WO1988000587A3 - 5-HETERO- OU IMIDAZO [2,1-alpha] ISOQUINOLINES A SUBSTITUTION ARYLE - Google Patents

5-HETERO- OU IMIDAZO [2,1-alpha] ISOQUINOLINES A SUBSTITUTION ARYLE Download PDF

Info

Publication number
WO1988000587A3
WO1988000587A3 PCT/EP1987/000366 EP8700366W WO8800587A3 WO 1988000587 A3 WO1988000587 A3 WO 1988000587A3 EP 8700366 W EP8700366 W EP 8700366W WO 8800587 A3 WO8800587 A3 WO 8800587A3
Authority
WO
WIPO (PCT)
Prior art keywords
hydrogen
chem
isoquinolines
imidazo
hetero
Prior art date
Application number
PCT/EP1987/000366
Other languages
English (en)
Other versions
WO1988000587A2 (fr
Inventor
William Joseph Houlihan
Original Assignee
Sandoz Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz Ag filed Critical Sandoz Ag
Priority to HU873833A priority Critical patent/HU206114B/hu
Publication of WO1988000587A2 publication Critical patent/WO1988000587A2/fr
Priority to FI881165A priority patent/FI88159C/fi
Priority to KR88700272A priority patent/KR960003609B1/ko
Priority to DK138388A priority patent/DK170213B1/da
Publication of WO1988000587A3 publication Critical patent/WO1988000587A3/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/0803—Compounds with Si-C or Si-Si linkages
    • C07F7/081—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te
    • C07F7/0812—Compounds with Si-C or Si-Si linkages comprising at least one atom selected from the elements N, O, halogen, S, Se or Te comprising a heterocyclic ring

Abstract

Des composés ont la formule (I), dans laquelle chaque R représente indépendamment hydrogène ou méthyle, R1 est en position 8 ou 9 et représente hydrogène, chloro, fluoro ou C1-3 alkyl et R2 représente thiényle, furyle ou (a), où chaque Ro représente indépendamment hydrogène, fluoro, chloro, C1-10 alkyl, C1-10 alkoxyle ou C1-10 alkylthio, ou un Ro représente hydrogène et l'autre représente tri-(C1-3 alkyl), silyl trifluorométhyl, phényle, monochlorophényl, monofluorophényl, (b), (c), (d), où X, Y, R3, R3' ou R4 ont la définition donnée ci-dedans ou deux Ro sur des atomes de carbone adjacents forment du méthylènedioxyle. Ces composés sont indiqués pour le traitement de bronchoconstriction et extravasation dont le médiateur est le facteur d'activation des plaquettes (PAF).
PCT/EP1987/000366 1986-07-14 1987-07-07 5-HETERO- OU IMIDAZO [2,1-alpha] ISOQUINOLINES A SUBSTITUTION ARYLE WO1988000587A2 (fr)

Priority Applications (4)

Application Number Priority Date Filing Date Title
HU873833A HU206114B (en) 1986-07-14 1987-07-07 Process for producing 5-hetero- or aryl-substituted imidazo(2,1-a)iso-quinoline derivatives and pharmaceutical compositions comprising same as active ingredient
FI881165A FI88159C (fi) 1986-07-14 1988-03-11 Foerfarande foer framstaellning av farmaceutiskt aktiva 5-arylsubstituerade-2,3-dihydroimidazo/2,1-a/isokinolinderivat
KR88700272A KR960003609B1 (en) 1986-07-14 1988-03-11 5-hetero-or aryl-substituted-imidazo(2,1-a)isoquinolines
DK138388A DK170213B1 (da) 1986-07-14 1988-03-14 Imidazo[2,1-a]isoquinolinderivater, fremgangsmåde til fremstilling deraf, farmaceutiske præparater indeholdende forbindelserne samt forbindelsernes anvendelse

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US88511586A 1986-07-14 1986-07-14
US885,115 1986-07-14
US1351587A 1987-02-11 1987-02-11
US013,515 1987-02-11

Publications (2)

Publication Number Publication Date
WO1988000587A2 WO1988000587A2 (fr) 1988-01-28
WO1988000587A3 true WO1988000587A3 (fr) 1988-04-07

Family

ID=26684931

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1987/000366 WO1988000587A2 (fr) 1986-07-14 1987-07-07 5-HETERO- OU IMIDAZO [2,1-alpha] ISOQUINOLINES A SUBSTITUTION ARYLE

Country Status (22)

Country Link
EP (1) EP0258175B1 (fr)
JP (1) JPH01500270A (fr)
KR (1) KR960003609B1 (fr)
AT (1) ATE74357T1 (fr)
AU (1) AU604739B2 (fr)
CA (1) CA1317942C (fr)
CY (1) CY1828A (fr)
DE (1) DE3777919D1 (fr)
DK (1) DK170213B1 (fr)
ES (1) ES2032861T3 (fr)
FI (1) FI88159C (fr)
GR (1) GR3004258T3 (fr)
HK (1) HK71295A (fr)
HU (1) HU206114B (fr)
IE (1) IE60277B1 (fr)
IL (1) IL83164A (fr)
MY (1) MY101895A (fr)
NZ (1) NZ221054A (fr)
PH (1) PH24430A (fr)
PL (1) PL154159B1 (fr)
SG (1) SG8595G (fr)
WO (1) WO1988000587A2 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4910206A (en) * 1986-07-14 1990-03-20 Sandoz Pharmaceuticals Corp. 5-hetero-or aryl-substituted-imidazo(2,1-a)isoquinolines and their use as PAF receptor antagonists
EP0338993A1 (fr) * 1988-04-21 1989-10-25 Sandoz Ag 4H-thiéno[2,3-e][1,2,4]triazolo[3,4-c][1,4]diazépines substituées par aryle sur la position 6
DE68921239T2 (de) * 1988-05-05 1995-09-14 Sandoz Ag 5-Aryl-substituierte-2,3-dihydro-imidazo[1,2-a]furo[3,2-c]- oder Thieno[2,3-c]pyridine.
US5939090A (en) 1996-12-03 1999-08-17 3M Innovative Properties Company Gel formulations for topical drug delivery
CN1076728C (zh) * 1999-02-05 2001-12-26 浙江大学 2－芳基咪唑并[2,1－a]异喹啉的衍生物及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2125378A1 (fr) * 1971-02-11 1972-09-29 Aspro Nicholas Ltd

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2125378A1 (fr) * 1971-02-11 1972-09-29 Aspro Nicholas Ltd

Also Published As

Publication number Publication date
DK138388D0 (da) 1988-03-14
ES2032861T3 (es) 1993-03-01
CY1828A (en) 1995-12-01
PL266801A1 (en) 1988-09-29
EP0258175B1 (fr) 1992-04-01
IL83164A0 (en) 1987-12-31
EP0258175A2 (fr) 1988-03-02
IL83164A (en) 1991-05-12
SG8595G (en) 1995-06-16
IE871876L (en) 1988-01-14
FI88159B (fi) 1992-12-31
NZ221054A (en) 1990-10-26
EP0258175A3 (en) 1988-05-04
CA1317942C (fr) 1993-05-18
PH24430A (en) 1990-06-25
DK138388A (da) 1988-03-14
JPH0588713B2 (fr) 1993-12-24
FI881165A (fi) 1988-03-11
HUT46005A (en) 1988-09-28
FI88159C (fi) 1993-04-13
ATE74357T1 (de) 1992-04-15
FI881165A0 (fi) 1988-03-11
DE3777919D1 (de) 1992-05-07
JPH01500270A (ja) 1989-02-02
AU604739B2 (en) 1991-01-03
KR880701718A (ko) 1988-11-04
HU206114B (en) 1992-08-28
AU7694187A (en) 1988-02-10
PL154159B1 (en) 1991-07-31
GR3004258T3 (fr) 1993-03-31
IE60277B1 (en) 1994-06-29
KR960003609B1 (en) 1996-03-20
MY101895A (en) 1992-02-15
HK71295A (en) 1995-05-19
WO1988000587A2 (fr) 1988-01-28
DK170213B1 (da) 1995-06-19

Similar Documents

Publication Publication Date Title
AU3461697A (en) Heterocyclic compounds, their production and use
EP1473294A3 (fr) I1,3-oxathiolanes substitués avec des propriétés antivirales
AU1739092A (en) 1-methylcarbapenem derivatives, their preparation and their use as antibiotics
DE69127691T2 (de) Be-13793c-derivat mit antitumorwirkung
WO1988000587A3 (fr) 5-HETERO- OU IMIDAZO [2,1-alpha] ISOQUINOLINES A SUBSTITUTION ARYLE
CO4340691A1 (es) 2-HETEROARIL-5,11-DIHIDRO-6H-DIPIRIDO(3,2-b:2´, 3´ -e) (1, 4)-DIAZEPINAS .
MX170732B (es) Composicion de derivados de succinimida y su uso
DE240890T1 (de) Prostazyklin-(pgi2)-analoge.
FR2491470B1 (fr)
TW357140B (en) Substituted benzenesulfonylureas and -thioureas having cardiac activity, processes for their preparation, and the pharmaceutical compositions thereof
EP0367671A3 (fr) Bêta-D-phénylthioxylosides, procédé pour leur préparation et leur utilisation comme médicaments
IL78625A0 (en) Furanone derivatives and their preparation
ATE283863T1 (de) Verfahren zur herstellung von indolopyrrolocarbazol-derivaten
DK0598396T3 (da) Forbedret fremgangsmåde til fremstilling af 3-amino-2-chlor-4-alkylpyridiner
GR3004981T3 (fr)

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A2

Designated state(s): AU DK FI HU JP KR

WWE Wipo information: entry into national phase

Ref document number: 881165

Country of ref document: FI

AK Designated states

Kind code of ref document: A3

Designated state(s): AU DK FI HU JP KR

WWG Wipo information: grant in national office

Ref document number: 881165

Country of ref document: FI