WO1996023420A1 - Astaxanthin suspension - Google Patents
Astaxanthin suspension Download PDFInfo
- Publication number
- WO1996023420A1 WO1996023420A1 PCT/EP1996/000373 EP9600373W WO9623420A1 WO 1996023420 A1 WO1996023420 A1 WO 1996023420A1 EP 9600373 W EP9600373 W EP 9600373W WO 9623420 A1 WO9623420 A1 WO 9623420A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- astaxanthin
- suspension
- oil
- feed
- particle size
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C403/00—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone
- C07C403/24—Derivatives of cyclohexane or of a cyclohexene or of cyclohexadiene, having a side-chain containing an acyclic unsaturated part of at least four carbon atoms, this part being directly attached to the cyclohexane or cyclohexene or cyclohexadiene rings, e.g. vitamin A, beta-carotene, beta-ionone having side-chains substituted by six-membered non-aromatic rings, e.g. beta-carotene
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/179—Colouring agents, e.g. pigmenting or dyeing agents
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/80—Feeding-stuffs specially adapted for particular animals for aquatic animals, e.g. fish, crustaceans or molluscs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L5/00—Preparation or treatment of foods or foodstuffs, in general; Food or foodstuffs obtained thereby; Materials therefor
- A23L5/40—Colouring or decolouring of foods
- A23L5/42—Addition of dyes or pigments, e.g. in combination with optical brighteners
- A23L5/43—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives
- A23L5/44—Addition of dyes or pigments, e.g. in combination with optical brighteners using naturally occurring organic dyes or pigments, their artificial duplicates or their derivatives using carotenoids or xanthophylls
Definitions
- This invention relates to a stable oil suspension of astaxanthin with high bioavailability, and the use thereof.
- Astaxanthin belongs to the carotenoids, which is a group of compounds exhibiting a wide range of yellow to red colour nuances. Carotenoids give rise to several of the colour characteristics of plants, and aquatic animals, for example.
- Carotenoids are insoluble in water and are only slightly fat soluble which means that solutions of carotenoids for direct application are unavailable. Furthermore, carotenoids are very sensible to oxidation.
- Astaxanthin is used in fish-farming to impart a pink colour to shrimp, trout, salmon etc.
- the invention comprises thus the following:
- the suspension according to the invention can be prepared by milling of astaxanthin, if desired in the presence of oil.
- astaxanthin is milled without oil, whereafter oil is added and the milling continued, if desired. Oxidation of astaxanthin during the dry milling operation can be reduced by the application of an inert gas atmosphere.
- the astaxanthin particles in the suspension of the invention have a particle size less than 2 ⁇ m, especially less than 1 ⁇ m. More preferred is an astaxanthin particle size less than 0.5 ⁇ m, especially less than 0J ⁇ m.
- the oil can be any animal or vegetable oil suitable for use in feed for aquatic animals.
- oil includes fish oil, such as for example mackerel oil, sprat oil and launce oil.
- Antioxidants such as for example tocopherols, especially ⁇ -tocopherol, butylhydroxyanisole (BHA), butylhydroxytoluene (BHT), ascorbylpalmitate or ethoxyquin, can be added to the suspension to avoid oxidation.
- tocopherols especially ⁇ -tocopherol, butylhydroxyanisole (BHA), butylhydroxytoluene (BHT), ascorbylpalmitate or ethoxyquin
- BHA butylhydroxyanisole
- BHT butylhydroxytoluene
- ascorbylpalmitate or ethoxyquin can be added to the suspension to avoid oxidation.
- Feed for aquatic animals suitably contains 15-30 % fat. Fat can be added by absorption of oil into the feed after extrusion, if desired using vacuum.
- the oil suspension of the invention could suitably be added to the feed using the same procedure, whereby an addition of fat and astaxanthin is obtained in one step.
- the suspension of the invention has a high concentration of astaxanthin and is diluted with additional oil before use.
- the final concentration of astaxanthin in fish feed is suitable between 25 and 100 ppm.
- Astaxanthin OJ g is milled for one hour totally in a Fritsen planetary micro mill pulverisette 7, speed 6. 5 ml of Launce oil ( Esbjerg Fiskeindustri ) is added and milling is continued for 15 min, speed 1.5. Particle size is measured by microscopy and found to be less than 2 ⁇ m for the majority of the particles. This suspension is poured on to a glass and placed in the dark at room temperature for 14 days.
- the small particles show a tendency to agglomeration but nothing indicates that the particles grow when standing. There is no sedimentation of astaxanthin.
- Launce oil solidifies at -18°C.
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Organic Chemistry (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Nutrition Science (AREA)
- Health & Medical Sciences (AREA)
- Insects & Arthropods (AREA)
- Marine Sciences & Fisheries (AREA)
- Birds (AREA)
- Feed For Specific Animals (AREA)
- Fodder In General (AREA)
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8523250A JPH10511270A (ja) | 1995-01-31 | 1996-01-30 | アスタキサンチン サスペンジョン |
AU47156/96A AU4715696A (en) | 1995-01-31 | 1996-01-30 | Astaxanthin suspension |
NZ301672A NZ301672A (en) | 1995-01-31 | 1996-01-30 | A suspension of astaxanthin in oil |
EP96902947A EP0812135A1 (en) | 1995-01-31 | 1996-01-30 | Astaxanthin suspension |
FI972961A FI972961A (fi) | 1995-01-31 | 1997-07-11 | Astaksantiinisuspensio |
NO973473A NO973473L (no) | 1995-01-31 | 1997-07-28 | Astaxantinsuspensjon |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DK0108/95 | 1995-01-31 | ||
DK10895 | 1995-01-31 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1996023420A1 true WO1996023420A1 (en) | 1996-08-08 |
Family
ID=8089837
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP1996/000373 WO1996023420A1 (en) | 1995-01-31 | 1996-01-30 | Astaxanthin suspension |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0812135A1 (no) |
JP (1) | JPH10511270A (no) |
AU (1) | AU4715696A (no) |
CA (1) | CA2211107A1 (no) |
FI (1) | FI972961A (no) |
NO (1) | NO973473L (no) |
NZ (1) | NZ301672A (no) |
WO (1) | WO1996023420A1 (no) |
Cited By (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5863953A (en) * | 1996-11-27 | 1999-01-26 | Basf Aktiengesellschaft | Liquid, oil-miscible carotenoid preparations |
WO2004016099A1 (en) * | 2002-08-14 | 2004-02-26 | Zoolife International Limited | Composition for dietary enrichment |
WO2006034556A1 (en) * | 2004-09-29 | 2006-04-06 | Michael Ary Bos | Caratenoid composition and method for preparation thereof |
US7105176B2 (en) | 2000-11-29 | 2006-09-12 | Basf Aktiengesellschaft | Production of solid preparations of water-soluble, sparingly water-soluble or water-insoluble active compounds |
WO2006125591A1 (en) * | 2005-05-23 | 2006-11-30 | Phares Pharmaceutical Research N.V. | Direct dissolution |
ES2304835A1 (es) * | 2005-12-29 | 2008-10-16 | Universidad De Las Palmas De Gran Canaria | Pienso y procedimiento de alimentacion para peces de piel rosado-rojiza procedentes de la acuicultura, para obtener en los mismos una coloracion y apariencia externa semejante a dichos organismos cuando son obtenidos directamente del mar mediante pesca extractiva. |
WO2009065928A1 (de) * | 2007-11-23 | 2009-05-28 | Basf Se | Verfahren zur herstellung von carotinoidlösungen |
WO2009065929A1 (de) * | 2007-11-23 | 2009-05-28 | Basf Se | Verfahren zur herstellung von carotinoid-lösungen |
US8809398B2 (en) | 2007-01-16 | 2014-08-19 | Basf Se | Liquid formulations containing a carotinoid |
EP2792246A1 (de) | 2013-04-17 | 2014-10-22 | Basf Se | Verfahren zur Herstellung einer Astaxanthin-Suspension |
US9375387B2 (en) | 2008-10-07 | 2016-06-28 | Basf Se | Ready-to-use, stable emulsion |
US11185093B2 (en) | 2007-11-29 | 2021-11-30 | Christian Köpsel | Pulverulent carotenoid preparation for colouring drinks |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0239949A2 (de) * | 1986-04-04 | 1987-10-07 | BASF Aktiengesellschaft | Verfahren zur Herstellung von feinverteilten, pulverförmigen Carotinoidpräparaten |
WO1988008025A1 (en) * | 1987-04-15 | 1988-10-20 | Danisco Bioteknologi A/S | Astaxanthin-producing yeast cells, methods for their preparation and their use |
WO1989006910A1 (en) * | 1988-02-08 | 1989-08-10 | Microbio Resources, Inc. | Pigmentation supplements for animal feed compositions |
WO1991006292A1 (en) * | 1989-11-02 | 1991-05-16 | Danochemo A/S | Process of preparing a water dispersible hydrophobic or aerophilic solid |
EP0551638A1 (de) * | 1992-01-14 | 1993-07-21 | BASF Aktiengesellschaft | Stabile, flüssige Präparate fettlöslicher Substanzen |
WO1993014645A1 (en) * | 1992-01-24 | 1993-08-05 | Gist-Brocades N.V | Method for the preparation of feed pellets |
-
1996
- 1996-01-30 NZ NZ301672A patent/NZ301672A/en unknown
- 1996-01-30 EP EP96902947A patent/EP0812135A1/en not_active Withdrawn
- 1996-01-30 AU AU47156/96A patent/AU4715696A/en not_active Abandoned
- 1996-01-30 CA CA002211107A patent/CA2211107A1/en not_active Abandoned
- 1996-01-30 JP JP8523250A patent/JPH10511270A/ja active Pending
- 1996-01-30 WO PCT/EP1996/000373 patent/WO1996023420A1/en not_active Application Discontinuation
-
1997
- 1997-07-11 FI FI972961A patent/FI972961A/fi unknown
- 1997-07-28 NO NO973473A patent/NO973473L/no unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0239949A2 (de) * | 1986-04-04 | 1987-10-07 | BASF Aktiengesellschaft | Verfahren zur Herstellung von feinverteilten, pulverförmigen Carotinoidpräparaten |
WO1988008025A1 (en) * | 1987-04-15 | 1988-10-20 | Danisco Bioteknologi A/S | Astaxanthin-producing yeast cells, methods for their preparation and their use |
WO1989006910A1 (en) * | 1988-02-08 | 1989-08-10 | Microbio Resources, Inc. | Pigmentation supplements for animal feed compositions |
WO1991006292A1 (en) * | 1989-11-02 | 1991-05-16 | Danochemo A/S | Process of preparing a water dispersible hydrophobic or aerophilic solid |
EP0551638A1 (de) * | 1992-01-14 | 1993-07-21 | BASF Aktiengesellschaft | Stabile, flüssige Präparate fettlöslicher Substanzen |
WO1993014645A1 (en) * | 1992-01-24 | 1993-08-05 | Gist-Brocades N.V | Method for the preparation of feed pellets |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5863953A (en) * | 1996-11-27 | 1999-01-26 | Basf Aktiengesellschaft | Liquid, oil-miscible carotenoid preparations |
US7105176B2 (en) | 2000-11-29 | 2006-09-12 | Basf Aktiengesellschaft | Production of solid preparations of water-soluble, sparingly water-soluble or water-insoluble active compounds |
WO2004016099A1 (en) * | 2002-08-14 | 2004-02-26 | Zoolife International Limited | Composition for dietary enrichment |
WO2006034556A1 (en) * | 2004-09-29 | 2006-04-06 | Michael Ary Bos | Caratenoid composition and method for preparation thereof |
US8197851B2 (en) | 2004-09-29 | 2012-06-12 | Michael Ary Bos | Carotenoid composition and method for preparation thereof |
EP2266419A1 (en) * | 2005-05-23 | 2010-12-29 | Phares Drug Delivery AG | Direct dissolution of carotenoids in edible oils and fats |
WO2006125591A1 (en) * | 2005-05-23 | 2006-11-30 | Phares Pharmaceutical Research N.V. | Direct dissolution |
US8632832B2 (en) | 2005-05-23 | 2014-01-21 | Phares Pharmaceutical Research N.V. | Direct dissolution |
ES2304835A1 (es) * | 2005-12-29 | 2008-10-16 | Universidad De Las Palmas De Gran Canaria | Pienso y procedimiento de alimentacion para peces de piel rosado-rojiza procedentes de la acuicultura, para obtener en los mismos una coloracion y apariencia externa semejante a dichos organismos cuando son obtenidos directamente del mar mediante pesca extractiva. |
US8809398B2 (en) | 2007-01-16 | 2014-08-19 | Basf Se | Liquid formulations containing a carotinoid |
WO2009065928A1 (de) * | 2007-11-23 | 2009-05-28 | Basf Se | Verfahren zur herstellung von carotinoidlösungen |
WO2009065929A1 (de) * | 2007-11-23 | 2009-05-28 | Basf Se | Verfahren zur herstellung von carotinoid-lösungen |
US11185093B2 (en) | 2007-11-29 | 2021-11-30 | Christian Köpsel | Pulverulent carotenoid preparation for colouring drinks |
US9375387B2 (en) | 2008-10-07 | 2016-06-28 | Basf Se | Ready-to-use, stable emulsion |
US10004670B2 (en) | 2008-10-07 | 2018-06-26 | Basf Se | Ready-to-use, stable emulsion |
EP2792246A1 (de) | 2013-04-17 | 2014-10-22 | Basf Se | Verfahren zur Herstellung einer Astaxanthin-Suspension |
WO2014170225A1 (de) * | 2013-04-17 | 2014-10-23 | Basf Se | Verfahren zur herstellung einer astaxanthin-suspension |
Also Published As
Publication number | Publication date |
---|---|
FI972961A0 (fi) | 1997-07-11 |
EP0812135A1 (en) | 1997-12-17 |
FI972961A (fi) | 1997-07-31 |
CA2211107A1 (en) | 1996-08-08 |
JPH10511270A (ja) | 1998-11-04 |
NZ301672A (en) | 1997-12-19 |
NO973473D0 (no) | 1997-07-28 |
NO973473L (no) | 1997-07-28 |
AU4715696A (en) | 1996-08-21 |
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