WO1999037764A3 - New members of the glypican gene family - Google Patents

New members of the glypican gene family Download PDF

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Publication number
WO1999037764A3
WO1999037764A3 PCT/EP1999/000329 EP9900329W WO9937764A3 WO 1999037764 A3 WO1999037764 A3 WO 1999037764A3 EP 9900329 W EP9900329 W EP 9900329W WO 9937764 A3 WO9937764 A3 WO 9937764A3
Authority
WO
WIPO (PCT)
Prior art keywords
gene
glypican
primers
specific
fragments
Prior art date
Application number
PCT/EP1999/000329
Other languages
French (fr)
Other versions
WO1999037764A2 (en
Inventor
Mark Paul Dittmar Veugelers
Guido Joseph Frans David
Original Assignee
Vlaams Interuniv Inst Biotech
Mark Paul Dittmar Veugelers
Guido Joseph Frans David
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vlaams Interuniv Inst Biotech, Mark Paul Dittmar Veugelers, Guido Joseph Frans David filed Critical Vlaams Interuniv Inst Biotech
Priority to AU24229/99A priority Critical patent/AU2422999A/en
Publication of WO1999037764A2 publication Critical patent/WO1999037764A2/en
Publication of WO1999037764A3 publication Critical patent/WO1999037764A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4725—Proteoglycans, e.g. aggreccan

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The invention relates to a novel polynucleotide encoding a new glypican-related protein ('glypican-6') and the gene for glypican-4 as well as derivatives of both genes for use in methods of diagnosis and therapy. Derivatives comprise for example fragments of the gene either isolated or synthetic and having a length that is smaller than the complete gene; primers, comprising at least 10 consecutive gene specific nucleotides, preferably about 20 gene specific consecutive nucleotides of the nucleotide sequence of the gene; longer oligonucleotides up to the full length of the gene; antisense variants of the gene, the fragments or the primers; antibodies directed to the gene, fragments, primers or complementary strands thereof; any specific ligand for DNA that can be used as a specific probe, peptide nucleic acid probes.
PCT/EP1999/000329 1998-01-27 1999-01-20 New members of the glypican gene family WO1999037764A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU24229/99A AU2422999A (en) 1998-01-27 1999-01-20 New members of the glypican gene family

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98200226 1998-01-27
EP98200226.3 1998-01-27

Publications (2)

Publication Number Publication Date
WO1999037764A2 WO1999037764A2 (en) 1999-07-29
WO1999037764A3 true WO1999037764A3 (en) 2000-02-03

Family

ID=8233325

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1999/000329 WO1999037764A2 (en) 1998-01-27 1999-01-20 New members of the glypican gene family

Country Status (2)

Country Link
AU (1) AU2422999A (en)
WO (1) WO1999037764A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60326567D1 (en) * 2002-05-23 2009-04-23 Sunnybrook & Womens College DIAGNOSIS OF HEPATOCELLULAR CARCINOMA
WO2004022595A1 (en) * 2002-09-04 2004-03-18 Chugai Seiyaku Kabushiki Kaisha CONSTRUCTION OF ANTIBODY USING MRL/lpr MOUSE
US7303914B2 (en) * 2003-01-30 2007-12-04 Hongyang Wang Monoclonal antibody against human hepatoma and use thereof
WO2006090136A2 (en) * 2005-02-22 2006-08-31 University Court Of The University Of Edinburgh Genetic screening of animals
WO2007018199A1 (en) * 2005-08-09 2007-02-15 Kumamoto University Cancer-rejection antigen peptide derived from glypican-3 (gpc3) for use in hal-a2-positive patient and pharmaceutical comprising the antigen
CN107531755B (en) * 2015-01-16 2022-02-25 美侬米克国际有限公司 Phosphatidylglycoproteoglycan epitopes and uses thereof
US11612149B2 (en) 2015-07-10 2023-03-28 Chugai Seiyaku Kabushiki Kaisha Non-human animal having human CD3 gene substituted for endogenous CD3 gene
WO2018038046A1 (en) * 2016-08-22 2018-03-01 中外製薬株式会社 Gene-modified non-human animal expressing human gpc3 polypeptide
CN107338306A (en) * 2017-07-23 2017-11-10 嘉兴允英医学检验有限公司 A kind of kit for GPC1mRNA detection of expression
JP7053058B2 (en) * 2020-05-28 2022-04-12 グリピー ホールディングス ピーティーワイ リミテッド Glypican epitopes and their use

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
DATABASE EMBL 20 July 1996 (1996-07-20), HILLIER L ET AL: "zh83a06.r1 Soares fetal liver spleen 1NFLS S1 Homo sapiens cDNA clone 427858 5' similar to SW:GLYP_HUMAN P35052 GLYPICAN PRECURSOR", XP002109642 *
DATABASE EMBL 25 July 1996 (1996-07-25), LIEW C C: "LL1806F Fetal heart, Lambda ZAP Express Homo sapiens cDNA clone LL1806 5' similar to K-glypican.", XP002109643 *
FILMUS J ET AL: "Identification of a new membrane-bound heparan sulphate proteoglycan", BIOCHEMICAL JOURNAL., vol. 311, 15 October 1995 (1995-10-15), LONDON, GB, pages 561 - 565, XP002109639, ISSN: 0264-6021 *
HUBER R ET AL: "Analysis of exon/intron structure and 400 kb of genomic sequence surrounding the 5'-promoter and 3'-terminal ends of the human glypican 3 (GPC3) gene", GENOMICS., vol. 45, no. 1, 1 October 1997 (1997-10-01), SAN DIEGO., US, pages 48 - 58, XP002109641, ISSN: 0888-7543 *
VEUGELERS M ET AL: "Characterization of glypican-5 and chromosomal localization of human GPC5, a new member of the glypican gene family.", GENOMICS., vol. 40, no. 1, 15 February 1997 (1997-02-15), SAN DIEGO., US, pages 24 - 30, XP002109640, ISSN: 0888-7543 *
WATANABE K.: "K-glypican: a novel GPI-anhcored heparan sulfate proteoglycan that is highly expressed in developing brain and kidney.", THE JOURNAL OF CELL BIOLOGY., vol. 130, no. 5, September 1995 (1995-09-01), pages 1207 - 1218, XP002109638 *

Also Published As

Publication number Publication date
AU2422999A (en) 1999-08-09
WO1999037764A2 (en) 1999-07-29

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