WO1997004733A1 - Doseur buccal - Google Patents

Doseur buccal Download PDF

Info

Publication number
WO1997004733A1
WO1997004733A1 PCT/JP1996/002044 JP9602044W WO9704733A1 WO 1997004733 A1 WO1997004733 A1 WO 1997004733A1 JP 9602044 W JP9602044 W JP 9602044W WO 9704733 A1 WO9704733 A1 WO 9704733A1
Authority
WO
WIPO (PCT)
Prior art keywords
cylinder
plunger
wall
oral administration
administration device
Prior art date
Application number
PCT/JP1996/002044
Other languages
English (en)
Japanese (ja)
Inventor
Hirotaka Nishida
Hirokazu Mihashi
Mitsuru Yasumura
Kazunari Yamashita
Original Assignee
Taisei Kako Co., Ltd.
Fujisawa Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taisei Kako Co., Ltd., Fujisawa Pharmaceutical Co., Ltd. filed Critical Taisei Kako Co., Ltd.
Publication of WO1997004733A1 publication Critical patent/WO1997004733A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015—Devices specially adapted for taking medicines
    • A61J7/0053—Syringes, pipettes or oral dispensers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3104—Caps for syringes without needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe

Definitions

  • the present invention relates to a device for orally administering a solid drug or the like to a patient and / or an infant or the like in the form of a solution or suspension thereof (hereinafter sometimes referred to as a “drug”).
  • Dosing device Specifically, the present invention combines a container for dissolving or suspending a solid drug such as a granule in a solvent such as water to prepare a drug solution, and a tool for oral administration of the obtained drug solution to a patient as described above.
  • Drug delivery device combines a container for dissolving or suspending a solid drug such as a granule in a solvent such as water to prepare a drug solution, and a tool for oral administration of the obtained drug solution to a patient as described above.
  • FIG. 1 Each figure collectively shown in FIG. 1 is a schematic diagram sequentially showing a conventional preparation of a drug solution and an oral administration method.
  • the stage shown in Fig. 1A is a stage in which the medicinal solution prepared in the measuring cup (M) is sucked from the measuring cup (M) with a normal syringe (S).
  • the stage shown in FIG. 1B shows a stage in which oral administration is performed by inserting the tip of the syringe (S) that has absorbed the prepared drug solution into the patient's mouth.
  • a solid pharmaceutical particularly granules or fine granules
  • water is added to a measuring cup (M) containing the drug to dissolve or suspend the drug.
  • Dosing method Have been done.
  • Some drugs to be administered require that the entire amount of the measured drug be administered accurately from the viewpoint of their efficacy or side effects.
  • the drug to be administered is water-soluble, there is no particular problem in the combination of the conventional drug preparation method and the administration method whether or not the prepared drug is exactly administered in the entire amount.
  • the drug to be administered is administered as a suspension because it is difficult to dissolve in water, a portion of the insoluble drug may be dispensed at the time of administration with a measuring cup (M) and a cylinder (S). ), There is a problem that the dose may be inaccurate as a result.
  • An object of the present invention is to solve the above-mentioned problems inevitable in the conventional method.
  • An object of the present invention is to develop an oral administration device having the following advantages.
  • Oral administration of a medicinal solution consisting mainly of a cylinder with a liquid passage hole at the outlet end of the body, a hakama tube crowned at the outlet end area, and a plunger inserted into the cylinder
  • the hakama tube is the inner surface of the bottom plate
  • a first plug pin that rises up from the front end, and wherein the first plug pin is fitted in a liquid-tight manner in a liquid hole of a cylinder body.
  • the hakama tube accommodates the lower half of the cylinder body, in which state the hakama tube can be substantially upright by its bottom surface, and has a substantially upright first plug pin substantially at the center of the bottom plate.
  • a drug solution oral administration tool that watertightly fits the plug pin into the liquid hole at the lower end of the cylinder body.
  • a drug solution oral administration device wherein a first engaging means is provided on an outer wall of a cylinder body, and a second engaging means is provided on an inner wall of a skirt tube, and the two can be engaged with each other.
  • a second plug pin that can be fitted into the through-hole of the cylinder, a plunger having a shape in which the plunger can be in close contact with the inner wall of the tip of the cylinder, a liquid extrusion flange adjacent to the head of the plunger;
  • a chemical solution oral administration device equipped with a sliding gasket.
  • One or more vertical grooves are provided on the inner wall of the upper half of the cylinder body from the opening edge of the upper end toward the container bottom, and the lower end is located at a position lower than the position where the content liquid comes into contact with the liquid extrusion flange of the plunger.
  • Oral administration device for drug solution located at the top.
  • a drug solution oral administration device with an upper opening hopper formed at the upper end of the cylinder body.
  • a drug solution oral administration device provided with a finger hook on the outer wall of the body of the cylinder to facilitate gripping with fingers and the like.
  • a drug solution oral administration device in which a detachment prevention device is slidably fitted on a section from an intermediate flange to a tail end on an outer wall of a plunger.
  • Fig. 1 is a schematic diagram showing the procedure for preparing a drug solution by the conventional method and the stage in which the patient takes the obtained drug solution orally.
  • Fig. 1A shows the drug solution prepared in the measuring cup.
  • Fig. 1B shows a stage in which the prepared syringe is sucked with a normal syringe, and the tip of the syringe, in which the prepared drug solution is sucked, is inserted into a patient's mouth to perform oral administration.
  • FIG. 2 is a schematic longitudinal sectional view showing a procedure for preparing a drug solution using the administration device according to the embodiment of the present invention
  • FIG. 2A is a cylinder constituting the administration device of the present invention
  • FIG. 2B is an upright skirt tube constituting the administration device of the present invention
  • FIG. 2C is a schematic cross-sectional view showing a procedure for preparing a drug solution in a cylinder.
  • Figure 3 shows the solid drug and water contained in the cylinder and the stage immediately before the plunger is inserted until the solid drug is shaken and dissolved or suspended.
  • Figure 3A shows the solid drug and water.
  • Figure 3B shows a state in which the fitting body between the cylinder housing the stake and the hakama tube stands upright with the opening posture upward, and the stopper is detached from the plunger. The inserted state is shown, and
  • FIG. 3C shows the stage of dissolving or suspending the solid drug.
  • Figure 4 is a schematic cross-sectional view showing a state in which the solid drug is sufficiently dissolved or suspended, and subsequently, a state in which the skirt tube has been removed from the cylinder.
  • Fig. 5 shows the state in which the medicinal solution is actually administered after the medicinal solution is prepared, that is, the plunger rod is inserted into the cylinder with the flow tube located at the tip of the cylinder facing the target. Indicates the finished state 0
  • the dispensing device of the present invention and the shape and structure thereof will be described with reference to the drawings while comparing the conventional dispensing method with the dispensing device used therein.
  • the terms “up, down, left, and right” in the drawings are expressions for convenience of description, and are based on the relative positional relationships in the drawings.
  • the “upstream side” is the hopper below, and the “downstream side” is the flow pipe side.
  • FIG. 2 is a schematic longitudinal sectional view showing a procedure for preparing a drug solution using the oral administration device according to the embodiment of the present invention.
  • the embodiment shown in FIG. 2A is a cylinder (1) that constitutes the dispensing device of the present invention, and an upper opening hopper (or funnel) (3) is formed at the upper end of the body (2).
  • a rod-like member protrudes from the outer wall downstream of the hopper (3) as a finger hook (4) for pushing the plunger (described later).
  • the donation makes it easy to store the medicine and / or water in the cylinder (1), and also makes it easier to administer the prepared medicinal solution.
  • a male screw is provided as a first engagement means (5) in a lower part of the outer wall of the cylinder body (2).
  • the first engagement means (5) is provided in relation to a skirt tube (6) described below. Further, the downstream end (head) outer wall (7) of the cylinder body (2) is formed into a soft curved surface (usually a spherical surface), and a liquid passage pipe (8) is provided substantially on the central axis thereof. A liquid passage hole (9) penetrating the liquid passage pipe (8) allows liquid to flow inside and outside the cylinder body (2).
  • the soft curved surface is usually a spherical surface, but other examples are quadratic portions lacking an angular portion or a sharp portion such as a spheroidal surface, a paraboloid of revolution, or a hyperboloid of revolution. It is a curved surface.
  • the inner wall (10) of the cylinder body (2) is provided with a vertical groove (11) starting from the lower end of the hopper (3) and facing downward.
  • the lower end position of the vertical groove (11) is selected to be higher than the position where the liquid extrusion flange (14) reaches when the head (13) of the plunger (12) described below is completely immersed in the liquid.
  • the vertical groove (11) plays the role of the plunger head (13).
  • the surface of the liquid contained in the cylinder body (2) to allow air or the like to flow out to prevent an increase in internal pressure.
  • only one vertical groove (1 1) is sufficient, usually two or more vertical grooves are provided. In each figure of FIG. 2, four vertical grooves (11) are arranged at substantially equal intervals on the circumference (at a central angle of about 90 degrees).
  • the inner wall downstream of the cylinder body (2) is The inner wall near the boundary where it transitions to a normally spherical surface is provided with a reduced diameter portion (15) to support the surface facing the head of the liquid extrusion flange (14) of the later-mentioned plunger (12). (14) Prevent the risk of failure due to the unreasonable approach.
  • the secondary curved surface of the inner wall of the head of the cylinder body (2) is also preferably a curved surface that is as close as possible (fitted) to the shape of the outer wall of the plunger head described later.
  • the secondary curved surface of the inner wall of the head of the cylinder body (2) is also the secondary curved surface of the outer wall of the plunger head.
  • the curved surface is also spherical.
  • the embodiment shown in FIG. 2B is an upright hakama tube (6), which is formed into a substantially flat bottomed cylindrical body, and a first plug pin (17) is provided substantially at the center of the bottom plate (16).
  • the first plug pin (17) stands upright and fits in a fluid-tight hole (9) of the cylinder body (2) in a water-tight manner to prevent leakage of the content liquid.
  • first engagement means (5) provided on the lower portion of the outer wall of the cylinder body (2) is provided on the inner wall (18) of the tubular member (6) of the embodiment shown in FIG. 2B.
  • a female screw is provided as a second engaging means (19) for engaging with the male screw.
  • the two engaging means are not limited to the screw mount type, but may be a bayonet mount type or a snap type such as a combination of an elastic ridge and a concave.
  • FIG. 2C shows a procedure for preparing a chemical solution in the cylinder (1) constituting the administration device of the present invention, and the male screw (5) and the hakama tube (6) of the cylinder (1) are used.
  • the female thread (19) of the cylinder (1) is engaged, and the liquid passage pipe (8) of the cylinder (1) is inserted upright into the first plug pin (17) of the hakama pipe (6).
  • the solid medicine is dropped into the cylinder (1) from the upper container (20), and in the right figure, water is poured into the cylinder (1) from the upper container (21).
  • the fitting body of the cylinder (1) and the hakama tube (6) prepared in the embodiment shown in FIG. 2C stands upright with the opening posture upward.
  • the stage immediately before the plunger (12) is inserted from above into the system in which the solid drug and water are contained in the underbody (2) is shown.
  • the bottom of the bottom plate (16) of the hakama pipe (6) goes upward from the center of the bottom plate (16) in the liquid flow hole (9) provided near the center of the liquid pipe (8) at the lower end of the cylinder body (2).
  • the protruding first plug pin (17) is fitted in a watertight manner to prevent leakage of water and the like contained in the cylinder body (2).
  • the plunger (12) is composed of a rod (22), a sliding gasket (piston) (23), a rod (22) and a sliding gasket (23). ) And the plunger head (13), and the liquid extrusion flange between the sliding gasket (23) and one plunger head (13). (14) and a second Bragg pin (25) projecting from the tip of the plunger head (13).
  • a stopper (26) is shown.
  • the stopper (26) is provided with a plunger (12) passed through an opening (27) therein.
  • a plunger (12) passed through an opening (27) therein.
  • FIG. 3B shows a state in which the plunger (12) has been inserted into the cylinder body (2). From the embodiment shown in FIG. In the process of reaching the above mode, gas interposed between the surface of the liquid contained in the cylinder body (2) and the head (13) of the plunger (12) is discharged from the flute (11). ing. Therefore, at this stage, the head (13) of the plunger (12) is in close contact with the liquid surface, and the desorption prevention tool (26) is used here as the hopper (3) that constitutes the cylinder (1). Substantially touches the upper edge (28) of the.
  • the detachment preventing device (26) is substantially flat and has an outer edge region having a shape to be engaged with the upper edge (28) of the hopper (3), and the plunger (12) comes out of the opening (27). If not, it is enough. However, since the stopper (26) does not need to completely cover the upper end opening of the hopper (3), the outer shape does not have to be similar to the outer edge shape of the opening, For example, it may be Y-shaped, triangular, cross-shaped, star-shaped or gear-shaped.
  • the detachment preventing device (26) includes an engagement projection (29) extending downward from the peripheral edge thereof, as exemplified in any of the embodiments shown in FIG. 3, and the center of the extension (29).
  • a through-hole that can be drilled to fit a protrusion sandwiched between two adjacent notches (30) provided on the upper edge (28) of the hopper (3) and the overhang (29)
  • Two or more engaging overhangs (29) having a lower detachment prevention type sander cut (31) on the inner wall of the lower edge are provided substantially symmetrically (point symmetrical or line symmetrical) about the center axis thereof, and the opening (
  • An opening (27) that is slidable on the outer surface of the rod-shaped portion (22) and whose inner diameter is sufficiently smaller than the outer diameter of the intermediate flange (24) located at the upper end of the sliding gasket (23).
  • the detachment prevention device (26) is substantially disk-shaped, and engagement protrusions (29) stand at substantially equal intervals (at a center angle of approximately 90 degrees) from four locations on the outer periphery. The top is on.
  • the notch (30) corresponding to the above-mentioned engaging overhang (29) is also provided at the corresponding location at the upper edge (28) of the hopper (3) located at the upper end of the cylinder body (2). The number is provided (not shown). In the embodiment shown in FIG.
  • the engagement overhang (29) of the anti-disengagement device (26) is cut out (30) in order to fix the state where the insertion of the plunger (12) has reached the expected stage. ), And then rotated in a predetermined range of angle in either direction to complete the engagement between the two.
  • What is formed by the combination of this engagement and insertion is referred to as a fitting insertion body.
  • the above-mentioned engagement means is merely an example, and the engagement projection (29) is connected to the disengagement prevention device (26). ) Is a so-called snap coupling that uses the flexibility (elasticity) of the engaging overhang (29) without providing a corresponding cutout (30) on the cylinder (1) side only by providing it in the outer peripheral area of (1). You can do that too.
  • the steps of the embodiment shown in FIG. 3C are those of the dissolution or suspension operation of the solid drug. That is, at this stage, leakage of the liquid is a harm that is prevented, so the fitting insert is shaken up and down, preferably along its long axis, to promote dissolution or suspension. Of course, it may be shaken by a swinging method while supporting any part of the drug solution oral administration device.
  • FIG. 4 shows the state in which the solid drug is sufficiently dissolved or suspended, and the solid drug (the first engaging means (5) of 0) and the second engaging means (19) of the skirt tube. ) Is disengaged and the skirt tube (6) is removed from the cylinder (1), and the medicinal-oral administration device can be used after this point.
  • the stage shown in Fig. 5 is a state in which the chemical solution is actually applied after the preparation of the chemical solution, that is, the liquid flow pipe (8) located at the tip of the cylinder body (2) is directed toward the target. The rod (22) of the plunger (12) has been inserted into the cylinder body (2).
  • the head (13) of the plunger (12) is in contact with the reduced diameter portion (15) of the cylinder (1) and protrudes from the tip of the head (13) of the plunger (12).
  • the second plug pin (25) is tightly fitted into the liquid passage hole (9) located at the downstream end of the cylinder (1).
  • the material for forming the drug solution oral administration device of the present invention is a resin, and that the resin is excellent in moisture barrier properties and has high rigidity. Further, it is even more preferable that the gas barrier property is excellent.
  • the cylinder (1) and the head (13) of the plunger (12) are made of a resin having the above properties, but the rigidity of the stopper (26) is very high. Is not required separately, but rather it is important to have elasticity that can be called moderate flexibility. It is also important for the gasket (23) to have self-lubricating properties in addition to moderate flexibility.
  • the head (13) of the cylinder (1) and the plunger (12) is a polymer resin of an alicyclic hydrocarbon containing a condensed ring structure or a 1-olefin (-) such as ethylene.
  • a gasket (23) for the desorption preventive device (26) and gasket (23). It is preferably formed of a flexible resin represented by a homopolymer resin, a copolymer resin or a composition thereof. Representative examples of this type of resin are described in JP-A-4-14685.
  • the term "resin” is not limited to crystalline polymers, but also includes polymers that are recognized as "resins" in the resin processing industry and distributed even if they are low-crystalline or amorphous polymers. I do.
  • the attached stopper prevents the plunger from slipping out of the plunger, so that there is no risk of leakage of the drug solution before administration.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

L'invention porte sur un doseur buccal dont l'utilisation consiste à introduire un cylindre (1) présentant un orifice de passage pour un fluide (9) dans un tube gaine (6) muni d'une première aiguille d'emboîtement (17) saillant de son fond (16), puis à introduire dans l'orifice (9) un filetage extérieur constituant un premier moyen d'introduction (5) formé sur la partie extérieure d'un corps cylindrique (2) de manière à assurer une liaison étanche entre la première aiguille d'emboîtement (17) et un filetage intérieur constituant un second moyen emboîtement (19) formé sur la paroi intérieure du tube gaine (6). On remplit alors le cylindre (1) d'eau et d'un médicament solide, puis on y insère un piston (12) présentant un ordre ascendant: une seconde aiguille d'emboîtement (25), une tête de piston (13), un flasque (14) repoussant le liquide (14), un joint (23), un flasque repoussant le liquide (14), un joint (23), un flasque intermédiaire (24) et une tige (22). Le doseur permet non seulement de préparer une solution de médicament dans son cylindre, mais de la doser avec précision selon les prescriptions car aucun débris insoluble ne reste dans dans le cylindre après la prise.
PCT/JP1996/002044 1995-07-27 1996-07-22 Doseur buccal WO1997004733A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP21107995 1995-07-27
JP7/211079 1995-07-27

Publications (1)

Publication Number Publication Date
WO1997004733A1 true WO1997004733A1 (fr) 1997-02-13

Family

ID=16600067

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1996/002044 WO1997004733A1 (fr) 1995-07-27 1996-07-22 Doseur buccal

Country Status (1)

Country Link
WO (1) WO1997004733A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7312025B2 (en) 2002-07-12 2007-12-25 University Of Washington Methods and systems for extended in vitro culture of neuronal cells
JP2008206531A (ja) * 2007-02-23 2008-09-11 Top:Kk 薬剤容器
JP2008295839A (ja) * 2007-05-31 2008-12-11 Nutri Kk 投薬補助容器
WO2011115811A1 (fr) * 2010-03-15 2011-09-22 Eurand Pharmaceuticals Ltd. Bouchon filtrant pour seringue et son procédé d'utilisation pour l'administration de dose de médicament
GB2530808A (en) * 2014-10-03 2016-04-06 Special Products Ltd A syringe assembly
CN107362048A (zh) * 2017-08-03 2017-11-21 王美芝 一种重症监护室护理用喂药器
CN113018195A (zh) * 2021-02-24 2021-06-25 颍上县人民医院 一种肿瘤内科给药装置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05508569A (ja) * 1990-07-06 1993-12-02 ジョンズ，マーティン　ネイル 液体の経口投与装置
JPH06218027A (ja) * 1993-01-14 1994-08-09 Q P Corp 流動状食物封入容器体およびそれに使用する注出用キャップとその流動状食物注出方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05508569A (ja) * 1990-07-06 1993-12-02 ジョンズ，マーティン　ネイル 液体の経口投与装置
JPH06218027A (ja) * 1993-01-14 1994-08-09 Q P Corp 流動状食物封入容器体およびそれに使用する注出用キャップとその流動状食物注出方法

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7312025B2 (en) 2002-07-12 2007-12-25 University Of Washington Methods and systems for extended in vitro culture of neuronal cells
JP2008206531A (ja) * 2007-02-23 2008-09-11 Top:Kk 薬剤容器
JP2008295839A (ja) * 2007-05-31 2008-12-11 Nutri Kk 投薬補助容器
WO2011115811A1 (fr) * 2010-03-15 2011-09-22 Eurand Pharmaceuticals Ltd. Bouchon filtrant pour seringue et son procédé d'utilisation pour l'administration de dose de médicament
GB2530808A (en) * 2014-10-03 2016-04-06 Special Products Ltd A syringe assembly
WO2016051200A1 (fr) * 2014-10-03 2016-04-07 Special Products Limited Ensemble seringue
US20170296434A1 (en) * 2014-10-03 2017-10-19 Special Products Limited A syringe assembly
AU2015326554B2 (en) * 2014-10-03 2019-11-14 Veriton Pharma Limited A syringe assembly
US10940090B2 (en) 2014-10-03 2021-03-09 Veriton Pharma Limited Syringe assembly
CN107362048A (zh) * 2017-08-03 2017-11-21 王美芝 一种重症监护室护理用喂药器
CN113018195A (zh) * 2021-02-24 2021-06-25 颍上县人民医院 一种肿瘤内科给药装置
CN113018195B (zh) * 2021-02-24 2022-04-19 颍上县人民医院 一种肿瘤内科给药装置

Similar Documents

Publication Publication Date Title
US20170014310A1 (en) Enteral feeding adapter and method of use
JP3285366B2 (ja) 活性薬剤放出デバイス用の流動制御手段構造
AU625179B2 (en) Delivery device for orally administered therapeutic agents
US5129532A (en) Pediatric-medicinal dispensing system
CN1191808C (zh) 奶嘴,定量给药装置及定量给药装置与药物容器的组合体
CA2869661C (fr) Dispositif de securite de fiole de medicament
CN109862930A (zh) 具有连接器的注射器
JPH05508569A (ja) 液体の経口投与装置
SK1692001A3 (en) Two-piece capsule for receiving pharmaceutical preparations for powder inhalers
US20110224648A1 (en) Syringe Filter Cap and Method of Using the Same for Administration of Medication Dosage
WO2012052853A2 (fr) Dispositif de dosage oral pour l'administration de médicament
JP2000509312A (ja) 活性物質送出装置のクロージャ・システム
US20220347055A1 (en) Drug preparation kit and process of preparing a drug
WO1997004733A1 (fr) Doseur buccal
JP2004002271A (ja) 可撓性容器入り局所止血用医薬組成物
US20080223807A1 (en) Collar for liquid and medicine dispensing bottle
JP2009131629A (ja) 小動物経口投与用器具
WO2018013716A1 (fr) Tétine sécurisée pour enfant.
CA2964537A1 (fr) Adaptateur d'alimentation par voie enterale et methode d'utilisation
EP0300783A1 (fr) Distributeur jetable de médicament
JP7209849B2 (ja) 点滴用ボトルと共に使用するための液体移送装置
RU2811660C2 (ru) Система, содержащая предварительно наполняемый шприц и упаковку для предварительно наполняемого шприца
CN101209227A (zh) 一种输送活性成分的输送装置

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LU MC NL PT SE

DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
121 Ep: the epo has been informed by wipo that ep was designated in this application
122 Ep: pct application non-entry in european phase