WO1995034650A3 - Proteine et gene mn - Google Patents

Proteine et gene mn Download PDF

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Publication number
WO1995034650A3
WO1995034650A3 PCT/US1995/007628 US9507628W WO9534650A3 WO 1995034650 A3 WO1995034650 A3 WO 1995034650A3 US 9507628 W US9507628 W US 9507628W WO 9534650 A3 WO9534650 A3 WO 9534650A3
Authority
WO
WIPO (PCT)
Prior art keywords
proteins
gene
polypeptides
nucleic acid
disclosed
Prior art date
Application number
PCT/US1995/007628
Other languages
English (en)
Other versions
WO1995034650A2 (fr
WO1995034650A9 (fr
Inventor
Jan Zavada
Silvia Pastorekova
Jaromir Pastorek
Original Assignee
Ciba Corning Diagnostics Corp
Inst Virology
Jan Zavada
Silvia Pastorekova
Jaromir Pastorek
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/260,190 external-priority patent/US6774117B1/en
Priority claimed from US08/487,077 external-priority patent/US6069242A/en
Priority claimed from US08/485,863 external-priority patent/US6093548A/en
Priority claimed from US08/485,862 external-priority patent/US5989838A/en
Priority claimed from US08/486,756 external-priority patent/US5981711A/en
Priority claimed from US08/481,658 external-priority patent/US5955075A/en
Priority claimed from US08/485,049 external-priority patent/US6204370B1/en
Priority to EP95923907A priority Critical patent/EP0763110B9/fr
Priority to JP1996502486A priority patent/JP3977416B6/ja
Priority to DE69534246T priority patent/DE69534246T2/de
Application filed by Ciba Corning Diagnostics Corp, Inst Virology, Jan Zavada, Silvia Pastorekova, Jaromir Pastorek filed Critical Ciba Corning Diagnostics Corp
Priority to AU28616/95A priority patent/AU2861695A/en
Priority to AT95923907T priority patent/ATE296883T1/de
Priority to CA2192678A priority patent/CA2192678C/fr
Publication of WO1995034650A2 publication Critical patent/WO1995034650A2/fr
Publication of WO1995034650A3 publication Critical patent/WO1995034650A3/fr
Publication of WO1995034650A9 publication Critical patent/WO1995034650A9/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Cell Biology (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

L'invention concerne une séquence du génome complète comprenant une séquence d'ADNc entière pour le gène MN, un oncogène putatif, ainsi que des protéines/polypeptides codés par cette séquence. Elle porte aussi sur des molécules d'acide nucléique recombinées pour exprimer des protéines/polypeptides MN et des protéines recombinées. On décrit l'expression du gène MN comme étant associée à la tumorigénicité, et l'invention se rapporte à des procédés et compositions pour détecter et/ou quantifier l'antigène MN et/ou les anticorps spécifiques de MN dans des échantillons de vertébrés et constituant un moyen diagnostique/pronostique pour les maladies néoplasiques et pré-néoplasiques. Des trousses pour les dosages immunologiques selon l'invention sont également décrites. Des anticorps spécifiques de MN pouvant être utilisés pour le diagnostic/pronostic et le traitement, pour l'imagerie et/ou la purification par affinité des protéines/polypeptides MN sont décrits, ainsi que des sondes d'acide nucléique pour le gène MN et des trousses d'essai contenant lesdites sondes. L'invention concerne également des vaccins qui comprennent les protéines/polypeptides MN et sont efficaces pour immuniser efficacement un vertébré contre les maladies néoplasiques associées à l'expression des protéines MN. Elle porte également sur des séquences d'acides nucléiques antisens qui peuvent être utilisées pour inhiber l'expression du gène MN, et des techniques d'amplification en chaîne (PCR) pour détecter les réorganisations génétiques dans les gènes MN.
PCT/US1995/007628 1994-06-15 1995-06-15 Proteine et gene mn WO1995034650A2 (fr)

Priority Applications (6)

Application Number Priority Date Filing Date Title
CA2192678A CA2192678C (fr) 1994-06-15 1995-06-15 Proteine et gene mn
AT95923907T ATE296883T1 (de) 1994-06-15 1995-06-15 Mn-gen und -protein
AU28616/95A AU2861695A (en) 1994-06-15 1995-06-15 Mn gene and protein
EP95923907A EP0763110B9 (fr) 1994-06-15 1995-06-15 Proteine et gene mn
DE69534246T DE69534246T2 (de) 1994-06-15 1995-06-15 Mn-gen und -protein
JP1996502486A JP3977416B6 (ja) 1994-06-15 1995-06-15 Ｍｎ遺伝子およびｍｎ蛋白質

Applications Claiming Priority (16)

Application Number Priority Date Filing Date Title
US08/260,190 US6774117B1 (en) 1992-03-11 1994-06-15 MN gene and protein
US08/260,190 1994-06-15
US44750495A 1995-06-07 1995-06-07
US08/485,863 1995-06-07
US08/485,049 US6204370B1 (en) 1992-03-11 1995-06-07 MN gene and protein
US08/486,756 1995-06-07
US08/485,049 1995-06-07
US08/481,658 US5955075A (en) 1992-03-11 1995-06-07 Method of inhibiting tumor growth using antibodies to MN protein
US08/485,862 1995-06-07
US08/481,658 1995-06-07
US08/486,756 US5981711A (en) 1992-03-11 1995-06-07 MN-specific antibodies and hybridomas
US08/485,862 US5989838A (en) 1992-03-11 1995-06-07 Immunological methods of detecting MN proteins and MN polypeptides
US08/447,504 1995-06-07
US08/485,863 US6093548A (en) 1992-03-11 1995-06-07 Detection and quantitation of MN-specific antibodies.
US08/487,077 1995-06-07
US08/487,077 US6069242A (en) 1992-03-11 1995-06-07 MN gene and protein

Publications (3)

Publication Number Publication Date
WO1995034650A2 WO1995034650A2 (fr) 1995-12-21
WO1995034650A3 true WO1995034650A3 (fr) 1996-02-15
WO1995034650A9 WO1995034650A9 (fr) 1996-02-22

Family

ID=27575294

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1995/007628 WO1995034650A2 (fr) 1994-06-15 1995-06-15 Proteine et gene mn

Country Status (3)

Country Link
AU (1) AU2861695A (fr)
CA (1) CA2192678C (fr)
WO (1) WO1995034650A2 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5387676A (en) * 1992-03-11 1995-02-07 Ciba Corning Diagnostics Corp. MN gene and protein
US6297051B1 (en) * 1997-01-24 2001-10-02 Institute Of Virology, Slovak Academy Of Sciences MN gene and protein
US6297041B1 (en) 1992-03-11 2001-10-02 Institute Of Virology, Slovak Academy Of Sciences MN gene and protein
DE69937364T2 (de) * 1998-10-23 2008-07-17 Institute Of Virology Mn gen und protein
US7713704B1 (en) 1998-10-23 2010-05-11 Institute Of Virology Of The Slovak Academy Of Science MN gene and protein
US7910691B2 (en) 1999-10-22 2011-03-22 Institute Of Virology Of The Slovak Academy Of Sciences MN gene and protein
US6902890B1 (en) 1999-11-04 2005-06-07 Diadexus, Inc. Method of diagnosing monitoring, staging, imaging and treating cancer
US7572891B2 (en) 2000-02-14 2009-08-11 The Regents Of The University Of California Kidney-specific tumor vaccine directed against kidney tumor antigen G-250
AR036833A1 (es) * 2001-10-18 2004-10-06 Bayer Corp Anticuerpos humanos que se unen a mn y tienen actividad neutralizante de la adhesion celular.
US7910549B2 (en) 2001-12-13 2011-03-22 Institute Of Virology Of The Slovak Academy Of Sciences MN gene and protein
DK1487972T3 (en) 2002-02-21 2015-10-19 Inst Virology MN / CA IX-specific monoclonal antibodies generated from MN / CA IX-poor mice, as well as methods of use.
CA2704273C (fr) 2002-02-21 2016-01-05 Institute Of Virology Anticorps dirige contre mn/ca ix se liant specifiquement a un epitope non immunodominant de mn/ca ix et les utilisations dudit anticorps
ATE437235T1 (de) * 2002-04-16 2009-08-15 Univ California Verfahren zur prognose von nierenzellkarzinom und behandlungsauswahl mit carboanhydrase ix
WO2004048544A2 (fr) 2002-11-26 2004-06-10 Bayer Healthcare Inhibiteurs specifiques de ca ix
WO2005108623A2 (fr) 2004-05-04 2005-11-17 Bayer Healthcare Mn/ca ix/ca9 et pronostic du cancer du rein
JP5479099B2 (ja) 2006-10-12 2014-04-23 インスティトゥート オブ ヴァイロロジー Ｍｎ／ｃａ９スプライス変異体
US7820159B2 (en) 2006-10-31 2010-10-26 Instiute of Virology of the Slovak Academy of Sciences MN/CA IX and EGFR pathway inhibition
US8378084B2 (en) 2006-12-22 2013-02-19 The Regents Of The University Of California Fusion molecule based on novel TAA variant
US8097423B2 (en) 2007-07-30 2012-01-17 Institute Of Virology MN/CA IX and breast cancer therapy
WO2014128258A1 (fr) 2013-02-22 2014-08-28 Wilex Ag Traitement du cancer basé sur une stratification caix

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018152A1 (fr) * 1992-03-11 1993-09-16 Ciba Corning Diagnostics Corp. Gene mn et proteine mn

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993018152A1 (fr) * 1992-03-11 1993-09-16 Ciba Corning Diagnostics Corp. Gene mn et proteine mn

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
J.PASTOREK ET AL.: "Cloning and characterization of MN, a human tumor-associated protein with a domain homologous to carbonic anhydrase and a putative helix-loop-helix DNA binding segment", ONCOGENE, vol. 9, no. 10, pages 2877 - 2888 *
M.A.FROHMAN ET AL.: "Rapid production of full-length cDNAs from rare transcripts: Amplification using a single gene-specific oligonucleotide primer", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA, vol. 85, WASHINGTON US, pages 8998 - 9002 *
S.PASTOREKOVÁ ET AL.: "A novel quasi-viral agent, MaTu, is a two-component system", VIROLOGY, vol. 187, no. 2, ORLANDO US, pages 620 - 626 *

Also Published As

Publication number Publication date
WO1995034650A2 (fr) 1995-12-21
CA2192678C (fr) 2010-12-14
AU2861695A (en) 1996-01-05
CA2192678A1 (fr) 1995-12-21
MX9606402A (es) 1998-10-31

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