WO2001082892A3 - Wirkstoffhaltige liposome - Google Patents

Wirkstoffhaltige liposome Download PDF

Info

Publication number
WO2001082892A3
WO2001082892A3 PCT/EP2001/004900 EP0104900W WO0182892A3 WO 2001082892 A3 WO2001082892 A3 WO 2001082892A3 EP 0104900 W EP0104900 W EP 0104900W WO 0182892 A3 WO0182892 A3 WO 0182892A3
Authority
WO
WIPO (PCT)
Prior art keywords
active substances
containing active
liposomes containing
encapsulated
producing
Prior art date
Application number
PCT/EP2001/004900
Other languages
English (en)
French (fr)
Other versions
WO2001082892A2 (de
Inventor
Juergen Ebert
Gerd Berger
Original Assignee
Pharmacept Gmbh
Juergen Ebert
Gerd Berger
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacept Gmbh, Juergen Ebert, Gerd Berger filed Critical Pharmacept Gmbh
Priority to AU2001260270A priority Critical patent/AU2001260270A1/en
Priority to EP01933914A priority patent/EP1427393A2/de
Publication of WO2001082892A2 publication Critical patent/WO2001082892A2/de
Publication of WO2001082892A3 publication Critical patent/WO2001082892A3/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Liposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Es werden liposomal verkapselte Wirkstoffe beansprucht, die dadurch gekennzeichnet sind, dass der bzw. die Wirkstoffe in einem Anteil von 1 Gew.- % bis 90 Gew.- %, bezogen auf die eingesetzte Wirkstoffmenge, verkapselt sind. Diese Wirkstoffe sind insbesondere zur Behandlung von Tumoren, als Nahrungsergänzungsmittel, zur Herstellung von Kontrastmitteln für bildgebende Verfahren und zur Herstellung von Diagnostikmitteln für Krankheiten geeignet.
PCT/EP2001/004900 2000-05-02 2001-05-02 Wirkstoffhaltige liposome WO2001082892A2 (de)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2001260270A AU2001260270A1 (en) 2000-05-02 2001-05-02 Liposomes containing active substances
EP01933914A EP1427393A2 (de) 2000-05-02 2001-05-02 Wirkstoffhaltige liposome

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10021030.9 2000-05-02
DE10021030 2000-05-02

Publications (2)

Publication Number Publication Date
WO2001082892A2 WO2001082892A2 (de) 2001-11-08
WO2001082892A3 true WO2001082892A3 (de) 2004-04-15

Family

ID=7640324

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2001/004900 WO2001082892A2 (de) 2000-05-02 2001-05-02 Wirkstoffhaltige liposome

Country Status (4)

Country Link
US (1) US20030124180A1 (de)
EP (1) EP1427393A2 (de)
AU (1) AU2001260270A1 (de)
WO (1) WO2001082892A2 (de)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9107824B2 (en) 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004087105A1 (en) * 2003-04-02 2004-10-14 Celator Pharmaceuticals, Inc. Combination formulations of platinum agents and fluoropyrimidines
US20050255154A1 (en) * 2004-05-11 2005-11-17 Lena Pereswetoff-Morath Method and composition for treating rhinitis
JP5735724B2 (ja) * 2004-11-08 2015-06-17 インスメッド， インコーポレイテッド 腹腔内投与される脂質ベースの白金化合物製剤を用いた、癌の治療方法
EP1745788A1 (de) * 2005-07-22 2007-01-24 KTB Tumorforschungsgesellschaft mbH Acylglycerophospholipide zur Behandlung von Krebs und Tumorkachexie
DE102009031274A1 (de) 2009-06-30 2011-01-13 Justus-Liebig-Universität Giessen Liposomen zur pulmonalen Applikation
US20110070291A1 (en) * 2009-09-11 2011-03-24 T*Amine, Llc. Food or beverage composition fortified with thyronamines and/or thyronamine precursors
MX2015002842A (es) 2012-09-04 2015-08-12 Eleison Pharmaceuticals LLC Prevencion de la recurrencia pulmonar del cancer con cisplatino lipido-complejado.
WO2015061449A1 (en) 2013-10-22 2015-04-30 Lipella Pharmaceuticals, Inc. Delivery of agents using metastable liposomes
WO2017097196A1 (zh) * 2015-12-08 2017-06-15 正大天晴药业集团股份有限公司 脂质体的制备方法
DE102018006443A1 (de) * 2018-08-14 2020-02-20 Abnoba Gmbh Verfahren zur Verkapselung von Wirkstoffen in Liposomen

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4762720A (en) * 1984-09-21 1988-08-09 Shionogi & Co., Ltd. Process for preparing liposome compositions
EP0290296A2 (de) * 1987-03-05 1988-11-09 The Liposome Company, Inc. Liposomen-Formulierungen mit hohem antineoplastischem Wirkstoff/Lipid-Verhältnis
US5252336A (en) * 1990-04-18 1993-10-12 Takeda Chemical Industries, Ltd. Liposome composition whose liposome membrane contains a polyoxyethylene derivative
WO1998055103A1 (de) * 1997-06-06 1998-12-10 Max-Delbrück-Centrum für Molekulare Medizin Mittel zur antitumortherapie

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2126648C (en) * 1993-11-09 2000-10-10 Tomas De Paoli Liposomes containing bioavailable iron (ii) and method for obtaining them
CN1148812A (zh) * 1994-03-28 1997-04-30 尼科梅德成像有限公司 “脂质体”
US5702722A (en) * 1994-09-30 1997-12-30 Bracco Research S.A. Liposomes with enhanced entrapment capacity, method and use
US6041252A (en) * 1995-06-07 2000-03-21 Ichor Medical Systems Inc. Drug delivery system and method

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4762720A (en) * 1984-09-21 1988-08-09 Shionogi & Co., Ltd. Process for preparing liposome compositions
EP0290296A2 (de) * 1987-03-05 1988-11-09 The Liposome Company, Inc. Liposomen-Formulierungen mit hohem antineoplastischem Wirkstoff/Lipid-Verhältnis
US5252336A (en) * 1990-04-18 1993-10-12 Takeda Chemical Industries, Ltd. Liposome composition whose liposome membrane contains a polyoxyethylene derivative
WO1998055103A1 (de) * 1997-06-06 1998-12-10 Max-Delbrück-Centrum für Molekulare Medizin Mittel zur antitumortherapie

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CROSASSO P ET AL: "Preparation, characterization and properties of sterically stabilized paclitaxel-containing liposomes", JOURNAL OF CONTROLLED RELEASE, ELSEVIER SCIENCE PUBLISHERS B.V., AMSTERDAM, NL, vol. 63, no. 1-2, January 2000 (2000-01-01), pages 19 - 30, XP004185068, ISSN: 0168-3659 *
FICHTNER I ET AL: "PHARMACOLOGICAL EFFECTS OF CARBOPLATIN-LIPOSOMES -CPL0 IN MICE: A REVIEV OF PRESENT KNOWLEDGE", JOURNAL OF LIPOSOME RESEARCH, MARCEL DEKKER, NEW YORK, US, vol. 5, no. 1, 1 February 1995 (1995-02-01), pages 75 - 89, XP000491778, ISSN: 0898-2104 *
FICHTNER IDUNA ET AL: "Carboplatin-liposomes (CPL) in immunodeficient mice: Improved antitumor activity for breast carcinomas and stimulation of hematopoiesis.", MEDICAL ONCOLOGY (NORTHWOOD), vol. 11, no. 3-4, 1994, pages 111 - 119, XP001015492 *
ONYEJI C O ET AL: "EFFICACIES OF LIPOSOME-ENCAPSULATED CLARITHROMYCIN AND OFLOXACIN AGAINST MYCOBACTERIUM AVIUM-M. INTRACELLULARE COMPLEX IN HUMAN MACROPHAGES", ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, AMERICAN SOCIETY FOR MICROBIOLOGY, WASHINGTON, DC, US, vol. 38, no. 3, 1 March 1994 (1994-03-01), pages 523 - 527, XP002065380, ISSN: 0066-4804 *
POHLEN U ET AL: "Increased carboplatin concentration in liver tumors through temporary flow retardation with starch microspheres (Spherex) and gelatin powder (Gelfoam): An experimental study in liver tumor-bearing rabbits.", JOURNAL OF SURGICAL RESEARCH, vol. 92, no. 2, August 2000 (2000-08-01), pages 165 - 170, XP001015715, ISSN: 0022-4804 *
POHLEN UWE ET AL: "5-FU-MLV-PEG liposomas: A drug carrier in the therapy of liver tumors. An experimental study in CC531 liver-tumor-bearing WAG/RIJ rats.", GASTROENTEROLOGY, vol. 116, no. 4 PART 2, April 1999 (1999-04-01), Digestive Disease Week and the 100th Annual Meeting of the American Gastroenterological Association;Orlando, Florida, USA; May 16-19, 1999, pages A486, XP001015703, ISSN: 0016-5085 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9107824B2 (en) 2005-11-08 2015-08-18 Insmed Incorporated Methods of treating cancer with high potency lipid-based platinum compound formulations administered intraperitoneally

Also Published As

Publication number Publication date
AU2001260270A1 (en) 2001-11-12
EP1427393A2 (de) 2004-06-16
WO2001082892A2 (de) 2001-11-08
US20030124180A1 (en) 2003-07-03

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