WO1991012824A3 - Composes marques au 19f utiles comme agents de spectroscopie et d'imagerie par rmn - Google Patents

Composes marques au 19f utiles comme agents de spectroscopie et d'imagerie par rmn Download PDF

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Publication number
WO1991012824A3
WO1991012824A3 PCT/US1991/001150 US9101150W WO9112824A3 WO 1991012824 A3 WO1991012824 A3 WO 1991012824A3 US 9101150 W US9101150 W US 9101150W WO 9112824 A3 WO9112824 A3 WO 9112824A3
Authority
WO
WIPO (PCT)
Prior art keywords
perfluorocarbon emulsion
tissue
subject
spin
oxygen tension
Prior art date
Application number
PCT/US1991/001150
Other languages
English (en)
Other versions
WO1991012824A2 (fr
Inventor
Peter P Antich
Padmakar V Kulkarni
Original Assignee
Univ Texas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Texas filed Critical Univ Texas
Priority to DE69111798T priority Critical patent/DE69111798T2/de
Priority to JP91505438A priority patent/JPH05506432A/ja
Priority to EP91905554A priority patent/EP0517788B1/fr
Publication of WO1991012824A2 publication Critical patent/WO1991012824A2/fr
Publication of WO1991012824A3 publication Critical patent/WO1991012824A3/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/12—Macromolecular compounds
    • A61K49/126—Linear polymers, e.g. dextran, inulin, PEG
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10—Organic compounds
    • A61K49/14—Peptides, e.g. proteins
    • A61K49/146—Peptides, e.g. proteins the peptide being a polyamino acid, e.g. poly-lysine
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/24—Nuclear magnetic resonance, electron spin resonance or other spin effects or mass spectrometry

Abstract

Des composés marqués au 19F sont utiles dans des procédés d'imagerie et de spectroscopie par RMN. Les composés comprennent une moitié détectrice contenant du 19F et un substrat ou polymère de transport, et peuvent, le cas échéant, comprendre également une moitié d'écartement qui sépare la moitié détectrice du polymère de transport.
PCT/US1991/001150 1990-02-21 1991-02-21 Composes marques au 19f utiles comme agents de spectroscopie et d'imagerie par rmn WO1991012824A2 (fr)

Priority Applications (3)

Application Number Priority Date Filing Date Title
DE69111798T DE69111798T2 (de) 1990-02-21 1991-02-21 19f-markierte verbindungen zur verwendung als nmr-bilderzeugungs- und spektroskopiermittel.
JP91505438A JPH05506432A (ja) 1990-02-21 1991-02-21 Ｎｍｒ画像化及び分光剤としての↑１↑９ｆ標識化合物
EP91905554A EP0517788B1 (fr) 1990-02-21 1991-02-21 Composes marques au 19 f utiles comme agents de spectroscopie et d'imagerie par rmn

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/482,879 US5236694A (en) 1990-02-21 1990-02-21 19f labelled dextrans and antibodies as nmr imaging and spectroscopy agents
US482,879 1990-02-21

Publications (2)

Publication Number Publication Date
WO1991012824A2 WO1991012824A2 (fr) 1991-09-05
WO1991012824A3 true WO1991012824A3 (fr) 1992-02-20

Family

ID=23917811

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1991/001150 WO1991012824A2 (fr) 1990-02-21 1991-02-21 Composes marques au 19f utiles comme agents de spectroscopie et d'imagerie par rmn

Country Status (9)

Country Link
US (3) US5236694A (fr)
EP (1) EP0517788B1 (fr)
JP (1) JPH05506432A (fr)
AT (1) ATE125712T1 (fr)
AU (1) AU641233B2 (fr)
CA (1) CA2075953A1 (fr)
DE (1) DE69111798T2 (fr)
ES (1) ES2075433T3 (fr)
WO (1) WO1991012824A2 (fr)

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US5807978A (en) * 1995-06-07 1998-09-15 Kokolus; William J. Immunogenic peptides of prostate specific antigen
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US5753207A (en) * 1995-08-21 1998-05-19 Beth Israel Deaconess Medical Center, Inc. Use of paramagnetic compounds to measure temperature and pH in vivo
US5828216A (en) * 1996-08-19 1998-10-27 The United States Of America As Represented By The Department Of Health And Human Services Gated RF preamplifier for use in pulsed radiofrequency electron paramagnetic resonance and MRI
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US6419174B1 (en) * 2000-08-18 2002-07-16 J. M. Huber Corporation Abrasive compositions and methods for making same
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US20040171128A1 (en) * 2003-02-28 2004-09-02 Manssur Yalpani Halogenated emulsans
AU2005209169B2 (en) 2004-01-16 2010-12-16 Carnegie Mellon University Cellular labeling for nuclear magnetic resonance techniques
BRPI0517790A (pt) * 2004-11-12 2008-10-21 Neurochem Int Ltd métodos e composições fluoradas para tratar doenças relacionadas à amilóide
DE102005005704B4 (de) 2005-02-03 2010-08-12 Leibniz-Institut Für Festkörper- Und Werkstoffforschung Dresden E.V. Verwendung von Partikeln für die Ermittlung der lokalen Temperatur in organischen und nichtorganischen Körpern
US8263043B2 (en) * 2006-04-14 2012-09-11 Carnegie Mellon University Cellular labeling and quantification for nuclear magnetic resonance techniques
WO2008054509A2 (fr) * 2006-04-14 2008-05-08 Celsense, Inc. Procédés de détermination du marquage de cellules
GB0711662D0 (en) * 2007-06-15 2007-07-25 Cancercure As Magnetic resonance guided cancer treatment system
AU2008275578B2 (en) * 2007-07-10 2014-04-10 Carnegie Mellon University Compositions and methods for producing cellular labels for nuclear magnetic resonance techniques
US8093060B2 (en) * 2008-02-28 2012-01-10 Canon Kabushiki Kaisha Multisite phosphorylated peptide (protein) recognizing compound and detection method, imaging method, alzheimer's disease diagnosing method and reagent kit using the same
CA2723171C (fr) * 2008-05-02 2018-03-27 Celsense, Inc. Compositions d'emulsion et methodes destinees a l'imagerie par resonance magnetique nucleaire et d'autres types d'imagerie
EP2459235B1 (fr) 2009-07-31 2014-04-23 Koninklijke Philips N.V. Perfluoro-t-butyl cyclohexane pour l'imagerie
US20130289259A1 (en) * 2010-12-10 2013-10-31 Merck Patent Gmbh Aptamer labelled with f-19 nucleus for targeted molecular imaging by mri
WO2012142670A1 (fr) * 2011-04-20 2012-10-26 The University Of Queensland Agent de résonance magnétique nucléaire
JP6234064B2 (ja) * 2012-05-23 2017-11-22 キヤノン株式会社 重合体、前記重合体を用いた核磁気共鳴分析用または磁気共鳴イメージング用の造影剤、化合物、前記重合体を用いた核磁気共鳴分析方法および磁気共鳴イメージング方法

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Also Published As

Publication number Publication date
ATE125712T1 (de) 1995-08-15
EP0517788A1 (fr) 1992-12-16
DE69111798T2 (de) 1995-11-30
EP0517788B1 (fr) 1995-08-02
WO1991012824A2 (fr) 1991-09-05
US5236694A (en) 1993-08-17
JPH05506432A (ja) 1993-09-22
AU7453991A (en) 1991-09-18
AU641233B2 (en) 1993-09-16
CA2075953A1 (fr) 1991-08-22
US5397562A (en) 1995-03-14
ES2075433T3 (es) 1995-10-01
DE69111798D1 (de) 1995-09-07
US5422094A (en) 1995-06-06

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