WO1994005630B1 - PROCEDES DE PREPARATION ET D'UTILISATION DE LA VITAMINE D2 1α,24(S)-DIHYDROXY - Google Patents

PROCEDES DE PREPARATION ET D'UTILISATION DE LA VITAMINE D2 1α,24(S)-DIHYDROXY

Info

Publication number
WO1994005630B1
WO1994005630B1 PCT/US1993/008141 US9308141W WO9405630B1 WO 1994005630 B1 WO1994005630 B1 WO 1994005630B1 US 9308141 W US9308141 W US 9308141W WO 9405630 B1 WO9405630 B1 WO 9405630B1
Authority
WO
WIPO (PCT)
Prior art keywords
dihydroxy vitamin
converted
vitamin
formation
hydroxyergosterol
Prior art date
Application number
PCT/US1993/008141
Other languages
English (en)
Other versions
WO1994005630A1 (fr
Filing date
Publication date
Application filed filed Critical
Priority to CA002121689A priority Critical patent/CA2121689C/fr
Priority to EP93921243A priority patent/EP0614456B1/fr
Priority to DE69325253T priority patent/DE69325253T2/de
Priority to DK93921243T priority patent/DK0614456T3/da
Priority to AU48411/93A priority patent/AU4841193A/en
Priority to JP50736194A priority patent/JP3179495B2/ja
Publication of WO1994005630A1 publication Critical patent/WO1994005630A1/fr
Publication of WO1994005630B1 publication Critical patent/WO1994005630B1/fr
Priority to GR990402020T priority patent/GR3030939T3/el

Links

Abstract

Cette invention concerne l'utilisation de la vitamine D2 1α,24(S)-dihydroxy comme composé actif dans des compositions pharmaceutiques employées pour traiter des dérèglements du métabolisme du calcium et diverses affections cutanées. Cette invention concerne également la préparation de vitamine D2 1α,24(S)-dihydroxy de synthèse avec de l'ergostérol comme matière de départ qu'on transforme en six étapes en 24-hydroxyergostérol. On irradie le 24-hydroxyergostérol et on le transforme thermiquement en vitamine D2 24-hydroxy qu'on transforme en six étapes en vitamine D2 1α,24(S)-dihydroxy. Les synthèses produisent également de nouveaux intermédiaires.
PCT/US1993/008141 1992-08-28 1993-08-30 PROCEDES DE PREPARATION ET D'UTILISATION DE LA VITAMINE D2 1α,24(S)-DIHYDROXY WO1994005630A1 (fr)

Priority Applications (7)

Application Number Priority Date Filing Date Title
CA002121689A CA2121689C (fr) 1992-08-28 1993-08-30 1.alpha.,24(s)-dihydroxy vitamine d2, sa formation et son utilisation
EP93921243A EP0614456B1 (fr) 1992-08-28 1993-08-30 Procedes de preparation et d'utilisation de la vitamine 1alpha,24(s)-dihydroxy d2
DE69325253T DE69325253T2 (de) 1992-08-28 1993-08-30 1alpha,24(s)-dihydroxy vitamin d2, seine synthese und verwendung
DK93921243T DK0614456T3 (da) 1992-08-28 1993-08-30 1alfa,24(S)-dihydroxy-vitamin D2, dets fremstilling og anvendelse
AU48411/93A AU4841193A (en) 1992-08-28 1993-08-30 1alpha,24(S)-dihydroxy vitamin D2, its formation and use
JP50736194A JP3179495B2 (ja) 1992-08-28 1993-08-30 １α，２４（Ｓ）−ジヒドロキシビタミンＤ▲下２▼の調製及び使用方法
GR990402020T GR3030939T3 (en) 1992-08-28 1999-08-10 1-g(a),24(S)-DIHYDROXY VITAMIN D 2?, ITS FORMATION AND USE.

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94024692A 1992-08-28 1992-08-28
US07/940,246 1992-08-28

Publications (2)

Publication Number Publication Date
WO1994005630A1 WO1994005630A1 (fr) 1994-03-17
WO1994005630B1 true WO1994005630B1 (fr) 1994-04-14

Family

ID=25474483

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1993/008141 WO1994005630A1 (fr) 1992-08-28 1993-08-30 PROCEDES DE PREPARATION ET D'UTILISATION DE LA VITAMINE D2 1α,24(S)-DIHYDROXY

Country Status (11)

Country Link
US (1) US6143910A (fr)
EP (1) EP0614456B1 (fr)
JP (1) JP3179495B2 (fr)
AT (1) ATE181062T1 (fr)
AU (2) AU4841193A (fr)
CA (1) CA2121689C (fr)
DE (1) DE69325253T2 (fr)
DK (1) DK0614456T3 (fr)
ES (1) ES2134267T3 (fr)
GR (1) GR3030939T3 (fr)
WO (1) WO1994005630A1 (fr)

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Publication number Priority date Publication date Assignee Title
US5602116A (en) * 1988-08-02 1997-02-11 Bone Care International, Inc. Method for treating and preventing secondary hyperparathyroidism
US6538037B2 (en) 1991-01-08 2003-03-25 Bone Care International, Inc. Methods for preparation and use of 1α,24(S)-dihydroxyvitamin D2
US6376479B1 (en) 1995-04-03 2002-04-23 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
US6242434B1 (en) * 1997-08-08 2001-06-05 Bone Care International, Inc. 24-hydroxyvitamin D, analogs and uses thereof
TW584627B (en) * 1996-07-01 2004-04-21 Chugai Pharmaceutical Co Ltd The method for purifying vitamin D derivatives and its crystalline products
US6573256B2 (en) 1996-12-30 2003-06-03 Bone Care International, Inc. Method of inhibiting angiogenesis using active vitamin D analogues
US6503893B2 (en) * 1996-12-30 2003-01-07 Bone Care International, Inc. Method of treating hyperproliferative diseases using active vitamin D analogues
US20020128240A1 (en) * 1996-12-30 2002-09-12 Bone Care International, Inc. Treatment of hyperproliferative diseases using active vitamin D analogues
US6566353B2 (en) 1996-12-30 2003-05-20 Bone Care International, Inc. Method of treating malignancy associated hypercalcemia using active vitamin D analogues
CA2326117A1 (fr) * 1998-03-27 1999-10-07 Oregon Health Sciences University Vitamine d et ses analogues pour le traitement de tumeurs et d'autres troubles d'hyperproliferation
US6362350B1 (en) * 1999-07-01 2002-03-26 Wisconsin Alumni Research Foundation Crystalline 1α, 24(S)-dihydroxyvitamin D2 and method of purification thereof
JP2004504295A (ja) * 2000-07-18 2004-02-12 ボーン　ケア　インターナショナル　インコーポレイテッド 安定化１α−ヒドロキシビタミンＤ
BRPI0114927B8 (pt) * 2000-10-27 2021-05-25 Leo Pharma As composição de gel farmacêutica não aquosa para aplicação na pele, e, uso de uma composição
US7094775B2 (en) * 2004-06-30 2006-08-22 Bone Care International, Llc Method of treating breast cancer using a combination of vitamin D analogues and other agents
WO2009100258A1 (fr) * 2008-02-05 2009-08-13 Hollis-Eden Pharmaceuticals, Inc. Formes pharmaceutiques à l'état solide
KR101841260B1 (ko) * 2016-11-25 2018-03-23 정미영 재난 대피용 테이블 장치

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4670190A (en) * 1973-01-10 1987-06-02 Hesse Robert H 1-α-hydroxy vitamin D compounds and process for preparing same
US3880894A (en) * 1974-05-24 1975-04-29 Wisconsin Alumni Res Found 1,25-Dihydroxyergocalciferol
US4022891A (en) * 1974-06-18 1977-05-10 Teijin Limited Novel 1α,24-dihydroxycholecalciferol compositions, novel precursors thereof, and processes for preparing them
GB1583749A (en) * 1976-06-03 1981-02-04 Res Inst Medicine Chem Vitamin d derivatives
US4195027A (en) * 1978-01-16 1980-03-25 Wisconsin Alumni Research Foundation Process for preparing 1α-hydroxylated compounds
US4338250A (en) * 1981-04-27 1982-07-06 Wisconsin Alumni Research Foundation 1-Hydroxylation process
US4719205A (en) * 1984-01-30 1988-01-12 Wisconsin Alumini Research Foundation Side-chain unsaturated 1-hydroxyvitamin D compounds
US4719204A (en) * 1984-03-05 1988-01-12 Wisconsin Alumni Research Foundation Fowl bone mineralization with 28-NOR 1α-hydroxyvitamin D2 analogs
US5104864A (en) * 1988-08-02 1992-04-14 Bone Care International, Inc. Method for treating and preventing loss of bone mass
US5098899A (en) * 1989-03-06 1992-03-24 Trustees Of Boston University Method for therapeutically treating psoriatic arthritis using vitamin D analogues and metabolites
US4973584A (en) * 1989-03-09 1990-11-27 Deluca Hector F Novel 1α-hydroxyvitamin D2 epimer and derivatives
US5260290A (en) * 1990-02-14 1993-11-09 Wisconsin Alumni Research Foundation Homologated vitamin D2 compounds and the corresponding 1α-hydroxylated derivatives
WO1992012165A1 (fr) * 1991-01-08 1992-07-23 Lunar Corporation PROCEDES DE PREPARATION ET UTILISATION DE LA VITAMINE 1α,24-DIHYDROXY D¿2?

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