WO1989005139A1 - Medicament comprenant l'association de colistine, de tobramycine et d'amphotericine b administree par vaporisation - Google Patents
Medicament comprenant l'association de colistine, de tobramycine et d'amphotericine b administree par vaporisation Download PDFInfo
- Publication number
- WO1989005139A1 WO1989005139A1 PCT/FR1988/000593 FR8800593W WO8905139A1 WO 1989005139 A1 WO1989005139 A1 WO 1989005139A1 FR 8800593 W FR8800593 W FR 8800593W WO 8905139 A1 WO8905139 A1 WO 8905139A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- administered
- atomization
- tobramycin
- colistin
- precise
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/7036—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin having at least one amino group directly attached to the carbocyclic ring, e.g. streptomycin, gentamycin, amikacin, validamycin, fortimicins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/14—Peptides containing saccharide radicals; Derivatives thereof, e.g. bleomycin, phleomycin, muramylpeptides or vancomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0043—Nose
Definitions
- the present invention relates to a spray medication intended to prevent the risks of infection in patients at risk by decontaminating the nasal and oropharyngeal cavities.
- Gram-negative bacillus infections and yeast infections are common in at-risk patients. They cause significant morbidity, they are one of the main causes of the death of these patients, they increase health expenditure by increasing the length of hospital stay.
- the present invention overcomes this drawback. It includes the combination of three antibiotics administered by spraying into the nasal and oropharyngeal cavities.
- the three antibiotics asso ⁇ ciated in the preparation are colistin, tobramycin and 1 amphotéri ⁇ cine B.
- the preparation must adhere to the nasal mucosa and buccal, slowly releasing antibiotics' and have a surface tension permitting maximum spread on mucous membranes nasal and oropharyngeal.
- the preparation is administered by precise spraying either in the form of a pressurized aerosol dispensed by a continuous or metering valve or in the form of a nebulization dispensed by a precise pump.
- Two pushers are supplied with each bottle: one with a long and fine cannula allowing the introduction through the nostrils and vaporization of the nasal cavities, the other with a cannula allowing a broad vaporization of the oropharyngeal cavity.
- valves or pumps will be very precise. They are of course a function of the concentration of antibiotics within the preparation.
- the frequency of applications also depends on the concentration of these products.
- valve or pump must be adapted to deliver 0.5 ml each time it is pressed.
- 40,000,000 units of colistin, 360 mg of tobramycin and 2,000 mg of amphotericin B are administered per day.
- this drug is very broad: it must be emplo ⁇ ye whenever a risk of gram-negative infection or fungus is present: intensive care, hematology, surgery, anesthesiology t oncology, etc. ..
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Gastroenterology & Hepatology (AREA)
- Otolaryngology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
Description
Claims
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR8716766A FR2624015B1 (fr) | 1987-12-03 | 1987-12-03 | Medicament comprenant l'association de colistine, de tobramycine et d'amphotericine b administre par vaporisation |
FR87/16766 | 1987-12-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1989005139A1 true WO1989005139A1 (fr) | 1989-06-15 |
Family
ID=9357419
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/FR1988/000593 WO1989005139A1 (fr) | 1987-12-03 | 1988-12-05 | Medicament comprenant l'association de colistine, de tobramycine et d'amphotericine b administree par vaporisation |
Country Status (4)
Country | Link |
---|---|
EP (1) | EP0390832A1 (fr) |
AU (1) | AU2791689A (fr) |
FR (1) | FR2624015B1 (fr) |
WO (1) | WO1989005139A1 (fr) |
Cited By (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996000576A2 (fr) * | 1994-06-28 | 1996-01-11 | Dr. Zerle Gmbh | Nouvelles utilisations cliniques de polyenes-macrolides |
WO1996014849A1 (fr) * | 1994-11-11 | 1996-05-23 | HAIDER, Angelika | Utilisation des aminoglycosides pour le diagnostic des desordres formant barriere sang-air |
US9545487B2 (en) | 2012-04-13 | 2017-01-17 | Boehringer Ingelheim International Gmbh | Dispenser with encoding means |
US9682202B2 (en) | 2009-05-18 | 2017-06-20 | Boehringer Ingelheim International Gmbh | Adapter, inhalation device, and atomizer |
US9724482B2 (en) | 2009-11-25 | 2017-08-08 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9744313B2 (en) | 2013-08-09 | 2017-08-29 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9757750B2 (en) | 2011-04-01 | 2017-09-12 | Boehringer Ingelheim International Gmbh | Medicinal device with container |
US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9943654B2 (en) | 2010-06-24 | 2018-04-17 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10004857B2 (en) | 2013-08-09 | 2018-06-26 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10011906B2 (en) | 2009-03-31 | 2018-07-03 | Beohringer Ingelheim International Gmbh | Method for coating a surface of a component |
US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10099022B2 (en) | 2014-05-07 | 2018-10-16 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10124125B2 (en) | 2009-11-25 | 2018-11-13 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10124129B2 (en) | 2008-01-02 | 2018-11-13 | Boehringer Ingelheim International Gmbh | Dispensing device, storage device and method for dispensing a formulation |
US10195374B2 (en) | 2014-05-07 | 2019-02-05 | Boehringer Ingelheim International Gmbh | Container, nebulizer and use |
US10722666B2 (en) | 2014-05-07 | 2020-07-28 | Boehringer Ingelheim International Gmbh | Nebulizer with axially movable and lockable container and indicator |
-
1987
- 1987-12-03 FR FR8716766A patent/FR2624015B1/fr not_active Expired - Lifetime
-
1988
- 1988-12-05 WO PCT/FR1988/000593 patent/WO1989005139A1/fr not_active Application Discontinuation
- 1988-12-05 EP EP19890900266 patent/EP0390832A1/fr not_active Withdrawn
- 1988-12-05 AU AU27916/89A patent/AU2791689A/en not_active Abandoned
Non-Patent Citations (2)
Title |
---|
Chemical Abstracts, volume 80, no. 3, 21 janvier 1974, (columbus, Ohio, US), W.R. Lockwood et al.: "Susceptibility of 150 consecutive clinical isolates of Pseudomonas aeruginosa to tobramycin, gentamicin, colistin, carbenicillin, and five other antimicrobials", voir page 65 * |
Chemical Abstracts, volume 81, no. 5, 5 aout 1974, (Columbus, Ohio, US), S.D. Davis: "Dissociation between results of in vitro and in vivo antibiotic susceptibility tests for some strains of Pseudomonas aeruginosa", voir page 19 * |
Cited By (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1996000576A3 (fr) * | 1994-06-28 | 1996-05-23 | Evocon Gmbh | Nouvelles utilisations cliniques de polyenes-macrolides |
WO1996000576A2 (fr) * | 1994-06-28 | 1996-01-11 | Dr. Zerle Gmbh | Nouvelles utilisations cliniques de polyenes-macrolides |
WO1996014849A1 (fr) * | 1994-11-11 | 1996-05-23 | HAIDER, Angelika | Utilisation des aminoglycosides pour le diagnostic des desordres formant barriere sang-air |
US10124129B2 (en) | 2008-01-02 | 2018-11-13 | Boehringer Ingelheim International Gmbh | Dispensing device, storage device and method for dispensing a formulation |
US10011906B2 (en) | 2009-03-31 | 2018-07-03 | Beohringer Ingelheim International Gmbh | Method for coating a surface of a component |
US9682202B2 (en) | 2009-05-18 | 2017-06-20 | Boehringer Ingelheim International Gmbh | Adapter, inhalation device, and atomizer |
US9724482B2 (en) | 2009-11-25 | 2017-08-08 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10016568B2 (en) | 2009-11-25 | 2018-07-10 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10124125B2 (en) | 2009-11-25 | 2018-11-13 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9943654B2 (en) | 2010-06-24 | 2018-04-17 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9757750B2 (en) | 2011-04-01 | 2017-09-12 | Boehringer Ingelheim International Gmbh | Medicinal device with container |
US9827384B2 (en) | 2011-05-23 | 2017-11-28 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9545487B2 (en) | 2012-04-13 | 2017-01-17 | Boehringer Ingelheim International Gmbh | Dispenser with encoding means |
US10220163B2 (en) | 2012-04-13 | 2019-03-05 | Boehringer Ingelheim International Gmbh | Nebuliser with coding means |
US10894134B2 (en) | 2013-08-09 | 2021-01-19 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10004857B2 (en) | 2013-08-09 | 2018-06-26 | Boehringer Ingelheim International Gmbh | Nebulizer |
US9744313B2 (en) | 2013-08-09 | 2017-08-29 | Boehringer Ingelheim International Gmbh | Nebulizer |
US11642476B2 (en) | 2013-08-09 | 2023-05-09 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10716905B2 (en) | 2014-02-23 | 2020-07-21 | Boehringer Lngelheim International Gmbh | Container, nebulizer and use |
US10099022B2 (en) | 2014-05-07 | 2018-10-16 | Boehringer Ingelheim International Gmbh | Nebulizer |
US10722666B2 (en) | 2014-05-07 | 2020-07-28 | Boehringer Ingelheim International Gmbh | Nebulizer with axially movable and lockable container and indicator |
US10195374B2 (en) | 2014-05-07 | 2019-02-05 | Boehringer Ingelheim International Gmbh | Container, nebulizer and use |
Also Published As
Publication number | Publication date |
---|---|
FR2624015B1 (fr) | 1990-06-29 |
EP0390832A1 (fr) | 1990-10-10 |
FR2624015A1 (fr) | 1989-06-09 |
AU2791689A (en) | 1989-07-05 |
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