Classifications

• • C—CHEMISTRY; METALLURGY
  • C07—ORGANIC CHEMISTRY
  • C07J—STEROIDS
  • C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane

Definitions

• the present invention relates to qualitative control of the isolation of sterols.
• Sterols are valuable intermediates for the manufacture of a se ⁇ ries of important pharmaceutical. Different derivatives of cor- tisone and contraceptive agents relate to this area. Sterols have a biological activity of its own, as well. They are pre ⁇ sent in most organisms. Physio-chemically the sterols function as barrier compounds as they are readily piled onto each other. Compounds, which in this way provide mono or oligomeric sur- faces are called spreading.
• sterols can be isolated from several natural sources. Soya desodorisates , bile, and tall oil are the most common. As the sterols are most often present in esterified form these are released suitably by hydrolysis. The sterols can then be extracted using any suitable solvent, and are then pre ⁇ cipitated.
• the present invention discloses a solution to this problem, whereby not only a constant ratio can be obtained, but moreover a ratio which is optimal with regard to the subsequent isola ⁇ tion of sterols.
• the process is aimed at transforming a determined part of the acids and/or esters to derivatives which do not distil with the mixture of sterols.
• One way is hereby to add a limited amount of sodium or potassium hydroxide, whereby one obtains salts of mainly fatty acids. These salts will not distil but one adds then a complementing amount of an amine or ammonia, which gives amides which can constitute a dragging liquid.
• Another way is to add a determined amount of two or more polyalcohols at the re-esterification. This results in esters having a higher boil ⁇ ing point which do not distil under prevailing conditions.
• a third way is to add a determined amount of di or polyvalent amines or high boiling amines or amino alkanols. These form different amides which do not distil under prevailing condi ⁇ tions. Like in the previous cases one may then add a certain amount of a lower amine for the formation of an amide having a lower boiling point to obtain a dragging liquid.

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• Chemical & Material Sciences (AREA)
• Organic Chemistry (AREA)
• Health & Medical Sciences (AREA)
• General Health & Medical Sciences (AREA)
• Steroid Compounds (AREA)

Applications Claiming Priority (2)

Publications (1)

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Family Applications (1)

Country Status (2)

Cited By (1)

Citations (3)

• 1992
  • 1992-08-06 SE SE9202305A patent/SE9202305L/sv not_active Application Discontinuation
• 1993
  • 1993-08-04 WO PCT/SE1993/000651 patent/WO1994003473A1/en active Application Filing

Patent Citations (3)

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