WO1987000204A3 - Purification de somatotropine a partir de micro-organismes transformes - Google Patents
Purification de somatotropine a partir de micro-organismes transformesInfo
- Publication number
- WO1987000204A3 WO1987000204A3 PCT/US1986/001289 US8601289W WO8700204A3 WO 1987000204 A3 WO1987000204 A3 WO 1987000204A3 US 8601289 W US8601289 W US 8601289W WO 8700204 A3 WO8700204 A3 WO 8700204A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- purification
- somatotropin
- transformed microorganisms
- microorganisms
- purifying
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormones [GH] (Somatotropin)
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/256,297 US6916914B1 (en) | 1985-06-26 | 1986-06-13 | Purification of somatotropin from transformed microorganisms |
DE8686904011T DE3685424D1 (de) | 1985-06-26 | 1986-06-13 | Solubilisation und oxidation von somatotropin aus transformierten mikroorganismen. |
JP61503479A JPH06104070B2 (ja) | 1985-06-26 | 1986-06-13 | 形質転換した微生物からのソマトトロピンの精製 |
AT86904011T ATE76435T1 (de) | 1985-06-26 | 1986-06-13 | Solubilisation und oxidation von somatotropin aus transformierten mikroorganismen. |
US08/447,381 US6586575B1 (en) | 1985-06-26 | 1995-05-23 | Purification of somatotropin from transformed microorganisms |
HK64897A HK64897A (en) | 1985-06-26 | 1997-05-15 | Solubilization and oxidation of somatotropin from transformed microorganisms |
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US74901685A | 1985-06-26 | 1985-06-26 | |
US749,016 | 1985-06-26 | ||
EP86307769A EP0263902B1 (fr) | 1985-06-26 | 1986-10-08 | Solubilisation et oxydation de somatotropine de micro-organismes transformés |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US74901685A Continuation-In-Part | 1985-06-26 | 1985-06-26 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US08/256,297 Continuation-In-Part US6916914B1 (en) | 1985-06-26 | 1986-06-13 | Purification of somatotropin from transformed microorganisms |
Publications (2)
Publication Number | Publication Date |
---|---|
WO1987000204A2 WO1987000204A2 (fr) | 1987-01-15 |
WO1987000204A3 true WO1987000204A3 (fr) | 1987-03-12 |
Family
ID=25011872
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1986/001289 WO1987000204A2 (fr) | 1985-06-26 | 1986-06-13 | Purification de somatotropine a partir de micro-organismes transformes |
Country Status (9)
Country | Link |
---|---|
US (2) | US6916914B1 (fr) |
EP (2) | EP0229110B1 (fr) |
JP (1) | JPH06104070B2 (fr) |
AT (1) | ATE76435T1 (fr) |
DE (1) | DE3685424D1 (fr) |
ES (1) | ES2032383T3 (fr) |
GR (1) | GR3004917T3 (fr) |
HK (1) | HK64897A (fr) |
WO (1) | WO1987000204A2 (fr) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6916914B1 (en) * | 1985-06-26 | 2005-07-12 | Pharmacia & Upjohn Co. | Purification of somatotropin from transformed microorganisms |
JPH01132598A (ja) * | 1987-10-14 | 1989-05-25 | Pitman Moore Inc | 変性剤溶液中に含まれる組換え蛋白質における分子内ジスルフィド結合の生成を促進する方法 |
US4958007A (en) * | 1988-05-17 | 1990-09-18 | Schering-Plough Corp. | Extraction of human interleukin-4- from bacteria |
US5079230A (en) * | 1988-09-12 | 1992-01-07 | Pitman-Moore, Inc. | Stable bioactive somatotropins |
US5023323A (en) * | 1990-09-12 | 1991-06-11 | Monsanto Company | Method of somatotropin naturation |
ZA9711733B (en) | 1996-12-31 | 1998-07-01 | Monsanto Co | Method for solubilization and naturation of somatotropins |
PE20090100A1 (es) * | 2007-03-30 | 2009-02-26 | Wyeth Corp | Metodos de separacion y deteccion de acetato de bacedoxifeno en composiciones farmaceuticas |
CN102089319B (zh) * | 2008-05-08 | 2013-11-13 | 味之素株式会社 | 蛋白质的重折叠方法 |
CN102844326B (zh) * | 2010-03-31 | 2017-09-29 | 安西尔克公司 | 不溶性目标蛋白质的分离 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0114506A1 (fr) * | 1982-12-22 | 1984-08-01 | Genentech, Inc. | Méthodes de purification et réactivation des protéines hétérologues précipitées |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4443539A (en) * | 1980-02-05 | 1984-04-17 | The Upjohn Company | Process for preparing bovine growth hormone |
IL59690A (en) | 1980-03-24 | 1983-11-30 | Yeda Res & Dev | Production of bovine growth hormone by microorganisms and modified microorganisms adapted to produce it |
IE52755B1 (en) | 1980-08-26 | 1988-02-17 | Univ California | Bovine pre-growth and growth hormone |
EP0085036A1 (fr) | 1982-01-18 | 1983-08-03 | Monsanto Company | Méthode pour une production améliorée de lait de bovins |
CA1224432A (fr) | 1982-08-17 | 1987-07-21 | Gary N. Buell | Sequences d'adn, molecules d'adn recombinant et procede de production a grande echelle de polypeptides ressemblant a l'hormone de croissance des bovins |
US4620948A (en) * | 1982-12-22 | 1986-11-04 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4599197A (en) * | 1982-12-22 | 1986-07-08 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4512922A (en) * | 1982-12-22 | 1985-04-23 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4511502A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4518526A (en) * | 1982-12-22 | 1985-05-21 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
US4511503A (en) * | 1982-12-22 | 1985-04-16 | Genentech, Inc. | Purification and activity assurance of precipitated heterologous proteins |
BG49718A3 (en) | 1983-07-15 | 1992-01-15 | Bio Technology General Corp | Method for preparing of polypeptid with superoxiddismutasne activitty |
US4652630A (en) * | 1985-02-22 | 1987-03-24 | Monsanto Company | Method of somatotropin naturation |
US5037806A (en) * | 1985-02-22 | 1991-08-06 | Monsanto Company | Biologically active method using somatotropins |
US4612367A (en) * | 1985-04-08 | 1986-09-16 | Eli Lilly And Company | Process for purifying growth hormone-like materials |
US6916914B1 (en) * | 1985-06-26 | 2005-07-12 | Pharmacia & Upjohn Co. | Purification of somatotropin from transformed microorganisms |
US5023323A (en) * | 1990-09-12 | 1991-06-11 | Monsanto Company | Method of somatotropin naturation |
US5240834A (en) * | 1991-01-22 | 1993-08-31 | Albert Einstein College Of Medicine Of Yeshiva University | Solubilization of protein after bacterial expression using sarkosyl |
-
1986
- 1986-06-13 US US08/256,297 patent/US6916914B1/en not_active Expired - Fee Related
- 1986-06-13 EP EP86904011A patent/EP0229110B1/fr not_active Expired - Lifetime
- 1986-06-13 JP JP61503479A patent/JPH06104070B2/ja not_active Expired - Lifetime
- 1986-06-13 WO PCT/US1986/001289 patent/WO1987000204A2/fr active IP Right Grant
- 1986-06-13 AT AT86904011T patent/ATE76435T1/de not_active IP Right Cessation
- 1986-06-13 DE DE8686904011T patent/DE3685424D1/de not_active Expired - Fee Related
- 1986-10-08 EP EP86307769A patent/EP0263902B1/fr not_active Expired - Lifetime
- 1986-10-08 ES ES198686307769T patent/ES2032383T3/es not_active Expired - Lifetime
-
1992
- 1992-06-12 GR GR920401278T patent/GR3004917T3/el unknown
-
1995
- 1995-05-23 US US08/447,381 patent/US6586575B1/en not_active Expired - Fee Related
-
1997
- 1997-05-15 HK HK64897A patent/HK64897A/xx not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0114506A1 (fr) * | 1982-12-22 | 1984-08-01 | Genentech, Inc. | Méthodes de purification et réactivation des protéines hétérologues précipitées |
Non-Patent Citations (3)
Title |
---|
B.D. DAVIS et al.: "Microbiology", 3rd edition, 1980, Harper & Row, New York (US), see page 1271, right-hand column, lines 9-13 * |
CHEMICAL ABSTRACTS, Volume 66, No. 5, 30 January 1967, Columbus, Ohio (US) M. TEUBER: "Degradation of RNA from Escherichia Coli after Cytoplasmic Membrane Destruction by Toluene" see pages 1593-4, Abstract 16597y & Arch. Mikrobiol. 55(1), 31-45 (1966) * |
CHEMICAL ABSTRACTS, Volume 81, No. 17, 28 October 1974, Columbus, Ohio (US) A.M. PLOMMET et al.: "Killing of Diverse Pathogenic Bacteria in Bovine Liquid Manure by Xylene", see page 138, Abstract 100544w, & Ann. Rech. Vet. 1974, 5(2), 213-21 * |
Also Published As
Publication number | Publication date |
---|---|
US6586575B1 (en) | 2003-07-01 |
GR3004917T3 (fr) | 1993-04-28 |
US6916914B1 (en) | 2005-07-12 |
JPH06104070B2 (ja) | 1994-12-21 |
ATE76435T1 (de) | 1992-06-15 |
EP0229110A1 (fr) | 1987-07-22 |
DE3685424D1 (de) | 1992-06-25 |
HK64897A (en) | 1997-05-23 |
JPS62503143A (ja) | 1987-12-17 |
EP0263902A1 (fr) | 1988-04-20 |
WO1987000204A2 (fr) | 1987-01-15 |
EP0263902B1 (fr) | 1992-05-27 |
ES2032383T3 (es) | 1993-02-16 |
EP0229110B1 (fr) | 1992-05-20 |
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