WO1997005917A1 - Device in inhalers - Google Patents

Device in inhalers Download PDF

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Publication number
WO1997005917A1
WO1997005917A1 PCT/SE1996/000969 SE9600969W WO9705917A1 WO 1997005917 A1 WO1997005917 A1 WO 1997005917A1 SE 9600969 W SE9600969 W SE 9600969W WO 9705917 A1 WO9705917 A1 WO 9705917A1
Authority
WO
WIPO (PCT)
Prior art keywords
gas
flow path
air
air flow
constriction
Prior art date
Application number
PCT/SE1996/000969
Other languages
English (en)
French (fr)
Inventor
Lars Asking
Kjell Bäckström
Henri Hansson
Magnus Jahnsson
Original Assignee
Astra Aktiebolag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to SK171-98A priority Critical patent/SK17198A3/sk
Priority to EP96925235A priority patent/EP0902700A1/en
Priority to JP9508364A priority patent/JPH11510411A/ja
Priority to US08/817,800 priority patent/US5918594A/en
Application filed by Astra Aktiebolag filed Critical Astra Aktiebolag
Priority to AU65391/96A priority patent/AU703128B2/en
Priority to CA002227547A priority patent/CA2227547A1/en
Priority to BR9609880A priority patent/BR9609880A/pt
Priority to EE9800042A priority patent/EE9800042A/xx
Priority to MX9800826A priority patent/MX9800826A/es
Priority to IL12276096A priority patent/IL122760A0/xx
Priority to PL96324865A priority patent/PL324865A1/xx
Priority to NZ313351A priority patent/NZ313351A/en
Publication of WO1997005917A1 publication Critical patent/WO1997005917A1/en
Priority to IS4661A priority patent/IS4661A/is
Priority to NO980565A priority patent/NO980565L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M11/00—Sprayers or atomisers specially adapted for therapeutic purposes
    • A61M11/001—Particle size control
    • A61M11/002—Particle size control by flow deviation causing inertial separation of transported particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2202/00—Special media to be introduced, removed or treated
    • A61M2202/06—Solids
    • A61M2202/064—Powder

Definitions

  • the present invention relates to an inhalation device comprising means for breaking down aggregates of finely divided powdered medicament having a particle size less than 10 ⁇ m to provide a finely divided medicament having a large amount of particles within the respiratory range, i.e. having particle sizes less than 10 ⁇ m.
  • the diameter of particles of the medicament to be inhaled is less than 10 ⁇ m to ensure the adequate penetration of the particles into the bronchial region of the lungs.
  • Non-defined agglomerates or aggregates are formed at random when this finely divided powdered medicament is handled, for instance during storage, conveying, sieving, sifting, mixing or grinding.
  • the inhalation device is provided with means which break down just before or during inhalation the said agglomerates or aggregates formed from the finely divided powder into the primary particles having a particles size within the respiratory range, of less than 10 ⁇ m, preferably less than 5 ⁇ m
  • the particles are bigger than 10 ⁇ m they will not penetrate to the bronchial region of the lungs but will end up in the oro-laryngeal tract or, if swallowed, in the gastrointestinal tract where they could lead to unwanted side-effects. Particles could more easily be retained in the device which also leads to a loss of particles which will have a negative effect on the exactness of the doses.
  • Means for breaking down agglomerates/aggregates of powder created in finely divided powdered medicaments having a particle size less than 10 ⁇ m are known in the prior art.
  • One example of such means is described in EP-B-069715.
  • a rotating, propeller-like device is provided in the air conduit as deagglomeration means.
  • Another example is described in EP-B-237 507, where a stationary deflector device is provided in the mouth-piece and/or the air conduit of a breath-actuated dry powder inhaler having a container for multiple doses.
  • These stationary deflector devices will, during inhalation, provide a deaggregating effect as they are constructed to create a turbulent movement in the air flow carrying the substance. Due to this turbulent movement the particles will impact on the walls of the air conduit and the deflector devices and collide with each other and in this manner break down into particles within the respiratory range.
  • a disposable breath-actuated dry powder inhaler for single use is disclosed.
  • This inhaler is provided with means for breaking down agglomerates /aggregates in the air conduit.
  • the deagglomerating means are also in this inhaler constructed to create a turbulent movement in the air flow during inhalation. This is achieved as all of the deagglomerating means are constructed as planar surfaces oriented about 30° relative to the longitudinal direction of the tubular housing of the inhaler.
  • an inhalation device comprising means for breaking down aggregates, the device being characterised in that said means comprise at least one pair of surfaces in a gas/air flow path, the first surface of the pair providing an inlet surface of a constriction in the gas/air flow path whereby the speed of gas/air passing along the flow path through the constriction is increased, and the second surface of the pair is situated at or near the outlet of the constriction and provides an impact surface so that in use aggregates or particles impact said second surface whereby said first and second surfaces are oriented at different angles to the longitudinal direction of the flow path and whereby said first and second surfaces are oriented at different angles to the longitudinal direction of the flow path.
  • Figure 1 shows a preferred embodiment of the deaggregation means according to the present invention
  • Figure 2 shows first deaggregation means according to the invention as shown in figure 1 ; and Figure 3 shows the two bodies of the second deaggregation means according to the invention as shown in figure 1.
  • deaggregation means are placed in the gas/air flow path of the inhalation device.
  • deaggregation means can be provided as walls, as described in the above mentioned documents.
  • the deaggregation means of the present invention are in the preferred embodiment designed to be placed in the gas/air flow path of a unit dose dry powder inhaler but the construction of the deaggregation means could easily be adapted to be placed in the gas/air flow path of any dry powder inhaler having a dose 8 which comprises aggregates of a powdered substance placed in an gas/air flow path 10, an air inlet 5 and an air outlet 6. Said air inlet 5 and air oudet 6 are positioned at a distance from each other, whereby the gas/air flow during inhalation will pass in said gas/air flow path between the air inlet and the air outlet thereby lifting the dose so that it can be carried along by the gas in the gas/air flow.
  • a dose 8 which comprises aggregates of a powdered substance placed in an gas/air flow path 10, an air inlet 5 and an air outlet 6.
  • Said air inlet 5 and air oudet 6 are positioned at a distance from each other, whereby the gas/air flow during inhalation will pass in said gas
  • the description of the device is related to this embodiment but this is only given as an example and for the matter of clarity.
  • several sets of oblique planar surfaces are provided along the gas/air flow path 10 in the inhaler.
  • the dose 8 is placed in a magazine (not shown) which could be a unit dose magazine or a magazine which could be refilled for the following inhalations.
  • Said oblique surfaces provide constrictions in the gas/air flow path which will result in an acceleration of the inhalation gas/air flow and guidance during its passage through the gas/air flow path.
  • the aggregates and/or particles will thereby be forced to impact on the walls and surfaces of the gas/air flow path.
  • the deaggregation means have substantially two different forms and constructions.
  • the first deaggregation means 20 and 30 are formed as pairs of walls 21a, 21b and 31a, 31b respectively extending with an angle eta and oct * respectively, to the main direction (Arrow A in the figures) of the gas/air flow and the longitudinal centre axis of symmetry of the gas/air flow path 10 and the device seen from the air inlet to the air outlet.
  • Said longitudinal centre axis is marked with X-X in figures 1-3.
  • said pairs of walls extend from the edges of the housing on both sides of the gas/air flow path symmetrically and are spaced apart so as to provide a passage for the gas/air flow and a restriction in the gas/air flow path.
  • the first pair of walls 21a, 21b are placed adjacent the release area of the dose 8.
  • Said pairs of walls 21a, 21b and 31a, 31b are connected to a part 22a, 22b and 32a, 32b respectively being longitudinal in the main direction A of the gas/air flow.
  • Said longitudinal parts extend parallel to the main direction A of the gas air flow and are spaced apart so as to provide a passage for the gas/air flow.
  • the other end of said longitudinal parts 22a, 22b and 32a, 32b are connected to a wall 23a, 23b and 33a, 33b respectively which together with the first wall and the longitudinal part of each deaggregation means form a quadrangle 20, 30 respectively.
  • FIGS 1 and 2 a preferred embodiment of these first deaggregation means are shown.
  • the angle and form of the walls 23a, 23b and 33a, 33b are only of importance for the construction and geometry of the deaggregation means and the gas/air flow path and is not important for the function of the device.
  • the important feature for the function is the aim to minimise the retention of substance in the gas/air flow path. Therefore any angle and/or form of said walls having this function can be used.
  • the second deaggregation means 40, 50 are formed as pairs of walls 41a, 41b and 51a, 51b respectively.
  • the two walls in each pair of walls are connected to each other and form a tip or point 42, 52 respectively.
  • Said tip or point 42, 52 is provided in the centre of the gas/air flow path 10 and coincides with the longitudinal axis of symmetry X-X of the gas/air flow path and also with the main direction A of the gas/air flow seen from the air inlet 5 to the air outlet 6.
  • said second deaggregation means 40, 50 are formed as quadrangles being symmetrical around their longitudinal axis Y-Y as can be seen in figures 3. Said quadrangles will thereby be foimed so that the longitudinal axis of each quadrangle will be parallel and in the preferred embodiment coincide with the longitudinal axis of symmetry X-X of the gas/air flow path.
  • the impaction surface 41a, 41b and 51a, 51b of said deaggregation means are provided at angles ⁇ and ⁇ , respectively, to the main direction A of the gas/air flow and the longitudinal axis of symmetry X-X of the gas/air flow path and the device seen from the air inlet 5 to the air outlet 6.
  • the preferred embodiment of the second deaggregation means 40 and 50 are shown in figure 3.
  • the first and second deaggregation means 20, 30 and 40, 50 are positioned in the gas/air flow path in a manner which give rise to acceleration areas for the gas/air flow and the aggregates/particles as well as guidance whereby the aggregates and particles are forced to impact on the walls of said deaggregation means.
  • the form of the deaggregation means has been determined by tests and the most optimal forms for the above mentioned purpose have shown to be the ones represented in figure 1.
  • the forms of the deaggregation means are also of importance for retention of substance in the gas/air flow path as well as for the gas/air flow resistance of an inhaler in which the deaggregation means are provided.
  • the deaggregation means are formed as triangles with the tip of the triangles facing the direction of the air flow during inhalation the backside of the means will have a generally flat surface positioned perpendicular to the inhalation air flow. This will give rise to substantial retention.
  • the ⁇ , and ott should be substantially about 30° to the main direction of the gas/air flow seen from the air inlet to the air outlet and to a longitudinal axis being parallel to the longitudinal axis of symmetry of the device.
  • the choice of 30° for these angles is dependent on minimising the flow resistance and retention of substance as well as optimising the acceleration of the air/gas flow upon entry into the first constriction in the gas/air flow path.
  • the value of the angle ⁇ is substantially about 45° to the main direction of the gas air flow seen from the air inlet to the air outlet and to the longitudinal axis of the device.
  • the value of the angle ⁇ is substantially about 60° to the main direction of the gas/air flow seen from the air inlet to the air outlet and to the longitudinal axis of the device. The choice of these values is based on test results, a summary of which is shown below.
  • index is based on the following calculation:
  • I is the Index
  • F is the fraction of fine particles
  • Re is the retention in percentage of total dose
  • C is the inhalation resistance (C-value).
  • test no. 2 with ⁇ being 45° and ⁇ being 60° showed the highest index.
  • test no. 4 with ⁇ being 45° and ⁇ being 21° showed the lowest index. This indicates that ⁇ ⁇ ⁇ is more favourable then ⁇ > ⁇ .
  • the device according to the invention is simple to produce. It is preferably produced in two pieces, a first substantially flat part and a second part in which the air flow path with the constrictions and the deaggregation parts is formed during a moulding or cold forming procedure. The two parts are then connected to each other in manner that provides a air tight seal between the two parts. For this purpose heat- or cold-sealing, laser-welding or ultra sonic welding could be used as well as any other suitable sealing method.
  • the two parts of the device are preferably made of plastic material but any other material in which the required air flow path can be easily formed can be used.
  • the device could also be formed by two identical parts which are sealingly connected to each other. This is however a more complicated method.
  • first and second deagglomeration means are formed as quadrangles having the described form. It is however clear that the form of the deagglomeration means can be varied.
  • the "backside" of the deagglomeration means can have any form which preferably does not give raise to a significant reduction in the speed of the gas/air flow or substantial retention of substance as mentioned above.
  • the second deagglomeration means could for example be formed as triangles or being V-formed whereby the top of the triangle or the tip of the V is placed in the center of the gas/air flow path of the device.
  • the values of angles ⁇ ,, ⁇ *, and ⁇ , ⁇ could be changed although the performed tests show that the most optimate value of these angles are the ones as stated above.

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PCT/SE1996/000969 1995-08-10 1996-07-23 Device in inhalers WO1997005917A1 (en)

Priority Applications (14)

Application Number Priority Date Filing Date Title
CA002227547A CA2227547A1 (en) 1995-08-10 1996-07-23 Device in inhalers
JP9508364A JPH11510411A (ja) 1995-08-10 1996-07-23 吸入器における装置
US08/817,800 US5918594A (en) 1995-08-10 1996-07-23 Inhaler with deagglomerating device
EE9800042A EE9800042A (et) 1995-08-10 1996-07-23 Inhalaatorites kasutatav seade
AU65391/96A AU703128B2 (en) 1995-08-10 1996-07-23 Device in inhalers
EP96925235A EP0902700A1 (en) 1995-08-10 1996-07-23 Device in inhalers
BR9609880A BR9609880A (pt) 1995-08-10 1996-07-23 Dispositivo de inalação
SK171-98A SK17198A3 (en) 1995-08-10 1996-07-23 Device in inhalers
MX9800826A MX9800826A (es) 1995-08-10 1996-07-23 Dispositivo para inhaladores.
IL12276096A IL122760A0 (en) 1995-08-10 1996-07-23 Device in inhalers
PL96324865A PL324865A1 (en) 1995-08-10 1996-07-23 Apparatus for use in inhalers
NZ313351A NZ313351A (en) 1995-08-10 1996-07-23 Inhalation device with paired surfaces which provide airflow speed increase then impingement to enhance breakdown of powdered aggregate
IS4661A IS4661A (is) 1995-08-10 1998-01-27 Tæki í innúðara
NO980565A NO980565L (no) 1995-08-10 1998-02-10 Anordning ved inhalatorer

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9502799A SE9502799D0 (sv) 1995-08-10 1995-08-10 Device in inhalers
SE9502799-1 1995-08-10

Publications (1)

Publication Number Publication Date
WO1997005917A1 true WO1997005917A1 (en) 1997-02-20

Family

ID=20399154

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SE1996/000969 WO1997005917A1 (en) 1995-08-10 1996-07-23 Device in inhalers

Country Status (24)

Country Link
US (1) US5918594A (ja)
EP (1) EP0902700A1 (ja)
JP (1) JPH11510411A (ja)
KR (1) KR19990036287A (ja)
CN (1) CN1192702A (ja)
AR (1) AR003078A1 (ja)
AU (1) AU703128B2 (ja)
BR (1) BR9609880A (ja)
CA (1) CA2227547A1 (ja)
CZ (1) CZ38398A3 (ja)
EE (1) EE9800042A (ja)
HU (1) HUP9802454A3 (ja)
ID (1) ID15911A (ja)
IL (1) IL122760A0 (ja)
IS (1) IS4661A (ja)
MX (1) MX9800826A (ja)
NO (1) NO980565L (ja)
NZ (1) NZ313351A (ja)
PL (1) PL324865A1 (ja)
SE (1) SE9502799D0 (ja)
SK (1) SK17198A3 (ja)
TR (1) TR199800198T1 (ja)
WO (1) WO1997005917A1 (ja)
ZA (1) ZA966776B (ja)

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NO980565D0 (no) 1998-02-10
ZA966776B (en) 1997-02-10
HUP9802454A2 (hu) 1999-02-01
JPH11510411A (ja) 1999-09-14
US5918594A (en) 1999-07-06
KR19990036287A (ko) 1999-05-25
IL122760A0 (en) 1998-08-16
SK17198A3 (en) 1998-09-09
CZ38398A3 (cs) 1998-05-13
HUP9802454A3 (en) 1999-04-28
AR003078A1 (es) 1998-05-27
AU703128B2 (en) 1999-03-18
SE9502799D0 (sv) 1995-08-10
TR199800198T1 (xx) 1998-06-22
IS4661A (is) 1998-01-27
ID15911A (id) 1997-08-21
AU6539196A (en) 1997-03-05
MX9800826A (es) 1998-04-30
NZ313351A (en) 1999-04-29
EP0902700A1 (en) 1999-03-24
NO980565L (no) 1998-02-10
CN1192702A (zh) 1998-09-09
EE9800042A (et) 1998-08-17
PL324865A1 (en) 1998-06-22
CA2227547A1 (en) 1997-02-20
BR9609880A (pt) 1999-03-23

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