EP0711153A1 - Emballage pour systeme a liberation transdermique - Google Patents

Emballage pour systeme a liberation transdermique

Info

Publication number
EP0711153A1
EP0711153A1 EP94920731A EP94920731A EP0711153A1 EP 0711153 A1 EP0711153 A1 EP 0711153A1 EP 94920731 A EP94920731 A EP 94920731A EP 94920731 A EP94920731 A EP 94920731A EP 0711153 A1 EP0711153 A1 EP 0711153A1
Authority
EP
European Patent Office
Prior art keywords
release liner
transdermal
transdermal delivery
delivery device
liner
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP94920731A
Other languages
German (de)
English (en)
Inventor
Dan W. Connors
Jia Chen
Scott A. Huie
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cygnus Inc
Original Assignee
Cygnus Therapeutic Systems
Cygnus Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cygnus Therapeutic Systems, Cygnus Inc filed Critical Cygnus Therapeutic Systems
Publication of EP0711153A1 publication Critical patent/EP0711153A1/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches

Definitions

  • This invention relates generally to a package for a transdermal delivery system and, in particular, to a release liner and pouch for use with multiple transdermal delivery systems.
  • Transdermal delivery systems deliver substances to a user's tissues and/or blood stream through the user's skin.
  • Examples are NICOTROL ® nicotine transdermal systems and MINITRAN ® nitroglycerin transdermal systems, both available from Cygnus Therapeutic Systems.
  • Such systems are typically formed as a flexible patch containing the substance within a reservoir. The patch attaches to the user with adhesive. Contact between the patch's active face and the user's skin permits the substance to transfer from the reservoir to the user at a rate determined in part by the construction of the patch and in part by the nature of the substance.
  • the substance within the transdermal delivery system may be adversely affected by contact with light, water, air, or airborne substances.
  • Packaging must be provided, therefore, to prevent loss or degradation of the substance within the system's reservoir.
  • One prior art packaging approach is described in U.S. Patent No. 5,077,104.
  • Transdermal delivery systems may be provided to the user with adhesive already applied to the delivery side of the patch.
  • the system's packaging must therefore also prevent degradation of the adhesive and inadvertent attachment of the patch to the wrong object.
  • Transdermal delivery systems are therefore typically releasably mounted on liners, as shown in U.S. Patent No. 4,915,102 and European Patent Application No. 401 949.
  • transdermal delivery systems have a limited life, and multiple systems may be needed by a single user to accomplish the purpose for which the system was prescribed. What is needed, therefore, is a way to package multiple transdermal delivery systems together.
  • the devices are adhesive patches mounted on a release liner.
  • the liner surface is chosen so that it will not adhere to the adhesive on the devices. Rather, the devices may be peeled off easily by the user.
  • the release liner is preferably perforated or scored to permit a portion of the liner below each device to be torn off by the user.
  • the device may be lifted from the liner by the torn-off portion.
  • the torn-off portion of the liner is itself removed from the device only after the uncovered portion of the device is applied to the user's skin.
  • Figure 1(a) is a top elevational view of the transdermal delivery system package of this invention designed to hold multiple transdermal delivery systems.
  • Figure 1(b) is a top elevational view of the transdermal delivery system package of this invention designed to hold a single transdermal delivery system.
  • Figure 2 is a side cross-sectional view of the preferred embodiment of this invention.
  • Figure 3(a) is a top elevational view of a single transdermal delivery system showing how the package may be used to apply the system.
  • Figure 3 (b) is a bottom elevational view of the single transdermal system of Figure 3(a).
  • Transdermal delivery devices 10 are mounted on a release liner 12 so that the devices' substance delivery surfaces 13 face toward liner 12 and the devices' top protective surface 11 face award from liner 12.
  • release liner 12 is made from polyester, polyethylene, polystyrene, polycarbonate or paper coated with silicone or a fluorochemical compound, or a combination of these materials.
  • devices 10 each have an internal reservoir layer 14, a bottom adhesive layer 15, and a top protective layer 16 in a manner known in the art.
  • Devices 10 and liner 12 are preferably stored in an air-tight, resealable bag 18 made of a plastic film or a foil laminate.
  • Bag 18 may include a plastic zipper or zip-lock mechanism 19.
  • Bag 18 may also include a non- resealable seal mechanism (not shown) that must be unsealed by the user the first time the package is opened.
  • Liner 12 has scores or perforations 20 that permit portions 22 of the liner to be torn away from liner 12. Perforations 20 run beneath a portion of each device 10, as shown in Figure 1. At least part of each liner portion 22 is not covered by a device 10. In use, the devices and release liner are removed from the resealable bag.
  • a single device may be removed from the release liner by tearing liner 12 along one of the perforated lines 20, and lifting the device 10 off the liner 12 with the torn-off portion 22.
  • torn-off portion 22 provides a means for the user to hold device 10 without actually coming into contact with the device.
  • the portion of device 10 not covering torn-off portion 22 may be placed at, and adhered to, the chosen site on the user's skin. Thereafter, torn-off portion 22 may be removed, and the remaining portion of device 10 may be adhered to the. user's skin.
  • the liner and devices may be placed back inside bag 18, and the bag may be resealed.
  • transdermal delivery systems examples include systems delivering natural or synthetic estrogens, progestins, or combinations of the two; systems delivering anti-hypertensives for high blood pressure; systems delivering nitroglycerin; and systems delivering nicotine compounds. Modifications to the invention may be made without departing from the scope of the invention. For example, other shapes and configurations of the entire release liner and of the removable portion of the release liner may be used.

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Media Introduction/Drainage Providing Device (AREA)

Abstract

L'invention concerne un nouveau système d'emballage de dispositifs transdermiques (10). Dans le mode de réalisation préféré, les dispositifs sont des timbres adhésifs montés sur un papier à détacher (12). La surface de ce papier est choisie de manière à ne pas adhérer à l'adhésif du dispositif. En effet, les dispositifs peuvent être facilement détachés par l'utilisateur. De préférence, le papier à détacher (12) est perforé (20) ou strié pour permettre à une portion (22) dudit papier située sous chaque dispositif d'être arrachée par l'utilisateur. On peut enlever le dispositif du papier en utilisant la portion arrachée comme prise. La portion arrachée du papier ne peut elle-même être enlevée du dispositif qu'après que la portion non recouverte de celui-ci a été appliquée sur la peau de l'utilisateur.
EP94920731A 1993-06-24 1994-06-14 Emballage pour systeme a liberation transdermique Withdrawn EP0711153A1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8292693A 1993-06-24 1993-06-24
US82926 1993-06-24
PCT/US1994/006681 WO1995000122A1 (fr) 1993-06-24 1994-06-14 Emballage pour systeme a liberation transdermique

Publications (1)

Publication Number Publication Date
EP0711153A1 true EP0711153A1 (fr) 1996-05-15

Family

ID=22174343

Family Applications (1)

Application Number Title Priority Date Filing Date
EP94920731A Withdrawn EP0711153A1 (fr) 1993-06-24 1994-06-14 Emballage pour systeme a liberation transdermique

Country Status (5)

Country Link
EP (1) EP0711153A1 (fr)
JP (1) JPH09501909A (fr)
AU (1) AU7172794A (fr)
CA (1) CA2166191A1 (fr)
WO (1) WO1995000122A1 (fr)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9425783D0 (en) * 1994-12-21 1995-02-22 Ethical Pharma Ltd Packaging of patches
DE19650329A1 (de) * 1996-12-04 1998-06-10 Hexal Ag Flächiges selbsthaftendes Wirkstoffpflaster
DE19814084B4 (de) 1998-03-30 2005-12-22 Lts Lohmann Therapie-Systeme Ag D2-Agonist enthaltendes transdermales therapeutisches System zur Behandlung des Parkinson-Syndroms und Verfahren zu seiner Herstellung
DE10056234A1 (de) * 2000-11-13 2002-05-29 Lohmann Therapie Syst Lts Primärverpackung für transdermale therapeutische Systeme oder medizinische Pflaster
DE10234673B4 (de) 2002-07-30 2007-08-16 Schwarz Pharma Ag Heißschmelz-TTS zur Verabreichung von Rotigotin und Verfahren zu seiner Herstellung sowie Verwendung von Rotigotin bei der Herstellung eines TTS im Heißschmelzverfahren
DE102006011340A1 (de) * 2006-03-09 2007-09-20 Grünenthal GmbH Wirkstoffhaltige Pflaster mit verbesserter Handhabung
WO2014013344A2 (fr) * 2012-07-16 2014-01-23 Nometics Inc. Emballage de timbres transdermiques par unités multiples selon un calendrier
ES2906065T3 (es) * 2016-12-30 2022-04-13 Euromed Inc Parche adhesivo que contiene un sistema de revestimiento de liberación mejorada

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2358246A (en) * 1937-12-23 1944-09-12 Nicolle Charles Plastic material wrapper
US3247957A (en) * 1964-08-17 1966-04-26 Hospital Supply And Dev Compan Sterile packaging and the like
US4666441A (en) * 1985-12-17 1987-05-19 Ciba-Geigy Corporation Multicompartmentalized transdermal patches
US5064422A (en) * 1990-10-18 1991-11-12 Bertek, Inc. Twin patch applicator

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
See references of WO9500122A1 *

Also Published As

Publication number Publication date
AU7172794A (en) 1995-01-17
WO1995000122A1 (fr) 1995-01-05
CA2166191A1 (fr) 1995-01-05
JPH09501909A (ja) 1997-02-25

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19960110

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): DE ES FR GB IT

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: CYGNUS, INC.

RAP1 Party data changed (applicant data changed or rights of an application transferred)

Owner name: CYGNUS, INC.

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN WITHDRAWN

18W Application withdrawn

Withdrawal date: 19970825