WO1991018866A3 - 1,4-diamino-2,3-dihydroxybutanes - Google Patents

1,4-diamino-2,3-dihydroxybutanes Download PDF

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Publication number
WO1991018866A3
WO1991018866A3 PCT/US1991/003852 US9103852W WO9118866A3 WO 1991018866 A3 WO1991018866 A3 WO 1991018866A3 US 9103852 W US9103852 W US 9103852W WO 9118866 A3 WO9118866 A3 WO 9118866A3
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WIPO (PCT)
Prior art keywords
dihydroxybutanes
diamino
diamine
preparing
compounds
Prior art date
Application number
PCT/US1991/003852
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English (en)
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WO1991018866A2 (fr
Inventor
Prabhakar Kondaji Jadhav
Lawrence Ray Mcgee
Ashok Shenvi
Carl Nicholas Hodge
Original Assignee
Du Pont Merck Pharma
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Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Priority to AU82054/91A priority Critical patent/AU8205491A/en
Priority to JP3512068A priority patent/JPH07502970A/ja
Priority to BR919106540A priority patent/BR9106540A/pt
Publication of WO1991018866A2 publication Critical patent/WO1991018866A2/fr
Publication of WO1991018866A3 publication Critical patent/WO1991018866A3/fr
Priority to NO92924615A priority patent/NO924615L/no
Priority to FI925441A priority patent/FI925441A0/fi

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    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
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    • C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
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    • C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
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    • C07C217/10—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical containing six-membered aromatic rings
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Abstract

L'invention se rapporte à de nouveaux composés 1,4-diamine-2,3-dihydroxybutanes, qui sont utiles comme agents antiviraux, à des compositions pharmaceutiques contenant ces composés et à des procédés servant à les préparer.
PCT/US1991/003852 1990-06-01 1991-05-31 1,4-diamino-2,3-dihydroxybutanes WO1991018866A2 (fr)

Priority Applications (5)

Application Number Priority Date Filing Date Title
AU82054/91A AU8205491A (en) 1990-06-01 1991-05-31 1,4-diamino-2,3-dihydroxybutanes
JP3512068A JPH07502970A (ja) 1990-06-01 1991-05-31 １，４―ジアミノ―２，３―ジヒドロキシブタン類
BR919106540A BR9106540A (pt) 1990-06-01 1991-05-31 1,4-diamino-2,3-didroxibutanos
NO92924615A NO924615L (no) 1990-06-01 1992-11-30 1,4-diamino-2,3-dihydroksybutaner
FI925441A FI925441A0 (fi) 1990-06-01 1992-11-30 1,4-diamino-2,3-dihydroxibutaner

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US53197190A 1990-06-01 1990-06-01
US531,971 1990-06-01

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WO1991018866A2 WO1991018866A2 (fr) 1991-12-12
WO1991018866A3 true WO1991018866A3 (fr) 1992-04-30

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US (1) US5294720A (fr)
EP (2) EP0532693A1 (fr)
JP (1) JPH07502970A (fr)
BR (1) BR9106540A (fr)
CA (1) CA2084087A1 (fr)
HU (2) HU9203505D0 (fr)
TW (1) TW204336B (fr)
WO (1) WO1991018866A2 (fr)
ZA (1) ZA914194B (fr)

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Tetrahedron, vol. 45, no. 23, 1989, Pergamon Press (GB), M. Saniere et al.: "Syntheses of enantiomerically pure 9(S)- and 9(R)-hete from D-mannitol. Use of a malic dialdehyde equivalent", pages 7317 - 7328 *
Tetrahedron, vol. 45, no. 23, 1989, Pergamon Press (GB), M. Saniere et al.: "Syntheses of enantiomerically pure 9(S)- and 9(R)-hete from D-mannitol. Use of a malic dialdehyde equivalent", pages 7317-7328, see page 7319, scheme I, page 7321, scheme II *
The Journal of Organic Chemistry, vol. 54, no. 10, 12 May 1989 (US), Y. Le Merrer et al.: "Total synthesis of leukotriene B4[(+)-LTB4] and homo-LTB4 from D-mannitol", pages 2409 - 2416 *
The Journal of Organic Chemistry, vol. 54, no. 10, 12 May 1989 (US), Y. Le Merrer et al.: "Total synthesis of leukotriene B4[(+)-LTB4] and homo-LTB4 from D-mannitol", pages 2409-2416, see page 2411, scheme IV *
The Journal of Organic Chemistry, vol. 54, no. 22, 27 October 1989, American Chemical Soc. (US), A. Dureault et al.: ""Nucleophilic opening of chiral bis-(aziridines): a route to enantiomerically pure alpha-amino aldehydes or acids and polysubstituted piperidines", pages 5324 - 5330 *
The Journal of Organic Chemistry, vol. 54, no. 22, 27 October 1989, American Chemical Soc. (US), A. Dureault et al.: ""Nucleophilic opening of chiral bis-(aziridines): a route to enantiomerically pure alpha-amino aldehydes or acids and polysubstituted piperidines", pages 5324-5330, see page 5324, column 1, line 1 - column 2, line 43, table 1, entries 7 and 8; page 5328, column 2, lines 19-43; scheme II *

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JPH07502970A (ja) 1995-03-30
WO1991018866A2 (fr) 1991-12-12
HU9203505D0 (en) 1993-01-28
TW204336B (fr) 1993-04-21
CA2084087A1 (fr) 1991-12-02
BR9106540A (pt) 1993-05-25
HUT64738A (en) 1994-02-28
ZA914194B (en) 1993-02-24
US5294720A (en) 1994-03-15
EP0532693A1 (fr) 1993-03-24
EP0665215A1 (fr) 1995-08-02

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