WO1992007487A1 - Brosse a dents comportant des fibres creuses semi-permeables - Google Patents

Brosse a dents comportant des fibres creuses semi-permeables Download PDF

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Publication number
WO1992007487A1
WO1992007487A1 PCT/US1991/007432 US9107432W WO9207487A1 WO 1992007487 A1 WO1992007487 A1 WO 1992007487A1 US 9107432 W US9107432 W US 9107432W WO 9207487 A1 WO9207487 A1 WO 9207487A1
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WO
WIPO (PCT)
Prior art keywords
agent
medium
fiber
applying
diffusible
Prior art date
Application number
PCT/US1991/007432
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English (en)
Inventor
Pauline H. Pan
David B. Van Dongen
Original Assignee
Warner-Lambert Company
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner-Lambert Company filed Critical Warner-Lambert Company
Publication of WO1992007487A1 publication Critical patent/WO1992007487A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A46—BRUSHWARE
    • A46B—BRUSHES
    • A46B11/00—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water
    • A—HUMAN NECESSITIES
    • A46—BRUSHWARE
    • A46B—BRUSHES
    • A46B2200/00—Brushes characterized by their functions, uses or applications
    • A46B2200/10—For human or animal care
    • A46B2200/1066—Toothbrush for cleaning the teeth or dentures

Definitions

  • the present invention relates generally to toothbrushes. More particularly, the present invention relates to toothbrushes which incorporate active agents contained in gels, slurries, pastes, solutions, and powders that are held in agent dispensers.
  • the present invention is particularly, though not exclusively, useful for toothbrushes that directly apply active agents contained in gels, slurries, pastes, solutions, and powders that are held in agent dispensers onto the teeth and gums as the teeth and gums are being brushed.
  • the most common method of preventing dental disease and maintaining dental health is by brushing the teeth and gums.
  • toothpastes and gels that contain certain dental health agents have been introduced which can be applied to the teeth and gums during the brushing process.
  • the toothpaste is typically transferred onto the bristles of the toothbrush from a separate tube for subsequent application to the teeth and gums during the brushing process.
  • the brush itself may contain the gel or paste which is to be applied to the teeth and gums.
  • toothbrushes which conveniently store toothpaste or gel in a portion of the brush.
  • the device disclosed in U.S. Patent No. 4,039,261 dispenses paste or gel contained in the brush through the ends of hollow bristles onto the teeth during the brushing process.
  • Such devices are convenient to use because a separate paste or gel container is not required.
  • Devices which dispense agent-containing paste or gel only through the ends of hollow bristles are typically unable to uniformly apply the agents to all of the dental surfaces on which the agent is to be dispensed.
  • the areas between the teeth are typically contacted only by the sides of the individual bristles during brushing, and not necessarily by the paste- or gel-dispensing bristle ends. Under such circumstances, the agent-containing paste or gel is not effectively applied to the areas between the teeth.
  • U.S. Patent No. 4,175,326 to Goodson discloses such a device. More particularly, Goodson discloses semi-permeable hollow fibers which contain dental agents that diffuse through the sides of the fiber when the fiber is wetted.
  • the fiber is positioned between the teeth and the gum line to release the agents onto the teeth and gums over a period of time. The fiber is then removed.
  • precisely placing the hollow fiber in the mouth is cumbersome and inconvenient.
  • the agents are not vigorously delivered to the effected areas. In any event, brushing is still the preferred way to apply dental agents to the teeth and gums.
  • the present -invention recognizes that a toothbrush can be provided which contains a variety of dental agents and which can dispense these agents relatively uniformly over the teeth and gums during the entire brushing episode. Accordingly, it is an object of the present invention to provide an agent-containing toothbrush which can relatively efficiently dispense more than one agent onto the teeth and gums and slowly release these agents so as to permit such toothbrush to be used repetitiously over a period of time. It is a further object of the present invention to provide an agent-containing toothbrush which holds the agents to be dispensed in relatively sterile holding sites within the brush.
  • a toothbrush containing a diffusible medium has an elongated handle formed with a head on one end.
  • Several semi-permeable hollow fibers are attached to and extend outwardly from one side of the head.
  • the fibers are hollow and consequently are fillable with the diffusible medium, which may be a powder, gel, slurry, paste or solution.
  • the diffusible medium contains one or more dental agents that diffuse through the sides of the fibers and onto the teeth and gums when the fibers are wetted during the brushing process.
  • the medium may also contain an indicator constituent which changes color to indicate when the dental agent has been spent from the toothbrush.
  • the medium may be held entirely within the permeable fibers. Additionally, the medium may be stored in the handle of the toothbrush.
  • the fibers are hollow, the handle is formed with an internal reservoir for holding the medium, and one end of each of the hollow fibers extends through the head of the toothbrush into the reservoir. A path is thereby provided for communication of the medium from the reservoir to the respective lumens of the fibers.
  • a plunger that has substantially the same cross-sectional area and shape as the reservoir may also be disposed in the reservoir. The plunger, if present, is connected to an elongated stem to provide a means for urging the plunger into the reservoir to expel the medium from the reservoir.
  • the semi-permeable fibers are attached to the head of the toothbrush in groups, or tufts. Additionally, tufts of relatively stiff standard toothbrush monofilaments, or bristles, may be attached to the head of the toothbrush on the same side of the head as the fibers. Like the semi-permeable fibers, the bristles are attached to the head of the brush and extend outwardly from the head. The tufts of bristles and tufts of fibers may be arranged on the head of the toothbrush in various patterns in order to efficaciously cleanse the teeth and gums and to evenly and completely apply controlled amounts of active agents to the teeth and gums.
  • each fiber may have a relatively stiff monofilament coaxially positioned within the fiber's lumen.
  • the monofilament has a diameter smaller than the inner diameter of the lumen of the fiber. Consequently, a passageway for the medium exists through the lumen of the fiber around the monofilament that is positioned within the lumen.
  • the ends of the hollow semi-permeable fibers may be left open, or sealed shut, depending on the particular application.
  • Figure 1 is a perspective view of the novel toothbrush of the present invention
  • Figure 2 is a cross-sectional view of the head of the novel toothbrush of the present invention as seen along the line 2-2 in Figure 1;
  • Figure 3 is a perspective view of an alternate embodiment of the novel toothbrush of the present invention, which incorporates a medium-containing reservoir;
  • Figure 4 is a cross-sectional diagram of the alternate embodiment of the novel toothbrush of the present invention as seen along the line 4-4 in Figure 3;
  • Figure 5 is a top plan view of the head of the novel toothbrush of the present invention, showing an alternate arrangement of the tufts on the head of the toothbrush;
  • Figure 6 is a top plan view of the head of the novel toothbrush of the present invention, showing another alternate tuft arrangement
  • Figure 7 is a side cross-sectional view showing only a single hollow fiber of the novel toothbrush of the present invention which has a strengthening monofilament disposed therein, as seen from the same view as Figure 2, with portions cut away for clarity.
  • a toothbrush generally designated 10 which has an elongated handle 12.
  • handle 12 is formed with a shank portion 14 and a head portion 16.
  • handle 12 is made of any lightweight material, such as plastic, which is suitable for daily dental care use.
  • Typical handle materials are polyproylene and cellulose acetate propanoate.
  • a large number of bristles 18 and semi-permeable hollow fibers 20 are attached to head portion 16.
  • the bristles 18 are grouped into tufts 22 which extend outwardly from one side of head 16.
  • the bristles 18 are standard dental monofilaments, i.e.. solid lengths of filament, which are preferably made of nylon.
  • the semi- permeable fibers 20 are composed of porous membranes that are familiarly known in the art as ultrafiltration membranes and reverse-osmosis membranes.
  • porous membranes that are familiarly known in the art as ultrafiltration membranes and reverse-osmosis membranes.
  • examples of such membranes include the ultrafiltration membrane marketed under the name Nadir 1 " by Hoechst AG, as well as the reverse-osmosis membranes which are used in the permeator devices marketed by E. I. du Pont de Nemours & Co. under the name Permasep®.
  • such membranes are porous to relatively small (i.e., molecular-sized) agents which are contained in a medium 24 that can be disposed in the respective lumina 26 of the semi-permeable fibers 20, shown in Figure 2. More particularly, as shown in Figure 2, the lumen 26 of each hollow fiber 20 may be filled with the diffusible medium 24.
  • Medium 24 is a solution, paste, gel, slurry or powder that contains certain agents which it may be desirable to apply onto the teeth and gums during the brushing process.
  • the particular pore size of the porous membrane or membranes used for the semi-permeable hollow fibers 20 is selected to permit efficacious diffusion of various dental agents which can be contained in medium 24. More specifically, the molecules of each dental agent contained in medium 24 have particular molecular sizes, or weights. The molecular weights of the various dental agents typically vary from agent to agent. Consequently, predetermined rates of diffusion through the wall of the semi-permeable fibers 20 for the variously-sized molecules of the various dental agents can be established by forming the hollow fibers 20 from a membrane material which has an appropriate pore size. This porous material may even have pores of various size to establish predetermined diffusion rates for more than one agent. Moreover, the rates of diffusion of the various agents through semi- permeable fibers 20 which are hollow can also be established by appropriately sizing the diameters of the respective lumina 26 of the hollow fibers 20.
  • the rates of diffusion of the dental agents through semi-permeable fibers 20 can be established by selecting an appropriate gel, slurry, powder, solution, or paste carrier material for medium
  • a less viscous medium 24 will establish a relatively greater diffusion rate through the fibers 20 for the various dental agents that are included in medium 24. Consequently, a predetermined diffusion rate through the fibers 20 can be established for each of a number of dental agents that may be included in medium
  • Figure 2 also shows that a single tuft 22 is held in a cavity 28 which is formed on head 16 by a retaining wire 29. More specifically, each of the bristles 18 is looped around wire 29, the bristles 18 being successively nested inside each other. Wire 29, in turn, is fixedly attached to head 16 within cavity 28, so that wire 29 . retains the bristles 18 within cavity 28. Likewise, fiber 20 is also looped around wire 29 and is nested within the bristles 18. Therefore, fiber 20 is also retained within cavity 28 by wire 29.
  • each fiber 20 can be retained by a wire 29 in a respective cavity 28 of head 16
  • other methods of retaining the individual fibers 20 on head 16 may be used.
  • a plurality of hollow fibers 30 are shown which extend through a handle 32 into a reservoir 34. Reservoir 34 is used to hold medium 24 prior to use of toothbrush 100.
  • each of the hollow semi-permeable fibers 30 extends through a respective passageway 36a, 36b that is formed in head 38 of toothbrush 100. Fibers 30a, 30b extend through head 38 into reservoir 34, as shown.
  • Fibers " 30a, 30b are fixedly attached to head 38 within respective passageways 36a, 36b, e.g., by bonding fibers 30a, 30b to respective passageways 36a, 36b.
  • a number of bristles 40 are grouped into tufts 42. Each tuft 42 is retained in an associated cavity 44 of head 38 by a retaining wire 46.
  • the medium 24 which is contained in reservoir 34 enters fibers 30a, b for diffusion through the fibers 30a, b onto the teeth and gums. More specifically, using fiber 30a as an example, medium 24 enters fiber 30a through open end 48 of fiber 30a as indicated by arrow 50. Additionally, medium 24 diffuses into fiber 30a through the sides of fiber 30a, as indicated by the arrow 52.
  • a plunger 56 that has substantially the same cross-sectional shape as the reservoir 34 is disposed in reservoir 34. More particularly, plunger 56 may be urged into reservoir 34. in the direction of arrow 50 by appropriately urging against an extension 58 of a stem 60, which is attached to plunger 56.
  • extension 58 of stem 60 protrudes from a slot 62 which is formed in one side of handle 32.
  • medium 24 is in turn urged through the fiber 30a.
  • Arrows 64 indicate that the agents contained in medium 24 then diffuse out of fiber 30a near closed end 66 of fiber 30a and onto and among bristles 40, for application of the agents onto the surface (e.g., teeth and gums) being brushed by toothbrush 100.
  • end 66 of fiber 30a could be open (not shown) , in which case the agents contained in medium 24 would pass substantially through fiber 30a and out the end 66.
  • Figures 5 and 6 show other embodiments of toothbrush 10 which use various arrangement patterns of the bristles and fibers of toothbrush 10. More particularly, Figure 5 shows that a plurality of individual hollow fibers 68 can be attached to a head 70 of a toothbrush, generally designated 200, and may be interspersed among tufts 72.
  • the tufts 72 shown in Figure 5 are groups of monofilament bristles 74.
  • a head 76 of yet another embodiment of a toothbrush is shown to have a plurality of tuft rows, each tuft row in turn including a plurality of individual tufts.
  • tuft row 78 has a plurality of tufts 80, each of the tufts 80 in turn being a group of semi-permeable fibers 82.
  • tuft row 84 has a plurality of tufts 86, each of the tufts 86 in turn being a group of monofilament bristles 88.
  • the tufts 80 and 86 may each be a combination of monofilament bristles and hollow fibers.
  • medium 24 can contain agents to prevent or inhibit tooth and/or gum pain and inflammation (e.g., (steroidal and nonsteroidal anti-inflammatories (such as aspirin, naproxen, meclofenamate, indomethacin, sulindac, flurbiprofen, ibuprofen, fenoprofen, phenylbutazone, hydrocortisone) ) .
  • agents to prevent or inhibit tooth and/or gum pain and inflammation e.g., (steroidal and nonsteroidal anti-inflammatories (such as aspirin, naproxen, meclofenamate, indomethacin, sulindac, flurbiprofen, ibuprofen, fenoprofen, phenylbutazone, hydrocortisone) ) .
  • steroidal and nonsteroidal anti-inflammatories such as aspirin, naproxen, meclofenamate, indomethacin, sulinda
  • medium 24 can include agents to prevent or inhibit tooth and/or gum sensitivity (such as formaldehyde, sodium fluoride, dibasic sodium citrate, silver nitrate, potassium nitrate, calcium hydroxide, strontium chloride, stannous fluoride, strontium acetate, and potassium oxalate) .
  • Medium 24 can also include topically effective anesthetics (such as benzocaine, chlorobutanol, lidocaine, butacaine, tetracaine, cocaine, etidocaine, and dyclonine) .
  • medium 24 can contain tooth-whitening agents with or without effervescent activity (e.g., urea peroxide, bleaching agents (such as protease, lysozyme, and catalase) , as well as denture-cleaning agents (such as sodium perborate and sodium persulfate) ) .
  • tooth-whitening agents with or without effervescent activity e.g., urea peroxide, bleaching agents (such as protease, lysozyme, and catalase) , as well as denture-cleaning agents (such as sodium perborate and sodium persulfate)
  • effervescent activity e.g., urea peroxide, bleaching agents (such as protease, lysozyme, and catalase)
  • denture-cleaning agents such as sodium perborate and sodium persulfate
  • Medium 24 can also include agents to prevent or inhibit plaque, gingivitis, and periodontitis (e.g., essential oils (such as eugenol, thymol, eucalyptol, and menthol) , heavy metal salts (such as zinc chloride and magnesium chloride) , sanguinarine, hexetidine, quaternary ammonium compounds (such as cetyl pyridinium chloride and domiphen bromide) , boric acid, benzoic acid, phenolic compounds (such as phenol, resorcinol, triclosan, and cresols) , delmopinol, and bisbiguanides (such as chlorhexidine, alexidine, and octihexidine) ) .
  • essential oils such as eugenol, thymol, eucalyptol, and menthol
  • heavy metal salts such as zinc chloride and magnesium chloride
  • sanguinarine hexetidine
  • medium 24 can also contain oral antiseptic agents (such as chloramine-1, chloroazodin, sodium hypochlorite, calcium hydroxide, hydrogen peroxide, sec-amyltricresol, parachlorophenol, creosote, eugenol, formocresol and zinc oxide-eugenol) .
  • oral antiseptic agents such as chloramine-1, chloroazodin, sodium hypochlorite, calcium hydroxide, hydrogen peroxide, sec-amyltricresol, parachlorophenol, creosote, eugenol, formocresol and zinc oxide-eugenol
  • medium 24 can contain agents to prevent or inhibit mouth malodor or halitosis (such as chlorophyll, mints, copper salts, and zinc salts) , as well as flavors for nondentifrice users with or without effervescent and foaming activity (e.g., natural and artificial flavors (such as peppermint, spearmint, cinnamon, wintergreen, anethole) and artificial sweeteners (such as xylitol, saccharin, Aspartame, and Acesulfame-K) ) .
  • mouth malodor or halitosis such as chlorophyll, mints, copper salts, and zinc salts
  • flavors for nondentifrice users with or without effervescent and foaming activity e.g., natural and artificial flavors (such as peppermint, spearmint, cinnamon, wintergreen, anethole) and artificial sweeteners (such as xylitol, saccharin, Aspartame, and Acesulfame-K) )
  • Medium 24 can also include plaque and tartar disclosants (such as FD&C Red #3, FD&C Green #3, Bismark Brown, and fluorescein sodium) , immunomodulators (such as penicillamine and levamisole) , bone- and tissue-growth promoters, and wound-healing promoters (such as tissue growth factor beta, interleukin-1, interleukin-6, and alpha-macro- globulin) . Further, medium 24 can include remineralization agents (such as calcium phosphate and calcium fluoride) , and agents to prevent or inhibit calculus formation (such as sodium pyrophosphate and calcium pyrophosphate) .
  • plaque and tartar disclosants such as FD&C Red #3, FD&C Green #3, Bismark Brown, and fluorescein sodium
  • immunomodulators such as penicillamine and levamisole
  • bone- and tissue-growth promoters such as tissue growth factor beta, interleukin-1, interleukin-6, and alpha-
  • medium 24 can contain antifungal agents (such as tolnaftate, clotrimazole, griseofluvin, ketoconazole, ecoconazole, and miconazole) , antiviral agents (such as acyclovir, amantadine, - and tromantadine hydrochloride) , and antibiotics (such as penicillin, tetracycline, cephalosporin, streptomycin, and erythromycin) .
  • medium 24 can contain an indicator agent which changes color to indicate when one or more of the agents disclosed above have been spent (such as natural or synthetic dyes and phenolphthalein) .
  • medium 24 can also contain non-nutritive sweetening agents (such as xylitol, saccharin, Aspartame and Acesulfame-K) ; glycerin related compounds (such as glycerin, propylene glycol, polyethylene glycol, polysorbates) ; synthetic detergents (such as docusate sodium, sodium lauryl sulfate, sodium lauryl sarcosinate and poloxamers) .
  • non-nutritive sweetening agents such as xylitol, saccharin, Aspartame and Acesulfame-K
  • glycerin related compounds such as glycerin, propylene glycol, polyethylene glycol, polysorbates
  • synthetic detergents such as docusate sodium, sodium lauryl sulfate, sodium lauryl sarcosinate and poloxamers
  • FIG. 7 shows an alternate embodiment of the toothbrush of the present invention, generally designated 400, wherein a hollow semi-permeable fiber 90 is reinforced with a monofilament 92. More particularly, monofilament 92 is coaxially disposed within fiber 90 on head 94 of brush 400 and extends through fiber 90 substantially in the center of lumen 96 of fiber 90. As shown in Figure 7, monofilament 92 does not completely fill lumen 96. Instead, an annular region 98, in which medium 24 can be disposed, is established within lumen 96. Both monofilament 92 and fiber 90 are retained in head 94 by retaining wire 102.
  • toothbrush 10 is positioned adjacent the teeth and gums (not shown) to be brushed. Then, toothbrush 10 is drawn across the teeth and gums to brush the teeth and gums. As toothbrush 10 is moistened during the brushing process, the agents that are contained in medium 24 begin to diffuse through fibers 20 and onto the teeth and gums which are being brushed. As the agents diffuse through fibers 20, they are applied directly onto the teeth and gums by the brushing action described above.
  • the rate at which each of the various agents diffuse out of fibers 20 may vary agent-to-agent. These various rates of diffusion are established by appropriately establishing medium 24 viscosity, fiber 20 pore size (or sizes) , and lumen 26 diameter.
  • plunger 56 is urged into reservoir 34 in the direction of arrow 50 by appropriately urging against extension 58 of stem 60. Consequently, medium 24 is urged through the lumen 54 of fiber 30a.
  • medium 24 passes through fiber 30a and the agents which are contained in medium 24 diffuse out of fiber 30a near closed end 62 of fiber 30a as indicated by arrows 64.
  • the agents contained in medium 24 are then applied directly onto the teeth and gums being brushed by toothbrush 100.
  • end 66 of fiber 30a may be open to permit the passage of the agents contained in medium 24 through end 66.

Abstract

Brosse à dents (10) comportant une poignée (12) et une tête (16) formée sur la poignée (12). Une pluralité de fibres (82) creuses semi-perméables sont groupées sur la tête (16) en touffes faisant saillie vers l'extérieur (86). Un milieu diffusible (24) contenant des agents dentaires appropriés est maintenu dans le lumen (96) de chaque fibre (82). De plus, un réservoir (34) peut être formé dans la poignée (32) de la brosse à dents (10) pour contenir le milieu (24) et pour laisser passer le milieu (24) du réservoir (34) jusqu'au lumen (54) de chaque fibre (68). Quand les fibres creuses (82) sont mouillées durant le processus de brossage, les agents sont diffusés à travers les parois des fibres (82) creuses semi-perméables jusque sur les dents et les gencives. En outre, des poils de monofilaments de brosse à dents standard (74) peuvent aussi être groupés sur la tête (76) de la brosse à dents (10) en touffes (72) qui sont entremêlées avec les touffes (86) de fibres creuses (82). Les touffes (86) de fibres creuses (82) et les touffes (72) de poils (74) peuvent être disposées en diverses configuration sur la tête (70) de la brosse à dents (10) pour nettoyer efficacement les dents et les gencives et pour appliquer directement les agents dentaires sur les dents et sur les gencives.
PCT/US1991/007432 1990-10-31 1991-10-08 Brosse a dents comportant des fibres creuses semi-permeables WO1992007487A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60637090A 1990-10-31 1990-10-31
US606,370 1990-10-31

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WO1992007487A1 true WO1992007487A1 (fr) 1992-05-14

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AU (1) AU9036591A (fr)
EC (1) ECSP910782A (fr)
IE (1) IE913798A1 (fr)
MX (1) MX9101847A (fr)
WO (1) WO1992007487A1 (fr)
ZA (1) ZA918642B (fr)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2280361A (en) * 1993-08-25 1995-02-01 Fortune Dragon Pte Limited Toothbrush
GB2289212A (en) * 1994-05-05 1995-11-15 David Grundy Reservoir toothbrush
GB2290702A (en) * 1994-06-22 1996-01-10 Ian Wooldridge Reservoir toothbrush
US7886397B2 (en) * 2003-03-03 2011-02-15 L'oreal S.A. Applicator and application device including the applicator
WO2012148423A1 (fr) * 2011-04-29 2012-11-01 Colgate-Palmolive Company Accessoire de soin oral comportant un indicateur visuel d'épuisement d'un fluide

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2163766A1 (fr) * 1993-05-25 1994-12-08 Benjamin John Gilmer Mecanisme de distribution

Citations (4)

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Publication number Priority date Publication date Assignee Title
DE451728C (de) * 1927-11-03 Cornelius Gordijn Jr Buerste mit einem mit Hohlraeumen zur Aufnahme eines Antiseptikums versehenen Buerstenkoerper
EP0168741A1 (fr) * 1984-07-16 1986-01-22 Henkel Kommanditgesellschaft auf Aktien Appareil pour traitement des cheveux
WO1987007484A1 (fr) * 1986-06-04 1987-12-17 Heinrich Schaiper Brosse a dents
GB2210778A (en) * 1987-10-15 1989-06-21 Sangi Kk Toothbrushes

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE451728C (de) * 1927-11-03 Cornelius Gordijn Jr Buerste mit einem mit Hohlraeumen zur Aufnahme eines Antiseptikums versehenen Buerstenkoerper
EP0168741A1 (fr) * 1984-07-16 1986-01-22 Henkel Kommanditgesellschaft auf Aktien Appareil pour traitement des cheveux
WO1987007484A1 (fr) * 1986-06-04 1987-12-17 Heinrich Schaiper Brosse a dents
GB2210778A (en) * 1987-10-15 1989-06-21 Sangi Kk Toothbrushes

Cited By (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2280361A (en) * 1993-08-25 1995-02-01 Fortune Dragon Pte Limited Toothbrush
GB2280361B (en) * 1993-08-25 1995-07-05 Fortune Dragon Pte Limited Toothbrush
US5464294A (en) * 1993-08-25 1995-11-07 Fortune Dragon Pte Ltd Folding toothbrush
GB2289212A (en) * 1994-05-05 1995-11-15 David Grundy Reservoir toothbrush
GB2290702A (en) * 1994-06-22 1996-01-10 Ian Wooldridge Reservoir toothbrush
US7886397B2 (en) * 2003-03-03 2011-02-15 L'oreal S.A. Applicator and application device including the applicator
WO2012148423A1 (fr) * 2011-04-29 2012-11-01 Colgate-Palmolive Company Accessoire de soin oral comportant un indicateur visuel d'épuisement d'un fluide
CN103491825A (zh) * 2011-04-29 2014-01-01 高露洁-棕榄公司 具有流体耗尽的视觉指示器的口腔护理器具
US20140026811A1 (en) * 2011-04-29 2014-01-30 Colgate-Palmolive Company Oral care implement having visual indicator of depletion of a fluid
AU2011366903B2 (en) * 2011-04-29 2015-01-22 Colgate-Palmolive Company Oral care implement having visual indicator of depletion of a fluid
KR20150036803A (ko) * 2011-04-29 2015-04-07 콜게이트-파아므올리브캄파니 유체의 고갈의 시각적 인디케이터를 갖는 구강 관리 기구
EP2896317A1 (fr) * 2011-04-29 2015-07-22 Colgate-Palmolive Company Accessoire de soin oral comportant un indicateur visuel d'épuisement d'un fluide
KR101558071B1 (ko) * 2011-04-29 2015-10-06 콜게이트-파아므올리브캄파니 유체의 고갈의 시각적 인디케이터를 갖는 구강 관리 기구
RU2570774C2 (ru) * 2011-04-29 2015-12-10 Колгейт-Палмолив Компани Устройство для ухода за полостью рта с визуальным индикатором расходования текучей среды
CN105394923A (zh) * 2011-04-29 2016-03-16 高露洁-棕榄公司 具有流体耗尽的视觉指示器的口腔护理器具
KR101653513B1 (ko) * 2011-04-29 2016-09-01 콜게이트-파아므올리브캄파니 유체의 고갈의 시각적 인디케이터를 갖는 구강 관리 기구
US9510668B2 (en) 2011-04-29 2016-12-06 Colgate-Palmolive Company Oral care implement having visual indicator of depletion of a fluid
TWI565438B (zh) * 2011-04-29 2017-01-11 美國棕欖公司 口腔保健用具、配送器及提供具有毛細材料形成的輸送構件之口腔保健用具的貯器內所含的口腔保健流體耗竭的視覺指示方法
CN105394923B (zh) * 2011-04-29 2017-08-08 高露洁-棕榄公司 具有流体耗尽的视觉指示器的口腔护理器具
US10076182B2 (en) 2011-04-29 2018-09-18 Colgate-Palmolive Company Method of providing a visual indication of depletion of a fluid

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IE913798A1 (en) 1992-05-22
ZA918642B (en) 1992-08-26
AU9036591A (en) 1992-05-26
MX9101847A (es) 1992-06-05
ECSP910782A (es) 1992-06-03

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