WO1990002127A1 - Hemiphosphate hemihydrate of 2-(1-pentyl-3-guanidino-4-imidazolyl)thiazole - Google Patents

Hemiphosphate hemihydrate of 2-(1-pentyl-3-guanidino-4-imidazolyl)thiazole Download PDF

Info

Publication number
WO1990002127A1
WO1990002127A1 PCT/US1988/003019 US8803019W WO9002127A1 WO 1990002127 A1 WO1990002127 A1 WO 1990002127A1 US 8803019 W US8803019 W US 8803019W WO 9002127 A1 WO9002127 A1 WO 9002127A1
Authority
WO
WIPO (PCT)
Prior art keywords
guanidino
imidazolyl
thiazole
pentyl
hemihydrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
PCT/US1988/003019
Other languages
English (en)
French (fr)
Inventor
Ward M. Smith
Troy A. Appleton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Corp Belgium
Pfizer Corp SRL
Original Assignee
Pfizer Corp Belgium
Pfizer Corp SRL
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Corp Belgium, Pfizer Corp SRL filed Critical Pfizer Corp Belgium
Priority to PCT/US1988/003019 priority Critical patent/WO1990002127A1/en
Priority to ES89308480T priority patent/ES2059773T3/es
Priority to AT89308480T priority patent/ATE96794T1/de
Priority to DE89308480T priority patent/DE68910444T2/de
Priority to EP89308480A priority patent/EP0357315B1/en
Priority to PT91562A priority patent/PT91562B/pt
Priority to CA000609568A priority patent/CA1320207C/en
Priority to JP1221384A priority patent/JPH02108690A/ja
Priority to DK424189A priority patent/DK424189A/da
Priority to IE276589A priority patent/IE61736B1/en
Publication of WO1990002127A1 publication Critical patent/WO1990002127A1/en
Priority to FI910956A priority patent/FI94248C/fi
Anticipated expiration legal-status Critical
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Definitions

  • Potency is defined as the ratio of the molecular weights of the free base to the salt form.

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Cephalosporin Compounds (AREA)
PCT/US1988/003019 1988-08-30 1988-08-30 Hemiphosphate hemihydrate of 2-(1-pentyl-3-guanidino-4-imidazolyl)thiazole Ceased WO1990002127A1 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
PCT/US1988/003019 WO1990002127A1 (en) 1988-08-30 1988-08-30 Hemiphosphate hemihydrate of 2-(1-pentyl-3-guanidino-4-imidazolyl)thiazole
ES89308480T ES2059773T3 (es) 1988-08-30 1989-08-22 Hemihidrato de hemifosfato de 2-(1-pentil-3-guanidino)-4-(2-metil-4-imidazolil)tiazol.
AT89308480T ATE96794T1 (de) 1988-08-30 1989-08-22 2-(1-pentyl-3-guanidino)-4-(2-methyl-4imidazolyl)-thiazol-hemiphosphat-hemihydrat.
DE89308480T DE68910444T2 (de) 1988-08-30 1989-08-22 2-(1-Pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)-Thiazol-Hemiphosphat-Hemihydrat.
EP89308480A EP0357315B1 (en) 1988-08-30 1989-08-22 Hemiphosphate hemihydrate of 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole
PT91562A PT91562B (pt) 1988-08-30 1989-08-28 Processo para a preparacao de hemi-hidrato de hemi-fosfato de 2-(1-pentil-3-guanidino-4-imidazolil)tiazole
CA000609568A CA1320207C (en) 1988-08-30 1989-08-28 Hemiphosphate hemihydrate of 2(2-pentyl-3-guanidino) -4-(2-methyl-4-imidazolyl)thiazole
JP1221384A JPH02108690A (ja) 1988-08-30 1989-08-28 ２―（１―ペンチル―３―グアニジノ―４―イミダゾリル）チアゾールの半燐酸半水塩
DK424189A DK424189A (da) 1988-08-30 1989-08-29 Hemiphosphat-hemihydrat af 2-(1-pentyl-3-guanidino-4-imidazolyl)thiazol
IE276589A IE61736B1 (en) 1988-08-30 1989-08-29 Hemiphosphate hemihydrate of 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole
FI910956A FI94248C (fi) 1988-08-30 1991-02-27 Menetelmä terapeuttisesti käyttökelpoisen 2-(1-(pentyyli-3-guanidino)-2-metyyli-4-imidatsolyyli)tiatsolihemifosfaattihemihydraattisuolan valmistamiseksi

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1988/003019 WO1990002127A1 (en) 1988-08-30 1988-08-30 Hemiphosphate hemihydrate of 2-(1-pentyl-3-guanidino-4-imidazolyl)thiazole

Publications (1)

Publication Number Publication Date
WO1990002127A1 true WO1990002127A1 (en) 1990-03-08

Family

ID=22208884

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1988/003019 Ceased WO1990002127A1 (en) 1988-08-30 1988-08-30 Hemiphosphate hemihydrate of 2-(1-pentyl-3-guanidino-4-imidazolyl)thiazole

Country Status (11)

Country Link
EP (1) EP0357315B1 (enExample)
JP (1) JPH02108690A (enExample)
AT (1) ATE96794T1 (enExample)
CA (1) CA1320207C (enExample)
DE (1) DE68910444T2 (enExample)
DK (1) DK424189A (enExample)
ES (1) ES2059773T3 (enExample)
FI (1) FI94248C (enExample)
IE (1) IE61736B1 (enExample)
PT (1) PT91562B (enExample)
WO (1) WO1990002127A1 (enExample)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560690A (en) * 1984-04-30 1985-12-24 Pfizer Inc. 2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4621424A (en) * 1982-09-17 1986-11-11 The Gillette Company Razor blade assembly
US4632993A (en) * 1984-10-11 1986-12-30 Pfizer Inc. Process for making 2-guanidino-4-(2-methyl-4-imidazolyl) thiazole dihydrobromide
ES2054684T3 (es) * 1986-10-29 1994-08-16 Pfizer Procedimientos para la preparacion de 2-(1-pentil-3-guanidino)-4-(2-metil-4-imidazolil) tiazol y el dihidrocloruro trihidratado cristalino del mismo.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4560690A (en) * 1984-04-30 1985-12-24 Pfizer Inc. 2-(N-substituted guanidino)-4-hetero-arylthiazole antiulcer agents

Also Published As

Publication number Publication date
DE68910444T2 (de) 1994-03-03
DK424189A (da) 1990-03-01
EP0357315A3 (en) 1990-08-16
CA1320207C (en) 1993-07-13
PT91562B (pt) 1995-05-31
PT91562A (pt) 1990-03-30
EP0357315A2 (en) 1990-03-07
ATE96794T1 (de) 1993-11-15
JPH02108690A (ja) 1990-04-20
IE61736B1 (en) 1994-11-30
IE892765L (en) 1990-02-28
FI94248B (fi) 1995-04-28
ES2059773T3 (es) 1994-11-16
DE68910444D1 (de) 1993-12-09
JPH0456038B2 (enExample) 1992-09-07
FI94248C (fi) 1995-08-10
EP0357315B1 (en) 1993-11-03
DK424189D0 (da) 1989-08-29
FI910956A0 (fi) 1991-02-27

Similar Documents

Publication Publication Date Title
US8329695B2 (en) Crystalline form of the free base N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7r)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide
AU2005274340B2 (en) Hydrates and polymorphs of 4-[[(7r)-8-cyclopentyl-7-ethyl-5,6,7,8-tetrahydro-5-methyl-4-6-oxo-2-piperidinyl]amino]-3-methoxy-N-(1-methyl-4-piperidinyl) benzamide, methods for the production thereof, and use thereof as medicaments
WO2007090844A1 (en) Trihydrochloride forms of a dihydropteridinone derivative and processes for preparation
NL8204126A (nl) Werkwijze voor het bereiden van een farmaceutisch preparaat met locaal-anesthetische werking dat een dialylamino-2',6'acetoxylidide en/of een farmaceutisch aanvaardbaar zout daarvan bevat, alsmede de onder toepassing van deze werkwijze verkregen gevormde farmaceutische preparaten en werkwijze voor het bereiden van dialkylamino-2',6'acetoxylididen en de farmaceutisch aanvaardbare zouten daarvan.
AU2008255518A1 (en) Process for preparing the stable, amorphous calcium salt of (6S)-N(5)-methyl-5,6,7,8-tetrahydrofolic acid
US2890985A (en) Composition and method for relieving spasticity
EP0008802B1 (en) Ergoline derivatives, their preparation and therapeutic composition containing them
US3890318A (en) Derivatives of triiodo aminobenzenecarboxylic acids and the preparation thereof
WO1990002127A1 (en) Hemiphosphate hemihydrate of 2-(1-pentyl-3-guanidino-4-imidazolyl)thiazole
JPS5827796B2 (ja) テオフイリニルメチルジオキソラン誘導体およびその製法
CA1103163A (en) Anti-cancer composition containing uracil
US4256752A (en) Treatment of ulcers with acylated aminoalkyl cyanoguanidines containing a heterocyclic residue
EP0009608B1 (en) N-phenethylacetamide compounds, processes for their preparation and therapeutic compositions containing them
TWI285204B (en) Polymorphs of a crystalline azabicyclo[2,2.2]octan-3-amine citrate and their pharmaceutical compositions
US5387597A (en) Hemiphosphate hemihydrate of 2-(1-pentyl-3-guanidino)-4-(2-methyl-4-imidazolyl)thiazole
US2631146A (en) Biguanide salts of penicillin
CA1070616A (en) Anti-tumor composition
GB2068963A (en) Basic ethers of 4-hydroxy-benzophenones acting as beta-blocking agents and relevant preparation processes
US2753340A (en) Maleate salts of protoveratrine a and protoveratrine b
CA1077941A (en) Piperidine derivatives of indole
US2978458A (en) 2-amino-6-chlorobenzoxazole and pharmaceutically acceptable salts
US2980689A (en) 2-amino-5-chloro-6-bromobenzoxazole and pharmaceutically acceptable salts
US5767312A (en) NG -monomethyl-L-arginine hydrochloride derivatives and their use in the treatment of septic shock
AU669557B2 (en) Ng-monomethyl-L-arginine hydrochloride derivatives and their use in the treatment of septic shock
US2620350A (en) Nitrogen containing organic compounds

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): FI HU NO RO SU US

WWE Wipo information: entry into national phase

Ref document number: 910956

Country of ref document: FI

WWG Wipo information: grant in national office

Ref document number: 910956

Country of ref document: FI