IL155607A - Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs - Google Patents
Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungsInfo
- Publication number
- IL155607A IL155607A IL155607A IL15560703A IL155607A IL 155607 A IL155607 A IL 155607A IL 155607 A IL155607 A IL 155607A IL 15560703 A IL15560703 A IL 15560703A IL 155607 A IL155607 A IL 155607A
- Authority
- IL
- Israel
- Prior art keywords
- hyperpolarized
- agent
- lungs
- breathhold
- magnetic resonance
- Prior art date
Links
- 210000004072 lung Anatomy 0.000 title claims 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 title 1
- 238000001514 detection method Methods 0.000 title 1
- 239000007789 gas Substances 0.000 title 1
- 239000001301 oxygen Substances 0.000 title 1
- 229910052760 oxygen Inorganic materials 0.000 title 1
- 238000000034 method Methods 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 6
- 230000002102 hyperpolarization Effects 0.000 claims 3
- 239000012216 imaging agent Substances 0.000 claims 1
- 238000002595 magnetic resonance imaging Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 230000010287 polarization Effects 0.000 claims 1
- 230000000717 retained effect Effects 0.000 claims 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
- G01R33/00—Arrangements or instruments for measuring magnetic variables
- G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
- G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
- G01R33/48—NMR imaging systems
- G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
- G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
- G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
Landscapes
- Physics & Mathematics (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Signal Processing (AREA)
- General Health & Medical Sciences (AREA)
- High Energy & Nuclear Physics (AREA)
- Condensed Matter Physics & Semiconductors (AREA)
- General Physics & Mathematics (AREA)
- Magnetic Resonance Imaging Apparatus (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measurement Of The Respiration, Hearing Ability, Form, And Blood Characteristics Of Living Organisms (AREA)
Claims (7)
1. A method for estimating the lung volume of an air-breathing animal subject, said method comprising administering into the lungs of said subject an effective amount of a gaseous hyperpolarized magnetic resonance imaging agent, and monitoring the hyperpolarization value of said hyperpolarized agent to determine the integrated magnetic resonance signal following inhalation of said hyperpolarized agent without air, breathhold and expiration, wherein the expired volume is measured indirectly and the residual hyperpolarization of the retained hyperpolarized agent is extrapolated from the hyperpolarization value monitored during breathhold.
2. A method as claimed in claim 1 wherein said hyperpolarized agent is 3He.
3. A method as claimed in claim 1 wherein the 3He has a polarization degree of 10 to 50%.
4. A method as claimed in claim 1 wherein said hyperpolarized agent is administered as a bolus.
5. A method as claimed in Claim 4 wherein said hyperpolarized agent is administered to a human as a bolus of volume 1 to 1000 ml_.
6. A method as claimed in claim 1 wherein said breathhold is effected during a period of at least 1 second.
7. A method as claimed in claim 1 wherein a mr imager with a primary field strength in the range of 0.05 to 3.5T is used to detect the magnetic resonance signal. For the Applicants, REINHOLD COHN AND PARTNERS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9807879.3A GB9807879D0 (en) | 1998-04-09 | 1998-04-09 | Magnetic resonance imaging method |
| PCT/GB1999/001095 WO1999053332A1 (en) | 1998-04-09 | 1999-04-09 | Use of a hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL155607A true IL155607A (en) | 2007-08-19 |
Family
ID=10830295
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13894299A IL138942A0 (en) | 1998-04-09 | 1999-04-09 | Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs |
| IL138942A IL138942A (en) | 1998-04-09 | 2000-10-10 | Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs |
| IL155607A IL155607A (en) | 1998-04-09 | 2003-04-28 | Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL13894299A IL138942A0 (en) | 1998-04-09 | 1999-04-09 | Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs |
| IL138942A IL138942A (en) | 1998-04-09 | 2000-10-10 | Use of hyperpolarized gas for mri detection of regional variations in oxygen uptake from the lungs |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1070261A1 (en) |
| JP (1) | JP2002511329A (en) |
| CN (1) | CN1145042C (en) |
| AU (1) | AU760339B2 (en) |
| CA (1) | CA2327733C (en) |
| GB (1) | GB9807879D0 (en) |
| HU (1) | HUP0300952A2 (en) |
| IL (3) | IL138942A0 (en) |
| NO (1) | NO20005075L (en) |
| NZ (1) | NZ507434A (en) |
| PL (1) | PL192056B1 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7179450B2 (en) * | 2001-09-20 | 2007-02-20 | Medi-Physics, Inc. | Methods for in vivo evaluation of pulmonary physiology and/or function using NMR signals of polarized Xe |
| US8808193B2 (en) * | 2007-09-11 | 2014-08-19 | Carefusion 207, Inc. | Regional oxygen uptake/perfusion measuring device and method |
| CN105301543B (en) * | 2015-11-16 | 2017-12-19 | 中国科学院武汉物理与数学研究所 | A kind of hyperpolarization angle calibration system method excited based on multi-angle in single breath-hold |
| US11944424B2 (en) * | 2018-05-18 | 2024-04-02 | Duke University | Dynamic 129Xe gas exchange spectroscopy |
| CN111612860B (en) * | 2019-02-22 | 2023-09-15 | 曹生 | VRDS 4D medical image-based Ai identification method and product for embolism |
| CN115792758B (en) * | 2022-11-30 | 2024-10-15 | 中国科学院精密测量科学与技术创新研究院 | Magnetic resonance quantitative imaging method for living body hyperpolarized xenon molecular probe |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4775522A (en) * | 1983-03-04 | 1988-10-04 | Children's Hospital Research Foundation, A Division Of Children's Hospital Medical Center | NMR compositions for indirectly detecting a dissolved gas in an animal |
| US5545396A (en) * | 1994-04-08 | 1996-08-13 | The Research Foundation Of State University Of New York | Magnetic resonance imaging using hyperpolarized noble gases |
-
1998
- 1998-04-09 GB GBGB9807879.3A patent/GB9807879D0/en not_active Ceased
-
1999
- 1999-04-09 EP EP99915902A patent/EP1070261A1/en not_active Withdrawn
- 1999-04-09 AU AU34325/99A patent/AU760339B2/en not_active Ceased
- 1999-04-09 IL IL13894299A patent/IL138942A0/en not_active IP Right Cessation
- 1999-04-09 NZ NZ507434A patent/NZ507434A/en not_active Application Discontinuation
- 1999-04-09 HU HU0300952A patent/HUP0300952A2/en unknown
- 1999-04-09 JP JP2000543843A patent/JP2002511329A/en active Pending
- 1999-04-09 PL PL343379A patent/PL192056B1/en unknown
- 1999-04-09 CA CA002327733A patent/CA2327733C/en not_active Expired - Fee Related
- 1999-04-09 CN CNB998072273A patent/CN1145042C/en not_active Expired - Fee Related
-
2000
- 2000-10-09 NO NO20005075A patent/NO20005075L/en not_active Application Discontinuation
- 2000-10-10 IL IL138942A patent/IL138942A/en unknown
-
2003
- 2003-04-28 IL IL155607A patent/IL155607A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU3432599A (en) | 1999-11-01 |
| JP2002511329A (en) | 2002-04-16 |
| GB9807879D0 (en) | 1998-06-10 |
| AU760339B2 (en) | 2003-05-15 |
| IL138942A (en) | 2007-03-08 |
| CN1145042C (en) | 2004-04-07 |
| CA2327733C (en) | 2007-07-03 |
| PL343379A1 (en) | 2001-08-13 |
| CA2327733A1 (en) | 1999-10-21 |
| EP1070261A1 (en) | 2001-01-24 |
| NO20005075D0 (en) | 2000-10-09 |
| PL192056B1 (en) | 2006-08-31 |
| NZ507434A (en) | 2004-01-30 |
| HUP0300952A2 (en) | 2003-08-28 |
| NO20005075L (en) | 2000-12-07 |
| IL138942A0 (en) | 2001-11-25 |
| CN1305591A (en) | 2001-07-25 |
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