WO1991010735A3 - Human receptor of tsh. sequence coding for such receptor - Google Patents

Human receptor of tsh. sequence coding for such receptor Download PDF

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Publication number
WO1991010735A3
WO1991010735A3 PCT/FR1991/000025 FR9100025W WO9110735A3 WO 1991010735 A3 WO1991010735 A3 WO 1991010735A3 FR 9100025 W FR9100025 W FR 9100025W WO 9110735 A3 WO9110735 A3 WO 9110735A3
Authority
WO
WIPO (PCT)
Prior art keywords
receptor
tsh
sequence coding
human
nucleic acid
Prior art date
Application number
PCT/FR1991/000025
Other languages
French (fr)
Other versions
WO1991010735A2 (en
Inventor
Edwin Milgrom
Micheline Misrahi
Hugues Loosfelt
Michel Atger
Original Assignee
Inst Nat Sante Rech Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Inst Nat Sante Rech Med filed Critical Inst Nat Sante Rech Med
Publication of WO1991010735A2 publication Critical patent/WO1991010735A2/en
Publication of WO1991010735A3 publication Critical patent/WO1991010735A3/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
    • C07K14/723—G protein coupled receptor, e.g. TSHR-thyrotropin-receptor, LH/hCG receptor, FSH receptor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2869—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against hormone receptors

Abstract

The invention relates to a nucleic acid coding for the human receptor of TSH, a variant of or a part of said nucleic acid since it has the structural and/or functional and/or antigenic properties of the receptor. The invention is also aimed at antibodies directed against the receptor and also discloses means for the diagnosis of certain thyroid diseases.
PCT/FR1991/000025 1990-01-15 1991-01-15 Human receptor of tsh. sequence coding for such receptor WO1991010735A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR90/00397 1990-01-15
FR9000397A FR2657014A1 (en) 1990-01-15 1990-01-15 HUMAN RECEPTOR OF TSH. SEQUENCE ENCODING THIS RECEPTOR.

Publications (2)

Publication Number Publication Date
WO1991010735A2 WO1991010735A2 (en) 1991-07-25
WO1991010735A3 true WO1991010735A3 (en) 1991-10-03

Family

ID=9392766

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR1991/000025 WO1991010735A2 (en) 1990-01-15 1991-01-15 Human receptor of tsh. sequence coding for such receptor

Country Status (4)

Country Link
EP (1) EP0510075A1 (en)
JP (1) JPH05503849A (en)
FR (1) FR2657014A1 (en)
WO (1) WO1991010735A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6261800B1 (en) 1989-05-05 2001-07-17 Genentech, Inc. Luteinizing hormone/choriogonadotropin (LH/CG) receptor
ES2068388T3 (en) * 1989-05-05 1995-04-16 Genentech Inc GLUCOPROTEIN HORMONE RECEPTOR MOLECULES.
US5614363A (en) * 1990-01-25 1997-03-25 New England Medical Center Hospitals, Inc. TSH receptor
EP0493434A4 (en) * 1989-09-08 1993-05-05 New England Medical Center Hospitals, Inc. Tsh receptor
US7118911B1 (en) * 1990-03-05 2006-10-10 Genzyme Corporation DNA molecules stabilized for propagation in bacterial cells that encode cystic fibrosis transmembrane conductance regulator
DE19645729C1 (en) * 1996-11-06 1998-06-04 Brahms Diagnostica Gmbh Receptor binding assay for detecting auto-antibodies to thyroid stimulating hormone receptor
DE19651093C2 (en) * 1996-12-09 1999-06-10 Brahms Diagnostica Gmbh Receptor binding assay for the detection of TSH receptor autoantibodies and set of reagents for performing such a receptor binding assay
DE19949184C2 (en) * 1999-10-12 2003-07-17 Ulrich Loos A method for the determination of various types of autoantibodies against the TSH receptor by selective immunoprecipitation, fusion proteins for carrying out such a method and the use of labeled TSH receptor chimeras in such a method
DE50306067D1 (en) 2002-11-26 2007-02-01 Brahms Ag DETECTION OF TSH RECEPTOR AUTOANTIC BODIES WITH AFFINITY-CLEANED ANTIBODIES
WO2010113988A1 (en) * 2009-03-31 2010-10-07 国立大学法人三重大学 Method for producing anti-gpcr antibody and anti-gpcr antibody

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987005703A1 (en) * 1986-03-19 1987-09-24 Boehringer Mannheim Gmbh Antiparatypical antibodies, their use for detecting and treating auto-immune diseases

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560649A (en) * 1981-10-15 1985-12-24 Cornell Research Foundation Assaying for hLH or hCG with immobilized hormone receptors

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987005703A1 (en) * 1986-03-19 1987-09-24 Boehringer Mannheim Gmbh Antiparatypical antibodies, their use for detecting and treating auto-immune diseases

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
Biochemical and Biophysical Research Communications, vol. 165, no. 3, 29 Dècembre 1989, Academic Press, Inc., (Duluth, MN, US), F. Libert et al.: "Cloning, sequencing and expression of the human thyrotropin (TSH) receptor. Evidence for binding of autoantibodies", pages 1250-1255 *
Biochemical and Biophysical Research Communications, vol. 165, no. 3, 29 dècembre 1989, Academic Press, Inc., (Duluth, MN, US), Y. Nagayama et al.: "Molecular cloning, sequence and functional expression of the cDNA for the human thyrotropin receptor", pages 1184-1190 *
Clinical Chemistry, vol. 34, no. 8, 1988, (Winston, US), H. Tamaki et al.: "On standardization of the radioreceptor assay for anthithyrotropin receptor antibody", page 1662 *
Endocrinology, vol. 122, 1988, The Endocrine Society, (Springfield, US), B.L. Hill et al.: "Monoclonal antibodies to the thyrotropin receptor raised by an autoantiidiotypic protocol and their relationship to monoclonal autoantibodies from Graves patients", pages 2840-2850 *
L.D. Kohn et al.:"Autoimmune thyroid disease studied with monoclonal antibodies to the thyrotropin receptor", 1983, in B.F. Haynes, G.S. Eisenbarth (eds), Monoclonal antibodies: probes for the study of autoimmunity and immuno deficiency, Academic Press, (new York, US), pages 221-258 *
Proceedings of the National Academy of Science USA, vol. 79, novembre 1982, (Washington, US), W.A. Valente et al.: "Monoclonal anti-bodies to the thyrotropin receptor: Stimulating and blocking antibodies derived from the lymphocytes of patients with Graves disease", pages 6680-6684 *

Also Published As

Publication number Publication date
EP0510075A1 (en) 1992-10-28
JPH05503849A (en) 1993-06-24
FR2657014A1 (en) 1991-07-19
WO1991010735A2 (en) 1991-07-25

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