WO1995000122A1 - Emballage pour systeme a liberation transdermique - Google Patents

Emballage pour systeme a liberation transdermique Download PDF

Info

Publication number
WO1995000122A1
WO1995000122A1 PCT/US1994/006681 US9406681W WO9500122A1 WO 1995000122 A1 WO1995000122 A1 WO 1995000122A1 US 9406681 W US9406681 W US 9406681W WO 9500122 A1 WO9500122 A1 WO 9500122A1
Authority
WO
WIPO (PCT)
Prior art keywords
release liner
transdermal
transdermal delivery
delivery device
liner
Prior art date
Application number
PCT/US1994/006681
Other languages
English (en)
Inventor
Dan W. Connors
Jia Chen
Scott A. Huie
Original Assignee
Cygnus Therapeutic Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cygnus Therapeutic Systems filed Critical Cygnus Therapeutic Systems
Priority to JP7502908A priority Critical patent/JPH09501909A/ja
Priority to EP94920731A priority patent/EP0711153A1/fr
Priority to AU71727/94A priority patent/AU7172794A/en
Publication of WO1995000122A1 publication Critical patent/WO1995000122A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches

Definitions

  • This invention relates generally to a package for a transdermal delivery system and, in particular, to a release liner and pouch for use with multiple transdermal delivery systems.
  • Transdermal delivery systems deliver substances to a user's tissues and/or blood stream through the user's skin.
  • Examples are NICOTROL ® nicotine transdermal systems and MINITRAN ® nitroglycerin transdermal systems, both available from Cygnus Therapeutic Systems.
  • Such systems are typically formed as a flexible patch containing the substance within a reservoir. The patch attaches to the user with adhesive. Contact between the patch's active face and the user's skin permits the substance to transfer from the reservoir to the user at a rate determined in part by the construction of the patch and in part by the nature of the substance.
  • the substance within the transdermal delivery system may be adversely affected by contact with light, water, air, or airborne substances.
  • Packaging must be provided, therefore, to prevent loss or degradation of the substance within the system's reservoir.
  • One prior art packaging approach is described in U.S. Patent No. 5,077,104.
  • Transdermal delivery systems may be provided to the user with adhesive already applied to the delivery side of the patch.
  • the system's packaging must therefore also prevent degradation of the adhesive and inadvertent attachment of the patch to the wrong object.
  • Transdermal delivery systems are therefore typically releasably mounted on liners, as shown in U.S. Patent No. 4,915,102 and European Patent Application No. 401 949.
  • transdermal delivery systems have a limited life, and multiple systems may be needed by a single user to accomplish the purpose for which the system was prescribed. What is needed, therefore, is a way to package multiple transdermal delivery systems together.
  • the devices are adhesive patches mounted on a release liner.
  • the liner surface is chosen so that it will not adhere to the adhesive on the devices. Rather, the devices may be peeled off easily by the user.
  • the release liner is preferably perforated or scored to permit a portion of the liner below each device to be torn off by the user.
  • the device may be lifted from the liner by the torn-off portion.
  • the torn-off portion of the liner is itself removed from the device only after the uncovered portion of the device is applied to the user's skin.
  • Figure 1(a) is a top elevational view of the transdermal delivery system package of this invention designed to hold multiple transdermal delivery systems.
  • Figure 1(b) is a top elevational view of the transdermal delivery system package of this invention designed to hold a single transdermal delivery system.
  • Figure 2 is a side cross-sectional view of the preferred embodiment of this invention.
  • Figure 3(a) is a top elevational view of a single transdermal delivery system showing how the package may be used to apply the system.
  • Figure 3 (b) is a bottom elevational view of the single transdermal system of Figure 3(a).
  • Transdermal delivery devices 10 are mounted on a release liner 12 so that the devices' substance delivery surfaces 13 face toward liner 12 and the devices' top protective surface 11 face award from liner 12.
  • release liner 12 is made from polyester, polyethylene, polystyrene, polycarbonate or paper coated with silicone or a fluorochemical compound, or a combination of these materials.
  • devices 10 each have an internal reservoir layer 14, a bottom adhesive layer 15, and a top protective layer 16 in a manner known in the art.
  • Devices 10 and liner 12 are preferably stored in an air-tight, resealable bag 18 made of a plastic film or a foil laminate.
  • Bag 18 may include a plastic zipper or zip-lock mechanism 19.
  • Bag 18 may also include a non- resealable seal mechanism (not shown) that must be unsealed by the user the first time the package is opened.
  • Liner 12 has scores or perforations 20 that permit portions 22 of the liner to be torn away from liner 12. Perforations 20 run beneath a portion of each device 10, as shown in Figure 1. At least part of each liner portion 22 is not covered by a device 10. In use, the devices and release liner are removed from the resealable bag.
  • a single device may be removed from the release liner by tearing liner 12 along one of the perforated lines 20, and lifting the device 10 off the liner 12 with the torn-off portion 22.
  • torn-off portion 22 provides a means for the user to hold device 10 without actually coming into contact with the device.
  • the portion of device 10 not covering torn-off portion 22 may be placed at, and adhered to, the chosen site on the user's skin. Thereafter, torn-off portion 22 may be removed, and the remaining portion of device 10 may be adhered to the. user's skin.
  • the liner and devices may be placed back inside bag 18, and the bag may be resealed.
  • transdermal delivery systems examples include systems delivering natural or synthetic estrogens, progestins, or combinations of the two; systems delivering anti-hypertensives for high blood pressure; systems delivering nitroglycerin; and systems delivering nicotine compounds. Modifications to the invention may be made without departing from the scope of the invention. For example, other shapes and configurations of the entire release liner and of the removable portion of the release liner may be used.

Abstract

L'invention concerne un nouveau système d'emballage de dispositifs transdermiques (10). Dans le mode de réalisation préféré, les dispositifs sont des timbres adhésifs montés sur un papier à détacher (12). La surface de ce papier est choisie de manière à ne pas adhérer à l'adhésif du dispositif. En effet, les dispositifs peuvent être facilement détachés par l'utilisateur. De préférence, le papier à détacher (12) est perforé (20) ou strié pour permettre à une portion (22) dudit papier située sous chaque dispositif d'être arrachée par l'utilisateur. On peut enlever le dispositif du papier en utilisant la portion arrachée comme prise. La portion arrachée du papier ne peut elle-même être enlevée du dispositif qu'après que la portion non recouverte de celui-ci a été appliquée sur la peau de l'utilisateur.
PCT/US1994/006681 1993-06-24 1994-06-14 Emballage pour systeme a liberation transdermique WO1995000122A1 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP7502908A JPH09501909A (ja) 1993-06-24 1994-06-14 経皮送達システムパッケージ
EP94920731A EP0711153A1 (fr) 1993-06-24 1994-06-14 Emballage pour systeme a liberation transdermique
AU71727/94A AU7172794A (en) 1993-06-24 1994-06-14 Transdermal delivery system package

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8292693A 1993-06-24 1993-06-24
US08/082,926 1993-06-24

Publications (1)

Publication Number Publication Date
WO1995000122A1 true WO1995000122A1 (fr) 1995-01-05

Family

ID=22174343

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1994/006681 WO1995000122A1 (fr) 1993-06-24 1994-06-14 Emballage pour systeme a liberation transdermique

Country Status (5)

Country Link
EP (1) EP0711153A1 (fr)
JP (1) JPH09501909A (fr)
AU (1) AU7172794A (fr)
CA (1) CA2166191A1 (fr)
WO (1) WO1995000122A1 (fr)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998025257A1 (fr) * 1996-12-04 1998-06-11 Hexal Ag Timbre transdermique medicamenteux autocollant mince
US5950830A (en) * 1994-12-21 1999-09-14 Ethical Pharmaceuticals (U.K.) Limited Packaging for patches
DE10056234A1 (de) * 2000-11-13 2002-05-29 Lohmann Therapie Syst Lts Primärverpackung für transdermale therapeutische Systeme oder medizinische Pflaster
WO2007101659A1 (fr) * 2006-03-09 2007-09-13 Grünenthal GmbH Pansements contenant des substances actives caractérisés par un maniement amélioré
WO2014013344A2 (fr) * 2012-07-16 2014-01-23 Nometics Inc. Emballage de timbres transdermiques par unités multiples selon un calendrier
US9186335B2 (en) 2002-07-30 2015-11-17 Ucb Pharma Gmbh Hot melt TTS for administering rotigotine
WO2018126170A1 (fr) * 2016-12-30 2018-07-05 Euromed, Inc. Timbre adhésif contenant un système de doublure détachable améliorée
US10251844B2 (en) 1998-03-30 2019-04-09 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system and method of use thereof for treating parkinsonism

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2358246A (en) * 1937-12-23 1944-09-12 Nicolle Charles Plastic material wrapper
US3247957A (en) * 1964-08-17 1966-04-26 Hospital Supply And Dev Compan Sterile packaging and the like
US4666441A (en) * 1985-12-17 1987-05-19 Ciba-Geigy Corporation Multicompartmentalized transdermal patches
US5064422A (en) * 1990-10-18 1991-11-12 Bertek, Inc. Twin patch applicator

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2358246A (en) * 1937-12-23 1944-09-12 Nicolle Charles Plastic material wrapper
US3247957A (en) * 1964-08-17 1966-04-26 Hospital Supply And Dev Compan Sterile packaging and the like
US4666441A (en) * 1985-12-17 1987-05-19 Ciba-Geigy Corporation Multicompartmentalized transdermal patches
US5064422A (en) * 1990-10-18 1991-11-12 Bertek, Inc. Twin patch applicator

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5950830A (en) * 1994-12-21 1999-09-14 Ethical Pharmaceuticals (U.K.) Limited Packaging for patches
WO1998025257A1 (fr) * 1996-12-04 1998-06-11 Hexal Ag Timbre transdermique medicamenteux autocollant mince
AU725503B2 (en) * 1996-12-04 2000-10-12 Hexal Ag Flat self-adhering drug patches
US10251844B2 (en) 1998-03-30 2019-04-09 Lts Lohmann Therapie-Systeme Ag Transdermal therapeutic system and method of use thereof for treating parkinsonism
US10322093B2 (en) 1998-03-30 2019-06-18 Ucb Biopharma Sprl Method for producing a transdermal therapeutic system which contains a D2 agonist
DE10056234A1 (de) * 2000-11-13 2002-05-29 Lohmann Therapie Syst Lts Primärverpackung für transdermale therapeutische Systeme oder medizinische Pflaster
US9186335B2 (en) 2002-07-30 2015-11-17 Ucb Pharma Gmbh Hot melt TTS for administering rotigotine
WO2007101659A1 (fr) * 2006-03-09 2007-09-13 Grünenthal GmbH Pansements contenant des substances actives caractérisés par un maniement amélioré
WO2014013344A2 (fr) * 2012-07-16 2014-01-23 Nometics Inc. Emballage de timbres transdermiques par unités multiples selon un calendrier
WO2014013344A3 (fr) * 2012-07-16 2014-03-27 Nometics Inc. Emballage de timbres transdermiques par unités multiples selon un calendrier
WO2018126170A1 (fr) * 2016-12-30 2018-07-05 Euromed, Inc. Timbre adhésif contenant un système de doublure détachable améliorée
CN110402127A (zh) * 2016-12-30 2019-11-01 优而美公司 含有改进的防粘衬里系统的贴片

Also Published As

Publication number Publication date
AU7172794A (en) 1995-01-17
CA2166191A1 (fr) 1995-01-05
JPH09501909A (ja) 1997-02-25
EP0711153A1 (fr) 1996-05-15

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