CA2327733C - Utilisation d'un gaz hyperpolarise pour detecter par irm les variations de consommation d'oxygene dans diverses regions des poumons - Google Patents

Utilisation d'un gaz hyperpolarise pour detecter par irm les variations de consommation d'oxygene dans diverses regions des poumons Download PDF

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Publication number
CA2327733C
CA2327733C CA002327733A CA2327733A CA2327733C CA 2327733 C CA2327733 C CA 2327733C CA 002327733 A CA002327733 A CA 002327733A CA 2327733 A CA2327733 A CA 2327733A CA 2327733 C CA2327733 C CA 2327733C
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CA
Canada
Prior art keywords
magnetic resonance
lungs
imaging
image
agent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002327733A
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English (en)
Other versions
CA2327733A1 (fr
Inventor
Norbert Weiler
Anselm Deninger
Balthasar Eberle
Michael Ebert
Tino Grossman
Werner Heil
Hans-Ulrich Kauczor
Lars Lauer
Klaus Markstaller
Timothy Roberts
Wolfgang Schreiber
Reinhard Surkau
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Medi Physics Inc
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Medi Physics Inc
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Publication date
Application filed by Medi Physics Inc filed Critical Medi Physics Inc
Priority claimed from PCT/GB1999/001095 external-priority patent/WO1999053332A1/fr
Publication of CA2327733A1 publication Critical patent/CA2327733A1/fr
Application granted granted Critical
Publication of CA2327733C publication Critical patent/CA2327733C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent

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  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • General Health & Medical Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Abstract

L'invention concerne un procédé permettant de détecter les variations de consommation d'oxygène entre les différentes régions des poumons d'un sujet animal respirant de l'air. Ce procédé consiste à administrer dans les poumons de ce sujet une quantité efficace à titre diagnostique d'un agent gazeux hyperpolarisé d'imagerie par résonance magnétique, puis à détecter le signal de résonance magnétique de cet agent dans les poumons, pour ensuite calculer la variation temporelle de la vitesse de relaxation de ce signal dans au moins une région d'intérêt à l'intérieur des poumons. On peut alors calculer, à partir de cette variation, une valeur ou une image qualitative ou quantitative indiquant la concentration d'oxygène dans une moins une région d'intérêt, et le cas échéant, la distribution temporelle de cette concentration.
CA002327733A 1998-04-09 1999-04-09 Utilisation d'un gaz hyperpolarise pour detecter par irm les variations de consommation d'oxygene dans diverses regions des poumons Expired - Fee Related CA2327733C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GBGB9807879.3A GB9807879D0 (en) 1998-04-09 1998-04-09 Magnetic resonance imaging method
GB9807879.3 1998-04-09
PCT/GB1999/001095 WO1999053332A1 (fr) 1998-04-09 1999-04-09 Utilisation d'un gaz hyperpolarise pour detecter par irm les variations de consommation d'oxygene dans diverses regions des poumons

Publications (2)

Publication Number Publication Date
CA2327733A1 CA2327733A1 (fr) 1999-10-21
CA2327733C true CA2327733C (fr) 2007-07-03

Family

ID=10830295

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002327733A Expired - Fee Related CA2327733C (fr) 1998-04-09 1999-04-09 Utilisation d'un gaz hyperpolarise pour detecter par irm les variations de consommation d'oxygene dans diverses regions des poumons

Country Status (11)

Country Link
EP (1) EP1070261A1 (fr)
JP (1) JP2002511329A (fr)
CN (1) CN1145042C (fr)
AU (1) AU760339B2 (fr)
CA (1) CA2327733C (fr)
GB (1) GB9807879D0 (fr)
HU (1) HUP0300952A2 (fr)
IL (3) IL138942A0 (fr)
NO (1) NO20005075L (fr)
NZ (1) NZ507434A (fr)
PL (1) PL192056B1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7179450B2 (en) * 2001-09-20 2007-02-20 Medi-Physics, Inc. Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe
US8808193B2 (en) * 2007-09-11 2014-08-19 Carefusion 207, Inc. Regional oxygen uptake/perfusion measuring device and method
CN105301543B (zh) * 2015-11-16 2017-12-19 中国科学院武汉物理与数学研究所 一种基于单次屏气内多角度激发的超极化角度校准方法
CN111612860B (zh) * 2019-02-22 2023-09-15 曹生 基于VRDS 4D医学影像的栓塞的Ai识别方法及产品

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775522A (en) * 1983-03-04 1988-10-04 Children's Hospital Research Foundation, A Division Of Children's Hospital Medical Center NMR compositions for indirectly detecting a dissolved gas in an animal
US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases

Also Published As

Publication number Publication date
NO20005075D0 (no) 2000-10-09
JP2002511329A (ja) 2002-04-16
AU3432599A (en) 1999-11-01
AU760339B2 (en) 2003-05-15
GB9807879D0 (en) 1998-06-10
NO20005075L (no) 2000-12-07
NZ507434A (en) 2004-01-30
EP1070261A1 (fr) 2001-01-24
PL343379A1 (en) 2001-08-13
IL138942A (en) 2007-03-08
IL155607A (en) 2007-08-19
PL192056B1 (pl) 2006-08-31
IL138942A0 (en) 2001-11-25
HUP0300952A2 (hu) 2003-08-28
CN1305591A (zh) 2001-07-25
CA2327733A1 (fr) 1999-10-21
CN1145042C (zh) 2004-04-07

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