WO1996016601A1 - Dispositif chirurgical servant a proteger les organes pour empecher la formation d'adherences - Google Patents

Dispositif chirurgical servant a proteger les organes pour empecher la formation d'adherences Download PDF

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Publication number
WO1996016601A1
WO1996016601A1 PCT/US1995/001171 US9501171W WO9616601A1 WO 1996016601 A1 WO1996016601 A1 WO 1996016601A1 US 9501171 W US9501171 W US 9501171W WO 9616601 A1 WO9616601 A1 WO 9616601A1
Authority
WO
WIPO (PCT)
Prior art keywords
cover
pouch
porous
polytetrafluoroethylene
organ
Prior art date
Application number
PCT/US1995/001171
Other languages
English (en)
Inventor
Terry A. Hubbard
David W. Jansen
Mark M. Thurston
Original Assignee
W.L. Gore & Associates, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by W.L. Gore & Associates, Inc. filed Critical W.L. Gore & Associates, Inc.
Priority to AU16088/95A priority Critical patent/AU1608895A/en
Publication of WO1996016601A1 publication Critical patent/WO1996016601A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/42—Gynaecological or obstetrical instruments or methods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/00234—Surgical instruments, devices or methods, e.g. tourniquets for minimally invasive surgery
    • A61B2017/00287—Bags for minimally invasive surgery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/08—Accessories or related features not otherwise provided for
    • A61B2090/0815—Implantable devices for insertion in between organs or other soft tissues
    • A61B2090/0816—Implantable devices for insertion in between organs or other soft tissues for preventing adhesion
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/0063—Implantable repair or support meshes, e.g. hernia meshes
    • A61F2002/0072—Delivery tools therefor

Definitions

  • the present invention relates to a cover for protecting and isolating an internal organ or body tissue from surrounding organs or tissue and more particularly relates to a protective pouch of non-resorbable material which is pre ⁇ formed to conform to the shape of an ovary or other organ or tissue to protect the
  • Adhesions are scar tissue that binds anatomical surfaces which surfaces are normally separated from each other. Adhesions are most commonly found in the abdominal area where they form after surgery, inflammation or injury and cause abdominal pain, nausea, vomiting, distention. In some cases corrective surgery such as an adhesiotomy is necessary to remove adhesions.
  • the ovary is the center of focus in the field of infertility medicine. Conception depends upon the availability and migration of a single cell (the ovum) from the surface of the ovary into the fallopian tubes. Physicians are very concerned and very aggressive in protecting the ovary and keeping the ovary free from any conditions that would negatively impact this process. See Bronson, R.A., Wallach, E.E. Lvsis of Periadnexal Adhesions for Correction of Infertility, "Fertility
  • One adjuvant comprises a barrier of oxidized regenerated cellulose (ORC), and another comprises porous polytetrafluoroethylene (PTFE).
  • ORC has been shown to be ineffective in the presence of all but exacting hemostasis and may, in fact, be adhesiogenic due to its acidic nature and the brisk foreign body response it engenders.
  • Porous polytetrafluoroethylene in contrast, may be used in conditions that are not perfectly hemostatic and porous polytetrafluoroethylene has the characteristic of being one of the most inert biomaterials developed to date.
  • ORC and porous polytetrafluoroethylene as physical barriers to prevent and protect against ovarian adhesions has utilized these materials as flat sheets of material which sheets were not well suited to the application to a rounded or dome-like organ such as the ovary.
  • U. S. Patent 5,279,539 discloses a device and method for prevention of surgical adhesions, particularly ovarian adhesions, by endoscopic procedures utilizing a surgical drawstring pouch.
  • the patentees suggest placing a surgical pouch over an ovary after a surgical procedure and then cinching the mouth of the pouch closed about the ovary to isolate the ovary from the surrounding body tissue.
  • the pouch shown in this patent is bioabsorbable and is capable of breaking down over a period of several months.
  • the preferred material of the pouch is a warp knit fabric composed of oxidized regenerated cellulose (ORC) which may require neutralization to render it more compatible with body tissue.
  • ORC oxidized regenerated cellulose
  • the surgical pouch of the '539 patent has two drawstrings.
  • the first drawstring is detachable and is made up of resilient wire-like thread for maintaining the mouth of the pouch open during use.
  • the second drawstring is . intended to cinch the mouth of the pouch.
  • the pouch is preferably placed over the ovary by an endoscopic procedure.
  • the present invention relates to the prevention of ovarian adhesions by the use of a cover fabricated of a non-resorbable material such as porous polytetrafluoroethylene.
  • a cover fabricated of a non-resorbable material such as porous polytetrafluoroethylene.
  • the commercially available material sold under the designation "Gore-Tex Surgical Membrane” as manufactured by W.L. Gore •&
  • the cover is pre- formed by a suitable fabrication procedure such as heating and vacuum forming which locks the cover in the proper configuration.
  • the cover includes a pouch which may take various shapes which will incorporate at least one compound curve and thereby encompass the configuration of an injured post operative organ such as the ovary.
  • Compound curve as used herein means the state of being curved simultaneously in two perpendicular planes intersecting the curved region, whereby the cover incorporating the compound curves will encompass the configuration of an organ substantially without wrinkling as would normally occur if attempting to encompass such an organ with a flat sheet of flexible material which did not incorporate compound curves.
  • the material of the cover has a nominal mean fibril length of about five microns or less to prevent tissue attachment.
  • the pouch has a thickness in the range of 0.01 to 1.0 millimeters with 0.1 millimeters being preferred.
  • the cover is configured as a pouch with a dome-shaped closed end that extends to a straight open-sided skirt.
  • gathers which may be pleats or a series of notches, can also be provided in the skirt around the opposite, open mouth end.
  • Slits can be provided to accommodate strands which serve as ties that will close the pouch over the ovary or other organ by drawing or cinching the slits together.
  • the ties may be closed by tying one of the ties to the other or by securing the ties using laparoscopic ligaclips.
  • the entire cover can be introduced at the surgical site laparoscopically through a trocar sleeve as, for example, a five millimeter diameter trocar sleeve which will allow it to be
  • the pouch is surgically removed by laparoscopic procedures with minimum trauma to the patient.
  • Figure 1 is a perspective view of an organ cover according to the present invention.
  • Figure 2 is a side elevation view of the cover as it is shown in Figure 1;
  • Figure 3 is a top view of the organ cover shown in Figures 1 and 2;
  • FIGS. 4 and 5 are diagrammatic representations showing the method of forming the cover of the present invention:
  • Figure 6 is a side view of the cover with the ties inserted in the pouch:
  • Figure 7 a view similar to Figure 6 in which the ties have been tensioned to close the pouch;
  • FIGS 8 to 12 illustrate the surgical positioning of the cover by laparoscopic procedures
  • Figure 13 is a top view of an alternate embodiment of the cover; and Figure 14 is a side view of the cover of Figure 13. Detailed Description of the Preferred Embodiment
  • the cover 10 includes a pouch 12 which is shown as having a domed closed end 14 and a circumferential side wall or skirt 16.
  • the pouch 12 has an opening or mouth 18 opposite the closed end.
  • the shape of the pouch 12 may vary to conform to the shape of the organ to which the cover is to be attached.
  • the description of the invention will be with reference to the cover for application to an ovary, it being understood that the cover can be applied as a barrier to the formation of adhesions on other organs such as the uterus, fallopian tubes, spleen, pancreas and liver.
  • the ovary as the name implies, is generally oval in shape and is attached to a suspensory ligament. Thus the semi- oval bursiform configuration of the pouch is suited for ovarian applications.
  • the pouch may be cup-shaped or otherwise configured as required by the particular application.
  • the description of the pouch having at least one compound curve is intended to encompass these various shapes as well as
  • the cover 10 has a peripheral edge 20 which extends around the mouth or opening 18.
  • the peripheral edge is preferably provided with a series of vertically extending notches 24 which form a series of tabs 28 integral with the pouch.
  • the tabs 28 extend partially around the periphery of the pouch starting near the rear of the cover as best shown in Figure 3.
  • the tabs adjacent the rear of the pouch are of a height less than the corresponding tabs near the front of the pouch.
  • the terms "front” and “rear” are relative terms used for purposes of orientation only with the rear of the pouch being the area designated by the letter "R” and the front being the area designated by the letter “F” in Figure 3.
  • Each of the tabs define a centrally extending slit 30 through which a tie may be threaded to facilitate closure of the pouch about the organ.
  • the ties 32 and 34 are preferably strands cut from the material of the cover and are integral therewith and extend from the rear of the cover around the opposite sides of the pouch. Alternatively, separate ties may be used. In assembling the cover, the ties are threaded through the slits 30 as shown in Figure 6 which when tensioned, as shown in Figure 7, gathers the tabs in overlapping relationship and closes the mouth 18 of the cover.
  • the individual ties 32 and 34 are threaded through the slits 30 with the ends of the ties extending at the front of the pouch.
  • One significant advantage of the design of the present invention is that the pouch is pre-formed to conform to the shape of the organ to which it is to be attached.
  • An additional advantage is that the ties are an integral part of the structure so that the ties will not become detached from the pouch during surgical procedures. The result is a complex cover incorporating compound curves that is formed in the desired shape and is compatible with the configuration of the post operative organ such as an injured
  • the cover can be positioned by conventional surgical procedures such as endoscopy or standard laparoscopic procedures as seen in Figures 8 to 12.
  • Endoscopic surgery involves the use of an endoscope which is an instrument permitting the visual inspection and magnification of any cavity of the body.
  • the endoscope is inserted through a tubular sheath referred to as a "cannula" after puncturing the wall of the body cavity with a trocar.
  • the surgeon then performs the necessary procedures at the surgical site and with the aid of conventional instruments designed to fit through additional cannula.
  • the cover 10 can be inserted by laparoscopic instruments which is a type of endoscopy.
  • a tube with an optical system is inserted through the abdomen to permit examination of the ovaries and the fallopian tubes.
  • a trocar sleeve is inserted using laparoscopic instruments.
  • the porous PTFE cover of the present invention is flexible so it can be introduced through five millimeter or larger trocar sleeve 100 and can be easily maneuvered over the damaged ovary through the use of a standard instrument 106.
  • the cover 10 Once inserted in the abdominal cavity, the cover 10 will tend to return to its pre ⁇ formed shape conforming to the shape of the ovary or other organ.
  • the cover is placed with the pouch 12 over the ovary "O" in the manner shown in Figure 10.
  • the ties 32, 34 are an integral part with the cover and will not become detached. Once the cover is in place, the surgeon will grasp the ties with instrument 106 and tension the ties 32 and 34 which will cause the mouth of the cover to close about the organ as seen in Figure 11.
  • a ligating clip 115, as shown in Figure 12. or a suture may be used to retain the ties in place.
  • the procedure is relatively easy since the ties do not require threading but rather the threading has been accomplished prior to insertion of the pouch through the trocar.
  • the cover structure is integral in that no components remain which have to be later removed or which may become detached during the insertion procedure. In place, the cover envelopes a substantial portion of the surface of the ovary providing a significant benefit, protecting the ovary to reduce both the formation and severity of adhesions particularly in the area between the ovary and pelvic side wall.
  • An advantageous characteristic of porous PTFE of adequately small pore size is that tissue does not readily attach to it.
  • the pouch can be surgically removed using endoscopic or laparoscopic procedures as described above. Generally the pouch will be left in place for a period of at least about 7 to 30 days.
  • Use of a cover of the type according to the invention does not result in placement of an object which must be metabolized or otherwise eliminated from the body.
  • FIGS 13 and 14 show an alternate embodiment of the present invention generally designated by the numeral 10A.
  • the cover includes a pouch 12A having a domed, closed end 14A and a circumferential side wall or skirt 16A.
  • the cover has a peripheral edge 20A which extends around mouth 18A without notches.
  • Ties 32A and 34A extend through slits 30A formed at spaced intervals adjacent the edge.
  • the embodiment 10A is fabricated and surgically positioned about an organ in the manner described above. The fabrication of the cover 10 is accomplished by standard thermoforming techniques as seen in Figures 4 and 5.
  • a blank sheet 50 of non-resorbable material is first clamped in a frame 52 to constrain its edges.
  • the sheet 50 is substantially impervious to tissue growth and tissue penetration which material is preferably a microporous membrane having a small pore size and a thickness in the range of 0.01 to 1.0 mm.
  • a preferred material is porous PTFE such as that sold under the trademark "Gore-Tex Surgical Membrane".
  • porous PTFE such as that sold under the trademark "Gore-Tex Surgical Membrane”.
  • the restrained sheet 50 is positioned over suitable tooling such as a domed die 60 having the desired profile of the pouch.
  • suitable tooling such as a domed die 60 having the desired profile of the pouch.
  • the material is heated to a temperature of at least 290 ⁇ C by any conventional heat source 66, such as an oven or an infrared source.
  • a vacuum is applied to the die 60 by vacuum source 62 resulting in a cover with the pouch formed and locked in the desired shape.
  • the heat is removed and the material allowed to cool.
  • the cover 10 is trimmed from the sheet by die cutting, stamping or otherwise severing to the completed shape as shown in Figure 1.
  • Example 1 Example 1:
  • the following is a description of a method used to make a pouch from GORE-TEX® Surgical Membrane to fit a human ovary.
  • the method utilized thermoforming techniques involving vacuum drawing over a male form having the shape of the domed die 60 described by Figures 4 and 5, useful for making a pouch of the shape generally described by Figures 1 - 3.
  • the domed die was of 8 cm height; a horizontal cross section through the base of the domed die had a long axis dimension of 4.1 cm and a short axis dimension of 2.5 cm.
  • This domed die was made from 316 stainless steel of 2.0 mm thickness and was placed on a horizontally oriented vacuum plate 62 as shown by Figure 5.
  • a 12 X 12 cm sheet of porous PTFE (GORE-TEX Surgical Membrane, Part No. 1612012001, W.L. Gore & Associates, Inc., Flagstaff, AZ) was mounted in a perimeter frame to restrain the edges.
  • a cylindrical air-convection oven of 15 cm inside diameter and 10 cm inside length was used to heat the sheet of porous PTFE. The length of the oven was vertically oriented; the top of the oven was a closed horizontal surface with two small, 5 mm diameter perforations to allow subsequent air flow. The bottom of the oven was left open. The oven was heated to an indicated temperature of 340° C.
  • the restrained sheet of porous PTFE was
  • the domed die previously heated to about 75 °C, was pressed into the sheet of porous PTFE which had become softened by the heat from the oven.
  • the porous PTFE sheet conformed to the surface of the domed die and contacted the vacuum plate.
  • 380 mm Hg of vacuum was applied to the vacuum plate, causing the sheet of porous PTFE to closely conform to both the domed die and the vacuum plate.
  • the two small holes in the upper surface of the cylindri-cal oven allowed air flow during application of the vacuum.
  • the porous PTFE covered domed die was allowed to cool by continued air flow from the supplied vacuum. After cooling to about room temperature, the newly formed porous PTFE pouch was removed from the die. The pouch edges were trimmed to a desired shape using surgical scissors.

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Molecular Biology (AREA)
  • Medical Informatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Surgical Instruments (AREA)

Abstract

Enveloppe (10) utilisée pour protéger et isoler un organe ou des tissus corporels internes afin d'empêcher la formation d'adhérences post-opératoires. L'enveloppe (10) est réalisée dans une matière ne se résorbant pas et comporte une poche préformée de manière à comprendre au moins une courbe complexe s'adaptant à la forme de l'organe sur lequel elle doit être placée. Cette enveloppe comprend des liens (32, 34) solidaires par fabrication qui sont tendus chirurgicalement pour fixer l'enveloppe en place. Cette dernière (10) est de préférence fabriquée en polytétrafluoroéthylène (PTFE) poreux qui est moulé et chauffé pour que la poche (12) acquiert sa forme désirée et définitive.
PCT/US1995/001171 1994-11-30 1995-02-22 Dispositif chirurgical servant a proteger les organes pour empecher la formation d'adherences WO1996016601A1 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU16088/95A AU1608895A (en) 1994-11-30 1995-02-22 Surgical device for protecting organs from formation of adhesions

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34673694A 1994-11-30 1994-11-30
US08/346,736 1994-11-30

Publications (1)

Publication Number Publication Date
WO1996016601A1 true WO1996016601A1 (fr) 1996-06-06

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PCT/US1995/001171 WO1996016601A1 (fr) 1994-11-30 1995-02-22 Dispositif chirurgical servant a proteger les organes pour empecher la formation d'adherences

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AU (1) AU1608895A (fr)
WO (1) WO1996016601A1 (fr)

Cited By (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998058598A1 (fr) * 1997-06-21 1998-12-30 Hans Haindl Sachet destine a envelopper au moins partiellement un coeur
GB2352634A (en) * 1999-07-30 2001-02-07 Shantanu Kumar Ghosh Ovarian cap
WO2001050981A1 (fr) * 2000-01-14 2001-07-19 Acorn Cardiovascular, Inc. Deploiement d'une gaine de contrainte cardiaque
EP1269921A1 (fr) * 2001-06-29 2003-01-02 Ethicon Endo-Surgery, Inc. Poche de récupération d'échantillons pour fermeture uniforme
WO2005037107A1 (fr) 2003-10-17 2005-04-28 Xing Zhou Poche a echantillon biologique de recuperation facile
US7235042B2 (en) 2003-09-16 2007-06-26 Acorn Cardiovascular, Inc. Apparatus and method for applying cardiac support device
FR2915903A1 (fr) * 2007-05-10 2008-11-14 Carpentier Matra Carmat Procede pour la realisation d'un objet hemocompatible de configuration complexe et objet ainsi obtenu.
US7727142B2 (en) 2006-03-03 2010-06-01 Acorn Cardiovascular, Inc. Delivery tool for cardiac support device
USD717954S1 (en) 2013-10-14 2014-11-18 Mardil, Inc. Heart treatment device
US9005109B2 (en) 2000-05-10 2015-04-14 Mardil, Inc. Cardiac disease treatment and device
US9370425B2 (en) 2012-10-12 2016-06-21 Mardil, Inc. Cardiac treatment system and method
US9737404B2 (en) 2006-07-17 2017-08-22 Mardil, Inc. Cardiac support device delivery tool with release mechanism
US9737403B2 (en) 2006-03-03 2017-08-22 Mardil, Inc. Self-adjusting attachment structure for a cardiac support device
US10292821B2 (en) 2001-09-07 2019-05-21 Phoenix Cardiac Devices, Inc. Method and apparatus for external stabilization of the heart
EP3556298A1 (fr) * 2009-10-09 2019-10-23 Applied Medical Resources Corporation Système de récupération de tissus de laparoscopie à incision unique
CN112120801A (zh) * 2020-09-21 2020-12-25 拓普微创医疗科技常州有限公司 小肠隔离保护装置
CN112930203A (zh) * 2018-10-31 2021-06-08 株式会社海莱客思 生物体内非分解性的粘连阻止材料
US11357524B2 (en) 2005-10-14 2022-06-14 Applied Medical Resources Corporation Tissue retrieval system

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US4135495A (en) * 1975-05-21 1979-01-23 Borgen Jennings O Method and means for reversible sterilization
WO1988009647A1 (fr) * 1987-06-03 1988-12-15 Carinthia Textilindustriegesellschaft M.B.H. Procede de sterilisation reversible de femmes par sterilisation partielle, et contraceptif conforme a ce procede
EP0557963A1 (fr) * 1992-02-24 1993-09-01 United States Surgical Corporation Bras élastique pour déployer une maille
US5279539A (en) * 1992-08-17 1994-01-18 Ethicon, Inc. Drawstring surgical pouch and method of use for preventing ovarian adhesions

Patent Citations (5)

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US4135495A (en) * 1975-05-21 1979-01-23 Borgen Jennings O Method and means for reversible sterilization
US3983863A (en) * 1975-06-02 1976-10-05 American Hospital Supply Corporation Heart support for coronary artery surgery
WO1988009647A1 (fr) * 1987-06-03 1988-12-15 Carinthia Textilindustriegesellschaft M.B.H. Procede de sterilisation reversible de femmes par sterilisation partielle, et contraceptif conforme a ce procede
EP0557963A1 (fr) * 1992-02-24 1993-09-01 United States Surgical Corporation Bras élastique pour déployer une maille
US5279539A (en) * 1992-08-17 1994-01-18 Ethicon, Inc. Drawstring surgical pouch and method of use for preventing ovarian adhesions

Cited By (49)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998058598A1 (fr) * 1997-06-21 1998-12-30 Hans Haindl Sachet destine a envelopper au moins partiellement un coeur
US6416459B1 (en) 1997-06-21 2002-07-09 Acorn Cardiovascular Inc. Bag for at least partially enveloping a heart
US6645139B2 (en) 1997-06-21 2003-11-11 Acorn Cardiovascular Inc. Bag for at least partially enveloping a heart
GB2352634A (en) * 1999-07-30 2001-02-07 Shantanu Kumar Ghosh Ovarian cap
US6579226B2 (en) 2000-01-14 2003-06-17 Acorn Cardiovascular, Inc. Delivery of cardiac constraint jacket
US6689048B2 (en) 2000-01-14 2004-02-10 Acorn Cardiovascular, Inc. Delivery of cardiac constraint jacket
US6293906B1 (en) 2000-01-14 2001-09-25 Acorn Cardiovascular, Inc. Delivery of cardiac constraint jacket
WO2001050981A1 (fr) * 2000-01-14 2001-07-19 Acorn Cardiovascular, Inc. Deploiement d'une gaine de contrainte cardiaque
US6881185B2 (en) 2000-01-14 2005-04-19 Acorn Cardiovascular, Inc. Delivery of cardiac constraint jacket
US7819797B2 (en) 2000-01-14 2010-10-26 Acorn Cardiovascular, Inc. Delivery of cardiac constraint jacket
US7419466B2 (en) 2000-01-14 2008-09-02 Acorn Cardiovascular, Inc. Delivery of cardiac constraint jacket
US9005109B2 (en) 2000-05-10 2015-04-14 Mardil, Inc. Cardiac disease treatment and device
EP1269921A1 (fr) * 2001-06-29 2003-01-02 Ethicon Endo-Surgery, Inc. Poche de récupération d'échantillons pour fermeture uniforme
AU784606B2 (en) * 2001-06-29 2006-05-11 Ethicon Endo-Surgery, Inc. Improved specimen retrieval bag
US10292821B2 (en) 2001-09-07 2019-05-21 Phoenix Cardiac Devices, Inc. Method and apparatus for external stabilization of the heart
US7235042B2 (en) 2003-09-16 2007-06-26 Acorn Cardiovascular, Inc. Apparatus and method for applying cardiac support device
EP1679040A1 (fr) * 2003-10-17 2006-07-12 Xing Zhou Poche a echantillon biologique de recuperation facile
WO2005037107A1 (fr) 2003-10-17 2005-04-28 Xing Zhou Poche a echantillon biologique de recuperation facile
EP1679040A4 (fr) * 2003-10-17 2010-05-05 Xing Zhou Poche a echantillon biologique de recuperation facile
US11357524B2 (en) 2005-10-14 2022-06-14 Applied Medical Resources Corporation Tissue retrieval system
US9737403B2 (en) 2006-03-03 2017-08-22 Mardil, Inc. Self-adjusting attachment structure for a cardiac support device
US7727142B2 (en) 2006-03-03 2010-06-01 Acorn Cardiovascular, Inc. Delivery tool for cardiac support device
US10806580B2 (en) 2006-03-03 2020-10-20 Mardil, Inc. Self-adjusting attachment structure for a cardiac support device
US8870744B2 (en) 2006-03-03 2014-10-28 Mardil, Inc. Cardiac support device delivery tool with independently movable arms
US10307252B2 (en) 2006-07-17 2019-06-04 Mardil, Inc. Cardiac support device delivery tool with release mechanism
US9737404B2 (en) 2006-07-17 2017-08-22 Mardil, Inc. Cardiac support device delivery tool with release mechanism
US8728264B2 (en) 2007-05-10 2014-05-20 Carmat Process for producing a haemocompatible article of complex configuration and article thus obtained
AU2008257275B2 (en) * 2007-05-10 2013-09-26 Carmat Process for producing a haemocompatible article of complex configuration and article thus obtained.
FR2915903A1 (fr) * 2007-05-10 2008-11-14 Carpentier Matra Carmat Procede pour la realisation d'un objet hemocompatible de configuration complexe et objet ainsi obtenu.
WO2008145870A3 (fr) * 2007-05-10 2009-02-19 Carpentier Matra Carmat Procede pour la realisation d'un objet hemocompatible de configuration complexe et objet ainsi obtenu
KR101476160B1 (ko) * 2007-05-10 2014-12-24 까르마 복합 형상을 가지는 혈액 적합 제품의 제조방법 및 그로 인해 얻어지는 제품
WO2008145870A2 (fr) * 2007-05-10 2008-12-04 Carmat Procede pour la realisation d'un objet hemocompatible de configuration complexe et objet ainsi obtenu
EP1992369A1 (fr) 2007-05-10 2008-11-19 Groupement Coeur Artificiel Total Carpentier Matra Carmat Procédé pour la réalisation d'un objet hémocompatible de configuration complexe et objet ainsi obtenu
JP2010526573A (ja) * 2007-05-10 2010-08-05 カルマ 複合形状の血液適合性物品の製造方法とこれにより得られた物品
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US11191557B2 (en) 2009-10-09 2021-12-07 Applied Medical Resources Corporation Single incision laparoscopic tissue retrieval system
EP3556298A1 (fr) * 2009-10-09 2019-10-23 Applied Medical Resources Corporation Système de récupération de tissus de laparoscopie à incision unique
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