WO1996018387B1 - Formes galeniques a macher - Google Patents
Formes galeniques a macherInfo
- Publication number
- WO1996018387B1 WO1996018387B1 PCT/US1995/016781 US9516781W WO9618387B1 WO 1996018387 B1 WO1996018387 B1 WO 1996018387B1 US 9516781 W US9516781 W US 9516781W WO 9618387 B1 WO9618387 B1 WO 9618387B1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- dosage form
- matrix
- hydrogenated starch
- starch hydrolysate
- soft
- Prior art date
Links
- 239000002552 dosage form Substances 0.000 title claims abstract 10
- 239000011159 matrix material Substances 0.000 claims abstract 9
- 229920001908 Hydrogenated starch hydrolysate Polymers 0.000 claims abstract 6
- 239000004067 bulking agent Substances 0.000 claims abstract 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 6
- 239000004480 active ingredient Substances 0.000 claims abstract 3
- VTYYLEPIZMXCLO-UHFFFAOYSA-L calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 3
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 3
- 239000000600 sorbitol Substances 0.000 claims 3
- WNROFYMDJYEPJX-UHFFFAOYSA-K Aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims 2
- 229960003563 Calcium Carbonate Drugs 0.000 claims 2
- CXQXSVUQTKDNFP-UHFFFAOYSA-N Simethicone Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 claims 2
- 229940083037 Simethicone Drugs 0.000 claims 2
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims 2
- 229910000019 calcium carbonate Inorganic materials 0.000 claims 2
- 239000003906 humectant Substances 0.000 claims 2
- 229940024545 Aluminum Hydroxide Drugs 0.000 claims 1
- 229960005069 Calcium Drugs 0.000 claims 1
- VTHJTEIRLNZDEV-UHFFFAOYSA-L Magnesium hydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 claims 1
- 229940045997 Vitamin A Drugs 0.000 claims 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims 1
- 229960005467 algeldrate Drugs 0.000 claims 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims 1
- RJZNFXWQRHAVBP-UHFFFAOYSA-I aluminum;magnesium;pentahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Al+3] RJZNFXWQRHAVBP-UHFFFAOYSA-I 0.000 claims 1
- 239000003159 antacid agent Substances 0.000 claims 1
- 230000001458 anti-acid Effects 0.000 claims 1
- 229960001948 caffeine Drugs 0.000 claims 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 125000003346 cobalamin group Chemical group 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 238000007906 compression Methods 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000013355 food flavoring agent Nutrition 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N glycerol group Chemical group OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims 1
- 239000000347 magnesium hydroxide Substances 0.000 claims 1
- 229910001862 magnesium hydroxide Inorganic materials 0.000 claims 1
- 229960000816 magnesium hydroxide Drugs 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229960003471 retinol Drugs 0.000 claims 1
- 239000011719 vitamin A Substances 0.000 claims 1
- 235000019155 vitamin A Nutrition 0.000 claims 1
- 239000011715 vitamin B12 Substances 0.000 claims 1
- 239000011647 vitamin D3 Substances 0.000 claims 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims 1
Abstract
On décrit, dans la présente invention une forme galénique à mâcher comprenant une matrice d'hydrolysat d'amidon hydrogéné, un agent gonflant hydrosoluble et un agent gonflant insoluble dans l'eau. On décrit également un procédé de préparation d'une forme galénique à mâcher molle, y compris les étapes qui consistent à mélanger, sous l'action d'une force de cisaillement importante, un hydrolysat d'amidon hydrogéné, un agent gonflant hydrosoluble et un agent gonflant insoluble dans l'eau, en vue d'obtenir une matrice à mélange uniforme. A titre facultatif, des ingrédients actifs peuvent être incorporés dans la matrice.
Priority Applications (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP8519330A JPH10510817A (ja) | 1994-12-16 | 1995-12-15 | チュアブル製剤 |
GB9712183A GB2310802A (en) | 1994-12-16 | 1995-12-15 | Chewable dosage forms |
AU46067/96A AU4606796A (en) | 1994-12-16 | 1995-12-15 | Chewable dosage forms |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/357,506 US5637313A (en) | 1994-12-16 | 1994-12-16 | Chewable dosage forms |
US08/357,506 | 1994-12-16 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1996018387A1 WO1996018387A1 (fr) | 1996-06-20 |
WO1996018387B1 true WO1996018387B1 (fr) | 1996-08-15 |
Family
ID=23405913
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1995/016781 WO1996018387A1 (fr) | 1994-12-16 | 1995-12-15 | Formes galeniques a macher |
Country Status (6)
Country | Link |
---|---|
US (1) | US5637313A (fr) |
JP (1) | JPH10510817A (fr) |
CN (1) | CN1170358A (fr) |
AU (1) | AU4606796A (fr) |
GB (1) | GB2310802A (fr) |
WO (1) | WO1996018387A1 (fr) |
Families Citing this family (66)
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ES2787220T3 (es) | 2015-03-26 | 2020-10-15 | Patheon Softgels Inc | Cápsulas blandas llenas de líquido |
US20190022013A1 (en) | 2015-12-19 | 2019-01-24 | First Time Us Generics Llc | Soft-chew tablet pharmaceutical formulations |
WO2017106812A1 (fr) | 2015-12-19 | 2017-06-22 | First Time Us Generics Llc | Formulations pharmaceutiques de comprimés mous à mâcher |
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US11559491B2 (en) * | 2017-08-17 | 2023-01-24 | Ceva Sante Animale | Oral compositions and the preparation methods thereof |
US10980831B2 (en) | 2018-03-23 | 2021-04-20 | Fertin Pharma A/S | Solid pharmaceutical tablet |
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-
1994
- 1994-12-16 US US08/357,506 patent/US5637313A/en not_active Expired - Lifetime
-
1995
- 1995-12-15 JP JP8519330A patent/JPH10510817A/ja active Pending
- 1995-12-15 GB GB9712183A patent/GB2310802A/en not_active Withdrawn
- 1995-12-15 AU AU46067/96A patent/AU4606796A/en not_active Abandoned
- 1995-12-15 CN CN95196840A patent/CN1170358A/zh active Pending
- 1995-12-15 WO PCT/US1995/016781 patent/WO1996018387A1/fr not_active Application Discontinuation
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