WO1992000720A1 - Agent et procede pour stimuler la croissance et la regeneration des cheveux et des ongles - Google Patents

Agent et procede pour stimuler la croissance et la regeneration des cheveux et des ongles Download PDF

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Publication number
WO1992000720A1
WO1992000720A1 PCT/EP1991/001297 EP9101297W WO9200720A1 WO 1992000720 A1 WO1992000720 A1 WO 1992000720A1 EP 9101297 W EP9101297 W EP 9101297W WO 9200720 A1 WO9200720 A1 WO 9200720A1
Authority
WO
WIPO (PCT)
Prior art keywords
hair
composition according
leucine
valine
amino acid
Prior art date
Application number
PCT/EP1991/001297
Other languages
German (de)
English (en)
Inventor
Martin Schmidt-Achert
Original Assignee
Schmidt Achert Martin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schmidt Achert Martin filed Critical Schmidt Achert Martin
Publication of WO1992000720A1 publication Critical patent/WO1992000720A1/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/17—Amino acids, peptides or proteins
    • A23L33/175—Amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q3/00—Manicure or pedicure preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Definitions

  • the invention relates to an agent and a method for stimulating the growth and regeneration of hair in humans, which can also be used in veterinary medicine for pets or as an active ingredient for the quantitative promotion of hair growth in farm animals.
  • Irreversible alopecia is characterized by the absence or destruction of the hair or the regression of the terminal hair to lanugo hair (balding, for example, due to pressure and tension or, as a rule, with alopezia androgenetica).
  • Both human and animal hair go through a life cycle which comprises three phases, firstly the anagen phase, secondly the catagen phase and thirdly the telogenic phase.
  • the anagen phase represents a period of active hair growth and as far as the scalp hair is concerned, this period lasts 3 to 5 years.
  • the catagen phase is a short transition phase between the anagen and telogen phases, which lasts only 1 to 2 weeks.
  • the subsequent telogenic phase can also be referred to as the resting phase, in which all growth stops and the hair is rejected if necessary. Head hair in the telogenic phase has a very short life of about 3 to 4 months before it is rejected and new hair growth begins.
  • alopecia Another result of alopecia is a large reduction in hair follicles.
  • a person with hair loss has about 306 follicles per qcm, while a person with normal hair growth in the same age group has an average of 460 follicles per qcm. It is therefore assumed that balding is caused by a combination of different factors: regression of the terminal hair to Laugua hair, increasing number of hair in the te ⁇ logical phase, and loss of hair follicles.
  • Other reasons which lead to hair loss include functional disorders of the thyroid gland, the adrenal cortex, the pancreas, metabolic disorders, infections, medications and poisoning.
  • the agents for hair loss that have been commercially available up to now and the agents offered to stimulate hair growth are mostly built up from birch water, panthenol, zinc compounds, etc. Some of them also contain amino acids as active ingredients, such as S-carboxymethylcysteine, but this is very sensitive to oxidation and is easily dehydrated to the amino acid cystine.
  • the invention has for its object to provide a physiological hair restorer that is able to stimulate the growth and regeneration of the hair due to its physicochemical and biochemical properties, so that the quantitative hair growth and the quality of hair formation is improved, without being toxic Stress or danger to the organism arises. At the same time, the hair should be made more resistant to environmental influences and stresses. Finally, a method for stimulating hair growth and regeneration is to be made available.
  • the invention is based on the surprising knowledge of the trophic effect of the branched-chain essential amino acids L-valine, L-isoleucine and L-leucine as active ingredients for a qualitative and quantitative promotion of hair growth in humans.
  • the hair product according to the invention by daily treatment within a period of 12 months, the hair loss is stopped and the hair follicles are regenerated, so that the hair loss is slowed down and the hair growth is stimulated again. This affects "non-sexual" testosterone-independent hair such as scalp hair, eyebrows, eyelashes.
  • an optimal amino acid mixture consisting of L-leucine, L-isoleucine and L-valine is used. It is known that the need for the other branched-chain amino acids increases due to an excess of a single branched-chain amino acid, so that a balanced mixture ratio is sought.
  • the ratio of the amino acids L-valine: L-isoleucine: L-leucine was chosen to be approximately equal to 1: 0.74 to 1.25: 1.86 to 1.875, a ratio in which the keratin build-up was in place and site is optimally stimulated.
  • a ratio of L-valine: L-isoleucine: L-leucine 1: 1.25: 1.875 is particularly favorable. This creates the biochemical precursor for the synthesis of keratin.
  • branched chain amino acids are important for the anabolic insulin effect in the muscle; Filling the protein stores in the muscle postprandially is a function of the uptake of branched chains Amino acids.
  • amino acid mixture consisting of L-leucine, L-isoleucine and L-valine, which is suitable for oral and / or topical administration for the treatment of hair loss, is likely to continue - in addition to the regeneration of the hair follicles - The growth rate of the hair increased and the anagen phase of the hair cycle extended.
  • novel agent according to the invention can be administered orally in the form of tablets, liquids, powders or capsules.
  • the amino acid concentration of one or more or a mixture of the amino acids from the group consisting of L-leucine, L-isoleucine and L-valine is in the range between 0.1 and 25% by weight.
  • the agent according to the invention can also contain the customary auxiliaries, carriers, diluents and additives.
  • Foodstuffs in particular dietary foodstuffs, come into consideration as carriers. Dairy products such as yogurt, buttermilk, curd cheese, etc. are advantageously used as carriers. It is also possible to add the amino acid mixture according to the invention to dietary formulations. Depending on the application, the proportion of the respective amino acid may predominate and is not restricted to the above-mentioned ratio.
  • the hair growth agent administered according to the invention contains, as an active ingredient, one or more or a mixture of highly purified amino acids from the group of branched-chain essential amino acids, consisting of L-leucine, L-isoleucine and L-valine. However, it is also possible to use pa-quality amino acids which have a lower degree of purity.
  • the agent according to the invention can also be formulated as a topical lotion, cream, ointment, conditioning preparation or as a shampoo.
  • the amino acid concentration of one or more or of a mixture of the amino acids according to the invention in these formulations can be in the range between 0.1 and 25% by weight.
  • the shampoos can contain the usual detergents or soaps and other substances. Additions of surfactants such as polyoxyethylene sorbitan oleate and lecithin to these topical formulations give advantageous effects.
  • ethyl nicotinic acid or its salts can also be added to the hair product.
  • Conceivable contraindications are congenital disorders of the valine and leucine metabolism (leucinosis) such as "branched chain disease” (maple syrup disease); A reduction in the amino acid intake with a changed ratio of the branched-chain to aromatic amino acids is indicated in the case of hepatic encephalopathy, renal insufficiency and disorders in urea synthesis.
  • the agent according to the invention is not only limited to humans, but can also be used in veterinary medicine for pets and can be used to support the physiological hair growth in livestock by nutritional use as a feed additive.
  • the agent according to the invention is used in the livestock, preferably as a feed additive (nutritive) by admixing with the feed or by producing feed enriched with the agent, for example by pelleting.
  • the application dose can be in the range from about 0.2 to 0.4 mol of the amino acid mixture according to the invention / kg of body weight.
  • the dose is administered either continuously or discontinuously.
  • the powdery amino acid mixture administered according to Example 1 can also be administered in the form of tablets which have the following composition:
  • Such tablets can be administered orally to the patient as described in Example 1 so that the daily dose listed in Example 1 of 12 g L-leucine, 8 g L-isoleucine and 6.4 L-valine is achieved.
  • the amino acid mixture according to the invention can also be used as a food substitute to promote hair formation.
  • 3.0 g of L-leucine, 2.0 g of L-isoleucine and 1.6 g of L-valine are added to 93.4 g of yoghurt and mixed, so that a homogeneous mixture is formed.
  • Such a dose was administered to 8 to 10 patients four times a day over a period of 30 days. The total treatment period was 12 months, after which the patients showed significantly increased, quantitative hair and nail growth.
  • Example 1 The effects described in Example 1 can also be achieved with a daily dose, each consisting of 10.86 g L-leucine, 4.35 g L-isoleucine and 5.82 g L-valine and is administered orally in three divided doses.
  • Example 4 The daily dose given in Example 4 can also be administered in the form of tablets or coated tablets according to Example 2.
  • Example 4 The daily dose given in Example 4 can also be used in the form of a food substitute according to Example 3. So z. B. 3.62 g of L-leucine, 1.45 g of L-isoleucine and 1.94 g of L-valine are added to 93 g of yoghurt and mixed so that a homogeneous mixture is formed. This mixture is administered analogously to Example 3, but only three times a day.

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Nutrition Science (AREA)
  • Dermatology (AREA)
  • Polymers & Plastics (AREA)
  • Food Science & Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Birds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

L'invention décrit un agent et un procédé pour stimuler la croissance et la régénération des cheveux et des ongles. Une quantité efficace d'un ou plusieurs aminoacides ou un mélange de ceux-ci choisis dans le groupe composé de L-leucine, L-isoleucine et L-valine est administrée.
PCT/EP1991/001297 1990-07-12 1991-07-10 Agent et procede pour stimuler la croissance et la regeneration des cheveux et des ongles WO1992000720A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE4022288A DE4022288A1 (de) 1990-07-12 1990-07-12 Mittel und verfahren zur stimulierung des wachstums und der regenerierung des haares und der naegel
DEP4022288.8 1990-07-12

Publications (1)

Publication Number Publication Date
WO1992000720A1 true WO1992000720A1 (fr) 1992-01-23

Family

ID=6410200

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1991/001297 WO1992000720A1 (fr) 1990-07-12 1991-07-10 Agent et procede pour stimuler la croissance et la regeneration des cheveux et des ongles

Country Status (2)

Country Link
DE (1) DE4022288A1 (fr)
WO (1) WO1992000720A1 (fr)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5425954A (en) * 1993-09-30 1995-06-20 Curafas Incorporated Topical amino acid - vitamin complex compositions for pharmaceutical and cosmetic use
GB2322550A (en) * 1997-02-27 1998-09-02 Unilever Plc Hair treatment composition
WO2000071086A1 (fr) * 1999-05-24 2000-11-30 Unilever Plc Utilisation d'une combinaison d'acides amines a chaine laterale aliphatique et a chaine laterale basique dans le traitement local des cheveux
EP2042157A1 (fr) * 2006-06-08 2009-04-01 Ajinomoto Co., Inc. Préparation destinée à la croissance capillaire

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU4383196A (en) * 1996-01-17 1997-08-11 Friedrich Kisters Amino acid preparation for stimulating hair growth
AU6838996A (en) * 1996-05-27 1998-01-05 Alexei Nikolaevich Parfenov Use of streptococcus faecium strains and composition containing the same
US5962523A (en) * 1996-10-25 1999-10-05 Discovery Laboratories, Inc. Methods of using butyric acid derivatives to protect against hair loss

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0107885A1 (fr) * 1982-10-29 1984-05-09 Crinos Industria Farmacobiologica S.p.A. Préparations cosmétiques favorisant la nutrition de la peau et des follicules pileux adjacents
EP0184999A2 (fr) * 1984-12-12 1986-06-18 Boehringer Mannheim Italia S.P.A. Produits diététiques granulaires à base d'amino-acides et méthode pour leur préparation
FR2609393A1 (fr) * 1988-02-23 1988-07-15 Serobiologiques Lab Sa Composition notamment utile comme matiere de base pour la preparation de compositions pharmaceutiques, notamment dermatologiques et/ou cosmetiques comprenant une substance azotee, notamment aminoacides, oligo- ou polypeptides, proteines, et leurs derives, et composition pharmaceutique ou cosmetique ainsi preparee.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201235A (en) * 1978-01-03 1980-05-06 Mare Corporation Amino acid-vitamin formulations for skin, hair and scalp conditioners

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0107885A1 (fr) * 1982-10-29 1984-05-09 Crinos Industria Farmacobiologica S.p.A. Préparations cosmétiques favorisant la nutrition de la peau et des follicules pileux adjacents
EP0184999A2 (fr) * 1984-12-12 1986-06-18 Boehringer Mannheim Italia S.P.A. Produits diététiques granulaires à base d'amino-acides et méthode pour leur préparation
FR2609393A1 (fr) * 1988-02-23 1988-07-15 Serobiologiques Lab Sa Composition notamment utile comme matiere de base pour la preparation de compositions pharmaceutiques, notamment dermatologiques et/ou cosmetiques comprenant une substance azotee, notamment aminoacides, oligo- ou polypeptides, proteines, et leurs derives, et composition pharmaceutique ou cosmetique ainsi preparee.

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5425954A (en) * 1993-09-30 1995-06-20 Curafas Incorporated Topical amino acid - vitamin complex compositions for pharmaceutical and cosmetic use
GB2322550A (en) * 1997-02-27 1998-09-02 Unilever Plc Hair treatment composition
ES2139533A1 (es) * 1997-02-27 2000-02-01 Unilever Nv Composicion para el tratamiento del cabello.
GB2322550B (en) * 1997-02-27 2000-10-04 Unilever Plc Hair treatment composition
WO2000071086A1 (fr) * 1999-05-24 2000-11-30 Unilever Plc Utilisation d'une combinaison d'acides amines a chaine laterale aliphatique et a chaine laterale basique dans le traitement local des cheveux
EP2042157A1 (fr) * 2006-06-08 2009-04-01 Ajinomoto Co., Inc. Préparation destinée à la croissance capillaire
EP2042157A4 (fr) * 2006-06-08 2013-12-04 Ajinomoto Kk Préparation destinée à la croissance capillaire

Also Published As

Publication number Publication date
DE4022288A1 (de) 1992-01-16

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