WO1991002530A1 - Accelerator for periodontal tissue regeneration - Google Patents
Accelerator for periodontal tissue regeneration Download PDFInfo
- Publication number
- WO1991002530A1 WO1991002530A1 PCT/JP1990/001066 JP9001066W WO9102530A1 WO 1991002530 A1 WO1991002530 A1 WO 1991002530A1 JP 9001066 W JP9001066 W JP 9001066W WO 9102530 A1 WO9102530 A1 WO 9102530A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- acetyl
- periodontal
- periodontal tissue
- tissue regeneration
- accelerator
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7004—Monosaccharides having only carbon, hydrogen and oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
Definitions
- the present invention relates to an agent used for regenerating a periodontal membrane destroyed by periodontitis and promoting adhesion between a normal root and connective tissue.
- periodontitis has been treated mainly by mechanically removing plaque in periodontal pockets by scaling, etc., and in severe cases, by performing periodontal surgical treatment fi.
- chemotherapy with antibiotics has recently been attempted.
- these therapies are effective measures to stop the progression of periodontitis, they do not narrowly repair and regenerate broken periodontal tissue, and only improve clinical symptoms. It is due to the self-healing power of the living body.
- Periodontal tissue is a structure not found in other tissues, in which hard tissue ⁇ (root) and ⁇ tissue (gingiva) adhere to each other through fibrous firm coupling through the periodontal ligament
- hard tissue ⁇ (root) and ⁇ tissue (gingiva) adhere to each other through fibrous firm coupling through the periodontal ligament
- epithelial cells on the gingival surface cover the destroyed part before the periodontal ligament regenerates (epidermal downgrowth). Only loose coupling between epithelial tracks and tooth roots occurs. As a result, the restoration and regeneration of the surrounding area is prolonged, and street meat regression occurs frequently.
- the present invention relates to a periodontal tissue regenerating device having excellent safety, stability and efficacy.
- the purpose is to provide crude drugs.
- the present invention relates to N-acetyl-D-glucosamine, N-acetyl-D-galactosamine, N-acetyl-D-mannosamine, and an amino acid obtained by combining these amino sugars with each other.
- An object of the present invention is to provide a periodontal tissue regenerating agent characterized by containing an N-acetylated amino sugar selected from the group consisting of glycose as an active ingredient.
- N-acetylated amino sugars are disclosed in Japanese Patent Publication No. 58-119927 as an effective component of an oral composition for inhibiting the adhesion of plaque to teeth.
- this there is no report that applied this in the treatment of periodontitis.
- the present inventors have found that these N-acetylated amino sugars also have an effect of promoting periodontal tissue regeneration and are useful for treating periodontitis.
- N-Acetyl-D-glucosamine used as an active ingredient in the present invention N-acetyl-D-galactosamine is the main component of chondroitin sulfate, which is the main component of chitin, a polysaccharide of the shells of insects and crustaceans, and exists in nature along with N-acetyl-D-mannosamine.
- the N-acetyl-D-glucosamine oligomer hydrolyzes chitin, neutralizes and desalinates, and is isolated and purified by gel filtration.
- N-Acetyl-D-galactosamine oligomers are isolated and purified by the gel-pass method after hydrolyzing and acetylating 1,4-polygalactosamine, in which D-galactosamine is mainly 1,4-linked. .
- cytotoxicity to cultured human periodontal ligament cells is 10; ⁇ 9 / ⁇ ! ⁇ or more, and efficacy is observed between 10 and 1 0 0 / ⁇ ? / ⁇ shows no growth inhibition.
- the periodontal tissue regeneration-promoting agent of the present invention contains an effective and non-toxic amount of the peracetylated amino sugar in a pharmaceutically acceptable carrier such as a solvent, Combined with tonicity agent, emulsifier, suspending agent, stabilizer To give an external preparation (eg, liquid, emulsion, gel).
- a pharmaceutically acceptable carrier such as a solvent, Combined with tonicity agent, emulsifier, suspending agent, stabilizer
- an external preparation eg, liquid, emulsion, gel.
- Such a periodontal moth regeneration promoter of the present invention can be used by periodontal surgery, or by directly administering it to the ⁇ root after lubrication treatment ⁇ and to the detached gingival surface.
- the dose can be appropriately determined depending on the condition to be treated and the condition, but usually, the concentration of the N-acetylated amino sugar is 10 to 1009 / lK i .0.01 to 0.01%).
- the regeneration promoting effect was tested. The results are shown below.
- Betapaiita tissue ⁇ for dish in periodontal ligament fibroblasts assembly ⁇ 3.0 1 0 4 were seeded ⁇ , after incubation for 1 day at at 37, various ⁇ - Asechi Le of Amino sugar and Origo sugars 1 The mixture was added at a ratio of 0, and further incubated at 37 for 2 days. The cells were then stripped from the petri dish with a 0.15% trypsin solution, and the number of cells was counted using a hemocytometer. As a control, the same test was performed without adding any sample.
- Table 2 shows the number of cells grown in the Petri dish for each sample.
- the gingival flap was repositioned, and suture and back protection was applied for one week.
- the test site was sampled, a tissue specimen was prepared by a conventional method, and an eyepiece microphone was placed under a microscope.
- the distance between each part was also measured using a mouthpiece and quantified according to the following criteria.
- Table 3 shows the length of bone removal ⁇ 10 ⁇ .
- N-acetyl-D-galactosamin and its trimer, N-acetyl-D-mannosamine, and N-acetyl-D-glucosamino trimer slightly inhibit epithelial downgrowth and also reduce On the other hand, it clearly showed a promoting effect on the fibrous adhesion rate.
- N-acetylated amino sugars and oligosaccharides have excellent periodontal tissue regeneration promoting action.
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Cosmetics (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP1/220031 | 1989-08-25 | ||
JP1220031A JPH0383927A (ja) | 1989-08-25 | 1989-08-25 | 歯周組織再生促進剤 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1991002530A1 true WO1991002530A1 (en) | 1991-03-07 |
Family
ID=16744846
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/JP1990/001066 WO1991002530A1 (en) | 1989-08-25 | 1990-08-22 | Accelerator for periodontal tissue regeneration |
Country Status (3)
Country | Link |
---|---|
JP (1) | JPH0383927A (zh) |
CN (1) | CN1052045A (zh) |
WO (1) | WO1991002530A1 (zh) |
Cited By (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5286480A (en) * | 1992-06-29 | 1994-02-15 | The Procter & Gamble Company | Use of N-acetylated amino acid complexes in oral care compositions |
US5362480A (en) * | 1991-12-31 | 1994-11-08 | Lever Brothers Company, Division Of Conopco, Inc. | Oral hygiene compositions containing amino sugars as antiplaque agents |
WO2004014398A1 (en) | 2002-08-13 | 2004-02-19 | Third Military Medical University, Chinese People's Liberation Army, P.R. Of China | The use of n-acetyl-d-glucosamine for preparing medicines for urogenital tract infection’s treatment and prevention |
US6992073B2 (en) | 2001-02-28 | 2006-01-31 | Third Military Medical University, Chinese People's Liberation Army | Use of N-acetyl-D-glucosamine in the manufacture of a medicament for treating cervical erosion |
US7345030B2 (en) | 2003-03-27 | 2008-03-18 | Third Military Medical University, Chinese People's Liberation Army, P.R. Of China | Use of n-acetyl-d-aminoglycosamine in treatment of organ lesions related to toxicosis of drugs or chemicals |
WO2011006263A1 (en) * | 2009-07-17 | 2011-01-20 | Klox Technologies Inc. | Antibacterial oral composition |
US8632822B2 (en) | 2008-11-07 | 2014-01-21 | Klox Technologies Inc. | Combination of an oxidant and a photoactivator for the healing of wounds |
US8986719B2 (en) | 2005-11-09 | 2015-03-24 | Klox Technologies Inc. | Teeth whitening compositions and methods |
US9655829B2 (en) | 2012-09-14 | 2017-05-23 | Valeant Pharmaceuticals International, Inc. | Compositions and methods for teeth whitening |
US10130706B2 (en) | 2013-03-14 | 2018-11-20 | Klox Technologies Inc. | Biophotonic materials and uses thereof |
US10207029B2 (en) | 2014-04-01 | 2019-02-19 | Klox Technologies Inc. | Tissue filler compositions and methods of use |
US10213373B2 (en) | 2012-04-20 | 2019-02-26 | Klox Technologies, Inc. | Chromophore combinations for biophotonic uses |
US10881736B2 (en) | 2013-07-03 | 2021-01-05 | Klox Technologies Inc. | Biophotonic compositions comprising a chromophore and a gelling agent for treating wounds |
US11116841B2 (en) | 2012-04-20 | 2021-09-14 | Klox Technologies Inc. | Biophotonic compositions, kits and methods |
US11419806B2 (en) * | 2013-12-27 | 2022-08-23 | Colgate-Palmolive Company | Prebiotic oral care methods using a saccharide |
US11421349B2 (en) | 2014-10-31 | 2022-08-23 | Klox Technologies Inc. | Photoactivatable fibers and fabric media |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP7018899B2 (ja) * | 2016-05-26 | 2022-02-14 | スリーエム イノベイティブ プロパティズ カンパニー | 治療用歯科用ペースト並びに関連する方法及びキット |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5569506A (en) * | 1978-11-16 | 1980-05-26 | Sunstar Inc | Composition for oral cavity application |
JPS60142923A (ja) * | 1983-12-28 | 1985-07-29 | Lion Corp | 歯周病薬 |
JPS62294607A (ja) * | 1986-06-13 | 1987-12-22 | Kanebo Ltd | 口腔用組成物 |
-
1989
- 1989-08-25 JP JP1220031A patent/JPH0383927A/ja active Pending
-
1990
- 1990-08-22 WO PCT/JP1990/001066 patent/WO1991002530A1/ja unknown
- 1990-08-25 CN CN90107588A patent/CN1052045A/zh active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS5569506A (en) * | 1978-11-16 | 1980-05-26 | Sunstar Inc | Composition for oral cavity application |
JPS60142923A (ja) * | 1983-12-28 | 1985-07-29 | Lion Corp | 歯周病薬 |
JPS62294607A (ja) * | 1986-06-13 | 1987-12-22 | Kanebo Ltd | 口腔用組成物 |
Cited By (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5362480A (en) * | 1991-12-31 | 1994-11-08 | Lever Brothers Company, Division Of Conopco, Inc. | Oral hygiene compositions containing amino sugars as antiplaque agents |
US5286480A (en) * | 1992-06-29 | 1994-02-15 | The Procter & Gamble Company | Use of N-acetylated amino acid complexes in oral care compositions |
US5358705A (en) * | 1992-06-29 | 1994-10-25 | The Procter & Gamble Company | Use of N-acetylated amino acid complexes in oral care compositions |
US6992073B2 (en) | 2001-02-28 | 2006-01-31 | Third Military Medical University, Chinese People's Liberation Army | Use of N-acetyl-D-glucosamine in the manufacture of a medicament for treating cervical erosion |
WO2004014398A1 (en) | 2002-08-13 | 2004-02-19 | Third Military Medical University, Chinese People's Liberation Army, P.R. Of China | The use of n-acetyl-d-glucosamine for preparing medicines for urogenital tract infection’s treatment and prevention |
US7345030B2 (en) | 2003-03-27 | 2008-03-18 | Third Military Medical University, Chinese People's Liberation Army, P.R. Of China | Use of n-acetyl-d-aminoglycosamine in treatment of organ lesions related to toxicosis of drugs or chemicals |
US8986719B2 (en) | 2005-11-09 | 2015-03-24 | Klox Technologies Inc. | Teeth whitening compositions and methods |
US8658219B2 (en) | 2008-11-07 | 2014-02-25 | Klox Technologies Inc. | Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin |
US11020609B2 (en) | 2008-11-07 | 2021-06-01 | Klox Technologies Inc. | Methods and compositions for treatment of pigmented lesions |
US11691025B2 (en) | 2008-11-07 | 2023-07-04 | Klox Technologies Inc. | Methods and compositions for reversing or mitigating skin aging |
US10149985B2 (en) | 2008-11-07 | 2018-12-11 | Klox Technologies Inc. | Methods and compositions for treating rosacea |
US8911791B2 (en) | 2008-11-07 | 2014-12-16 | Klox Technologies Inc. | Method for acne treatment using an oxidative-photoactivated composition |
US8974833B2 (en) | 2008-11-07 | 2015-03-10 | Klox Technologies Inc. | Combination of an oxidant and a photoactivator for the healing of wounds |
US8986745B2 (en) | 2008-11-07 | 2015-03-24 | Klox Technologies Inc. | Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin |
US8637086B2 (en) | 2008-11-07 | 2014-01-28 | Klox Technologies Inc. | Method for acne treatment using an oxidative-photoactivated composition |
US8632822B2 (en) | 2008-11-07 | 2014-01-21 | Klox Technologies Inc. | Combination of an oxidant and a photoactivator for the healing of wounds |
US9375446B2 (en) | 2008-11-07 | 2016-06-28 | Klox Technologies Inc. | Oxidatitive photoactivated skin rejeuvenation composition comprising hyaluronic acid, glucosamine, or allantoin |
US10758744B2 (en) | 2008-11-07 | 2020-09-01 | Klox Technologies Inc. | Combination of an oxidant and a photoactivator for the wounds |
US9597349B2 (en) | 2008-11-07 | 2017-03-21 | Klox Technologies Inc. | Combination of an oxidant and a photoactivator for the healing of wounds |
US10485986B2 (en) | 2008-11-07 | 2019-11-26 | Klox Technologies Inc. | Methods and compositions for treatment of pigmented lesions |
US10384072B2 (en) | 2008-11-07 | 2019-08-20 | Klox Technologies Inc. | Combination of an oxidant and a photoactivator for the healing of wounds |
US8685466B2 (en) | 2009-07-17 | 2014-04-01 | Klox Technologies Inc. | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease |
US10322179B2 (en) | 2009-07-17 | 2019-06-18 | Klox Technologies Inc. | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease |
WO2011006263A1 (en) * | 2009-07-17 | 2011-01-20 | Klox Technologies Inc. | Antibacterial oral composition |
US10471147B2 (en) | 2009-07-17 | 2019-11-12 | Klox Technologies Inc. | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease |
US9603929B2 (en) | 2009-07-17 | 2017-03-28 | Klox Technologies Inc. | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfecton and treatment of oral disease |
EA025022B1 (ru) * | 2009-07-17 | 2016-11-30 | Клокс Текнолоджиз Инк. | Антибактериальная композиция для ротовой полости |
US11141482B2 (en) | 2009-07-17 | 2021-10-12 | Klox Technologies Inc. | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease |
US8986746B2 (en) | 2009-07-17 | 2015-03-24 | Klox Technologies Inc. | Combination of an oxidant, a photosensitizer and a wound healing agent for oral disinfection and treatment of oral disease |
US11116841B2 (en) | 2012-04-20 | 2021-09-14 | Klox Technologies Inc. | Biophotonic compositions, kits and methods |
US11723854B2 (en) | 2012-04-20 | 2023-08-15 | Fle International S.R.L. | Biophotonic compositions and methods for providing biophotonic treatment |
US10213373B2 (en) | 2012-04-20 | 2019-02-26 | Klox Technologies, Inc. | Chromophore combinations for biophotonic uses |
US10376455B2 (en) | 2012-04-20 | 2019-08-13 | Klox Technologies Inc. | Biophotonic compositions and methods for providing biophotonic treatment |
US11331257B2 (en) | 2012-04-20 | 2022-05-17 | Klox Technologies Inc. | Biophotonic compositions and methods for providing biophotonic treatment |
US9655829B2 (en) | 2012-09-14 | 2017-05-23 | Valeant Pharmaceuticals International, Inc. | Compositions and methods for teeth whitening |
US11324823B2 (en) | 2013-03-14 | 2022-05-10 | Klox Technologies Inc. | Biophotonic materials and uses thereof |
US10130706B2 (en) | 2013-03-14 | 2018-11-20 | Klox Technologies Inc. | Biophotonic materials and uses thereof |
US10881736B2 (en) | 2013-07-03 | 2021-01-05 | Klox Technologies Inc. | Biophotonic compositions comprising a chromophore and a gelling agent for treating wounds |
US11419806B2 (en) * | 2013-12-27 | 2022-08-23 | Colgate-Palmolive Company | Prebiotic oral care methods using a saccharide |
US10772990B2 (en) | 2014-04-01 | 2020-09-15 | Klox Technologies Inc. | Tissue filler compositions and methods of use |
US10207029B2 (en) | 2014-04-01 | 2019-02-19 | Klox Technologies Inc. | Tissue filler compositions and methods of use |
US11421349B2 (en) | 2014-10-31 | 2022-08-23 | Klox Technologies Inc. | Photoactivatable fibers and fabric media |
Also Published As
Publication number | Publication date |
---|---|
JPH0383927A (ja) | 1991-04-09 |
CN1052045A (zh) | 1991-06-12 |
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