WO1995010188A3 - Compositions herbicides d'acide aza-biphosphonique - Google Patents

Compositions herbicides d'acide aza-biphosphonique Download PDF

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Publication number
WO1995010188A3
WO1995010188A3 PCT/GB1994/002183 GB9402183W WO9510188A3 WO 1995010188 A3 WO1995010188 A3 WO 1995010188A3 GB 9402183 W GB9402183 W GB 9402183W WO 9510188 A3 WO9510188 A3 WO 9510188A3
Authority
WO
WIPO (PCT)
Prior art keywords
alkyl
substituted
halo
hydrocarbyl
thiomorpholine
Prior art date
Application number
PCT/GB1994/002183
Other languages
English (en)
Other versions
WO1995010188A2 (fr
Inventor
Karl Joseph Fisher
Frank Xavier Woolard
John Montgomery Gerdes
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Priority to AU77901/94A priority Critical patent/AU690581B2/en
Priority to JP7511442A priority patent/JPH09506075A/ja
Priority to BR9407762A priority patent/BR9407762A/pt
Priority to SK452-96A priority patent/SK45296A3/sk
Priority to EP94928482A priority patent/EP0722268A1/fr
Priority to PL94313820A priority patent/PL313820A1/xx
Priority to NZ274000A priority patent/NZ274000A/en
Publication of WO1995010188A2 publication Critical patent/WO1995010188A2/fr
Publication of WO1995010188A3 publication Critical patent/WO1995010188A3/fr
Priority to NO961389A priority patent/NO961389L/no
Priority to FI961520A priority patent/FI961520A/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/405—Esters of poly(thio)phosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N57/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds
    • A01N57/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic phosphorus compounds having phosphorus-to-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5532—Seven-(or more) membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/568—Four-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/572—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/59—Hydrogenated pyridine rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/60—Quinoline or hydrogenated quinoline ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/65031—Five-membered rings having the nitrogen atoms in the positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6503—Five-membered rings
    • C07F9/6506—Five-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6515—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having three nitrogen atoms as the only ring hetero atoms
    • C07F9/6518—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6527—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07F9/6533—Six-membered rings

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Pest Control & Pesticides (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

L'invention se rapporte à des compositions herbicides comprenant : (A) un composé de la formule (I), dans laquelle R1 représente hydrogène, hydroxy, alkoxy C¿1?-C4, halogène, alkyle C1-C4, haloalkyle C1-C4, hydroxy-C1-C4-alkyle, hydroxy-C1-C4-alcoxy ou N(R?6)(R7) où R6 et R7¿ représentent chacun, indépendamment, hydrogène ou alkyle C¿1?-C3; R?2 et R3¿ représentent chacun, indépendemment, hydrogène; hydrocarbyle; hydrocarbyle substitué; hydrocarbyloxy; hydrocarbyloxy substitué; hydrocarbyl-S(O)¿m?-; ou hydrocarbyle-S(O)m-substitué; ou bien R?2 et R3¿ forment, réunis, un cycle carbocyclique à 3 à 6 chaînons, éventuellement substitué par halogène, hydroxy, alkyle C¿1?-C6, alcoxy C1-C6, alkylthio C1-C6 ou bien N(R?8)(R9) où R8 et R9¿ représentent chacun, indépendamment, hydrogène ou alkyle C¿1?-C12; et R?4 et R5¿ représentent chacun, indépendamment, hydrogène; hydrocarbyle; hydrocarbyle substitué; hydrocarbyloxy; hydrocarbyloxy substitué; hydrocarbylthio; hydrocarbylthio substitué; pyridyle; pyridyle substitué; ou font partie de la formule N(R10)(R11) dans laquelle R?10 et R11¿ représentent indépendamment hydrogène, hydrocarbyle ou hydrocarbyle substitué; ou bien R4 et R5 réunis à l'azote auquel ils sont liés, forment un cycle aziridine, pipérazine, morpholine, thiomorpholine, thiomorpholine sulfinyle, thiomorpholine sulfonyle, hexamethyleneimine, pipéridine, tétrahydropyridine, pyrazole, imidazole, pyrrole, triazole, tétrahydropyrimidine, dihydroimidazole, pyrroline, azétidine, perhydroindole, perhydroquinoline, perhydroisoquinoline ou pyrrolidine, n'importe lequel d'entre eux pouvant être éventuellement substitué par alkyle C¿1?-C12, halo, aryle C6-C10, aryle C6-C10 substitué par halo ou alkyle C1-C6, aralkyle C7-C16, aralkyle C7-C16 substituté par halo ou alkyle C1-C6, nitro, halo-C1-C10-alkyle, alkoxy C1-C10, alkylthio C1-C10, alkylsulfonyle C1-C10, phénoxy, phénoxy substituté par halo ou alkyle C1-C6, alcényle C1-C10 ou cyano; ou bien R?2 et R4¿ réunis à l'azote et à des atomes de carbones auxquels ils sont liés, forment un cycle aziridine, pipérazine, morpholine, thiomorpholine, thiomorpholine sulfinyle, thiomorpholine sulfonyle, hexaméthylèneimine, pipéridine, tetrahydropyridine, pyrazole, imidazole, pyrrole, triazole, tétrahydropyrimidine, dihydroimidazole, pyrroline, azétidine, perhydroindole, perhydroquinoline, perhydroisoquinoline ou pyrrolidine, n'importe lequel d'entre eux pouvant être éventuellement substitué par alkyle C¿1?-C12, halo, aryle C6-C10, aryle C6-C10 substitué par halo ou alkyl C1-C6, aralkyle C7-C16, aralkyle C7-C16 substitué par halo ou alkyle C1-C6, nitro, halo-C1-C10-alkyle, alcoxy C1-C10, alkylthio C1-C10, alkylsulfonyle C1-C10, phénoxy, phénoxy substitué par halo ou alkyle C1-C6, alcényle C1-C10 ou cyano; et m vaut 0, 1 ou 2; et des sels agrochimiquement acceptables de ceux-ci; et (B) un excipient agrochimiquement acceptable s'appliquant à ces composés. Selon d'autres aspects, cette invention se rapporte à un procédé de régulation de la croissance de végétaux, qui consiste à appliquer sur la surface que l'on désire traiter une quantité effective d'un composé herbicide de la formule (I) décrite ci-dessus. Cette invention se rapporte aussi à certains nouveaux composés ayant une structure correspondant à celle de la formule (I) sus-mentionnée.
PCT/GB1994/002183 1993-10-07 1994-10-07 Compositions herbicides d'acide aza-biphosphonique WO1995010188A2 (fr)

Priority Applications (9)

Application Number Priority Date Filing Date Title
AU77901/94A AU690581B2 (en) 1993-10-07 1994-10-07 Herbicidal aza bisphosphonic acid compositions
JP7511442A JPH09506075A (ja) 1993-10-07 1994-10-07 除草性アザビスホスホン酸組成物
BR9407762A BR9407762A (pt) 1993-10-07 1994-10-07 Composiçao herbicida processo para controlar o crescimento de plantas e compostos
SK452-96A SK45296A3 (en) 1993-10-07 1994-10-07 Herbicidal composition on aza bisphosphonic acid base
EP94928482A EP0722268A1 (fr) 1993-10-07 1994-10-07 Compositions herbicides d'acide aza-biphosphonique
PL94313820A PL313820A1 (en) 1993-10-07 1994-10-07 Herbicidal compositions of aza-biphosphonic acid
NZ274000A NZ274000A (en) 1993-10-07 1994-10-07 Use of azabisphosphonic acid derivatives as herbicides, azabisphosphonic derivatives
NO961389A NO961389L (no) 1993-10-07 1996-04-03 Herbicide aza-bisfosfonsyreblandinger
FI961520A FI961520A (fi) 1993-10-07 1996-04-04 Heribisidiset atsabisfosfonihappoyhdisteet

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13372293A 1993-10-07 1993-10-07
US08/133,722 1993-10-07

Publications (2)

Publication Number Publication Date
WO1995010188A2 WO1995010188A2 (fr) 1995-04-20
WO1995010188A3 true WO1995010188A3 (fr) 1995-05-04

Family

ID=22460007

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1994/002183 WO1995010188A2 (fr) 1993-10-07 1994-10-07 Compositions herbicides d'acide aza-biphosphonique

Country Status (17)

Country Link
EP (1) EP0722268A1 (fr)
JP (1) JPH09506075A (fr)
CN (1) CN1134657A (fr)
AU (1) AU690581B2 (fr)
BR (1) BR9407762A (fr)
CA (1) CA2173607A1 (fr)
CZ (1) CZ101596A3 (fr)
FI (1) FI961520A (fr)
HU (1) HUT74893A (fr)
IL (2) IL111180A (fr)
NO (1) NO961389L (fr)
NZ (1) NZ274000A (fr)
PL (1) PL313820A1 (fr)
SK (1) SK45296A3 (fr)
TW (1) TW401276B (fr)
WO (1) WO1995010188A2 (fr)
ZA (1) ZA947814B (fr)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5728650A (en) * 1993-10-07 1998-03-17 Zeneca Limited Herbicidal aza bisphosphonic acids and compositions containing the same
WO1995034207A1 (fr) * 1994-06-13 1995-12-21 Zeneca Limited Procede permettant de moduler la croissance des plantes en inhibant la farnesyle pyrophosphate synthase
IL115041A0 (en) * 1995-08-23 1995-12-08 Yissum Res Dev Co Novel bisphosphonates process for their preparation and pharmaceutical compositions containing them
WO2007039635A2 (fr) * 2005-10-06 2007-04-12 Innate Pharma Sels phosphoantigenes de bases organiques et procedes de cristallisation correspondants
EP2001486A4 (fr) * 2006-03-17 2010-12-29 Univ Illinois Composés de biphosphonates et procédés
PT103600B (pt) * 2006-11-06 2009-01-30 Hovione Farmaciencia Sa Processo para a preparação de ácidos biosfónicos e seus sais farmaceuticamente aceitáveis

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU739076A1 (ru) * 1976-05-19 1980-06-05 Институт Химической Кинетики И Горения Со Ан Ссср Способ получени -аминоэтилидендифосфоновых кислот
EP0252504A1 (fr) * 1986-07-11 1988-01-13 Roche Diagnostics GmbH Dérivés d'acides diphosphoniques, procédé pour les préparer et médicaments contenant ces composés
EP0274158A1 (fr) * 1986-12-19 1988-07-13 Norwich Eaton Pharmaceuticals, Inc. Composés diphosphonates substitués par un hétérocycle, compositions pharmaceutiques, et méthodes pour traiter le métabolisme anormal du calcium et du phosphate
WO1993024496A1 (fr) * 1992-05-29 1993-12-09 Procter & Gamble Pharmaceuticals, Inc. Composes de phosphonate contenant du soufre, et destines au traitement du metabolisme anormal du calcium et du phosphate

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SU739076A1 (ru) * 1976-05-19 1980-06-05 Институт Химической Кинетики И Горения Со Ан Ссср Способ получени -аминоэтилидендифосфоновых кислот
EP0252504A1 (fr) * 1986-07-11 1988-01-13 Roche Diagnostics GmbH Dérivés d'acides diphosphoniques, procédé pour les préparer et médicaments contenant ces composés
EP0274158A1 (fr) * 1986-12-19 1988-07-13 Norwich Eaton Pharmaceuticals, Inc. Composés diphosphonates substitués par un hétérocycle, compositions pharmaceutiques, et méthodes pour traiter le métabolisme anormal du calcium et du phosphate
WO1993024496A1 (fr) * 1992-05-29 1993-12-09 Procter & Gamble Pharmaceuticals, Inc. Composes de phosphonate contenant du soufre, et destines au traitement du metabolisme anormal du calcium et du phosphate

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 100, no. 15, 1984, Columbus, Ohio, US; abstract no. 121244z, I. S. ALFEREV ET AL.: "Reaction of vinylidenediphosphonic acid with nucleophiles." *
CHEMICAL ABSTRACTS, vol. 101, no. 19, 1984, Columbus, Ohio, US; abstract no. 171346, I. S. ALFEREV ET AL: "Addition of nucleophilic agents to vinylidenediphosphonic acid." *
E. BAKUNIAK ET AL.: "Further studies on biological activity of aminophosphonates structurally related to n-(phosphonomethyl)glycine.", JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH, PART B, vol. B18, no. 4&5, 1983, pages 485 - 496 *
IZV. AKAD. NAUK SSSR, SER. KHIM., no. 12, 1983, pages 2802 - 2806 *
IZV. AKAD. NAUK SSSR, SER. KHIM., no. 5, 1984, pages 1122 - 1126 *
SOVIET INVENTIONS ILLUSTRATED Week 8106, Derwent World Patents Index; AN 81-09308D/06 *

Also Published As

Publication number Publication date
NO961389D0 (no) 1996-04-03
IL111180A0 (en) 1994-12-29
IL114381A0 (en) 1995-10-31
HU9600839D0 (en) 1996-05-28
TW401276B (en) 2000-08-11
CZ101596A3 (en) 1996-07-17
AU7790194A (en) 1995-05-04
SK45296A3 (en) 1996-09-04
EP0722268A1 (fr) 1996-07-24
NZ274000A (en) 1998-03-25
PL313820A1 (en) 1996-07-22
ZA947814B (en) 1995-08-14
HUT74893A (en) 1997-02-28
AU690581B2 (en) 1998-04-30
CA2173607A1 (fr) 1995-04-20
JPH09506075A (ja) 1997-06-17
FI961520A0 (fi) 1996-04-04
FI961520A (fi) 1996-05-27
CN1134657A (zh) 1996-10-30
WO1995010188A2 (fr) 1995-04-20
BR9407762A (pt) 1997-03-04
NO961389L (no) 1996-06-03
IL111180A (en) 1999-09-22

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