WO1991010735A3 - Recepteur humain de la tsh. sequence codant pour ce recepteur - Google Patents

Recepteur humain de la tsh. sequence codant pour ce recepteur Download PDF

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Publication number
WO1991010735A3
WO1991010735A3 PCT/FR1991/000025 FR9100025W WO9110735A3 WO 1991010735 A3 WO1991010735 A3 WO 1991010735A3 FR 9100025 W FR9100025 W FR 9100025W WO 9110735 A3 WO9110735 A3 WO 9110735A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor
tsh
sequence coding
human
nucleic acid
Prior art date
Application number
PCT/FR1991/000025
Other languages
English (en)
Other versions
WO1991010735A2 (fr
Inventor
Edwin Milgrom
Micheline Misrahi
Hugues Loosfelt
Michel Atger
Original Assignee
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med filed Critical Inst Nat Sante Rech Med
Publication of WO1991010735A2 publication Critical patent/WO1991010735A2/fr
Publication of WO1991010735A3 publication Critical patent/WO1991010735A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Cell Biology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

L'invention concerne un acide nucléique codant pour le récepteur humain de la TSH, un variant ou une partie de cet acide nucléique dès lors qu'il a les propriétés structurales et/ou fonctionnelles et/ou antigéniques du récepteur. L'invention vise aussi des anticorps dirigés contre le récepteur. L'invention concerne aussi des moyens pour le diagnostic de certaines maladies thyroïdiennes.
PCT/FR1991/000025 1990-01-15 1991-01-15 Recepteur humain de la tsh. sequence codant pour ce recepteur WO1991010735A2 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9000397A FR2657014A1 (fr) 1990-01-15 1990-01-15 Recepteur humain de la tsh. sequence codant pour ce recepteur.
FR90/00397 1990-01-15

Publications (2)

Publication Number Publication Date
WO1991010735A2 WO1991010735A2 (fr) 1991-07-25
WO1991010735A3 true WO1991010735A3 (fr) 1991-10-03

Family

ID=9392766

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1991/000025 WO1991010735A2 (fr) 1990-01-15 1991-01-15 Recepteur humain de la tsh. sequence codant pour ce recepteur

Country Status (4)

Country Link
EP (1) EP0510075A1 (fr)
JP (1) JPH05503849A (fr)
FR (1) FR2657014A1 (fr)
WO (1) WO1991010735A2 (fr)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE221123T1 (de) * 1989-05-05 2002-08-15 Genentech Inc Glykoprotein-hormonrezeptor-moleküle
US6261800B1 (en) 1989-05-05 2001-07-17 Genentech, Inc. Luteinizing hormone/choriogonadotropin (LH/CG) receptor
US5614363A (en) * 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
EP0493434A4 (en) * 1989-09-08 1993-05-05 New England Medical Center Hospitals, Inc. Tsh receptor
US7118911B1 (en) * 1990-03-05 2006-10-10 Genzyme Corporation DNA molecules stabilized for propagation in bacterial cells that encode cystic fibrosis transmembrane conductance regulator
DE19645729C1 (de) * 1996-11-06 1998-06-04 Brahms Diagnostica Gmbh Rezeptorbindungsassay, für den Rezeptorbindungsassay geeigneter rekombinanter Fusionsrezeptor, Vektor zu dessen Herstellung sowie Reagenziensatz für die Durchführung des Rezeptorbindungsassays
DE19651093C2 (de) * 1996-12-09 1999-06-10 Brahms Diagnostica Gmbh Rezeptorbindungsassay zum Nachweis von TSH-Rezeptor-Autoantikörpern sowie Reagenziensatz für die Durchführung eines solchen Rezeptorbindungsassays
DE19949184C2 (de) * 1999-10-12 2003-07-17 Ulrich Loos Verfahren zur Bestimmung von verschiedenen Typen von Autoantikörpern gegen den TSH-Rezeptor durch selektive Immunpräzipitation, Fusionsproteine zur Durchführung eines solchen Verfahrens und die Verwendung von markierten TSH-Rezeptor-Chimären bei einem solchen Verfahren
EP1565492B1 (fr) 2002-11-26 2006-12-20 B.R.A.H.M.S Aktiengesellschaft Mise en evidence d'auto-anticorps recepteurs tsh avec des anticorps sans affinite
WO2010113988A1 (fr) * 2009-03-31 2010-10-07 国立大学法人三重大学 Procédé de production d'anticorps anti-rcpg et anticorps anti-rcpg

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987005703A1 (fr) * 1986-03-19 1987-09-24 Boehringer Mannheim Gmbh Anticorps antiparatypiques, leur utilisation pour la detection et le traitement de maladies d'auto-immunite

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560649A (en) * 1981-10-15 1985-12-24 Cornell Research Foundation Assaying for hLH or hCG with immobilized hormone receptors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987005703A1 (fr) * 1986-03-19 1987-09-24 Boehringer Mannheim Gmbh Anticorps antiparatypiques, leur utilisation pour la detection et le traitement de maladies d'auto-immunite

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Biochemical and Biophysical Research Communications, vol. 165, no. 3, 29 Dècembre 1989, Academic Press, Inc., (Duluth, MN, US), F. Libert et al.: "Cloning, sequencing and expression of the human thyrotropin (TSH) receptor. Evidence for binding of autoantibodies", pages 1250-1255 *
Biochemical and Biophysical Research Communications, vol. 165, no. 3, 29 dècembre 1989, Academic Press, Inc., (Duluth, MN, US), Y. Nagayama et al.: "Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor", pages 1184-1190 *
Clinical Chemistry, vol. 34, no. 8, 1988, (Winston, US), H. Tamaki et al.: "On standardization of the radioreceptor assay for anthithyrotropin receptor antibody", page 1662 *
Endocrinology, vol. 122, 1988, The Endocrine Society, (Springfield, US), B.L. Hill et al.: "Monoclonal antibodies to the thyrotropin receptor raised by an autoantiidiotypic protocol and their relationship to monoclonal autoantibodies from Graves patients", pages 2840-2850 *
L.D. Kohn et al.:"Autoimmune thyroid disease studied with monoclonal antibodies to the thyrotropin receptor", 1983, in B.F. Haynes, G.S. Eisenbarth (eds), Monoclonal antibodies: probes for the study of autoimmunity and immuno deficiency, Academic Press, (new York, US), pages 221-258 *
Proceedings of the National Academy of Science USA, vol. 79, novembre 1982, (Washington, US), W.A. Valente et al.: "Monoclonal anti-bodies to the thyrotropin receptor: Stimulating and blocking antibodies derived from the lymphocytes of patients with Graves disease", pages 6680-6684 *

Also Published As

Publication number Publication date
EP0510075A1 (fr) 1992-10-28
JPH05503849A (ja) 1993-06-24
FR2657014A1 (fr) 1991-07-19
WO1991010735A2 (fr) 1991-07-25

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