GB2371548A - Sequences encoding human neoplastic marker - Google Patents

Sequences encoding human neoplastic marker Download PDF

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Publication number
GB2371548A
GB2371548A GB0210912A GB0210912A GB2371548A GB 2371548 A GB2371548 A GB 2371548A GB 0210912 A GB0210912 A GB 0210912A GB 0210912 A GB0210912 A GB 0210912A GB 2371548 A GB2371548 A GB 2371548A
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United Kingdom
Prior art keywords
sequences encoding
encoding human
human neoplastic
neoplastic marker
tnox
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
GB0210912A
Other versions
GB2371548B (en
GB0210912D0 (en
Inventor
D James Morre
Dorothy M Morre
Pin-Ju Chueh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Purdue Research Foundation
Original Assignee
Purdue Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Purdue Research Foundation filed Critical Purdue Research Foundation
Publication of GB0210912D0 publication Critical patent/GB0210912D0/en
Publication of GB2371548A publication Critical patent/GB2371548A/en
Application granted granted Critical
Publication of GB2371548B publication Critical patent/GB2371548B/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0012—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7)
    • C12N9/0036—Oxidoreductases (1.) acting on nitrogen containing compounds as donors (1.4, 1.5, 1.6, 1.7) acting on NADH or NADPH (1.6)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Physics & Mathematics (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Description

AUK Patent Application 'g,GB,,2 371 548 HA (43) Date of Printing by UK
Office 31.07.2002 (21) Application No 0210912.2 (51) INT CL7 C07H 21/02 21/04, C12N 5/00 15/00, C12P 21/06
(22) Date of Filing 01.11.2000 21/08, C12Q 1/68, G01N 33/53 (30) Priority Data (52) UK CL (Edition T) (31) 60162644 (32) 01.11.1999 (33) US C3H HB4A HB7E H650 H656 H714 H726
G1B BAC B200 B221 B223
(86) International Application Data PCT/US00/30190 En 01.11.2000 (56) Documents Cited by ISA GENBANK Accession No. AF207881. Chueh et al.129 (87) International Publication Data December 1999) WO01/32673 En 10.05. 2001 GENBANK Accession No. Q9UH82. Chueh et al.101 May 2000) GENBANK Accession No. X39889. Chen et al (28 (71) Applicant(s) January 1999) Purdue Research Foundation llacorporated in USA - Indiana) (58) Field of Search by ISA
Room 300, 1063 Hovde Hall, West Lafayette, U.S.: 536/23.1, 435/320.1, 325, 69.1, 6, 7.1; 530/387.9; IN 47907-1063, United States of America MEDLINE (72) Inventor(s) D James Morre (74) Agent and/or Address for Service Dorothy M Morre Carpmaels & Ransford Pin u Chush 43 Bloomsbury Square, LONDON, WC1A 2RA, United Kingdom (54) Abstract Title Sequences encoding human neoplastic marker {57) The present disclosure provides the nucleotide sequence encoding a cell surface NADII oxidase/protein
disulfide-thiol interchange protein {tNOX) characteristic of neoplastic and virus-infected cells. Also provided are recombinant DNA molecules comprising a sequence portion encoding full length or truncated tNOX, recombinant host cell which express ful length or truncated tNOX, methods for recombinant production of tNOX or truncated tNOX, and diagnostic methods which employ either nucleotide sequences of the neoplastic cellspecific tNOX or antibodies specific for the tNOX protein.
G) W n
GB0210912A 1999-11-01 2000-11-01 Sequences encoding NADH oxidase/protein disulphide-thiol interchange polypeptides and their use in diagnosing neoplasia Expired - Fee Related GB2371548B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16264499P 1999-11-01 1999-11-01
PCT/US2000/030190 WO2001032673A1 (en) 1999-11-01 2000-11-01 Sequences encoding human neoplastic marker

Publications (3)

Publication Number Publication Date
GB0210912D0 GB0210912D0 (en) 2002-06-19
GB2371548A true GB2371548A (en) 2002-07-31
GB2371548B GB2371548B (en) 2004-11-24

Family

ID=22586517

Family Applications (1)

Application Number Title Priority Date Filing Date
GB0210912A Expired - Fee Related GB2371548B (en) 1999-11-01 2000-11-01 Sequences encoding NADH oxidase/protein disulphide-thiol interchange polypeptides and their use in diagnosing neoplasia

Country Status (5)

Country Link
JP (1) JP2003517299A (en)
AU (1) AU1453701A (en)
CA (1) CA2388612A1 (en)
GB (1) GB2371548B (en)
WO (1) WO2001032673A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7053188B2 (en) 2002-02-22 2006-05-30 Purdue Research Foundation Monoclonal antibodies specific for neoplasia-specific NADH:disulfide reductase
US20060292577A1 (en) * 2005-06-27 2006-12-28 Purdue Research Foundation Neoplasia-specific splice variants and methods
GB2441860B (en) * 2006-09-01 2011-06-29 Nox Technologies Inc Detecting Neoplasia-specific tNOX isoforms
US9612243B1 (en) * 2016-05-31 2017-04-04 Mor-Nuco Enterprises, Inc. Methods and compositions for targeted two-dimensional western blot analysis for early cancer detection and cancer diagnosis up to ten years in advance of clinical symptoms of malignant disease

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5605810A (en) * 1994-04-05 1997-02-25 Purdue Research Foundation NADH oxidase assay for neoplasia determination
AU8571598A (en) * 1997-07-17 1999-02-10 Ludwig Institute For Cancer Research Cancer associated nucleic acids and polypeptides

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GENBANK Accession No. AF207881. Chueh et al. (29 December 1999) *
GENBANK Accession No. Q9UH82. Chueh et al. (01 May 2000) *
GENBANK Accession No. X39889. Chen et al (28 January 1999) *

Also Published As

Publication number Publication date
GB2371548B (en) 2004-11-24
GB0210912D0 (en) 2002-06-19
WO2001032673A9 (en) 2002-07-04
AU1453701A (en) 2001-05-14
JP2003517299A (en) 2003-05-27
CA2388612A1 (en) 2001-05-10
WO2001032673A1 (en) 2001-05-10

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Date Code Title Description
PCNP Patent ceased through non-payment of renewal fee

Effective date: 20081101