WO1990006943A3 - Neue tnf-peptide - Google Patents

Neue tnf-peptide Download PDF

Info

Publication number
WO1990006943A3
WO1990006943A3 PCT/EP1989/001470 EP8901470W WO9006943A3 WO 1990006943 A3 WO1990006943 A3 WO 1990006943A3 EP 8901470 W EP8901470 W EP 8901470W WO 9006943 A3 WO9006943 A3 WO 9006943A3
Authority
WO
WIPO (PCT)
Prior art keywords
tnf peptides
novel tnf
peptides
novel
tnf
Prior art date
Application number
PCT/EP1989/001470
Other languages
English (en)
French (fr)
Other versions
WO1990006943A2 (de
Inventor
Hans-Joachim Boehm
Lothar Daum
Andreas Haupt
Bernhard Schmied
Nigel Walker
Johann-Christian Zechel
Original Assignee
Basf Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Basf Ag filed Critical Basf Ag
Publication of WO1990006943A2 publication Critical patent/WO1990006943A2/de
Publication of WO1990006943A3 publication Critical patent/WO1990006943A3/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/525—Tumour necrosis factor [TNF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Es werden von TNF abgeleitete Peptide der Formel (I): X-A-Gly-Asp-Y, worin A Lys, Gln oder Arg ist und X und Y die in der Beschreibung angegebenen Bedeutungen besitzen, sowie deren Herstellung beschrieben. Die neuen Peptide eignen sich zur Bekämpfung von Krankheiten.
PCT/EP1989/001470 1988-12-12 1989-12-02 Neue tnf-peptide WO1990006943A2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE3841753A DE3841753A1 (de) 1988-12-12 1988-12-12 Neue tnf-peptide
DEP3841753.7 1988-12-12

Publications (2)

Publication Number Publication Date
WO1990006943A2 WO1990006943A2 (de) 1990-06-28
WO1990006943A3 true WO1990006943A3 (de) 1990-08-09

Family

ID=6368952

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1989/001470 WO1990006943A2 (de) 1988-12-12 1989-12-02 Neue tnf-peptide

Country Status (5)

Country Link
EP (1) EP0447435A1 (de)
JP (1) JPH04502314A (de)
CA (1) CA2005058A1 (de)
DE (1) DE3841753A1 (de)
WO (1) WO1990006943A2 (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5827821A (en) * 1987-12-10 1998-10-27 The Burnham Institute Conformationally stabilized cell adhesion peptides
EP0394326B1 (de) * 1987-12-10 1996-07-31 La Jolla Cancer Research Foundation Verfahren zur herstellung von conformationnell stabilisierten zelladhäsionspeptiden
US5686566A (en) * 1989-06-16 1997-11-11 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US5807828A (en) * 1989-06-16 1998-09-15 Cor Therapeutics, Inc. Platelet aggregation inhibitors
US6521594B1 (en) 1990-04-06 2003-02-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5648330A (en) * 1990-04-06 1997-07-15 La Jolla Cancer Research Foundation Method and composition for treating vascular graft occlusion
DK0527798T3 (da) * 1990-04-06 1997-12-15 Jolla Cancer Res Found Fremgangsmåde og sammensætning til behandling af thrombose
US5612311A (en) 1990-04-06 1997-03-18 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
US5780303A (en) * 1990-04-06 1998-07-14 La Jolla Cancer Research Foundation Method and composition for treating thrombosis
WO1992017492A1 (en) * 1991-04-05 1992-10-15 Genentech, Inc. PLATELET AGGREGATION INHIBITORS HAVING HIGH SPECIFICITY FOR GP IIbIII¿a?
US6107273A (en) * 1995-01-24 2000-08-22 Thomas Jefferson University Tumor necrosis factor inhibitors
CN1052464C (zh) * 1995-11-03 2000-05-17 康宁股份有限公司 抗氢致衰减的光纤

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0333517A2 (de) * 1988-03-18 1989-09-20 The Rockefeller University Methode und Mittel zur Hemmung der Bindung von menschlichen polymorphonuklearen Leukozyten an das Endothelium und sie enthaltende Zusammensetzungen
EP0275748B1 (de) * 1986-12-15 1992-08-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Peptid-Derivate und deren Verwendung in der Therapie

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0275748B1 (de) * 1986-12-15 1992-08-19 Institut National De La Sante Et De La Recherche Medicale (Inserm) Peptid-Derivate und deren Verwendung in der Therapie
EP0333517A2 (de) * 1988-03-18 1989-09-20 The Rockefeller University Methode und Mittel zur Hemmung der Bindung von menschlichen polymorphonuklearen Leukozyten an das Endothelium und sie enthaltende Zusammensetzungen

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, Band 108, 1988, (Columbus Ohio, US), K.R. GEHLSEN et al.: "Inhibition of in Vitro Tumor Cell Invasion by Arg-Gly-Asp-Containing Synthetic Peptides", siehe seite 391* Zusammenfassung 219712r, & J. Cell Biol. 1988, 106(3), 925-30* *
Proc. Natl. Acad. Sci. USA, Band 81, Oktober 1984, M.D. PIERSCHBACHER et al.: "Variants of the Cell Recognition Site of Fibronection that Retain Attachment-Promoting Activity", seiten 5985-5988 *
Proc. Natl. Acad. Sci. USA, Band 82, Dezember 1985, E.F. PLOW et al.: "The Effect of Arg-Gly-Asp-Containing Peptides on Fibrinogen and von Willebrand Factor Binding to Platelets", seiten 8057-8061 *
Proc. Natl. Acad. Sci. USA, Band 84, Dezember 1987, S.H. SOCHER et al.: "Antibodies against Amino Acids 1-15 of Tumor Necrosis Factor Block its binding to Cell-Surface Receptor", seiten 8829-8833 *

Also Published As

Publication number Publication date
DE3841753A1 (de) 1990-06-13
JPH04502314A (ja) 1992-04-23
CA2005058A1 (en) 1990-06-12
WO1990006943A2 (de) 1990-06-28
EP0447435A1 (de) 1991-09-25

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