WO1995032737A1 - Pharmaceutical composition - Google Patents

Pharmaceutical composition Download PDF

Info

Publication number
WO1995032737A1
WO1995032737A1 PCT/GB1995/001152 GB9501152W WO9532737A1 WO 1995032737 A1 WO1995032737 A1 WO 1995032737A1 GB 9501152 W GB9501152 W GB 9501152W WO 9532737 A1 WO9532737 A1 WO 9532737A1
Authority
WO
WIPO (PCT)
Prior art keywords
cyclodextrin
steroidal anti
pharmaceutical composition
inflammatory drug
paste
Prior art date
Application number
PCT/GB1995/001152
Other languages
English (en)
French (fr)
Inventor
Lawrence John Penkler
Luéta-Ann GLINTENKAMP
Mark David Bodley
Michiel Coenraad Bosch Van Oudtshoorn
Christopher Stubbs
Original Assignee
Farmarc Nederland Bv
Dyer, Alison, Margaret
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmarc Nederland Bv, Dyer, Alison, Margaret filed Critical Farmarc Nederland Bv
Priority to EP95919524A priority Critical patent/EP0760680A1/de
Priority to JP8500478A priority patent/JPH10500982A/ja
Priority to BR9507768A priority patent/BR9507768A/pt
Priority to AU25312/95A priority patent/AU2531295A/en
Publication of WO1995032737A1 publication Critical patent/WO1995032737A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid 
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/5415—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with carbocyclic ring systems, e.g. phenothiazine, chlorpromazine, piroxicam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6949—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes
    • A61K47/6951—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit inclusion complexes, e.g. clathrates, cavitates or fullerenes using cyclodextrin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
PCT/GB1995/001152 1994-05-27 1995-05-22 Pharmaceutical composition WO1995032737A1 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
EP95919524A EP0760680A1 (de) 1994-05-27 1995-05-22 Pharmazeutische zusammensetzungen
JP8500478A JPH10500982A (ja) 1994-05-27 1995-05-22 医薬組成物
BR9507768A BR9507768A (pt) 1994-05-27 1995-05-22 Composição farmacêutica
AU25312/95A AU2531295A (en) 1994-05-27 1995-05-22 Pharmaceutical composition

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
ZA94/3740 1994-05-27
ZA943740 1994-05-27

Publications (1)

Publication Number Publication Date
WO1995032737A1 true WO1995032737A1 (en) 1995-12-07

Family

ID=25583939

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1995/001152 WO1995032737A1 (en) 1994-05-27 1995-05-22 Pharmaceutical composition

Country Status (6)

Country Link
EP (1) EP0760680A1 (de)
JP (1) JPH10500982A (de)
AU (1) AU2531295A (de)
BR (1) BR9507768A (de)
CA (1) CA2190598A1 (de)
WO (1) WO1995032737A1 (de)

Cited By (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996014839A1 (en) * 1994-11-15 1996-05-23 Farmarc Nederland Bv Pharmaceutical composition comprising non-steroidal anti-inflammatory drugs
WO1996041646A2 (en) * 1995-06-13 1996-12-27 Dyer, Alison, Margaret Pharmaceutical compositions containing lornoxicam and cyclodextrin
WO1997044023A1 (en) * 1996-05-17 1997-11-27 Apr Patent Holder S.A. Pharmaceutical compositions based on diclofenac
WO1999004823A1 (en) * 1997-07-23 1999-02-04 Farmigea S.P.A. Process for solubilizing pharmaceutically active ingredients in water and in aqueous vehicles
WO2000015195A1 (en) * 1998-09-10 2000-03-23 Nycomed Danmark A/S Quick release pharmaceutical compositions of drug substances
US7935685B2 (en) * 2001-12-21 2011-05-03 Chiesi Farmaceutici S.P.A. Process for preparation of inclusion compounds between a non-steroidal anti-inflammatory drug and betacyclodextrin by microwave treatment
EP2394641A1 (de) 2010-05-30 2011-12-14 Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi Pharmazeutische Formulationen von Lornoxicam
US8097651B2 (en) 2005-06-17 2012-01-17 Apr Applied Pharma Research S.A. Diclofenac formulations and methods of use
US8231899B2 (en) * 1998-09-10 2012-07-31 Nycomed Danmark Aps Quick release pharmaceutical compositions of drug substances
US8580954B2 (en) 2006-03-28 2013-11-12 Hospira, Inc. Formulations of low dose diclofenac and beta-cyclodextrin

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996040077A2 (en) * 1995-06-07 1996-12-19 Quadrant Holdings Cambridge Limited Methods for stably incorporating substances within dry, foamed glass matrices and compositions obtained thereby
AU2003257791A1 (en) * 2002-08-15 2004-03-29 Tong Liu Soild nano pharmaceutical formulation and preparation method thereof

Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT52263B (de) * 1911-04-22 1912-02-26 Jean Baptiste Feilner Verfahren zur Herstellung von photographischen Kombinationsnegativen.
US4228160A (en) * 1978-01-27 1980-10-14 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. Inclusion complex of cyclodextrin and indomethacin and a process for the preparation thereof, method of use and pharmaceutical composition
GB2124489A (en) * 1982-07-19 1984-02-22 Ciba Geigy Ag Medicinal composition containing pirprofen and cyclodextrin
WO1985002767A1 (en) * 1983-12-21 1985-07-04 Janssen Pharmaceutica N.V. Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation
EP0346006A1 (de) * 1988-06-09 1989-12-13 Reckitt And Colman Products Limited Ibuprofen-Cyclodextrin-Einschlusskomplexe enthaltende pharmazeutische Zubereitungen
US4952565A (en) * 1986-11-13 1990-08-28 Janko Zmitek Inclusion complex of ibuproxam with beta-cyclodextrin, a process for preparing the same and a pharmaceutical preparation containing the same
EP0399902A1 (de) * 1989-05-24 1990-11-28 Rhone-Poulenc Sante Poröse Einheitsform und Verfahren
WO1991004026A1 (en) * 1989-09-14 1991-04-04 Australian Commercial Research & Development Limited Drug delivery compositions
EP0449731A1 (de) * 1990-03-28 1991-10-02 Laboratoires Crinex Entzündungshemmende und/oder analgetische pharmazeutische Zusammensetzung zur perlingualen Verabreichung
EP0519428A2 (de) * 1991-06-21 1992-12-23 Takeda Chemical Industries, Ltd. Zyklodextrin-Zusammensetzung
WO1993020850A1 (en) * 1992-04-10 1993-10-28 Smithkline Beecham Plc Pharmaceutical composition

Patent Citations (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT52263B (de) * 1911-04-22 1912-02-26 Jean Baptiste Feilner Verfahren zur Herstellung von photographischen Kombinationsnegativen.
US4228160A (en) * 1978-01-27 1980-10-14 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt. Inclusion complex of cyclodextrin and indomethacin and a process for the preparation thereof, method of use and pharmaceutical composition
GB2124489A (en) * 1982-07-19 1984-02-22 Ciba Geigy Ag Medicinal composition containing pirprofen and cyclodextrin
WO1985002767A1 (en) * 1983-12-21 1985-07-04 Janssen Pharmaceutica N.V. Pharmaceutical compositions containing drugs which are instable or sparingly soluble in water and methods for their preparation
US4952565A (en) * 1986-11-13 1990-08-28 Janko Zmitek Inclusion complex of ibuproxam with beta-cyclodextrin, a process for preparing the same and a pharmaceutical preparation containing the same
EP0346006A1 (de) * 1988-06-09 1989-12-13 Reckitt And Colman Products Limited Ibuprofen-Cyclodextrin-Einschlusskomplexe enthaltende pharmazeutische Zubereitungen
EP0399902A1 (de) * 1989-05-24 1990-11-28 Rhone-Poulenc Sante Poröse Einheitsform und Verfahren
WO1991004026A1 (en) * 1989-09-14 1991-04-04 Australian Commercial Research & Development Limited Drug delivery compositions
EP0449731A1 (de) * 1990-03-28 1991-10-02 Laboratoires Crinex Entzündungshemmende und/oder analgetische pharmazeutische Zusammensetzung zur perlingualen Verabreichung
EP0519428A2 (de) * 1991-06-21 1992-12-23 Takeda Chemical Industries, Ltd. Zyklodextrin-Zusammensetzung
WO1993020850A1 (en) * 1992-04-10 1993-10-28 Smithkline Beecham Plc Pharmaceutical composition

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5854226A (en) * 1994-11-15 1998-12-29 Farmarc Nederland Bv Pharmaceutical composition
WO1996014839A1 (en) * 1994-11-15 1996-05-23 Farmarc Nederland Bv Pharmaceutical composition comprising non-steroidal anti-inflammatory drugs
WO1996041646A2 (en) * 1995-06-13 1996-12-27 Dyer, Alison, Margaret Pharmaceutical compositions containing lornoxicam and cyclodextrin
WO1996041646A3 (en) * 1995-06-13 1997-02-13 Dyer Alison Margaret Pharmaceutical compositions containing lornoxicam and cyclodextrin
EP1159960A1 (de) * 1996-05-17 2001-12-05 Apr Applied Pharma Research S.A. Arzneimittel bestehend aus Diclofenac
WO1997044023A1 (en) * 1996-05-17 1997-11-27 Apr Patent Holder S.A. Pharmaceutical compositions based on diclofenac
US6346273B1 (en) 1997-07-23 2002-02-12 Farmigea S.P.A. Process for solubilizing pharmaceutically active ingredients in water and in aqueous vehicles
WO1999004823A1 (en) * 1997-07-23 1999-02-04 Farmigea S.P.A. Process for solubilizing pharmaceutically active ingredients in water and in aqueous vehicles
EA002326B1 (ru) * 1997-07-23 2002-04-25 Фармиджея С.П.А. Способ солюбилизации фармацевтически активных ингредиентов в воде и в водных носителях
WO2000015195A1 (en) * 1998-09-10 2000-03-23 Nycomed Danmark A/S Quick release pharmaceutical compositions of drug substances
US6713089B1 (en) 1998-09-10 2004-03-30 Nycomed Danmark A/S Quick release pharmaceutical compositions of drug substances
US8231899B2 (en) * 1998-09-10 2012-07-31 Nycomed Danmark Aps Quick release pharmaceutical compositions of drug substances
US7935685B2 (en) * 2001-12-21 2011-05-03 Chiesi Farmaceutici S.P.A. Process for preparation of inclusion compounds between a non-steroidal anti-inflammatory drug and betacyclodextrin by microwave treatment
US8097651B2 (en) 2005-06-17 2012-01-17 Apr Applied Pharma Research S.A. Diclofenac formulations and methods of use
US8580954B2 (en) 2006-03-28 2013-11-12 Hospira, Inc. Formulations of low dose diclofenac and beta-cyclodextrin
US8946292B2 (en) 2006-03-28 2015-02-03 Javelin Pharmaceuticals, Inc. Formulations of low dose diclofenac and beta-cyclodextrin
EP2394641A1 (de) 2010-05-30 2011-12-14 Abdi Ibrahim Ilac Sanayi ve Ticaret Anonim Sirketi Pharmazeutische Formulationen von Lornoxicam

Also Published As

Publication number Publication date
EP0760680A1 (de) 1997-03-12
JPH10500982A (ja) 1998-01-27
CA2190598A1 (en) 1995-12-07
AU2531295A (en) 1995-12-21
BR9507768A (pt) 1997-09-02

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