WO1994003473A1 - Maitrise qualitative de l'isolation de sterols - Google Patents
Maitrise qualitative de l'isolation de sterols Download PDFInfo
- Publication number
- WO1994003473A1 WO1994003473A1 PCT/SE1993/000651 SE9300651W WO9403473A1 WO 1994003473 A1 WO1994003473 A1 WO 1994003473A1 SE 9300651 W SE9300651 W SE 9300651W WO 9403473 A1 WO9403473 A1 WO 9403473A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- sterols
- acids
- amount
- dragging
- esterified
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Definitions
- the present invention relates to qualitative control of the isolation of sterols.
- Sterols are valuable intermediates for the manufacture of a se ⁇ ries of important pharmaceutical. Different derivatives of cor- tisone and contraceptive agents relate to this area. Sterols have a biological activity of its own, as well. They are pre ⁇ sent in most organisms. Physio-chemically the sterols function as barrier compounds as they are readily piled onto each other. Compounds, which in this way provide mono or oligomeric sur- faces are called spreading.
- sterols can be isolated from several natural sources. Soya desodorisates , bile, and tall oil are the most common. As the sterols are most often present in esterified form these are released suitably by hydrolysis. The sterols can then be extracted using any suitable solvent, and are then pre ⁇ cipitated.
- the present invention discloses a solution to this problem, whereby not only a constant ratio can be obtained, but moreover a ratio which is optimal with regard to the subsequent isola ⁇ tion of sterols.
- the process is aimed at transforming a determined part of the acids and/or esters to derivatives which do not distil with the mixture of sterols.
- One way is hereby to add a limited amount of sodium or potassium hydroxide, whereby one obtains salts of mainly fatty acids. These salts will not distil but one adds then a complementing amount of an amine or ammonia, which gives amides which can constitute a dragging liquid.
- Another way is to add a determined amount of two or more polyalcohols at the re-esterification. This results in esters having a higher boil ⁇ ing point which do not distil under prevailing conditions.
- a third way is to add a determined amount of di or polyvalent amines or high boiling amines or amino alkanols. These form different amides which do not distil under prevailing condi ⁇ tions. Like in the previous cases one may then add a certain amount of a lower amine for the formation of an amide having a lower boiling point to obtain a dragging liquid.
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
Abstract
L'invention concerne un procédé d'ajustement du rapport entre le volume de produit et le volume de liquide d'entraînement dans un procédé de distillation permettant de récupérer les stérols. Ces composants qui sont des acides organiques et/ou des acides estérifiés, principalement des acides gras, sont entièrement ou partiellement transformés pour obtenir un produit non distillable ne constituant pas un liquide d'entraînement.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9202305A SE9202305L (sv) | 1992-08-06 | 1992-08-06 | Kvalitativ styrning vid isolering av steroler |
SE9202305-0 | 1992-08-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1994003473A1 true WO1994003473A1 (fr) | 1994-02-17 |
Family
ID=20386893
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/SE1993/000651 WO1994003473A1 (fr) | 1992-08-06 | 1993-08-04 | Maitrise qualitative de l'isolation de sterols |
Country Status (2)
Country | Link |
---|---|
SE (1) | SE9202305L (fr) |
WO (1) | WO1994003473A1 (fr) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005116048A1 (fr) * | 2004-05-31 | 2005-12-08 | Cognis Ip Management Gmbh | Procede pour la recuperation de sterols sur materiau organique |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2262950A (en) * | 1937-06-29 | 1941-11-18 | Henry W F Lorenz | Process for the separation of unsaponifiable matter from saponifiable materials containing the same |
US2598269A (en) * | 1949-05-27 | 1952-05-27 | Colgate Palmolive Peet Co | Recovery of sterols |
EP0260243A1 (fr) * | 1986-09-12 | 1988-03-16 | Triple Crown Aktiebolag | Procédé d'aminolyse des esters stéroliques |
-
1992
- 1992-08-06 SE SE9202305A patent/SE9202305L/ not_active Application Discontinuation
-
1993
- 1993-08-04 WO PCT/SE1993/000651 patent/WO1994003473A1/fr active Application Filing
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2262950A (en) * | 1937-06-29 | 1941-11-18 | Henry W F Lorenz | Process for the separation of unsaponifiable matter from saponifiable materials containing the same |
US2598269A (en) * | 1949-05-27 | 1952-05-27 | Colgate Palmolive Peet Co | Recovery of sterols |
EP0260243A1 (fr) * | 1986-09-12 | 1988-03-16 | Triple Crown Aktiebolag | Procédé d'aminolyse des esters stéroliques |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005116048A1 (fr) * | 2004-05-31 | 2005-12-08 | Cognis Ip Management Gmbh | Procede pour la recuperation de sterols sur materiau organique |
Also Published As
Publication number | Publication date |
---|---|
SE9202305D0 (sv) | 1992-08-06 |
SE9202305L (sv) | 1994-02-07 |
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