WO1994003269A1 - Microbilles en matieres polyhydroxyliques - Google Patents

Microbilles en matieres polyhydroxyliques Download PDF

Info

Publication number
WO1994003269A1
WO1994003269A1 PCT/GB1993/001692 GB9301692W WO9403269A1 WO 1994003269 A1 WO1994003269 A1 WO 1994003269A1 GB 9301692 W GB9301692 W GB 9301692W WO 9403269 A1 WO9403269 A1 WO 9403269A1
Authority
WO
WIPO (PCT)
Prior art keywords
microspheres
polyhydroxylic
polysaccharide
microsphere
cross
Prior art date
Application number
PCT/GB1993/001692
Other languages
English (en)
Inventor
Paul Finch
Chui Sheung Leung
Ann Denise Wheeler
Helmut Weigel
Original Assignee
Royal Holloway And Bedford New College
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Royal Holloway And Bedford New College filed Critical Royal Holloway And Bedford New College
Publication of WO1994003269A1 publication Critical patent/WO1994003269A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0419—Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

L'invention concerne des microbilles polymères biodégradables à usage médical et autres qui se composent d'un polymère polyhydroxylique réticulé à l'aide de 1,1'-carbonyldiimidazole, de phosgène ou d'éthylchloroformate, lesdites microbilles étant directement réactives avec les nucléophiles. Les microbilles selon l'invention sont fabriquées par réticulation d'une émulsion aqueuse de ladite matière polymère à l'aide d'un des agents de réticulation mentionnés ci-dessus. Le polymère est généralement un polysaccharide, et les microbilles peuvent être directement liées à des produits tels que des médicaments, des protéines et d'autres réactifs diagnostiques.
PCT/GB1993/001692 1992-08-10 1993-08-10 Microbilles en matieres polyhydroxyliques WO1994003269A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929216925A GB9216925D0 (en) 1992-08-10 1992-08-10 Microspheres of polyhydroxylic materials
GB9216925.9 1992-08-10

Publications (1)

Publication Number Publication Date
WO1994003269A1 true WO1994003269A1 (fr) 1994-02-17

Family

ID=10720098

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/GB1993/001692 WO1994003269A1 (fr) 1992-08-10 1993-08-10 Microbilles en matieres polyhydroxyliques

Country Status (2)

Country Link
GB (1) GB9216925D0 (fr)
WO (1) WO1994003269A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000078358A2 (fr) * 1999-06-18 2000-12-28 The Collaborative Group, Ltd. Microspheres d'acide hyaluronique pour le transfert continu de genes
WO2005061603A1 (fr) * 2003-12-17 2005-07-07 The Procter & Gamble Company Structures polymeres comprenant un systeme hydrophile/lipophile
US7426775B2 (en) 2003-12-17 2008-09-23 The Procter + Gamble Company Polymeric structures comprising a hydrophile/lipophile system
US11642415B2 (en) 2017-03-22 2023-05-09 Ascendis Pharma A/S Hydrogel cross-linked hyaluronic acid prodrug compositions and methods

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2220304A1 (fr) * 1973-03-09 1974-10-04 Bayer Ag
US3899602A (en) * 1972-09-11 1975-08-12 Nat Starch Chem Corp Inhibited starch products containing labile and non-labile cross-links
JPS6130502A (ja) * 1984-07-23 1986-02-12 Nippon Kayaku Co Ltd 土壌害虫防除剤
JPS6354385A (ja) * 1986-08-26 1988-03-08 Tosoh Corp 混合酸型重合性リン脂質誘導体及びその製造法

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899602A (en) * 1972-09-11 1975-08-12 Nat Starch Chem Corp Inhibited starch products containing labile and non-labile cross-links
FR2220304A1 (fr) * 1973-03-09 1974-10-04 Bayer Ag
JPS6130502A (ja) * 1984-07-23 1986-02-12 Nippon Kayaku Co Ltd 土壌害虫防除剤
JPS6354385A (ja) * 1986-08-26 1988-03-08 Tosoh Corp 混合酸型重合性リン脂質誘導体及びその製造法

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 106, no. 15, 13 April 1987, Columbus, Ohio, US; abstract no. 116042b, MCCONWAY, M. G. ET AL: "Application of solid-phase antibodies to radioimmunoassay. Evaluation of two polymeric microparticles, Dynospheres and nylon activated by carbonyldiimidazole or tresyl chloride" *
DATABASE WPI Section Ch Week 8613, Derwent World Patents Index; Class A97, AN 86-084399 *
DATABASE WPI Section Ch Week 8815, Derwent World Patents Index; Class A11, AN 88-103090 *
J. IMMUNOL. METHODS, 95(2), 259-66, 1986 *

Cited By (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000078358A2 (fr) * 1999-06-18 2000-12-28 The Collaborative Group, Ltd. Microspheres d'acide hyaluronique pour le transfert continu de genes
WO2000078358A3 (fr) * 1999-06-18 2001-06-14 Collaborative Group Ltd Microspheres d'acide hyaluronique pour le transfert continu de genes
WO2005061603A1 (fr) * 2003-12-17 2005-07-07 The Procter & Gamble Company Structures polymeres comprenant un systeme hydrophile/lipophile
US7426775B2 (en) 2003-12-17 2008-09-23 The Procter + Gamble Company Polymeric structures comprising a hydrophile/lipophile system
US7714065B2 (en) 2003-12-17 2010-05-11 The Procter & Gamble Company Polymeric structures comprising a hydrophile/lipophile system
US8071203B2 (en) 2003-12-17 2011-12-06 The Procter & Gamble Company Polymeric structures comprising a hydrophile/lipophile system
US8137797B2 (en) 2003-12-17 2012-03-20 The Procter & Gamble Company Polymeric structures comprising a hydrophile
US8241738B2 (en) 2003-12-17 2012-08-14 The Procter & Gamble Company Polymeric structures comprising a sulfosuccinate
US8445100B2 (en) 2003-12-17 2013-05-21 The Procter & Gamble Company Polymeric structures comprising a sulfosuccinate
US8709585B2 (en) 2003-12-17 2014-04-29 The Procter & Gamble Company Polymeric structures comprising a siloxane
US9103051B2 (en) 2003-12-17 2015-08-11 The Procter & Gamble Company Polymeric structures comprising a sulfosuccinate
US11642415B2 (en) 2017-03-22 2023-05-09 Ascendis Pharma A/S Hydrogel cross-linked hyaluronic acid prodrug compositions and methods

Also Published As

Publication number Publication date
GB9216925D0 (en) 1992-09-23

Similar Documents

Publication Publication Date Title
ES2357889T3 (es) Composición y método para reticular o modificar homogéneamente quitosano en condiciones neutras.
Prabaharan et al. Chitosan derivatives bearing cyclodextrin cavitiesas novel adsorbent matrices
US5041292A (en) Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
AU622699B2 (en) Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
JP4230135B2 (ja) 多官能性架橋剤によって架橋したグリコサミノグリカン−コラーゲン複合体の製造法
RU2472809C2 (ru) Поперечно сшитые полисахаридные и белковые матрицы и способы их получения
CA2351711A1 (fr) Nanocapsules et leur procede de production
JPH08509246A (ja) エステル化した多糖類とポリアミン化またはポリヒドロキシル化した物質の間のトランスアシル化反応の微粒子製造への使用、そのようにして製造された微粒子、方法、およびそれを含有する組成物
EP0020183A1 (fr) Composé polyionique, procédé pour sa préparation et articles formés à partir de ce composé
Moyuan et al. A convenient scheme for synthesizing reduction‐sensitive chitosan‐based amphiphilic copolymers for drug delivery
JP2004521152A (ja) 生分解ポリマーを基にした材料及びその製造方法
KR20020031894A (ko) 소수성 다중복합 헤파린 결합체, 그의 제조방법 및 용도
CN107098988B (zh) 一种黄原胶纳米微凝胶的制备方法
JP4262090B2 (ja) 自己凝集体を形成する抗癌剤−キトサン複合体及びその製造方法
CN116178589B (zh) 一种两亲性硫辛酰基阳离子壳聚糖衍生物及其制备和应用
CN107227072A (zh) 一种两亲性壳聚糖衍生物抗蛋白质吸附涂层的制备方法和应用
Levy et al. Microcapsules prepared through interfacial cross-linking of starch derivatives
Jooybar et al. Enzymatically crosslinked hyaluronic acid microgels as a vehicle for sustained delivery of cationic proteins
EP0977780B1 (fr) Conjugues d'hetero-polysaccharides, gels de polysaccharide a reseaux polymeres a semi-interpenetration et procedes de production et d'utilisation desdits gels
Kung et al. Surface modifications of alginate/poly (L-lysine) microcapsular membranes with poly (ethylene glycol) and poly (vinyl alcohol)
WO1994003269A1 (fr) Microbilles en matieres polyhydroxyliques
AU2006273606A1 (en) Haemofilters for blood detoxification
CN105820267B (zh) 一种皮肤创面修复制剂及其制备方法和应用
DD279486A1 (de) Verfahren zur aktivierung von hydroxylgruppenhaltigen polymeren verbindungen
JPH0662678B2 (ja) ヒアルロン酸固定化蛋白質及びその製造方法

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): JP US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FR GB GR IE IT LU MC NL PT SE

121 Ep: the epo has been informed by wipo that ep was designated in this application
DFPE Request for preliminary examination filed prior to expiration of 19th month from priority date (pct application filed before 20040101)
122 Ep: pct application non-entry in european phase