WO1997004733A1 - Intraoral medicator - Google Patents

Intraoral medicator Download PDF

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Publication number
WO1997004733A1
WO1997004733A1 PCT/JP1996/002044 JP9602044W WO9704733A1 WO 1997004733 A1 WO1997004733 A1 WO 1997004733A1 JP 9602044 W JP9602044 W JP 9602044W WO 9704733 A1 WO9704733 A1 WO 9704733A1
Authority
WO
WIPO (PCT)
Prior art keywords
chemical
nda
barrel
silicon
plug pin
Prior art date
Application number
PCT/JP1996/002044
Other languages
French (fr)
Japanese (ja)
Inventor
Hirotaka Nishida
Hirokazu Mihashi
Mitsuru Yasumura
Kazunari Yamashita
Original Assignee
Taisei Kako Co., Ltd.
Fujisawa Pharmaceutical Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to JP7/211079 priority Critical
Priority to JP21107995 priority
Application filed by Taisei Kako Co., Ltd., Fujisawa Pharmaceutical Co., Ltd. filed Critical Taisei Kako Co., Ltd.
Publication of WO1997004733A1 publication Critical patent/WO1997004733A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
    • A61J7/00Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
    • A61J7/0015Devices specially adapted for taking medicines
    • A61J7/0053Syringes, pipettes or oral dispensers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M2005/3103Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3104Caps for syringes without needle
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178Syringes
    • A61M5/31Details
    • A61M2005/3117Means preventing contamination of the medicament compartment of a syringe

Abstract

An intraoral medicator constituted by inserting the outlet end of a cylinder (1) provided with a liquid passage hole (9) into a sheath tube (6) provided with a first plug pin (17) erected on the bottom plate (16) thereof, engaging in the hole (9) an external thread serving as a first engaging means (5) formed on the outer wall of a cylinder body (2) so as to fit the first plug pin (17) watertight with an internal thread serving as a second engaging means (19) formed on the inner wall of the sheath tube (6), feeding water and a solid drug into the cylinder (1), and inserting thereinto a plunger (12) provided in an ascending order with a second plug pin (25), a plunger head (13), a liquid pushing flange (14), a gasket (23), an intermediate flange (24) and a rod (22). The medicator has such advantages that not only a drug solution can be prepared in the cylinder but also the dose agrees accurately with the prescription because no insolubles remain in the cylinder after medication.

Description

Akira fine chemical liquid oral administration tool technology field

The present invention is the solution or suspension of a medicament solid like (hereinafter, there is a this called "chemical") in the form of, tool to buccal administration to the patient and / or infants like (hereinafter, "the present invention on the administration tools "and there is a child abbreviation). Specifically, the present invention also serves as a container for preparing the solid agent such as granules dissolved or suspended in a solvent such as water chemical, and equipment for oral administration of the resulting drug solution to the patient, such as described above, the on the chemical buccal administration tool,

BACKGROUND

The drawings to be generic in FIG. 1 is a schematic diagram showing the preparation and oral administration method of the drug solution that has been conventionally performed in this order. The indicated stages step that One blotter from the metering mosquito-up a drug solution prepared in total dimerization-up (M) (M) in the normal sheet re Nji (S) in FIG. 1 A, FIG. 1 indicated stage B shows the step doing the mouth cavity administering Syringe (S) tip blotted was prepared drug solution is inserted into the patient's mouth.

Traditionally, pharmaceuticals solid, especially in the case of oral administration of granules or fine granules in a patient or infant, etc., drug addition of water to dissolve or suspending the drug in metered mosquitoes was accommodating-up (M) after the directly or buccal administration, or wicking the chemical in FIG 1 a, 1 the measuring Ca-up as shown in B (M) or al disposable silica Sunda (S) from the metering mosquito-up (M) method of administering Te is our row.

From the viewpoint of its efficacy or side effects to the drug being administered, that exists is that the this the entire amount of the metered drug is administered precisely is required. No particular problem occurs on whether agents have also been prepared is exactly the total amount administered in combination with a conventional pharmaceutical preparation methods and dosing method if the drug to be administered is water-soluble. However, if the drug to be administered is administered as a suspension from the dissolve and difficulty go Metropolitan in water, weighed Ca-up portion of the insoluble drug upon administration (M) and silica Sunda (S ) problem causing inaccurate dose as a result residing remaining in such has been left.

The purpose is in the child develop a conventional scheme to solve such problems of the above-mentioned unavoidable. Buccal administration tool provided with such advantages of the invention described below.

(1) the preparation unit and the oral administration tool of the drug solution achieving space saving by the Kaneruko, also aims to speed up work by the simplified child work, the Raniwa, drugs associated with was transferred remaining to eliminate.

(2) to prevent the drug remaining in Syringe Using Improved plastics changers.

Disclosure of the Invention

The present invention originating volatilizing their effects by the components specified in improved arrangement 7 "of and" Improved conception 1 J ~ 'OF THE INVENTION "The basic configuration of the invention" below.

[Basic configuration of the invention]

Siri Nda having a liquid passage hole to the outlet end of the barrel, buccal administration of the drug solution constituted mainly from the inserted plunger skirt tube 及 Pi Siri Sunda one that is KanmuriSo to the outlet end region a tool, comprising a first plug pin which 該袴 pipe rises from the bottom plate inside surface, chemical buccal instrument said first plug pin is watertight manner fitting the liquid passage hole of the sheet re Nda barrel.

[Improvement of the invention Configuration 1]

Skirt tube accommodates the lower half of the silicon Nda barrel, comprising a first plug pin of substantially upright in a substantially center of the bottom plate with may generally upright by the bottom surface of 該袴 tubes pixel in that state, said first of the chemical solution buccal administration instrument for water-tightly fitted into the silicon Nda barrel lower end of the liquid passage hole of the plug pin.

[Improvement of the invention Configuration 2]

With the first engagement means is provided on the outer wall of the silicon Nda barrel, the second engagement means is provided on the skirt inner wall, both chemical buccal instrument is engageable to each other.

[Improved conception 3 of the Invention

Plastic changers is Siri Sunda one tip zone inner wall closely possible shape in its head, a second plug pin which can be fitted into liquid passage hole Siri Nda, liquid extrusion flange and adjacent to the head of the plan Jar the chemical buccal administration tool that example Bei a sliding gasket.

[Improvement of the invention Configuration 4]

One or more longitudinal grooves in only UtsuwasokoMuko from the upper opening edge is provided in the inner wall of the silicon Nda barrel upper half, than the position the lower end thereof to contact with the contents liquid in the liquid extrusion City flange of plastics changers chemical inlet lumen administration tool located above.

[Improved Configuration of the Invention 5]

Chemical buccal instrument hopper upper opening is formed on the upper end of the silicon Nda barrel. [Improvement of the invention Configuration 6]

Siri Sunda Ichido part chemical buccal administration tool provided fingerhold injury for facilitating gripping by fingers or the like to the outer wall of.

[Improved configuration 7 of the invention]

Chemical buccal administration tool the section extending from the intermediate flange to the tail end is slidably fitted in the outer wall of the detachment preventing member is plastics changers.

BRIEF DESCRIPTION OF THE DRAWINGS

Figure 1 is a schematic view of an operation patient a conventional drug solution preparation procedure and the resulting drug solution by techniques taking orally, 1 A is the measuring Ca-up a drug solution prepared in the metering mosquito-up stage are blotted normal Syringe from a Figure 1 B shows the step is performed buccal insert the sheet re Nji tip blotted was prepared drug solution into the mouth of the patient.

Figure 2 is a schematic 縱断 view showing the order hand are prepared drug solution using a dosing device is an aspect of the present invention, FIG. 2 A is a silicon Nda that make up the dosage device of the present invention, Figure 2 B is a skirt tube capable upright constituting the administration tool of the present invention, FIG. 2 C is a schematic cross-sectional view shows the procedure for preparing a drug solution in Siri Nda.

Figure 3 shows the up stage of solid agent from the previous is shaken by dissolving or suspending the next plug Nja one housed solid agent and water to the silica Sunda one is inserted, FIG. 3 A solid drug and water Sorted upright open upward posture fitting body is the accommodation the Siri Nda and trousers tube, showing a state where DatsuHanarebo stop is fitted on the plug changers, somewhat in FIG. 3 B is plug changers is Siri Nda It shows the inserted state, FIG. 3 C shows a step of dissolving or suspending the working of the solid agent. Figure 4 is Ru schematic sectional view showing a state where the skirt tube following the state and its solid agent is sufficiently dissolved or suspended is removed from the silicon Sunda one O

5 after the end of the preparation of the drug solution is inserted actually state chemical is administered, i.e., rod-like portion of the plunger toward the liquid passage pipe located at the top of the silicon Sunda one to target into Siri Nda 0 that shows the Owa One state

BEST MODE FOR CARRYING OUT THE INVENTION

Will be described with reference to the drawings while the administration tool and the shape and structure of the present invention in comparison with the conventional mode of administration and dosage device used therewith. Incidentally, "vertical and horizontal" in the figures is a convenience representation of description, based on the relative positional relationship on the drawings. Also, "upstream" is relieved path one side of the lower supra, "downstream" and passing liquid pipe side.

Each figure is a schematic longitudinal sectional view with the buccal administration device showing a procedure to prepare a drug solution is an aspect of the present invention which are generically referred to in FIG. Hopper (or funnel) (3) is formed of the upper opening to the upper end of the silicon Nda constituting the administration instrument body of a (1) Contents (2) of INDICATED aspects in FIG. 2 A is the invention is, from the outer wall of the downstream side of the hopper (3) a rod-shaped member is projected as a finger hook (4) of plastics changers (infra) for pushing. With the child receiving the preferred given the drug and / or water to the sheet re Nda (1) in is facilitated also facilitates administration of the prepared drug solution. Further, on an outer wall lower silicon Sunda Ichido section (2) male screw is provided as the first engagement means (5). The first engagement means (5) are provided in described next relationship with skirt tube (6). Furthermore, (usually spherical) silica Sunda Ichido portion downstream end of (2) (the head) the outer wall (7) is bland songs surface formed into, passed through pipe (8) is provided on its substantially central axis , liquid passage holes through vent liquid pipe (8) (9) is working to liquid flow inside and outside the silicon Nda barrel (2). In here, although the gentle curved surface is a spherical usually, the secondary Other examples lacking spheroid, such angular portion or sharp parts of the paraboloid, etc. or a hyperboloid of revolution it is a curved surface.

Siri Nda barrel (2) the inner wall longitudinal grooves starting from the lower end of the hopper (3) in the downward orientation to the (10) (11) of are provided now. Lower end position of the vertical groove (1 1) is chosen above the position where the head (13) reaches the liquid extrusion flange (14) when submerged all in the liquid below the plug changers (12). In other words, when the role of the vertical groove (1 1) which is Datsukimizo plunger (12) as (air one vent) is inserted Siri Nda barrel to (2), plug changers head (13 ) that there was outflow pressure rise to that air or the like interposed between the silicon Nda barrel (2) contained liquid surface in the and preventing child. It said longitudinal grooves (1 1) is sufficient for one, usually provided 2 or more. Are placed in flutes Te respective drawings odor 2 (1 1) is approximately equal intervals (center angle substantially 9 0 degrees per) on four is circumferential.

As is evident from the role of the longitudinal groove (11), if the stage of the downstream end of the liquid extrusion flange (14) by entering Buranja one (12) is advanced to contact the liquid surface, which grooves (1 degassing, which is the role of 1) becomes that you are finished. Conversely. When the lower end of the vertical groove (1 1) extends to the downstream side of the downstream end of the liquid extrusion flange at this stage (14), that the content liquid flows out from the longitudinal groove (1 1) causing a state.

In addition, silicon Nda barrel (2) lower reaches the inner wall of quadric surface (usually spherical) to the inner wall to the reduced diameter portion (15) and equipped with infra Bran jar near the boundary of the transition (12) liquid bearing a surface facing the head of the extrusion flange (14), to prevent the risk of failure due doers et a penetration of said flange (14). Siri Nda barrel (2) secondary curved head inner wall yet to preferred is that it is a curved surface which is in close contact as possible with the shape of the head outer wall of infra plunger (fitting) of. Such various aspects namely bland outline, as viewed from the fitting easiness and fabrication easiness, secondary head outer wall of the quadrics also plans jar head inner wall of the silicon Nda barrel (2) the curved surface is also spherical this and is favored arbitrariness.

Embodiment shown in FIG. 2 B is an upright possible skirt tube (6), is formed into a bottomed cylindrical body of substantially flat bottom, substantially at the center of the bottom plate (16) the first plug pin (17) upright, said first plug pin (17) is re Nda barrel (2) to the passing liquid holes (9) in a watertight manner fitted to prevent leakage of the content liquid. Therefore, the the gradient imparted child of 稍奥 fine to passing liquid holes (9) with the said first Buragupin (17) to impart a gradient of 稍先 fine are useful.

Moreover, the first engagement means provided on the outer wall lower sheet re Nda barrel (2) in the cylindrical inner wall (18) of the skirt tube embodiment shown in FIG. 2 B (6) (5) female screw is provided as a second engagement means for engaging with the male screw (19) is. However, the two engaging means may be a snap type such as combinations of Baiyone' Tomaun preparative method or elastic ridges and crypts not limited to disk re Yumaun preparative method.

Embodiment shown in FIG. 2 C illustrates a procedure for preparing a drug solution in Siri Nda (1) constituting the dosage device of the present invention, a male thread (5) and skirt tube Siri Sunda one (1) (6) the female screw (19) engages a liquid passage pipe Siri Nda (1) (8) is upright fitted state the first Buragupin (17) of the skirt tube (6), at its left figure from the solid drug above the container (20) is dropped to the silica Nda (1) within the right view that has water from above the container (21) to said silicon Nda (1) inside is poured. Next, description will be operated on the basis of the figures belonging to FIG.

Figure 3 embodiment shown in A are upright upwardly opened posture fitting body is 2 Siri Nda (1) that is created in advance embodiment shown in C and Hakamakan (6), said Siri It shows the stage immediately before Nda barrel (2) bra changers (12) into a solid drug and systems and is accommodated water into is inserted from above. Siri Nda barrel in this stage (2) passing liquid pipe at the lower end (8) the bottom plate of the passing was found provided in the vicinity of the center liquid hole (9) in the Hakamakan (6) (16) from the vicinity of the center upward first plug pin projecting (17) is prevented from leaking, such as water contained in a watertight manner fitted has been Siri Nda barrel (2).

Figure 3 Keep embodiment shown in A Bran jar (12) is rod-shaped portion (22), sliding gasket portion (piston tons portion) (23), a sliding gasket section bar portion (22) (23 clamping or the liquid extruded flange between the intermediate flange (24) and bra changers head (1 3) and sliding gasket portion (23) and Buranja one head (13) sandwiched between a) It is composed primarily of (14) and a second Buragupin that issued collision at the tip of the plug changers head (13) (25).

Furthermore, Buranja one (12 shown detachment prevention member (26) is, the detachment preventing member (26) which is 揷通 therein openings (27) in the embodiment shown in FIG. 3 A rod-like portion of) the outer surface (22) is shown as a substantially flat member that slidably supports, also the function of preventing the escape upward Blanc jar (12) is at the stage of Tsugi掲play.

Embodiment shown in FIG. 3 B shows a state in which the plunger (12) is inserted into the serial Nda barrel (2). Between embodiment shown in Figure 3 A of the head (13) of the contained liquid surface and plug changers (12) to the silicon Nda barrel (2) in the process leading to the embodiment shown in FIG. 3 B gas interposed is discharged from the longitudinal groove (1 1). Thus, the head of the plug in this stage changers (12) (13) hopper closely to the liquid surface, the detachment preventing member in here (26) constitutes the serial Sunda one (1) (3) substantially in contact with the upper edge (28).

Dehydration away preventer (26) is Bra from the opening (27) provided with a shape for engagement with the upper edge (28) of the hopper (3) in its outer region changers (12) exit a substantially flat plate if there is sufficient. However, detachment preventing member (26) and a sufficient This may not completely cover the top opening of the hopper (3), the outer shape has no requirement outer edge shape similar to the shape of the opening, For example Y-shape also properly triangular, cruciform, or may be a star or gear type.

Detachment preventing member (26) as that are exemplified in embodiments of any of the diagram belonging to Fig. 3, includes an overhang (29) for engagement extending downward from its periphery, the center of the overhang (29) close to the hopper one (3) upper edge (28) to the two that neighboring contact of the provided cut-out (30) sandwiched by holes may be drilled in order to fit the projection and 該張 out of (29) together comprise two or more substantially symmetrically (point symmetry or line symmetry) to the central axis overhang for engaging (29) having a lower desorption elimination Anda one mosquito Tsu City of (31) to the lower edge the inner wall, the opening ( the rod-shaped portion as 27) (2 2) of the sliding gasket portion a slideable on the outer surface of a sufficiently small inner diameter than the outer diameter (23) intermediate flange (24 you located at the upper end of) the opening ( equipped with a 27) as an integral part. Detachment preventing member (26) from the intermediate flange (24) located on the sliding gasket portion (23) the upper end of the bran jar (12) Bra Nja - slides section up to the tail end (12). Figure 3 B in the embodiment shown definitive elimination preventer (26) stands overhang for engaging the four portions of the outer periphery in a substantially disk-shaped (29) at substantially equal intervals (center angle substantially 9 0 degrees per) It is above the moon. Further, silicon Nda barrel (2) upper edge (28) also corresponding notches (30) corresponding in length and corresponds to the corresponding point on the above overhang for engaging (29) of the hopper (3) located at the upper end of It is provided by the number (not shown). Figure 3 In the embodiment shown in B, lock the coupling for overhang (29) notches (30 detachment prevention member (26) to secure the state where the insertion of the bran jar (12) has reached the desired stage ) and fitted both engagement only by the this pivoting angle of the predetermined range to right or left direction after allowed to complete. Those formed by a composite of the insertion and engagement of this to the fitting insert Nevertheless <, said engagement means is only an example, the overhang for engaging (29) detachment preventing member (26 only by providing the outer peripheral region without the Siri Sunda one (1) side is provided a corresponding notch (30) of) the so-called Sunappuka Tsupuri ring you use a flexible (elastic) overhanging the engaging (29) this to be able to also.

Stage embodiment shown in Figure 3 C is a stage of dissolving or suspending the working of the solid agent. That is, since in this stage is a harmful leakage of liquid being prevented, properly like the mating inserts to promote dissolution or suspension by shaking up and down along its longitudinal axis. Of course, it may be shaken by oscillating manner while supporting either Kano point of the chemical buccal administration tool.

First engagement means (5) and second engagement means skirt tube of FIG. 4 in the embodiment shown in solid agent is sufficiently dissolved or suspended state and it Siri Te 鐃I Sunda (0 (19 ) engagement is released, showing a state skirt tube (6) is Rihazusa taken Ass Nda (1), the chemical buccal instrument at this point or later shown in made. Figure 5 available step i.e. the state actually chemical after the end of the preparation of the drug solution is given projection, Siri Nda barrel (2) thereof Blanc jar toward passing liquid pipe located at the top (8) to a subject (12) rod portion (22) is in a state of finished inserted into Siri Nda barrel (2) in in this state Plastic Nja -. reduced diameter portion (15 (12) of the head (13) is silicon Nda (1) passing a second Puragupi down to (25) is located at the downstream end of the serial Nda (1)) in the abutting protruding both from the head (13) the tip of the plunger (12) Are contacted to fit up into the hole (9).

Material forming a chemical buccal administration device of the present invention is a resin, is that it is a resin-rich rigid with superior moisture barrier cross resistance is important. In addition, more preferred arbitrariness is that you have excellent care-blocking properties. For more information, Siri Sunda - (1) and is bra changers (12) head (13) is a child and is very important that the resin-rich aforementioned properties, rigidity against detachment prevention member (26) it is not separately required, that you have an elastic should be called rather moderate flexibility is important. Also, it is important with this which is equipped with a self-lubricating in addition to appropriate flexibility for gasket (23).

Accordingly, the first head (13) is polymeric resin or hydrocarbon and E alicyclic hydrocarbons containing fused ring structure styrene such Siri Nda (1) and plug changers (12) - Orefi down (- Orefi down), a copolymer resin verses preferred and this formed by cash rigid resins represented is, detachment preventing member (26) 及 beauty gasket (23) is lower 1 such Echiren or pro pyrene - Orefui down homopolymer resin, copolymer resin or this and is preferred arbitrarily formed by a flexible resin represented by those compositions. Representative examples of such resins are described in JP-A-4 one 1 4 6 8 5 JP. In here the term "resin" is not limited to crystalline polymers, also encompasses a low crystalline or amorphous polymer is a polymer in circulation is recognized as "resin" also in resin processing industry with body to.

Effect of the invention

The use of buccal administration device of the present invention can and this to achieve the various effects described below.

(1) solid drug was fitted Siri emissions Zehnder the skirt tube when dissolved or suspended in water to prepare a chemical solution, by the this for fitting the first plug pins of the skirt tube liquid passage hole Siri Nda drug even water also Ru is a container that does not leak is formed. Therefore, it is the this to advance easily and duck hygienically drug solution preparing work in Siri Nda without requiring a separate preparation vessel.

(2) in the administration of drug solution, sliding gasket is in close contact with the silicon Sunda one tip region wall, second plug pins of plug changers are in close contact fitted into liquid passage hole Siri Nda, liquid extruded hula from this state Nji is of being moved downward, the chemical liquid hardly remaining insoluble portion of the drug in Siri Nda even suspension, it is the child correctly administer the drug the total amount that has been prepared as a result.

(3) As a result of preventing desorption are attached instrument to prevent escape upward Blanc jar, may no leak drug solution prior to administration.

Claims

The scope of the claims
1. Siri Nda having a liquid passage hole to the outlet end of the barrel, the skirt tube and mainly oral administration tool composed chemical from a plunger that is inserted into silicon Sunda one is KanmuriSo to the exit end zone a is, with the first plug pin which該袴pipe rises from the bottom plate inside surface, chemical buccal device c which said first plug pin watertight manner fitting the liquid passage holes Siri Nda barrel
2. Skirt tube accommodates the lower half of the silicon Nda barrel, comprising a first plug pin of substantially upright in a substantially center of the bottom plate with may generally upright the skirt tube in this state by the bottom surface, said chemical buccal administration tool according to claim 1 for water-tightly fitted one of the plug pin to Siri Sunda one barrel lower end of the liquid passage holes.
3. Both the outer wall of the silicon Nda body portion first engagement means is provided, the second engagement means is provided on the skirt inner wall, according to claim both are engageable capacity mutually 1 or 2 the chemical buccal administration tool according to.
4. Plastic changers closely possible shapes in silicon Sunda one tip region the inner wall to the head, a second plug pin which can be fitted into liquid passage hole Siri Nda, liquid extrusion flange and adjacent to the head of the plunger chemical buccal administration device according to any one of claims 1 to 3, and a sliding gasket.
5. At the upper opening edge or al vessel bottom for the inner wall of the silicon Nda barrel on half the longitudinal grooves of the above one provided, than the position the lower end thereof to contact with the contents liquid to the liquid extrusion flange of the plunger chemical buccal administration device according to any one of claims 1 to 4, you located above.
6. Chemical buccal administration instrument according to any one of silicon Nda barrel upper end ~ claim 1, hopper upper opening is formed on the fifth.
7. Chemical buccal administration tool according to what Re one of claims 1 to 6, detachment preventing member is being fitted slidably the section extending from the intermediate flange to the tail end at the outer wall of the plug changers.
8. Chemical inlet lumen administration device according to any one of claims 1 to 7, finger hooking is provided for facilitating gripping by fingers or the like to the outer wall of the silicon Sunda Ichido unit.
PCT/JP1996/002044 1995-07-27 1996-07-22 Intraoral medicator WO1997004733A1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP7/211079 1995-07-27
JP21107995 1995-07-27

Publications (1)

Publication Number Publication Date
WO1997004733A1 true WO1997004733A1 (en) 1997-02-13

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Application Number Title Priority Date Filing Date
PCT/JP1996/002044 WO1997004733A1 (en) 1995-07-27 1996-07-22 Intraoral medicator

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7312025B2 (en) 2002-07-12 2007-12-25 University Of Washington Methods and systems for extended in vitro culture of neuronal cells
JP2008206531A (en) * 2007-02-23 2008-09-11 Top:Kk Pharmaceutical container
JP2008295839A (en) * 2007-05-31 2008-12-11 Nutri Kk Medication aid container
WO2011115811A1 (en) * 2010-03-15 2011-09-22 Eurand Pharmaceuticals Ltd. Syringe filter cap and method of using the same for administration of medication dosage
GB2530808A (en) * 2014-10-03 2016-04-06 Special Products Ltd A syringe assembly
CN107362048A (en) * 2017-08-03 2017-11-21 王美芝 A kind of intensive care unit nursing medicine-feeding device

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05508569A (en) * 1990-07-06 1993-12-02
JPH06218027A (en) * 1993-01-14 1994-08-09 Q P Corp Liquid food encapsulating container and cap for pouring used therefor and pouring method for liquid food

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH05508569A (en) * 1990-07-06 1993-12-02
JPH06218027A (en) * 1993-01-14 1994-08-09 Q P Corp Liquid food encapsulating container and cap for pouring used therefor and pouring method for liquid food

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7312025B2 (en) 2002-07-12 2007-12-25 University Of Washington Methods and systems for extended in vitro culture of neuronal cells
JP2008206531A (en) * 2007-02-23 2008-09-11 Top:Kk Pharmaceutical container
JP2008295839A (en) * 2007-05-31 2008-12-11 Nutri Kk Medication aid container
WO2011115811A1 (en) * 2010-03-15 2011-09-22 Eurand Pharmaceuticals Ltd. Syringe filter cap and method of using the same for administration of medication dosage
GB2530808A (en) * 2014-10-03 2016-04-06 Special Products Ltd A syringe assembly
WO2016051200A1 (en) * 2014-10-03 2016-04-07 Special Products Limited A syringe assembly
US20170296434A1 (en) * 2014-10-03 2017-10-19 Special Products Limited A syringe assembly
AU2015326554B2 (en) * 2014-10-03 2019-11-14 Veriton Pharma Limited A syringe assembly
CN107362048A (en) * 2017-08-03 2017-11-21 王美芝 A kind of intensive care unit nursing medicine-feeding device

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