WO1994027596A1 - Preparation pharmaceutique et son procede de fabrication - Google Patents

Preparation pharmaceutique et son procede de fabrication Download PDF

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Publication number
WO1994027596A1
WO1994027596A1 PCT/DE1994/000571 DE9400571W WO9427596A1 WO 1994027596 A1 WO1994027596 A1 WO 1994027596A1 DE 9400571 W DE9400571 W DE 9400571W WO 9427596 A1 WO9427596 A1 WO 9427596A1
Authority
WO
WIPO (PCT)
Prior art keywords
active ingredient
preparation
granules
water
coating
Prior art date
Application number
PCT/DE1994/000571
Other languages
German (de)
English (en)
Inventor
Manfred Dürr
Benedikt Gajdos
Original Assignee
Rhône-Poulenc Rorer GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhône-Poulenc Rorer GmbH filed Critical Rhône-Poulenc Rorer GmbH
Publication of WO1994027596A1 publication Critical patent/WO1994027596A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007—Effervescent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50

Abstract

L'invention concerne une préparation pharmaceutique dans une forme galénique administrable par voie orale. Cette préparation comprend un principe actif granulé à base de buflomédile-hydrochlorure, ainsi qu'éventuellement d'autres adjuvants et comporte un polymérisat d'acide acrylique, un éther cellulosique et/ou un dérivé d'éther cellulosique. La préparation contient en outre comme principe actif une substance hydrofugée à l'aide d'un agent d'hydrofugation.
PCT/DE1994/000571 1993-05-22 1994-05-13 Preparation pharmaceutique et son procede de fabrication WO1994027596A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP4317172.9 1993-05-22
DE19934317172 DE4317172A1 (de) 1993-05-22 1993-05-22 Geschmacksneutrale und schnellfreisetzende Buflomedil-Hydrochlorid-Arzneiform und Herstellungsverfahren desselben

Publications (1)

Publication Number Publication Date
WO1994027596A1 true WO1994027596A1 (fr) 1994-12-08

Family

ID=6488743

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/DE1994/000571 WO1994027596A1 (fr) 1993-05-22 1994-05-13 Preparation pharmaceutique et son procede de fabrication

Country Status (2)

Country Link
DE (1) DE4317172A1 (fr)
WO (1) WO1994027596A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1007012A1 (fr) * 1996-10-01 2000-06-14 Cima Labs Inc. Compositions en microcapsule a masquage de gout et procedes de fabrication
WO2007115381A2 (fr) 2006-04-10 2007-10-18 K.U. Leuven Research And Development Augmentation de la solubilité et de la vitesse de dissolution de médicaments faiblement solubles

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2770132B1 (fr) * 1997-10-23 2000-01-07 Louzeau Anne Marie Dupret Composition pharmaceutique pour le traitement de l'arteriopathie des membres inferieurs
DE10133546A1 (de) * 2001-07-11 2003-03-06 Petra Bastian Mischkomplexe zur Maskierung bitter schmeckender Substanzen

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2133983A (en) * 1983-01-25 1984-08-08 Lafon Labor Method for preparing galenic formulations particularly for pharmaceutical, dietary, cosmetic and diagnostic uses
GB2157170A (en) * 1984-03-23 1985-10-23 Ciba Geigy Ag Quick-disintegrating pressed shapes
JPS63183529A (ja) * 1986-10-22 1988-07-28 ビオメディカ・フォスカマ・インデュストリア・キミコ−ファルマチエウティカ・エッセ・ピ・ア 放出がコントロールされた錠剤形の、ブフロメジル塩酸塩に基づく医薬調製物およびその製造方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9104042D0 (en) * 1991-02-26 1991-04-10 Abbott Lab Taste-masked buflomedil preparation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2133983A (en) * 1983-01-25 1984-08-08 Lafon Labor Method for preparing galenic formulations particularly for pharmaceutical, dietary, cosmetic and diagnostic uses
GB2157170A (en) * 1984-03-23 1985-10-23 Ciba Geigy Ag Quick-disintegrating pressed shapes
JPS63183529A (ja) * 1986-10-22 1988-07-28 ビオメディカ・フォスカマ・インデュストリア・キミコ−ファルマチエウティカ・エッセ・ピ・ア 放出がコントロールされた錠剤形の、ブフロメジル塩酸塩に基づく医薬調製物およびその製造方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
DATABASE WPI Week 8843, Derwent World Patents Index; AN 88-302441 (43) *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1007012A1 (fr) * 1996-10-01 2000-06-14 Cima Labs Inc. Compositions en microcapsule a masquage de gout et procedes de fabrication
EP1007012A4 (fr) * 1996-10-01 2006-01-18 Cima Labs Inc Compositions en microcapsule a masquage de gout et procedes de fabrication
WO2007115381A2 (fr) 2006-04-10 2007-10-18 K.U. Leuven Research And Development Augmentation de la solubilité et de la vitesse de dissolution de médicaments faiblement solubles

Also Published As

Publication number Publication date
DE4317172A1 (de) 1995-01-05

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