WO1992001498A3 - Procede et dispositif d'analyse par precipitation en phase solide - Google Patents

Procede et dispositif d'analyse par precipitation en phase solide Download PDF

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Publication number
WO1992001498A3
WO1992001498A3 PCT/US1991/005004 US9105004W WO9201498A3 WO 1992001498 A3 WO1992001498 A3 WO 1992001498A3 US 9105004 W US9105004 W US 9105004W WO 9201498 A3 WO9201498 A3 WO 9201498A3
Authority
WO
WIPO (PCT)
Prior art keywords
fluid sample
hdl
matrix
vldl
ldl
Prior art date
Application number
PCT/US1991/005004
Other languages
English (en)
Other versions
WO1992001498A2 (fr
Inventor
Ronald M Jones
Original Assignee
Cholestech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/554,147 external-priority patent/US5213965A/en
Application filed by Cholestech Corp filed Critical Cholestech Corp
Priority to CA002087255A priority Critical patent/CA2087255C/fr
Priority to AT91913726T priority patent/ATE198796T1/de
Priority to DE69132513T priority patent/DE69132513T2/de
Priority to KR1019930700111A priority patent/KR930701750A/ko
Priority to DE9117297U priority patent/DE9117297U1/de
Priority to AU82986/91A priority patent/AU656733B2/en
Priority to EP91913726A priority patent/EP0539495B1/fr
Priority to JP3513080A priority patent/JP2981774B2/ja
Publication of WO1992001498A2 publication Critical patent/WO1992001498A2/fr
Publication of WO1992001498A3 publication Critical patent/WO1992001498A3/fr

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/92—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving lipids, e.g. cholesterol, lipoproteins, or their receptors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D39/00—Filtering material for liquid or gaseous fluids
    • B01D39/14—Other self-supporting filtering material ; Other filtering material
    • B01D39/20—Other self-supporting filtering material ; Other filtering material of inorganic material, e.g. asbestos paper, metallic filtering material of non-woven wires
    • B01D39/2003—Glass or glassy material
    • B01D39/2017—Glass or glassy material the material being filamentary or fibrous
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/60—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving cholesterol
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G01N33/525—Multi-layer analytical elements
    • G01N33/526—Multi-layer analytical elements the element being adapted for a specific analyte
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/04—Additives and treatments of the filtering material
    • B01D2239/0414—Surface modifiers, e.g. comprising ion exchange groups
    • B01D2239/0421—Rendering the filter material hydrophilic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2239/00—Aspects relating to filtering material for liquid or gaseous fluids
    • B01D2239/04—Additives and treatments of the filtering material
    • B01D2239/0471—Surface coating material
    • B01D2239/0492—Surface coating material on fibres
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2326/00—Chromogens for determinations of oxidoreductase enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2326/00—Chromogens for determinations of oxidoreductase enzymes
    • C12Q2326/90—Developer
    • C12Q2326/96—4-Amino-antipyrine
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/04—Endocrine or metabolic disorders
    • G01N2800/044—Hyperlipemia or hypolipemia, e.g. dyslipidaemia, obesity
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/10—Composition for standardization, calibration, simulation, stabilization, preparation or preservation; processes of use in preparation for chemical testing
    • Y10T436/104165—Lipid, cholesterol, or triglyceride standard or control

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Biophysics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Geology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Dispositif d'analyse (14) permettant de mesurer la concentration d'un analyte soluble, tel que le cholestérol associé à HDL, dans un échantillon fluide contenant des composés d'interférence tels que le cholestérol associé à LDL ou le cholestérol associé à VLDL, qui peuvent être précipités sélectivement. Le dispositif comprend une matrice de criblage (26) pouvant séparer le matériau soluble et précipité passant au travers de la matrice, et un réservoir (34) qui contient un agent de précipitation lequel est efficace, dans une plage de concentration donnée, pour précipiter sélectivement les composés d'interférence. Le réservoir est conçu pour retarder la libération de l'agent, lors du contact avec l'échantillon fluide, pour maintenir la concentration de l'agent de précipitation en contact avec l'échantillon fluide dans la plage de concentration donnée. Le dispositif comporte en outre un tampon d'analyse (64, 66, 68, 70) par lequel l'analyte soluble présent dans l'échantillon fluide peut être analysé. Un procédé de séparation de lipoprotéines très denses (HDL) de lipoprotéines de faible et de très faible densités (LDL et VLDL) utilise une matrice en fibres de verre revêtues qui inhibe la liaison de HDL comme un échantillon fluide de sang contenant HDL et LDL et VLDL précipités passent au travers de la matrice.
PCT/US1991/005004 1990-07-16 1991-07-15 Procede et dispositif d'analyse par precipitation en phase solide WO1992001498A2 (fr)

Priority Applications (8)

Application Number Priority Date Filing Date Title
CA002087255A CA2087255C (fr) 1990-07-16 1991-07-15 Appareil et methode d'essai de precipitation en phase solide
AT91913726T ATE198796T1 (de) 1990-07-16 1991-07-15 Vorrichtung und verfahren zur festphase- präzipitationsbestimmung von hdl-cholesterin
DE69132513T DE69132513T2 (de) 1990-07-16 1991-07-15 Vorrichtung und verfahren zur festphase-präzipitationsbestimmung von hdl-cholesterin
KR1019930700111A KR930701750A (ko) 1990-07-16 1991-07-15 고상 침전검정장치와 그 방법
DE9117297U DE9117297U1 (de) 1990-07-16 1991-07-15 Vorrichtung zur Festphasen-Präzipdation
AU82986/91A AU656733B2 (en) 1990-07-16 1991-07-15 Solid-phase precipitation assay device and method
EP91913726A EP0539495B1 (fr) 1990-07-16 1991-07-15 Procede et dispositif d'analyse de hdl-cholesterol par precipitation en phase solide
JP3513080A JP2981774B2 (ja) 1990-07-16 1991-07-15 固相沈澱アッセイ装置および方法

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US554,147 1990-07-16
US07/554,147 US5213965A (en) 1990-07-16 1990-07-16 Solid-phase precipitation assay device
US729,447 1991-07-12
US07/729,447 US5213964A (en) 1990-07-16 1991-07-12 High-density lipoprotein solid-base precipitation assay method

Publications (2)

Publication Number Publication Date
WO1992001498A2 WO1992001498A2 (fr) 1992-02-06
WO1992001498A3 true WO1992001498A3 (fr) 1992-03-05

Family

ID=27070513

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/005004 WO1992001498A2 (fr) 1990-07-16 1991-07-15 Procede et dispositif d'analyse par precipitation en phase solide

Country Status (9)

Country Link
US (3) US5213964A (fr)
EP (2) EP1028319A3 (fr)
JP (1) JP2981774B2 (fr)
AT (1) ATE198796T1 (fr)
AU (1) AU656733B2 (fr)
CA (1) CA2087255C (fr)
DE (2) DE69132513T2 (fr)
ES (1) ES2155057T3 (fr)
WO (1) WO1992001498A2 (fr)

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USRE39915E1 (en) 1989-09-01 2007-11-06 Roche Diagnostics Gmbh Method for the determination of HDL cholesterol by means of a rapid diagnostic agent with an integrated fractionating step
DE3929032C2 (de) * 1989-09-01 1998-09-03 Boehringer Mannheim Gmbh Verfahren zur Bestimmung von HDL-Cholesterin mittels eines Schnelldiagnostikums mit integriertem Fraktionierschritt
US5213964A (en) * 1990-07-16 1993-05-25 Cholestech Corporation High-density lipoprotein solid-base precipitation assay method
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JP2600065B2 (ja) * 1994-03-08 1997-04-16 協和メデックス株式会社 高密度リポ蛋白中のコレステロールの定量法
JP2653755B2 (ja) * 1994-03-08 1997-09-17 協和メデックス株式会社 高密度リポ蛋白中のコレステロールの定量法
JP3256241B2 (ja) * 1995-03-16 2002-02-12 協和メデックス株式会社 低密度リポ蛋白中のコレステロールの定量法
US5981294A (en) * 1995-11-29 1999-11-09 Metrika, Inc. Device for blood separation in a diagnostic device
US5968839A (en) * 1996-05-13 1999-10-19 Metrika, Inc. Method and device producing a predetermined distribution of detectable change in assays
US5945345A (en) * 1996-08-27 1999-08-31 Metrika, Inc. Device for preventing assay interference using silver or lead to remove the interferant
US20020182749A1 (en) * 1999-05-11 2002-12-05 Aclara Biosciences, Inc. Sample evaporative control
DE19962577A1 (de) * 1999-12-23 2001-07-12 Tittgen Biotechnologie Dr Chromatographiematerial und Verfahren unter Verwendung desselben
AU2002241602A1 (en) * 2000-11-16 2002-06-11 Burstein Technologies, Inc. Methods and apparatus for detecting and quantifying lymphocytes with optical biodiscs
US20030143637A1 (en) * 2001-08-31 2003-07-31 Selvan Gowri Pyapali Capture layer assemblies for cellular assays including related optical analysis discs and methods
JP2005502872A (ja) * 2001-09-07 2005-01-27 バースタイン テクノロジーズ，インコーポレイティド 光バイオディスクシステムを使用した、核の形態に基づく白血球の型の識別および定量
AU2002352735A1 (en) * 2001-11-20 2003-06-10 Burstein Technologies, Inc. Optical bio-discs and microfluidic devices for analysis of cells
US7087397B2 (en) * 2001-12-21 2006-08-08 Polymer Technology Systems, Inc, Method for determining HDL concentration from whole blood or plasma
ATE386266T1 (de) * 2001-12-28 2008-03-15 Polymer Technology Systems Inc Teststreifen zur bestimmung von triglyceridkonzentrationen
DE10204606C1 (de) * 2002-01-18 2003-10-16 Cholestech Corp Vorrichtung und Verfahren für Lipoproteine hoher Dichte
DE60207196T2 (de) * 2002-04-09 2006-07-20 Cholestech Corp., Hayward Verfahren und Vorrichtung zur Quantifizierung von Lipoprotein-Cholesterol hoher Dichte
US7682688B2 (en) * 2002-11-26 2010-03-23 University Of Utah Research Foundation Microporous materials, methods, and articles for localizing and quantifying analytes
US7597936B2 (en) * 2002-11-26 2009-10-06 University Of Utah Research Foundation Method of producing a pigmented composite microporous material
TWI333545B (en) * 2003-04-02 2010-11-21 Cholestech Corp Adhered membranes retaining porosity and biological activity
US20050074828A1 (en) * 2003-07-16 2005-04-07 Dimagno Theodore John Uae of lipase for high-density lipoprotein cholesterol detection
DE60319541T2 (de) * 2003-11-04 2009-05-07 Cholestech Corp., Hayward Reagenz-Membrane und -Laminate und Verfahren zur deren Herstellung
US7772007B2 (en) 2004-04-02 2010-08-10 Cholestech Corporation Assay device for direct measurement of LDL cholesterol
US7749775B2 (en) * 2006-10-03 2010-07-06 Jonathan Scott Maher Immunoassay test device and method of use
US7492312B2 (en) * 2006-11-14 2009-02-17 Fam Adly T Multiplicative mismatched filters for optimum range sidelobe suppression in barker code reception
DE602008002825D1 (de) * 2007-01-09 2010-11-11 Cholestech Corp Vorrichtung und verfahren zur messung des ldl-assoziierten cholesterols
WO2009037784A1 (fr) * 2007-09-21 2009-03-26 Tya K. K. Instrument analytique pour composant de fluide corporel
ES2622834T3 (es) 2007-11-13 2017-07-07 Bio-Technology General (Israel) Ltd. Procedimiento de esterilización por filtración en estado diluido para biopolímeros viscoelásticos
JP5313537B2 (ja) * 2008-04-10 2013-10-09 富士フイルム株式会社 高密度リポ蛋白コレステロール測定用乾式分析素子
US8460539B2 (en) * 2008-06-13 2013-06-11 Polymer Technology Systems, Inc. Hybrid strip
US9395373B2 (en) 2008-06-13 2016-07-19 Polymer Technology Systems, Inc. Hybrid strip
EP2387714B1 (fr) 2009-01-23 2018-03-14 Polymer Technology Systems, Inc. Bandelette réactive multicouche de diagnostic en phase sèche avec biocapteurs intégrés
US9562256B2 (en) * 2010-10-23 2017-02-07 Pop Test LLC Devices and formulations for detecting, screening and monitoring levels of certain constituents in bodily fluids and method
WO2019175962A1 (fr) * 2018-03-13 2019-09-19 デンカ生研株式会社 Procédé d'aide à la détermination du risque de maladie cardiovasculaire ou similaire

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US4215993A (en) * 1978-12-04 1980-08-05 Data Medical Associates, Inc. Precipitating reagent and method for isolation and determination of high density lipoproteins in human serum
EP0146654A2 (fr) * 1980-06-20 1985-07-03 Unilever Plc Procédé et dispositif pour la réalisation d'essais à liaison spécifique
WO1989005458A1 (fr) * 1987-12-03 1989-06-15 Oxford Virology Limited Procede servant a estimer les concentrations de cholesterol dans le sang
EP0353570A2 (fr) * 1988-07-30 1990-02-07 Roche Diagnostics GmbH Matrice de support imprégnée de réactifs pouvant être libérés
WO1990010869A1 (fr) * 1989-03-08 1990-09-20 Cholestech Corporation Dispositif et appareil de controle d'analytes
EP0415298A2 (fr) * 1989-09-01 1991-03-06 Roche Diagnostics GmbH Procédé pour la détermination d'HDL-cholestérine utilisant un élément analytique avec fractionnement intégré

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US5213964A (en) * 1990-07-16 1993-05-25 Cholestech Corporation High-density lipoprotein solid-base precipitation assay method

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Publication number Priority date Publication date Assignee Title
US3797494A (en) * 1969-04-01 1974-03-19 Alza Corp Bandage for the administration of drug by controlled metering through microporous materials
US4215993A (en) * 1978-12-04 1980-08-05 Data Medical Associates, Inc. Precipitating reagent and method for isolation and determination of high density lipoproteins in human serum
EP0146654A2 (fr) * 1980-06-20 1985-07-03 Unilever Plc Procédé et dispositif pour la réalisation d'essais à liaison spécifique
WO1989005458A1 (fr) * 1987-12-03 1989-06-15 Oxford Virology Limited Procede servant a estimer les concentrations de cholesterol dans le sang
EP0353570A2 (fr) * 1988-07-30 1990-02-07 Roche Diagnostics GmbH Matrice de support imprégnée de réactifs pouvant être libérés
WO1990010869A1 (fr) * 1989-03-08 1990-09-20 Cholestech Corporation Dispositif et appareil de controle d'analytes
EP0415298A2 (fr) * 1989-09-01 1991-03-06 Roche Diagnostics GmbH Procédé pour la détermination d'HDL-cholestérine utilisant un élément analytique avec fractionnement intégré

Also Published As

Publication number Publication date
ATE198796T1 (de) 2001-02-15
CA2087255A1 (fr) 1992-01-17
DE9117297U1 (de) 2000-08-03
DE69132513T2 (de) 2001-08-23
DE69132513D1 (de) 2001-02-22
JPH06502911A (ja) 1994-03-31
EP0539495B1 (fr) 2001-01-17
WO1992001498A2 (fr) 1992-02-06
AU8298691A (en) 1992-02-18
ES2155057T3 (es) 2001-05-01
EP0539495A1 (fr) 1993-05-05
CA2087255C (fr) 1999-08-31
AU656733B2 (en) 1995-02-16
US5451370A (en) 1995-09-19
EP1028319A3 (fr) 2004-01-21
EP1028319A2 (fr) 2000-08-16
US5316916A (en) 1994-05-31
JP2981774B2 (ja) 1999-11-22
US5213964A (en) 1993-05-25

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