WO1996024381A3 - Kontrastmittelhaltige liposomen für die darstellung des intravasalraumes - Google Patents

Kontrastmittelhaltige liposomen für die darstellung des intravasalraumes Download PDF

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Publication number
WO1996024381A3
WO1996024381A3 PCT/EP1996/000539 EP9600539W WO9624381A3 WO 1996024381 A3 WO1996024381 A3 WO 1996024381A3 EP 9600539 W EP9600539 W EP 9600539W WO 9624381 A3 WO9624381 A3 WO 9624381A3
Authority
WO
WIPO (PCT)
Prior art keywords
blood pool
contrast media
liposomes containing
containing contrast
pool imaging
Prior art date
Application number
PCT/EP1996/000539
Other languages
English (en)
French (fr)
Other versions
WO1996024381A2 (de
Inventor
Andreas Sachse
Georg Roessling
Jens Leike
Werner Krause
Gabriele Schuhmann-Giampieri
Peter Muschick
Wolf-Ruediger Press
Original Assignee
Schering Ag
Andreas Sachse
Georg Roessling
Jens Leike
Werner Krause
Schuhmann Giampieri Gabriele
Peter Muschick
Press Wolf Ruediger
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Ag, Andreas Sachse, Georg Roessling, Jens Leike, Werner Krause, Schuhmann Giampieri Gabriele, Peter Muschick, Press Wolf Ruediger filed Critical Schering Ag
Priority to EP96904033A priority Critical patent/EP0806969A2/de
Priority to AU47890/96A priority patent/AU4789096A/en
Priority to JP8523999A priority patent/JPH10513466A/ja
Publication of WO1996024381A2 publication Critical patent/WO1996024381A2/de
Publication of WO1996024381A3 publication Critical patent/WO1996024381A3/de
Priority to NO973666A priority patent/NO973666L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0447—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is a halogenated organic compound
    • A61K49/0461—Dispersions, colloids, emulsions or suspensions
    • A61K49/0466—Liposomes, lipoprotein vesicles, e.g. HDL or LDL lipoproteins, phospholipidic or polymeric micelles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
    • A61K49/1806—Suspensions, emulsions, colloids, dispersions
    • A61K49/1812—Suspensions, emulsions, colloids, dispersions liposomes, polymersomes, e.g. immunoliposomes

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Die Erfindung betrifft liposomale Kontrastmittelzubereitungen zur diagnostischen Darstellung des Intravasalraumes sowie deren Verwendung in der bildgebenden Diagnostik. Die Erfindung betrifft daher wirkstoffhaltige Liposomenformulierungen, dadurch gekennzeichnet, daß a) folgendes Mischungsverhältnis der Lipide vorliegt: 40-90 % Phospholipide oder Amphiphile, 10-50 % Sterole, 0-25 % Ladungsträger, b) die Liposomen einen mittleren Durchmesser von 100-400 nm aufweisen und c) der Wirkstoff ein Röntgen- oder MRI-Kontrastmittel oder ein Radiodiagnostikum ist.
PCT/EP1996/000539 1995-02-09 1996-02-09 Kontrastmittelhaltige liposomen für die darstellung des intravasalraumes WO1996024381A2 (de)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP96904033A EP0806969A2 (de) 1995-02-09 1996-02-09 Kontrastmittelhaltige liposomen für die darstellung des intravasalraumes
AU47890/96A AU4789096A (en) 1995-02-09 1996-02-09 Liposomes containing contrast media for blood pool imaging
JP8523999A JPH10513466A (ja) 1995-02-09 1996-02-09 脈管内空間を視覚化するための造影剤を含むリポソーム
NO973666A NO973666L (no) 1995-02-09 1997-08-08 Kontrastmiddelholdige liposomer for avbildning av det intravaskulære rom

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19505813 1995-02-09
DE19505813.5 1995-02-09

Publications (2)

Publication Number Publication Date
WO1996024381A2 WO1996024381A2 (de) 1996-08-15
WO1996024381A3 true WO1996024381A3 (de) 1996-10-03

Family

ID=7754530

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1996/000539 WO1996024381A2 (de) 1995-02-09 1996-02-09 Kontrastmittelhaltige liposomen für die darstellung des intravasalraumes

Country Status (7)

Country Link
EP (1) EP0806969A2 (de)
JP (1) JPH10513466A (de)
AU (1) AU4789096A (de)
CA (1) CA2212162A1 (de)
DE (1) DE19606326A1 (de)
NO (1) NO973666L (de)
WO (1) WO1996024381A2 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19529922A1 (de) * 1995-08-01 1997-02-06 Schering Ag Verwendung von liposomalen Zubereitungen in der indirekten MRT-Lymphographie
GB9624918D0 (en) * 1996-11-29 1997-01-15 Nycomed Imaging As Particulate components
AU5260301A (en) * 2000-04-28 2001-11-12 Fuji Photo Film Co Ltd Liposomes containing hydrophobic iodo compound
JPWO2006009022A1 (ja) * 2004-07-21 2008-05-01 コニカミノルタエムジー株式会社 リポソーム含有ｘ線造影剤およびその製造方法
JP5176320B2 (ja) * 2004-08-11 2013-04-03 コニカミノルタエムジー株式会社 リポソーム含有製剤の製造方法
EP2606912A1 (de) * 2011-12-23 2013-06-26 Central Medical Service Co., Ltd. Kontrastmittelzusammensetzung mit Kontrastverstärkungseffekt aufgrund des Umfassens eines hoch konzentrierten Mittels

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0179444A2 (de) * 1984-10-22 1986-04-30 Vestar, Inc. Verwendung eines Mittels mit chemotherapeutische Substanz einkapselnden Mizellteilchen für intravenöses Tumortargeting
WO1988001505A1 (en) * 1986-08-29 1988-03-10 The Government Of The United States Of America, As Scaled-up production of liposome-encapsulated hemoglobin
WO1990004943A1 (en) * 1988-11-09 1990-05-17 Unger Evan C Liposomal radiologic contrast agents
EP0405704A2 (de) * 1989-06-30 1991-01-02 Schering Aktiengesellschaft Derivatisierte DTPA-Komplexe, diese Verbindungen enthaltende pharmazeutische Mittel, ihre Verwendung und Verfahren zu deren Herstellung
WO1991005599A1 (de) * 1989-10-13 1991-05-02 Schering Aktiengesellschaft Berlin Und Bergkamen Verfahren zur herstellung von wässrigen dispersionen
WO1994008565A1 (en) * 1992-10-14 1994-04-28 The Liposome Company, Inc. Interdigitation-fusion liposomes and gels
WO1994008626A1 (de) * 1992-10-16 1994-04-28 Andreas Sachse Verfahren und vorrichtung zur herstellung flüssiger, disperser systeme
WO1995015153A1 (de) * 1993-12-02 1995-06-08 Schering Aktiengesellschaft Verfahren zur erhöhung der stabilität von hydrophile wirkstoffe enthaltenden liposomensuspensionen
DE4426438A1 (de) * 1994-07-26 1996-02-01 Schering Ag Verwendung von Chelaten als Röntgenkontrastmittel

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0179444A2 (de) * 1984-10-22 1986-04-30 Vestar, Inc. Verwendung eines Mittels mit chemotherapeutische Substanz einkapselnden Mizellteilchen für intravenöses Tumortargeting
WO1988001505A1 (en) * 1986-08-29 1988-03-10 The Government Of The United States Of America, As Scaled-up production of liposome-encapsulated hemoglobin
WO1990004943A1 (en) * 1988-11-09 1990-05-17 Unger Evan C Liposomal radiologic contrast agents
EP0405704A2 (de) * 1989-06-30 1991-01-02 Schering Aktiengesellschaft Derivatisierte DTPA-Komplexe, diese Verbindungen enthaltende pharmazeutische Mittel, ihre Verwendung und Verfahren zu deren Herstellung
WO1991005599A1 (de) * 1989-10-13 1991-05-02 Schering Aktiengesellschaft Berlin Und Bergkamen Verfahren zur herstellung von wässrigen dispersionen
WO1994008565A1 (en) * 1992-10-14 1994-04-28 The Liposome Company, Inc. Interdigitation-fusion liposomes and gels
WO1994008626A1 (de) * 1992-10-16 1994-04-28 Andreas Sachse Verfahren und vorrichtung zur herstellung flüssiger, disperser systeme
WO1995015153A1 (de) * 1993-12-02 1995-06-08 Schering Aktiengesellschaft Verfahren zur erhöhung der stabilität von hydrophile wirkstoffe enthaltenden liposomensuspensionen
DE4426438A1 (de) * 1994-07-26 1996-02-01 Schering Ag Verwendung von Chelaten als Röntgenkontrastmittel

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CAPELLIER M ET AL: "RADIOPAQUE LIPOSOMES FOR COMPUTED TOMOGRAPHY OPACIFICATION", CARDIOLOGY AND IMAGING, NEW ORLEANS, NOV. 4 - 7, 1988, vol. 10 PART 1/04, 4 November 1988 (1988-11-04), HARRIS G;WALKER C, pages 491 - 492, XP000093331 *

Also Published As

Publication number Publication date
CA2212162A1 (en) 1996-08-15
WO1996024381A2 (de) 1996-08-15
NO973666D0 (no) 1997-08-08
NO973666L (no) 1997-10-08
AU4789096A (en) 1996-08-27
JPH10513466A (ja) 1998-12-22
DE19606326A1 (de) 1996-08-22
EP0806969A2 (de) 1997-11-19

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