WO1987001374A3 - Procede et moyen de triage et d'identification d'informations biologiques - Google Patents

Procede et moyen de triage et d'identification d'informations biologiques Download PDF

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Publication number
WO1987001374A3
WO1987001374A3 PCT/US1986/001796 US8601796W WO8701374A3 WO 1987001374 A3 WO1987001374 A3 WO 1987001374A3 US 8601796 W US8601796 W US 8601796W WO 8701374 A3 WO8701374 A3 WO 8701374A3
Authority
WO
WIPO (PCT)
Prior art keywords
sorting
biological information
population
identifying biological
length
Prior art date
Application number
PCT/US1986/001796
Other languages
English (en)
Other versions
WO1987001374A2 (fr
Inventor
George Pieczenik
Original Assignee
George Pieczenik
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by George Pieczenik filed Critical George Pieczenik
Priority to EP86905604A priority Critical patent/EP0241487B1/fr
Priority to DE3650676T priority patent/DE3650676T2/de
Publication of WO1987001374A2 publication Critical patent/WO1987001374A2/fr
Publication of WO1987001374A3 publication Critical patent/WO1987001374A3/fr

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/005—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies constructed by phage libraries
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6878—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids in eptitope analysis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • Urology & Nephrology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physics & Mathematics (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Public Health (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Plant Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

Un des aspects de l'invention concerne une matrice comprenant une population de séquences peptides de même longueur, la longueur étant constituée d'environ 4 à environ 12 résidus d'acides aminés L, la population comprenant au moins 10% de toutes les séquences peptides de la longueur sélectionnée; et une population hétérogène d'anticorps comprenant des anticorps capables de se lier sensiblement à chaque membre de la population oligopeptide.
PCT/US1986/001796 1985-08-28 1986-08-28 Procede et moyen de triage et d'identification d'informations biologiques WO1987001374A2 (fr)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP86905604A EP0241487B1 (fr) 1985-08-28 1986-08-28 Procede et moyen de triage et d'identification d'informations biologiques
DE3650676T DE3650676T2 (de) 1985-08-28 1986-08-28 Verfahren und mittel zur sortierung und bestimmung biologischer informationen

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77039085A 1985-08-28 1985-08-28
US770,390 1985-08-28

Publications (2)

Publication Number Publication Date
WO1987001374A2 WO1987001374A2 (fr) 1987-03-12
WO1987001374A3 true WO1987001374A3 (fr) 1987-05-21

Family

ID=25088390

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1986/001796 WO1987001374A2 (fr) 1985-08-28 1986-08-28 Procede et moyen de triage et d'identification d'informations biologiques

Country Status (6)

Country Link
EP (1) EP0241487B1 (fr)
AT (1) ATE165363T1 (fr)
AU (1) AU626252B2 (fr)
DE (1) DE3650676T2 (fr)
IL (1) IL79881A (fr)
WO (1) WO1987001374A2 (fr)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US7413537B2 (en) 1989-09-01 2008-08-19 Dyax Corp. Directed evolution of disulfide-bonded micro-proteins
FR2656626B1 (fr) * 1989-12-29 1994-08-12 Pasteur Institut Fragment peptidique comprenant une sequence issue de la proteine 28 kda de schistosoma mansoni et compositions vaccinantes et/ou therapeutiques comprenant ledit fragment.
US5814460A (en) * 1990-02-14 1998-09-29 Diatide, Inc. Method for generating and screening useful peptides
US5366862A (en) * 1990-02-14 1994-11-22 Receptor Laboratories, Inc. Method for generating and screening useful peptides
US5723286A (en) 1990-06-20 1998-03-03 Affymax Technologies N.V. Peptide library and screening systems
EP0575485A1 (fr) 1991-03-01 1993-12-29 Dyax Corp. Procede de developpement de mini-proteines de liaison
US5747253A (en) * 1991-08-23 1998-05-05 Isis Pharmaceuticals, Inc. Combinatorial oligomer immunoabsorbant screening assay for transcription factors and other biomolecule binding
EP0673435A1 (fr) * 1991-08-23 1995-09-27 Isis Pharmaceuticals, Inc. Derandomisation synthetique de fragments oligomeres
US5270170A (en) * 1991-10-16 1993-12-14 Affymax Technologies N.V. Peptide library and screening method
US5733731A (en) * 1991-10-16 1998-03-31 Affymax Technologies N.V. Peptide library and screening method
US6828427B1 (en) 1994-01-11 2004-12-07 Isis Pharmaceuticals, Inc. Oligomeric aminodiol-containing compounds, libraries thereof, and process of preparing the same
US6448373B1 (en) 1994-01-11 2002-09-10 Isis Pharmaceuticals, Inc. Phosphate linked oligomers formed of monomeric diols and processes for preparing same
US6184389B1 (en) 1994-01-11 2001-02-06 Isis Pharmaceuticals, Inc. Combinatorial libraries having aminodiol monomer subunits
JP3498316B2 (ja) * 1997-12-15 2004-02-16 藤沢薬品工業株式会社 ディジィタルハイブリダイゼーションスクリーニング
US6248541B1 (en) 2000-04-21 2001-06-19 Genencor International, Inc. Screening under nutrient limited conditions
US6534292B1 (en) 2000-05-08 2003-03-18 Genencor International, Inc. Methods for forming recombined nucleic acids
US6582914B1 (en) 2000-10-26 2003-06-24 Genencor International, Inc. Method for generating a library of oligonucleotides comprising a controlled distribution of mutations

Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD143794A1 (de) * 1979-06-01 1980-09-10 Liebscher Dirck Hartmut Verfahren zur isolierung langer doppelstrang-cdns-molekuele aus einer heterogenen population
EP0048470A2 (fr) * 1980-09-22 1982-03-31 University Of Southern California DNA recombinant eucaryotiquement actif
EP0098118A1 (fr) * 1982-06-25 1984-01-11 Litton Bionetics, Incorporated Vecteurs contenant des cadres de lecture ouverts
DE3300632A1 (de) * 1982-12-13 1984-07-12 Christian Dipl.-Ing. 8900 Augsburg Strobel Verfahren genetischer analyse und synthese
WO1984002922A1 (fr) * 1983-01-28 1984-08-02 Univ New York Antigene de peptide protecteur
WO1984003564A1 (fr) * 1983-03-08 1984-09-13 Commw Serum Lab Commission Procede de determination de sequences d'acides amines antigeniquement actives
WO1985000807A1 (fr) * 1983-08-17 1985-02-28 Scripps Clinic And Research Foundation Anticorps monoclonaux d'oncoproteines induits par des polypeptides
EP0135277A1 (fr) * 1983-07-21 1985-03-27 Scripps Clinic And Research Foundation Polypeptides synthétiques correspondant aux portions de protéinoides traduites de mARNs spécifiques au cerveau, récepteurs, méthode et diagnose utilisant ceux-ci
WO1985003725A1 (fr) * 1984-02-20 1985-08-29 Biogen N.V. Sequences d'adn, adn recombinant et procedes de production d'antigenes de plasmodium falciparum
EP0154186A2 (fr) * 1984-02-10 1985-09-11 Cytoclonal Pharmaceutics Inc. Séparation d'un gène d'interféron et expression de celui-ci
EP0157643A2 (fr) * 1984-04-05 1985-10-09 Scripps Clinic And Research Foundation Anticorps à l'interleukine-2-humaine induite à l'aide de polypeptides synthetiques
WO1986000991A1 (fr) * 1984-07-24 1986-02-13 Commonwealth Serum Laboratories Commission Procede de determination de mimotopes

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU576750B2 (en) * 1983-03-08 1988-09-08 Chiron Mimotopes Pty Ltd Method of determining antigenically active amino acid sequences
DE3328832A1 (de) * 1983-08-10 1985-02-28 Boehringer Ingelheim Diagnostika GmbH, 8046 Garching Reagenz und verfahren zur quantitativen bestimmung von antikoerpern

Patent Citations (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD143794A1 (de) * 1979-06-01 1980-09-10 Liebscher Dirck Hartmut Verfahren zur isolierung langer doppelstrang-cdns-molekuele aus einer heterogenen population
EP0048470A2 (fr) * 1980-09-22 1982-03-31 University Of Southern California DNA recombinant eucaryotiquement actif
EP0098118A1 (fr) * 1982-06-25 1984-01-11 Litton Bionetics, Incorporated Vecteurs contenant des cadres de lecture ouverts
DE3300632A1 (de) * 1982-12-13 1984-07-12 Christian Dipl.-Ing. 8900 Augsburg Strobel Verfahren genetischer analyse und synthese
WO1984002922A1 (fr) * 1983-01-28 1984-08-02 Univ New York Antigene de peptide protecteur
WO1984003564A1 (fr) * 1983-03-08 1984-09-13 Commw Serum Lab Commission Procede de determination de sequences d'acides amines antigeniquement actives
EP0135277A1 (fr) * 1983-07-21 1985-03-27 Scripps Clinic And Research Foundation Polypeptides synthétiques correspondant aux portions de protéinoides traduites de mARNs spécifiques au cerveau, récepteurs, méthode et diagnose utilisant ceux-ci
WO1985000807A1 (fr) * 1983-08-17 1985-02-28 Scripps Clinic And Research Foundation Anticorps monoclonaux d'oncoproteines induits par des polypeptides
EP0154186A2 (fr) * 1984-02-10 1985-09-11 Cytoclonal Pharmaceutics Inc. Séparation d'un gène d'interféron et expression de celui-ci
WO1985003725A1 (fr) * 1984-02-20 1985-08-29 Biogen N.V. Sequences d'adn, adn recombinant et procedes de production d'antigenes de plasmodium falciparum
EP0157643A2 (fr) * 1984-04-05 1985-10-09 Scripps Clinic And Research Foundation Anticorps à l'interleukine-2-humaine induite à l'aide de polypeptides synthetiques
WO1986000991A1 (fr) * 1984-07-24 1986-02-13 Commonwealth Serum Laboratories Commission Procede de determination de mimotopes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Nature, Volume 305, No. 5929, 1 September 1983, (Chesham, Bucks, GB), G.N. GODSON et al.: "Identification and Chemical Synthesis of a Tandemly Repeated Immunogenic Region of Plasmodium Knowlesi Circumsporozoite Protein", pages 29-33, see Abstract *

Also Published As

Publication number Publication date
AU626252B2 (en) 1992-07-30
DE3650676T2 (de) 1998-09-17
IL79881A0 (en) 1986-11-30
EP0241487A1 (fr) 1987-10-21
DE3650676D1 (de) 1998-05-28
ATE165363T1 (de) 1998-05-15
EP0241487B1 (fr) 1998-04-22
IL79881A (en) 1995-12-08
WO1987001374A2 (fr) 1987-03-12
AU6338086A (en) 1987-03-24

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