IL155607A - Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs - Google Patents

Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs

Info

Publication number
IL155607A
IL155607A IL155607A IL15560703A IL155607A IL 155607 A IL155607 A IL 155607A IL 155607 A IL155607 A IL 155607A IL 15560703 A IL15560703 A IL 15560703A IL 155607 A IL155607 A IL 155607A
Authority
IL
Israel
Prior art keywords
hyperpolarized
agent
lungs
breathhold
magnetic resonance
Prior art date
Application number
IL155607A
Original Assignee
Medi Physics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from PCT/GB1999/001095 external-priority patent/WO1999053332A1/en
Application filed by Medi Physics Inc filed Critical Medi Physics Inc
Publication of IL155607A publication Critical patent/IL155607A/en

Links

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01RMEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00Arrangements or instruments for measuring magnetic variables
    • G01R33/20Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48NMR imaging systems
    • G01R33/54Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent

Landscapes

  • Physics & Mathematics (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • General Health & Medical Sciences (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)

Claims (7)

1. A method for estimating the lung volume of an air-breathing animal subject, said method comprising administering into the lungs of said subject an effective amount of a gaseous hyperpolarized magnetic resonance imaging agent, and monitoring the hyperpolarization value of said hyperpolarized agent to determine the integrated magnetic resonance signal following inhalation of said hyperpolarized agent without air, breathhold and expiration, wherein the expired volume is measured indirectly and the residual hyperpolarization of the retained hyperpolarized agent is extrapolated from the hyperpolarization value monitored during breathhold.
2. A method as claimed in claim 1 wherein said hyperpolarized agent is 3He.
3. A method as claimed in claim 1 wherein the 3He has a polarization degree of 10 to 50%.
4. A method as claimed in claim 1 wherein said hyperpolarized agent is administered as a bolus.
5. A method as claimed in Claim 4 wherein said hyperpolarized agent is administered to a human as a bolus of volume 1 to 1000 ml_.
6. A method as claimed in claim 1 wherein said breathhold is effected during a period of at least 1 second.
7. A method as claimed in claim 1 wherein a mr imager with a primary field strength in the range of 0.05 to 3.5T is used to detect the magnetic resonance signal. For the Applicants, REINHOLD COHN AND PARTNERS
IL155607A 1998-04-09 2003-04-28 Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs IL155607A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9807879.3A GB9807879D0 (en) 1998-04-09 1998-04-09 Magnetic resonance imaging method
PCT/GB1999/001095 WO1999053332A1 (en) 1998-04-09 1999-04-09 Use of a hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs

Publications (1)

Publication Number Publication Date
IL155607A true IL155607A (en) 2007-08-19

Family

ID=10830295

Family Applications (3)

Application Number Title Priority Date Filing Date
IL13894299A IL138942A0 (en) 1998-04-09 1999-04-09 Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs
IL138942A IL138942A (en) 1998-04-09 2000-10-10 Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs
IL155607A IL155607A (en) 1998-04-09 2003-04-28 Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs

Family Applications Before (2)

Application Number Title Priority Date Filing Date
IL13894299A IL138942A0 (en) 1998-04-09 1999-04-09 Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs
IL138942A IL138942A (en) 1998-04-09 2000-10-10 Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs

Country Status (11)

Country Link
EP (1) EP1070261A1 (en)
JP (1) JP2002511329A (en)
CN (1) CN1145042C (en)
AU (1) AU760339B2 (en)
CA (1) CA2327733C (en)
GB (1) GB9807879D0 (en)
HU (1) HUP0300952A2 (en)
IL (3) IL138942A0 (en)
NO (1) NO20005075L (en)
NZ (1) NZ507434A (en)
PL (1) PL192056B1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7179450B2 (en) * 2001-09-20 2007-02-20 Medi-Physics, Inc. Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe
US8808193B2 (en) * 2007-09-11 2014-08-19 Carefusion 207, Inc. Regional oxygen uptake/perfusion measuring device and method
CN105301543B (en) * 2015-11-16 2017-12-19 中国科学院武汉物理与数学研究所 A kind of hyperpolarization angle calibration system method excited based on multi-angle in single breath-hold
CN111612860B (en) * 2019-02-22 2023-09-15 曹生 VRDS 4D medical image-based Ai identification method and product for embolism

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4775522A (en) * 1983-03-04 1988-10-04 Children's Hospital Research Foundation, A Division Of Children's Hospital Medical Center NMR compositions for indirectly detecting a dissolved gas in an animal
US5545396A (en) * 1994-04-08 1996-08-13 The Research Foundation Of State University Of New York Magnetic resonance imaging using hyperpolarized noble gases

Also Published As

Publication number Publication date
JP2002511329A (en) 2002-04-16
GB9807879D0 (en) 1998-06-10
PL192056B1 (en) 2006-08-31
PL343379A1 (en) 2001-08-13
HUP0300952A2 (en) 2003-08-28
CA2327733A1 (en) 1999-10-21
IL138942A (en) 2007-03-08
AU3432599A (en) 1999-11-01
AU760339B2 (en) 2003-05-15
NO20005075L (en) 2000-12-07
NZ507434A (en) 2004-01-30
EP1070261A1 (en) 2001-01-24
CN1145042C (en) 2004-04-07
CN1305591A (en) 2001-07-25
NO20005075D0 (en) 2000-10-09
CA2327733C (en) 2007-07-03
IL138942A0 (en) 2001-11-25

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