines
WO1998011090A2 (en) * 1996-09-16 1998-03-19 Warner-Lambert Company 3-alkyl-3-phenyl-piperidines
US6602886B2 (en) 1996-09-16 2003-08-05 Warner-Lambert Company 3-alkyl-3-phenyl-piperidines
WO1998031364A1 (en) * 1997-01-21 1998-07-23 Merck & Co., Inc. 3,3-disubstituted piperidines as modulators of chemokine receptor activity
US6124319A (en) * 1997-01-21 2000-09-26 Merck & Co., Inc. 3,3-disubstituted piperidines as modulators of chemokine receptor activity
US6140349A (en) * 1998-02-02 2000-10-31 Merck & Co., Inc. Cyclic amine modulators of chemokine receptor activity
WO1999038514A1 (en) * 1998-02-02 1999-08-05 Merck & Co., Inc. Cyclic amine modulators of chemokine receptor activity
US6476054B1 (en) 1998-02-02 2002-11-05 Merck & Co., Inc. Cyclic amine modulators of chemokine receptor activity
EP0992493A1 (en) * 1998-10-08 2000-04-12 Pfizer Inc. Substituted benzoylpiperidine derivatives and their use as Neurokinin antagonists
WO2000021931A1 (fr) * 1998-10-09 2000-04-20 Sanofi-Synthelabo Derives d'ureidopiperidine comme antagonistes selectifs des recepteurs nk3 humains
US6465489B1 (en) 1998-10-09 2002-10-15 Sanofi-Synthelabo Ureidopiperidine derivatives as selective human NK3 receptor antagonists
WO2000035879A1 (fr) * 1998-12-15 2000-06-22 Sanofi-Synthelabo Derives de 3-phenyl-2, 6-dioxopiperidin-3-yl propionamide et leur procede de preparation
US6342607B1 (en) 1998-12-15 2002-01-29 Sanofi-Synthelabo 3-phenyl-2, 6-dioxopiperidin-3-yl propionamide derivatives and method for preparing same
US6452012B1 (en) 1998-12-15 2002-09-17 Sanofi-Synthelabo 3-phenyl-2,6-dioxopiperidin-3-ylpropionamide derivatives and method for preparing same
US6392039B1 (en) 1998-12-23 2002-05-21 Sanofi-Synthelabo Method for preparing (R)-(+)-3 {1-[2-(4-benzoyl-2(3, 4-difluorophenyl)morpholin-2-yl)ethyl]-4-phenylpiperidin-4-yl}-1,1-dimethylurea, its salts solvates and/or hydrates
WO2000039126A1 (fr) * 1998-12-23 2000-07-06 Sanofi-Synthelabo Procede de preparation du (r)- (+)-3-{1-[2- (4-benzoyl-2- (3,4-difluorophenyl)morpholin-2- yl)ethyl]-4-phenylpiperidin-4- yl}-1,1- dimethyluree, de ses sels, solvats et/ou hydrates
WO2000061125A3 (fr) * 1999-04-13 2001-04-19 Sanofi Synthelabo L'osanetant dans le traitement des troubles de l'humeur
US6420388B1 (en) 1999-04-13 2002-07-16 Sanofi-Synthelabo Osanetant in the treatment of depression and depressive disorders
WO2000061125A2 (fr) * 1999-04-13 2000-10-19 Sanofi-Synthelabo L'osanetant dans le traitement des troubles de l'humeur
FR2824828A1 (fr) * 2001-05-21 2002-11-22 Sanofi Synthelabo Nouveaux derives de piperidinecarboxamide, un procede pour leur preparation et les compositions pharmaceutiques les contenant
WO2002094821A1 (fr) * 2001-05-21 2002-11-28 Sanofi-Synthelabo Nouveaux derives de piperidinecarboxamide, un procede pour leur preparation et les compositions pharmaceutiques les contenant
WO2005016884A1 (en) 2003-08-15 2005-02-24 H. Lundbeck A/S Cyclopropyl derivatives as nk3 receptor antagonists
EA009477B1 (ru) * 2003-08-15 2008-02-28 Х. Лундбекк А/С Производные циклопропила в качестве антагонистов рецептора nk3
AU2004265020B2 (en) * 2003-08-15 2009-07-16 H. Lundbeck A/S Cyclopropyl derivatives as NK3 receptor antagonists
AU2004265020B8 (en) * 2003-08-15 2009-11-05 H. Lundbeck A/S Cyclopropyl derivatives as NK3 receptor antagonists
US7834008B2 (en) 2003-08-15 2010-11-16 H. Lundbeck A/S Cyclopropyl derivatives as NK3 receptor antagonists

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ATE254104T1 (de) 2003-11-15
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EP1019373B1 (fr) 2003-11-12
US20020049329A1 (en) 2002-04-25
EP1019373A1 (fr) 2000-07-19
US6028082A (en) 2000-02-22
FR2738819B1 (fr) 1997-12-05
JP2008115182A (ja) 2008-05-22
DE69630717D1 (de) 2003-12-18
BR9610081A (pt) 1999-01-05
US6291672B1 (en) 2001-09-18
DE69630717T2 (de) 2004-09-23
EP1241168A1 (fr) 2002-09-18
US6710042B2 (en) 2004-03-23
CA2232007A1 (en) 1997-03-20
US20040220223A1 (en) 2004-11-04

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