WO1988005315A1 - Ensemble d'injection a piston exempt de silicone - Google Patents

Ensemble d'injection a piston exempt de silicone Download PDF

Info

Publication number
WO1988005315A1
WO1988005315A1 PCT/CH1988/000008 CH8800008W WO8805315A1 WO 1988005315 A1 WO1988005315 A1 WO 1988005315A1 CH 8800008 W CH8800008 W CH 8800008W WO 8805315 A1 WO8805315 A1 WO 8805315A1
Authority
WO
WIPO (PCT)
Prior art keywords
piston
syringe
injection
piston rod
set according
Prior art date
Application number
PCT/CH1988/000008
Other languages
German (de)
English (en)
Inventor
Eckhard Schwöbel
Paul Zaugg
Original Assignee
Intermedicat Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Intermedicat Gmbh filed Critical Intermedicat Gmbh
Publication of WO1988005315A1 publication Critical patent/WO1988005315A1/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • A61M5/31513—Piston constructions to improve sealing or sliding
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/3145—Filters incorporated in syringes

Definitions

  • the invention described here relates to a syringe set, primarily for the controlled injection of medicaments, consisting essentially of a container cylinder with an attached injection cannula, counter plate and piston rod guide, made of a plastic provided movably in the container cylinder. Piston with automatic lip seal, which piston is parked in the back of the cylinder, and a piston rod with a pressure plate that is separate from the piston.
  • CH Patent 366 126 (published 1/31/63) a piston is described in a plastic syringe, which is also made of thermoplastic material, such as polystyrene or polyethylene the piston mentioned has a round sealing lip at the front, possibly also at the rear, in the spraying direction. During spraying, the front sealing lip is pressed away from the piston body against the inner wall of the syringe body by the pressure in the liquid and thus seals itself automatically.
  • the above-mentioned CH patent does not mention and therefore does not solve the problem of the relaxation of the tension in the round sealing lips even during the storage of such products, and thus the insufficient seal when used after a certain time.
  • FR patent 1,500,009 (published November 3, 677) teaches and claims a piston of the type described above in a plastic injection syringe.
  • the plunger is usually present in the container cylinder of the syringe separately from the rod. Since it has a smaller outside diameter compared to the inside diameter of the cylinder mentioned, and is only expanded by the reception of the piston rod and then seals, the tension in the sealing lip is maintained. Incidentally, the piston rod is always in the container cylinder of this syringe.
  • St styrene units
  • the invention according to the international application PCT / HU 83/00060 with publication number WO 84/02278 (published June 21, 1984) describes a single-use plastic syringe with a plunger in the form of a flexible part, preferably made of polyethylene.
  • the piston rod which is made separately from the piston and is made of a material with a higher degree of rigidity, is always connected to the piston when using this syringe.
  • the syringe set according to the invention now creates the application safety necessary for the purpose of reliable, controlled injection of medication, which is not readily derivable even for the person skilled in the art.
  • the syringe set mentioned primarily for the controlled injection of medicaments, essentially consists of a container cylinder 4.01 with an attached injection cannula 4.02, support plate 4.03 and piston rod guide 4.04, a movable one in the container cylinder and a rear one Cylinder section with expanded diameter, parked plastic pistons 5.05 with automatic lip seal as well a piston rod 5.01 separated from the piston with pressure plate 5.04, and is characterized in that the container cylinder in the rear section in the spraying direction has a compartment 4.06 with an enlarged inside diameter compared to its front part, that the piston in the compartment with an enlarged inside ⁇ diameter is parked, the piston in the direction of injection front and rear one sealing lip edge 4.051; Comprises 4.052 whose maximum outside diameter greater than the inner diameter of the front portion, but smaller than that of "lter cylinder of the parking compartment of the CONT in the rest position and that the piston-rod either disposed in front of the cannula as a protection for the same or adjacent to the syring
  • the other protection of the cannula 4.07 can include a protective tube and a filter 4.071, through which, when the protection is attached, while the plunger is pulled back into the parking position without aspirating, dust-free air is sucked into the container cylinder.
  • edge of the lip seal 4.051 on the piston 4.05 and the transition zone between the section with a larger inner diameter and the space 4.09 in the container cylinder 4.01 are rounded and matched to one another such that when the piston is pushed into the cavity 4.09 Container cylinder 4.01 the sealing lips are pressed against the inner wall of the piston and do not fold backwards.
  • the outside diameter of the piston rod 5.01 has to be smaller than the inside diameter of the cavity 4.09 to avoid contamination.
  • other protection 4.07 should be able to be accommodated in the rear cavity 5.03 of the piston rod 5.01, and the connection between the tip 5.05 of the piston rod 5.01 is to be accomplished by means of a guided fit and / or bayonet seat.
  • All components of the new syringe set, in particular also the piston 4.05, consist of injection-molded, sterilizable thermoplastic material, in particular of alkene polymers, such as polyethylene or propylene. This fundamentally solves the problem of medication being influenced by silicone oils which are used to increase the ease of movement of rubber pistons according to the prior art.
  • the set with the plunger parked is made sterile using gas or jets, especially to obtain sterile air in the cavity 4.09 for the storage of the set.
  • the syringe set according to the invention is preferably used in automatic infusion machines, but also for single injections. This combination of preferred uses is based on the fact that in both cases the delivery of a controlled amount of medication is essential.
  • the plastic syringe according to CH Patent 366 126 shows the automatically sealing pistons also made of plastic - however, the problem of the temporary sealing capacity of such arrangements is not mentioned. And especially in the case of single-use syringes, as specified in the above-mentioned CH patent - ie syringes that are manufactured in large quantities and some of which are stored - the mastery of this problem is a decisive factor in achieving a sufficiently high level of application safety.
  • FR Patent 1,500,009 covers the problem mentioned, but solves it in a different and rather complex manner from the invention described here; especially the embodiment according to FIGS. 5 and 6 does not appear to be easy to understand.
  • An important problem is also practically not dealt with: the question of materials. A deformation of a piston to the extent of FIGS. 1 to 4 within the container cylinder of a plastic syringe with the plugging in and loosening of the piston rod in or from the piston is very likely to result in special plastic materials; however, these are not mentioned in the FR patent mentioned.
  • the arrangement of the components in the syringe set according to the invention specified above permits both the automated manufacture of the syringe from proven, application-inert plastic materials and the preservation of the sealing capacity of the Plunger while the syringe is in storage and not in use (plunger parked) and the syringe is sufficiently safe to use for the same in infusion machines as well as by medically untrained and elderly people; yes, even using the two or three times
  • Syringes with plastic pistons are currently available, which are parked in the front in the spraying direction in the cylinder containers, also in sections with enlarged diameters. As a result, however, a little air (from behind) is aspirated at the start of the absorption of liquid medications; the tightness of the piston is only given after it has entered the cylinder space with a reduced diameter compared to the parking space.
  • the syringe set according to the invention therefore has two major advantages, also with regard to its practical use, compared to the products on the market: The aspiration of air when sucking up medication is completely avoided and siliconization of the plunger is generally no longer necessary .
  • Figures 1 to 3 show specifically plunger shapes to be used in the syringe set according to the invention
  • FIGS. 4 and 5 show an overall arrangement of an embodiment of the set mentioned in a schematic representation.
  • the sealing lips are designed so that the 1.06;
  • the sealing lips in the front spraying direction 3.06 during spraying and the sealing lips in the rear spraying direction 3.07 are pressed against the inner wall of the syringe cylinder body by the position of the rod body 3.02 in the sealing and delivery piston.
  • FIGS. 4 and 5 show a preferred embodiment of the syringe set according to the invention.
  • the piston rod 5.01 25 can be attached to the syringe separately from the syringe or, with or without an additional filter 4.07, as protection over the cannula 4.02 at the front.
  • the metal cannula 4.02 is applied at the front in the spraying direction. These cannulas are usually glued in today. An additional protective filter can be placed over the cannula
  • the container cylinder has a section 4.06
  • the parking of the plastic piston 4.05 in the room 4.06 is essential in the arrangement according to the invention.
  • the piston rod 5.01 has the pressure plate 5.04 on the back and the recess 5.03 for receiving the additional filter 4.07.
  • the tip 5.05 of the piston rod fits, e.g. by means of a fit with a bayonet catch, in the rear opening 4.08 of the piston 4.05.

Landscapes

  • Health & Medical Sciences (AREA)
  • Vascular Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Anesthesiology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

Un nouvel ensemble d'injection est utilisé principalement pour l'injection contrôlée de médicaments; il comporte essentiellement un récipient cylindrique (4.01) auquel sont fixées des canules creuses d'injection (4.02), une plaque-support (4.03) et un guide de tige de piston (4.04), ainsi qu'un piston en plastique (4.05) mobile dans le récipient cylindrique et présentant un joint à lèvres automatique, et une tige de piston (5.01) séparée de ce dernier et pourvue d'une plaque de pression (5.04). Le récipient cylindrique comprend une section arrière (4.06), vue dans le sens d'injection, ayant un diamètre intérieur agrandi, comparé à sa partie avant, section dans laquelle se loge le piston. Le piston en plastique présente, dans le sens d'injection, un rebord avant et arrière à lèvres d'étanchéité (4.051; 4.052). Cette configuration permet la mise en oeuvre d'un piston sans lubrifiants siliconés. La tige de piston peut être agencée soit devant la canule qu'ainsi elle protège, soit à côté de l'injection.
PCT/CH1988/000008 1987-01-27 1988-01-12 Ensemble d'injection a piston exempt de silicone WO1988005315A1 (fr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH26587A CH674942A5 (fr) 1987-01-27 1987-01-27
CH265/87-2 1987-01-27

Publications (1)

Publication Number Publication Date
WO1988005315A1 true WO1988005315A1 (fr) 1988-07-28

Family

ID=4183066

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CH1988/000008 WO1988005315A1 (fr) 1987-01-27 1988-01-12 Ensemble d'injection a piston exempt de silicone

Country Status (3)

Country Link
EP (1) EP0301040A1 (fr)
CH (1) CH674942A5 (fr)
WO (1) WO1988005315A1 (fr)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0654280A1 (fr) * 1993-11-19 1995-05-24 Firma Carl Freudenberg Seringue à usage unique
US6497684B2 (en) 2000-09-27 2002-12-24 Schering Aktiengesellschaft Syringe with a barrel having a sealing cap to hold a fluid medium within the barrel
WO2008037329A1 (fr) * 2006-09-27 2008-04-03 Lts Lohmann Therapie-Systeme Ag Ensemble cylindre-piston avec au moins trois éléments d'étanchéité
WO2009126596A3 (fr) * 2008-04-11 2009-12-10 Medtronic Minimed, Inc. Systèmes et procédés de tête de piston de réservoir
US8206353B2 (en) 2008-04-11 2012-06-26 Medtronic Minimed, Inc. Reservoir barrier layer systems and methods
US8858501B2 (en) 2008-04-11 2014-10-14 Medtronic Minimed, Inc. Reservoir barrier layer systems and methods
US9642969B2 (en) 2011-03-28 2017-05-09 Becton, Dickinson And Company Plastic stopper

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2001502568A (ja) * 1996-10-18 2001-02-27 シエーリング アクチエンゲゼルシヤフト ポリエチレンからなる注射器プラグを有する注射器

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1039984A (fr) * 1950-07-20 1953-10-12 Seringue pour usage médical
US3128765A (en) * 1962-07-17 1964-04-14 American Home Prod Hypodermic syringe and dose dispenser
FR1500009A (fr) * 1966-05-27 1967-11-03 Sodip Sa Perfectionnement aux seringues
US3378006A (en) * 1965-12-21 1968-04-16 Burron Medical Prod Inc Piercing device guard and connector assembly
FR2353303A1 (fr) * 1976-06-01 1977-12-30 Wimmer Pharma Gummi Gmbh Ensemble de seringue avec tige de plongeur et piston

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1039984A (fr) * 1950-07-20 1953-10-12 Seringue pour usage médical
US3128765A (en) * 1962-07-17 1964-04-14 American Home Prod Hypodermic syringe and dose dispenser
US3378006A (en) * 1965-12-21 1968-04-16 Burron Medical Prod Inc Piercing device guard and connector assembly
FR1500009A (fr) * 1966-05-27 1967-11-03 Sodip Sa Perfectionnement aux seringues
FR2353303A1 (fr) * 1976-06-01 1977-12-30 Wimmer Pharma Gummi Gmbh Ensemble de seringue avec tige de plongeur et piston

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0654280A1 (fr) * 1993-11-19 1995-05-24 Firma Carl Freudenberg Seringue à usage unique
US6497684B2 (en) 2000-09-27 2002-12-24 Schering Aktiengesellschaft Syringe with a barrel having a sealing cap to hold a fluid medium within the barrel
US8167850B2 (en) 2006-09-27 2012-05-01 Lts Lohmann Therapie-Systeme Ag Cylinder/piston unit with at least three sealing elements
WO2008037329A1 (fr) * 2006-09-27 2008-04-03 Lts Lohmann Therapie-Systeme Ag Ensemble cylindre-piston avec au moins trois éléments d'étanchéité
US8858501B2 (en) 2008-04-11 2014-10-14 Medtronic Minimed, Inc. Reservoir barrier layer systems and methods
US8206353B2 (en) 2008-04-11 2012-06-26 Medtronic Minimed, Inc. Reservoir barrier layer systems and methods
WO2009126596A3 (fr) * 2008-04-11 2009-12-10 Medtronic Minimed, Inc. Systèmes et procédés de tête de piston de réservoir
US9089637B2 (en) 2008-04-11 2015-07-28 Medtronic Minimed, Inc. Reservoir plunger head systems and methods
US9295776B2 (en) 2008-04-11 2016-03-29 Medtronic Minimed, Inc. Reservoir plunger head systems and methods
US9642969B2 (en) 2011-03-28 2017-05-09 Becton, Dickinson And Company Plastic stopper
US10543318B2 (en) 2011-03-28 2020-01-28 Becton, Dickinson And Company Plastic stopper
EP2691132B1 (fr) * 2011-03-28 2020-05-06 Becton, Dickinson and Company Bouchon en matière plastique
US11491280B2 (en) 2011-03-28 2022-11-08 Becton, Dickinson And Company Plastic stopper

Also Published As

Publication number Publication date
CH674942A5 (fr) 1990-08-15
EP0301040A1 (fr) 1989-02-01

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