WO1991005850A1 - Souche de bacterie de lactobacillus plantarum 38 de production d'une preparation biologique bacterienne - Google Patents

Souche de bacterie de lactobacillus plantarum 38 de production d'une preparation biologique bacterienne Download PDF

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Publication number
WO1991005850A1
WO1991005850A1 PCT/SU1989/000262 SU8900262W WO9105850A1 WO 1991005850 A1 WO1991005850 A1 WO 1991005850A1 SU 8900262 W SU8900262 W SU 8900262W WO 9105850 A1 WO9105850 A1 WO 9105850A1
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WO
WIPO (PCT)
Prior art keywords
strain
production
lactobacillus plantarum
biological preparation
bacterium strain
Prior art date
Application number
PCT/SU1989/000262
Other languages
English (en)
Russian (ru)
Inventor
Akivo Aronovich Lentsner
Khelga Peeterovna Lentsner
Marika Egonovna Mikelsaar
Mall Eugenovna Tjuri
Virginius Ionovich Brilis
Tatyana Anatolievna Brilene
Mai Endelovna Vyalyaots
Vasily Makarovich +Di Shilov
Nadezhda Nikolaevna Lizko
Lev Alexeevich Levkov
Vladimir Nikolaevich Frolov
Vyacheslav Ivanovich Korolkov
Kira Yakovlevna Sokolova
Galina Fedorovna Levanova
Ekaterina Anatolievna Yakimycheva
Original Assignee
Tartusky Gosudarstvenny Universitet
Institut Mediko-Biologicheskikh Problem
Gorkovsky Nauchno-Issledovatelsky Institut Epidemiologii I Mikrobiologii
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tartusky Gosudarstvenny Universitet, Institut Mediko-Biologicheskikh Problem, Gorkovsky Nauchno-Issledovatelsky Institut Epidemiologii I Mikrobiologii filed Critical Tartusky Gosudarstvenny Universitet
Priority to PCT/SU1989/000262 priority Critical patent/WO1991005850A1/fr
Priority to FR909000107A priority patent/FR2656798B1/fr
Publication of WO1991005850A1 publication Critical patent/WO1991005850A1/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A61K35/747—Lactobacilli, e.g. L. acidophilus or L. brevis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • C12P1/04—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes by using bacteria
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/225—Lactobacillus
    • C12R2001/245—Lactobacillus casei

Definitions

  • the invention is subject to the area of the world, and
  • ⁇ G ⁇ SH ⁇ EN ⁇ A BAS-BASABIB ⁇ 38 38 38 is concerned for the production of a biological biological product.
  • Bacteriological biological products contains live cultures of microorganisms from indigenous people. They are widely used in the quality of such lactobacilli.
  • the claimed strain is new and is not described in the literature.
  • the main task of the invention was to create a new strain for the use of a biological biological product that is not available to the user.
  • the claimed strain has 5 similarly high sustainability for digestive tombs, as well as for the ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇ ⁇
  • PRANIT-LAGIT 8 ⁇ - ⁇ Z was installed using a pre-pendicular cable in a tight environment
  • the sensitivity of these strains to antibacterial products was divided by the method of diffusion in the agar with the use of paper disks for the same paper.
  • the strain is stable ' widely used in medical 5 drugs: drugs, medicine, medicine, medicine, medicine, medicine, medicine, medicine, medicine, medicine, medicine, medicine moderately stable to methicillin and siramycin.
  • the absence of -plasma from the strains prevents the use of antibiotics-10 resistances.
  • the inventive strain is used for receiving a biological product.
  • the effect of a bacterium biological product, a result of the use of the claimed strain on the state of the intestine microbiota in animals has been studied.
  • the intestinal biocenosis of the intestine was studied by generally accepted methods
  • results of research carried out are indicative of a positive effect of a 7-day period.
  • Tests were carried out on 6 health owners at the age of 30–40 years in laboratory conditions.
  • Usl ⁇ viya is ⁇ y ⁇ any were as follows: d ⁇ b ⁇ v ⁇ ltsam ⁇ Y ⁇ O and ⁇ ⁇ p n ⁇ ln g ⁇ u ⁇ th / 6 and 6 chel ⁇ ve ⁇ / ⁇ v ⁇ dshsh 5 ⁇ n ⁇ vye issled ⁇ vaniya mi ⁇ l ⁇ y ⁇ e ⁇ aly for ⁇ edele- Nia s ⁇ s ⁇ yaniya mi ⁇ bi ⁇ tsen ⁇ za ⁇ ishechni ⁇ a. After the course of the diet, it was 0.25 g 4 times a day for 5 days, they were prescribed a bacterium biologic agent, which is the following:
  • Table 4 Changes to the contents of a separate group of products and the use of a separate unit for residents
  • the state of disbacteriosis is a microbial rate of the degree of norma for the intestinal tract of the expression
  • the product of the claimed strain is harmless, non-toxic, and ensures the normalization of the intestinal tract within 10-14 days after the payment.
  • a bacterial biological product obtained through the use of the claimed strain is applicable:
  • the method of cultivation of the claimed ' strain is carried out as follows.
  • the strain consumes the medium, which consists of 25 1/3 of the small-yielding medium and 2/3 of the solid medium, which contains manganese, isulant, isulant , glucose, pepper, sugar, twin-80, cysteine, carbohydrate, hepatic acid, sorbic acid. ⁇ After cultivation, 30. Adds gelatine, acid, folic acid and glucose.
  • Ampoules or salads with a freeze-dried strain are dispensed with the indicated medium and incubated for 6 hours, 35 from the initial generation.
  • the second generation of the culture is obtained after the cultivation in the indicated environment during the course of 7 ⁇ 4 hours and for the generation of the waste - II -
  • the resulting vintage culture is introduced into the process and increased within 10-12 hours at a temperature of 37 ° C in the atmosphere of nitrogen at a temperature of 5–2. Then ⁇ ⁇ the acclaimed bi-humass is concentrated by filtering and poured out into 5 stable capacities, which are installed in the cassettes and freeze at 38 degrees.
  • the resulting biomass contains 9.3 * 10 live cells of the v-culture in I ml. P ⁇ luchennuyu bi ⁇ massu ⁇ lazh- dayu ⁇ , ⁇ a ⁇ ntsen ⁇ i ⁇ uyu ⁇ 10 'of ⁇ il ⁇ vanie, zam ⁇ azhivayu ⁇ ⁇ i ⁇ em ⁇ e ⁇ a ⁇ u ⁇ e 38 ° C and li ⁇ iln ⁇ vysushivayu ⁇ . Intended use

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

La souche de bactérie Lactobacillus plantarum 38 a été déposée le 30 juin 1989 auprès de l'Institut Soviétique de Recherche Génétique et de Culture Industrielle de Microorganismes, sous le numéro VKPM V-4915. Ladite souche est destinée à la production d'une préparation biologique bactérienne utilisée dans la correction et dans la stabilisation de la microflore du tube disgestif, en cas de dysbactérioses d'étiologie diverse et de maladies urogénitales.
PCT/SU1989/000262 1989-10-10 1989-10-10 Souche de bacterie de lactobacillus plantarum 38 de production d'une preparation biologique bacterienne WO1991005850A1 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
PCT/SU1989/000262 WO1991005850A1 (fr) 1989-10-10 1989-10-10 Souche de bacterie de lactobacillus plantarum 38 de production d'une preparation biologique bacterienne
FR909000107A FR2656798B1 (fr) 1989-10-10 1990-01-05 Souche de bacteries lactobacillus casei subsp. casei 37 pour la preparation d'un produit bacterien doue d'une activite biologique.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/SU1989/000262 WO1991005850A1 (fr) 1989-10-10 1989-10-10 Souche de bacterie de lactobacillus plantarum 38 de production d'une preparation biologique bacterienne

Publications (1)

Publication Number Publication Date
WO1991005850A1 true WO1991005850A1 (fr) 1991-05-02

Family

ID=21617568

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/SU1989/000262 WO1991005850A1 (fr) 1989-10-10 1989-10-10 Souche de bacterie de lactobacillus plantarum 38 de production d'une preparation biologique bacterienne

Country Status (2)

Country Link
FR (1) FR2656798B1 (fr)
WO (1) WO1991005850A1 (fr)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993001823A1 (fr) * 1991-07-25 1993-02-04 Probi Ab Lactobacilles colonisant l'intestin
US8846029B2 (en) 2005-09-28 2014-09-30 Nordisk Rebalance A/S Treatment of IBD and IBS using both probiotic bacteria and fermented cereal as treatment effectors

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE519648C2 (sv) * 1998-03-06 2003-03-25 Essum Ab Ny stam av Lactobacillus plantarum

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1585863A (en) * 1977-08-24 1981-03-11 Seiken Kai Foundational Juridi Pharmaceutical lactobacillus preparations
WO1989009607A1 (fr) * 1988-04-15 1989-10-19 Orenburgsky Gosudarstvenny Meditsinsky Institut Preparation bacterienne pour prophylaxie et traitement de processus inflammatoires et d'affections allergiques

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52102419A (en) * 1976-02-23 1977-08-27 Seikenkai Lactic acid producing bacillus preparation
DE3125797A1 (de) * 1981-06-30 1983-01-13 Rudolf Dr. Schuler Diaetetisches mittel
AU624067B2 (en) * 1986-12-12 1992-06-04 Biorem C.C. Preparation suitable for use in the treatment of enteric disorders

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1585863A (en) * 1977-08-24 1981-03-11 Seiken Kai Foundational Juridi Pharmaceutical lactobacillus preparations
WO1989009607A1 (fr) * 1988-04-15 1989-10-19 Orenburgsky Gosudarstvenny Meditsinsky Institut Preparation bacterienne pour prophylaxie et traitement de processus inflammatoires et d'affections allergiques

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Zhurnal mikrobiologii, epidemiologii i immunobiologii, No. 9, 1982, (Meditsina, Moscow, SU), v.I. Brilis et al: "Adgezivnye i gemaggljutinirujuschie svoistva laktobatsill", pages 75-78 *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1993001823A1 (fr) * 1991-07-25 1993-02-04 Probi Ab Lactobacilles colonisant l'intestin
US5474932A (en) * 1991-07-25 1995-12-12 Probi Ab Intestine colonizing strains of lactobacilli
US8846029B2 (en) 2005-09-28 2014-09-30 Nordisk Rebalance A/S Treatment of IBD and IBS using both probiotic bacteria and fermented cereal as treatment effectors
US8900570B2 (en) 2005-09-28 2014-12-02 Nordisk Rebalance A/S Treatment of IBD and IBS using both probiotic bacteria and fermented cereal as treatment effectors
US9205114B2 (en) 2005-09-28 2015-12-08 Nordisk Rebalance A/S Probiotic fermented cereal compositions and methods for treatment of gastrointestinal diseases caused by pro-inflammatory bacteria
US10286026B2 (en) 2005-09-28 2019-05-14 Nordic Rebalance A/S Probiotic fermented cereal compositions and methods for treatment of gastrointestinal diseases caused by pro-inflammatory bacteria

Also Published As

Publication number Publication date
FR2656798A1 (fr) 1991-07-12
FR2656798B1 (fr) 1992-05-15

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