WO1990006943A3 - Nouveaux peptides tnf - Google Patents

Nouveaux peptides tnf Download PDF

Info

Publication number
WO1990006943A3
WO1990006943A3 PCT/EP1989/001470 EP8901470W WO9006943A3 WO 1990006943 A3 WO1990006943 A3 WO 1990006943A3 EP 8901470 W EP8901470 W EP 8901470W WO 9006943 A3 WO9006943 A3 WO 9006943A3
Authority
WO
WIPO (PCT)
Prior art keywords
tnf peptides
novel tnf
peptides
novel
tnf
Prior art date
Application number
PCT/EP1989/001470
Other languages
German (de)
English (en)
Other versions
WO1990006943A2 (fr
Inventor
Hans-Joachim Boehm
Lothar Daum
Andreas Haupt
Bernhard Schmied
Nigel Walker
Johann-Christian Zechel
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of WO1990006943A2 publication Critical patent/WO1990006943A2/fr
Publication of WO1990006943A3 publication Critical patent/WO1990006943A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Transplantation (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Peptides dérivés de TNF ayant la formule (I): X-A-Gly-Asp-Y, dans laquelle A représente Lys, Gln ou Arg et X et Y ont la signification donnée dans la description. Procédé de production de ces peptides. Ces nouveaux peptides sont utiles pour le traitement de maladies.
PCT/EP1989/001470 1988-12-12 1989-12-02 Nouveaux peptides tnf WO1990006943A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DEP3841753.7 1988-12-12
DE3841753A DE3841753A1 (de) 1988-12-12 1988-12-12 Neue tnf-peptide

Publications (2)

Publication Number Publication Date
WO1990006943A2 WO1990006943A2 (fr) 1990-06-28
WO1990006943A3 true WO1990006943A3 (fr) 1990-08-09

Family

ID=6368952

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1989/001470 WO1990006943A2 (fr) 1988-12-12 1989-12-02 Nouveaux peptides tnf

Country Status (5)

Country Link
EP (1) EP0447435A1 (fr)
JP (1) JPH04502314A (fr)
CA (1) CA2005058A1 (fr)
DE (1) DE3841753A1 (fr)
WO (1) WO1990006943A2 (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2547263B2 (ja) * 1987-12-10 1996-10-23 ラ・ジョラ・キャンサー・リサーチ・ファウンデーション 立体配座的に安定化された細胞付着ペプチド
US5827821A (en) * 1987-12-10 1998-10-27 The Burnham Institute Conformationally stabilized cell adhesion peptides
US5795867A (en) * 1989-06-16 1998-08-18 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5686568A (en) * 1989-06-16 1997-11-11 Cor Therapeutics, Inc. Platelet aggregration inhibitors
US5648330A (en) * 1990-04-06 1997-07-15 La Jolla Cancer Research Foundation Method and composition for treating vascular graft occlusion
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
DK0527798T3 (da) * 1990-04-06 1997-12-15 Jolla Cancer Res Found Fremgangsmåde og sammensætning til behandling af thrombose
US5612311A (en) 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
WO1992017492A1 (fr) * 1991-04-05 1992-10-15 Genentech, Inc. INHIBITEURS DE L'AGREGATION PLAQUETTAIRE PRESENTANT UNE SPECIFICITE ELEVEE POUR GP IIbIII¿a?
US6107273A (en) * 1995-01-24 2000-08-22 Thomas Jefferson University Tumor necrosis factor inhibitors
CN1052464C (zh) * 1995-11-03 2000-05-17 康宁股份有限公司 抗氢致衰减的光纤

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0333517A2 (fr) * 1988-03-18 1989-09-20 The Rockefeller University Méthode et agent pour inhiber la liaison des leucocytes humains polymorphonucléaires à l'endothélium et les compositions les contenant
EP0275748B1 (fr) * 1986-12-15 1992-08-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nouveaux dérivés peptidiques et leur application notamment en thérapeutique

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0275748B1 (fr) * 1986-12-15 1992-08-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Nouveaux dérivés peptidiques et leur application notamment en thérapeutique
EP0333517A2 (fr) * 1988-03-18 1989-09-20 The Rockefeller University Méthode et agent pour inhiber la liaison des leucocytes humains polymorphonucléaires à l'endothélium et les compositions les contenant

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Band 108, 1988, (Columbus Ohio, US), K.R. GEHLSEN et al.: "Inhibition of in Vitro Tumor Cell Invasion by Arg-Gly-Asp-Containing Synthetic Peptides", siehe seite 391* Zusammenfassung 219712r, & J. Cell Biol. 1988, 106(3), 925-30* *
Proc. Natl. Acad. Sci. USA, Band 81, Oktober 1984, M.D. PIERSCHBACHER et al.: "Variants of the Cell Recognition Site of Fibronection that Retain Attachment-Promoting Activity", seiten 5985-5988 *
Proc. Natl. Acad. Sci. USA, Band 82, Dezember 1985, E.F. PLOW et al.: "The Effect of Arg-Gly-Asp-Containing Peptides on Fibrinogen and von Willebrand Factor Binding to Platelets", seiten 8057-8061 *
Proc. Natl. Acad. Sci. USA, Band 84, Dezember 1987, S.H. SOCHER et al.: "Antibodies against Amino Acids 1-15 of Tumor Necrosis Factor Block its binding to Cell-Surface Receptor", seiten 8829-8833 *

Also Published As

Publication number Publication date
CA2005058A1 (fr) 1990-06-12
DE3841753A1 (de) 1990-06-13
WO1990006943A2 (fr) 1990-06-28
EP0447435A1 (fr) 1991-09-25
JPH04502314A (ja) 1992-04-23

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