WO1994012648A3 - Production de sous-unites de recepteurs t solubles par co-transfection, utilisations des produits ainsi obtenus - Google Patents
Production de sous-unites de recepteurs t solubles par co-transfection, utilisations des produits ainsi obtenus Download PDFInfo
- Publication number
- WO1994012648A3 WO1994012648A3 PCT/FR1993/001165 FR9301165W WO9412648A3 WO 1994012648 A3 WO1994012648 A3 WO 1994012648A3 FR 9301165 W FR9301165 W FR 9301165W WO 9412648 A3 WO9412648 A3 WO 9412648A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- receptors
- resulting products
- transfection
- producing soluble
- receptor
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
- C07K14/7051—T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
- C07K2319/75—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor containing a fusion for activation of a cell surface receptor, e.g. thrombopoeitin, NPY and other peptide hormones
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU55668/94A AU5566894A (en) | 1992-11-25 | 1993-11-25 | Method for producing soluble t-receptors by co-transfection, and use of resulting products |
EP94900880A EP0624201A1 (fr) | 1992-11-25 | 1993-11-25 | Production de sous-unites de recepteurs t solubles par co-transfection, utilisations des produits ainsi obtenus |
US08/256,964 US5723309A (en) | 1992-11-25 | 1993-11-25 | Production of subunits of soluble T cell receptors by co-transfection |
JP6512850A JPH07506495A (ja) | 1992-11-25 | 1993-11-25 | 可溶性t受容体のサブユニットの共トランスフェクションによる産生,得られた生成物の用途 |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR92/14203 | 1992-11-25 | ||
FR9214203A FR2698880B1 (fr) | 1992-11-25 | 1992-11-25 | Procédé de production de récepteurs T solubles, produits ainsi obtenus et leur utilisation dans des compositions diagnostiques ou thérapeutiques. |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1994012648A2 WO1994012648A2 (fr) | 1994-06-09 |
WO1994012648A3 true WO1994012648A3 (fr) | 1994-07-21 |
Family
ID=9435915
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR1993/001165 WO1994012648A2 (fr) | 1992-11-25 | 1993-11-25 | Production de sous-unites de recepteurs t solubles par co-transfection, utilisations des produits ainsi obtenus |
Country Status (7)
Country | Link |
---|---|
US (1) | US5723309A (fr) |
EP (1) | EP0624201A1 (fr) |
JP (1) | JPH07506495A (fr) |
AU (1) | AU5566894A (fr) |
CA (1) | CA2128705A1 (fr) |
FR (1) | FR2698880B1 (fr) |
WO (1) | WO1994012648A2 (fr) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996021028A2 (fr) * | 1995-01-03 | 1996-07-11 | Procept, Inc. | Recepteurs de lymphocytes t heterodimeres solubles et leurs anticorps |
US6759243B2 (en) | 1998-01-20 | 2004-07-06 | Board Of Trustees Of The University Of Illinois | High affinity TCR proteins and methods |
US6413776B1 (en) | 1998-06-12 | 2002-07-02 | Galapagos Geonomics N.V. | High throughput screening of gene function using adenoviral libraries for functional genomics applications |
US6534633B1 (en) | 1998-10-21 | 2003-03-18 | Altor Bioscience Corporation | Polyspecific binding molecules and uses thereof |
CN1464790A (zh) * | 2000-06-05 | 2003-12-31 | 苏诺尔分子公司 | T细胞受体融合物及共轭物以及其使用方法 |
AU2002220275A1 (en) * | 2000-12-08 | 2002-06-18 | The Board Of Trustees Of The University Of Illinois | Mutated class ii major histocompatibility proteins |
WO2003060097A2 (fr) * | 2002-01-10 | 2003-07-24 | National Jewish Medical And Research Center | Utilisation de recepteurs solubles de lymphocytes t $g(g)$g(d) pour reguler la fonction des lymphocytes t |
EP1551449B1 (fr) * | 2002-07-12 | 2010-10-06 | The Johns Hopkins University | Reactifs et procedes permettant d'impliquer des recepteurs clonotypiques de lymphocytes uniques |
AU2004289316B2 (en) * | 2003-11-10 | 2011-03-31 | Altor Bioscience Corporation | Soluble TCR molecules and methods of use |
EP2831109B1 (fr) | 2012-03-28 | 2017-12-06 | Gadeta B.V. | Echange combinatoire de chaîne des récepteurs des cellules 9 2t |
JP6617138B2 (ja) | 2014-04-10 | 2019-12-11 | ラヴァ・セラピューティクス・ベー・フェー | ヒトVγ9Vδ2 T細胞受容体と結合する免疫グロブリン |
JP2019525898A (ja) | 2016-06-10 | 2019-09-12 | ガデタ・ベー・フェー | ヒト白血球抗原拘束ガンマデルタt細胞受容体及びその使用方法 |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988000209A1 (fr) * | 1986-07-03 | 1988-01-14 | T Cell Sciences, Inc. | RECEPTEURS gamma, delta DE CELLULES T ET PROCEDES DE DETECTION |
WO1989003996A1 (fr) * | 1987-10-29 | 1989-05-05 | T Cell Sciences, Inc. | Polypeptides recepteurs d'antigenes de cellules t gamma, delta humaines et acides nucleiques |
WO1991010438A1 (fr) * | 1990-01-12 | 1991-07-25 | Protein Design Labs, Inc. | Antigenes chimeriques recepteurs d'antigenes de lymphocytes t solubles |
WO1991018019A1 (fr) * | 1990-05-15 | 1991-11-28 | E.R. Squibb & Sons, Inc. | Recepteurs solubles de lymphocytes t monocatenaires |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5314995A (en) * | 1990-01-22 | 1994-05-24 | Oncogen | Therapeutic interleukin-2-antibody based fusion proteins |
-
1992
- 1992-11-25 FR FR9214203A patent/FR2698880B1/fr not_active Expired - Fee Related
-
1993
- 1993-11-25 WO PCT/FR1993/001165 patent/WO1994012648A2/fr not_active Application Discontinuation
- 1993-11-25 AU AU55668/94A patent/AU5566894A/en not_active Abandoned
- 1993-11-25 US US08/256,964 patent/US5723309A/en not_active Expired - Lifetime
- 1993-11-25 EP EP94900880A patent/EP0624201A1/fr not_active Withdrawn
- 1993-11-25 CA CA002128705A patent/CA2128705A1/fr not_active Abandoned
- 1993-11-25 JP JP6512850A patent/JPH07506495A/ja active Pending
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1988000209A1 (fr) * | 1986-07-03 | 1988-01-14 | T Cell Sciences, Inc. | RECEPTEURS gamma, delta DE CELLULES T ET PROCEDES DE DETECTION |
WO1989003996A1 (fr) * | 1987-10-29 | 1989-05-05 | T Cell Sciences, Inc. | Polypeptides recepteurs d'antigenes de cellules t gamma, delta humaines et acides nucleiques |
WO1991010438A1 (fr) * | 1990-01-12 | 1991-07-25 | Protein Design Labs, Inc. | Antigenes chimeriques recepteurs d'antigenes de lymphocytes t solubles |
WO1991018019A1 (fr) * | 1990-05-15 | 1991-11-28 | E.R. Squibb & Sons, Inc. | Recepteurs solubles de lymphocytes t monocatenaires |
Non-Patent Citations (3)
Title |
---|
GREGOIRE C;REBAI N;SCHWEISGUTH F;NECKER A;MAZZA G;AUPHAN N;MILLWARD A;SCHMITT-VERHULST A M;MALISSEN B;: "Engineered secreted T-cell receptor alpha beta heterodimers", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 88, no. 18, 1991, WASHINGTON US, pages 8077 - 8081 * |
NOVOTNY J;GANJU RK;SMILEY ST;HUSSEY RE;LUTHER MA;RECNY MA;SILICIANO RF;REINHERZ EL;: "A soluble, single-chain T-cell receptor fragment endowed with antigen-combining properties.", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF USA., vol. 88, no. 19, 1991, WASHINGTON US, pages 8646 - 8650 * |
SLANETZ A E;BOTHWELL A L M;: "Heterodimeric, disulfide-linked alpha / beta T cell receptors in solution.", EUROPEAN JOURNAL OF IMMUNOLOGY, vol. 21, no. 1, 1991, VCH VERLAGSGESELLSCHAFT, DEUTSCHLAND, pages 179 - 183 * |
Also Published As
Publication number | Publication date |
---|---|
CA2128705A1 (fr) | 1994-06-09 |
EP0624201A1 (fr) | 1994-11-17 |
JPH07506495A (ja) | 1995-07-20 |
FR2698880A1 (fr) | 1994-06-10 |
WO1994012648A2 (fr) | 1994-06-09 |
US5723309A (en) | 1998-03-03 |
FR2698880B1 (fr) | 1995-02-24 |
AU5566894A (en) | 1994-06-22 |
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