WO1986001715A1 - Triglyceride preparations for the prevention of catabolism - Google Patents
Triglyceride preparations for the prevention of catabolism Download PDFInfo
- Publication number
- WO1986001715A1 WO1986001715A1 PCT/US1985/001747 US8501747W WO8601715A1 WO 1986001715 A1 WO1986001715 A1 WO 1986001715A1 US 8501747 W US8501747 W US 8501747W WO 8601715 A1 WO8601715 A1 WO 8601715A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- oil
- acid
- structured lipid
- chain triglyceride
- pharmaceutical composition
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
Definitions
- This invention relates to triglyceride preparations for enteral or parentral administration to prevent catabolism and to increase protein synthesis in subjects undergoing severe metabolic stress.
- This invention provides medium chain and long chain fatty acids chemically synthesized into structured triglycerides (lipids) for enteral or parentral administration as the lipid calorie source, in subjects undergoing severe metabolic stress.
- lipids structured triglycerides
- the structural lipids of this invention are randomly rearranged mixtures of medium chain triglycerides (MCT) and long chain triglycerides (LCT). They may be represented by the following formula,
- R 1 and R 2 may be independently a C 6 to C 12 acid, or a C 12 to C 18 ' acid, and R 3 may be a C 18 " or C 18 " acid.
- R 1 may be a C 6 to C 12 acid
- R 2 a C 12 to C 18 acid.
- C 18 ', C 18 " and C 18 " represent the number of double bonds in the fatty acid moiety being one, two and three double bonds respectively.
- the medium chain triglycerides may be lauric oils such as, balassee oil, coconut oil, cohune oil, palm kernel oil, tucum oil and fractions thereof.
- the preferred medium chain triglyceride oil is coconut oil.
- the long chain triglycerides may be polyunsaturated vegetable oils such as, corn oil, peanut oil, safflower oil, soybean oil, sunflower seed oil, and fish oils.
- the preferred long chain triglyceride oils are safflower oil, soybean oil, and sunflower seed oil.
- the percent composition of mixtures of medium chain triglycerides to long chain triglycerides of this invention may be 70 to 30%, 80 to 20%, 85 to 15%, or 90 to 10%. The 80 to 20% and the 85 to 15% mixtures are most preferred.
- the structured lipids of this invention may be mixtures of coconut oil and soybean oil, which lipids may have the following fatty acid carbon chain length (CCL) composition.
- CCL fatty acid carbon chain length
- the present invention provides enteral and parenteral preparations for use in stressed patients to prevent catabolism and to increase protein synthesis.
- the preparations provide from about 15 to 85% of the fat calories required in the stressed patient.
- compositions of this invention provide in a 70 Kg man, from about 0.7 gms of fat/Kg of body weight day to about 4.0 gms of fat/Kg of body weight/day.
- the lipid compositions are preferably administered with additional amino acids, vitamins and minerals as required. Modified amino acid formulas specifically designed for stressed subjects are preferred.
- the amino acids, vitamins and minerals can be administered in the same solution as the structured lipids or separately. It is preferred that the component groups be separately packaged to facilitate tailoring the diet to the patients specific needs.
- formulations may include preservatives or stablizers, as required.
- a structural lipid preparation of this invention is compared with a medium chain lipid, and a long chain lipid for the oxidation of lipids in traumatized animals.
- Group I a 20% medium chain lipid emulsion composed of 72.5% capric acid (C 8:0) and 27.5% coprylic acid (C 10:0) (obtained from Travenol Laboratories, Inc; Deerfield/ Illinois).
- Group II a 20% long chain triglyceride emulsion (20% Travamulsion®, Travenol Laboratories)
- Group III a 20% lipid emulsion composed of structured triglycerides chemically synthesized from 80% coconut oil and 20% soybean oil.
- Captex 710A Lot No. KH4022A Capital City Products Co., Columbus, Ohio
- the rats were placed in metabolic chambers that permitted the collection and analysis of their expired breath. At 15 minute intervals for twelve hours, the specific activity of expired carbon dioxide was determined. At the end of the study, the animals were sacrificed
- Such structured lipids should be preferable and suitable for both enteral and parenteral nutrition.
Landscapes
- Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65077184A | 1984-09-13 | 1984-09-13 | |
US650,771 | 1984-09-13 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1986001715A1 true WO1986001715A1 (en) | 1986-03-27 |
Family
ID=24610217
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1985/001747 WO1986001715A1 (en) | 1984-09-13 | 1985-09-13 | Triglyceride preparations for the prevention of catabolism |
Country Status (2)
Country | Link |
---|---|
EP (1) | EP0193602A1 (de) |
WO (1) | WO1986001715A1 (de) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0271909A2 (de) * | 1986-12-17 | 1988-06-22 | Green Cross Corporation | Triglycerid enthaltende Zusammensetzung |
FR2618332A1 (fr) * | 1987-07-23 | 1989-01-27 | Synthelabo | Emulsion lipidique destinee a la nutrition parenterale ou enterale |
EP0365532A1 (de) * | 1987-04-01 | 1990-05-02 | BISTRIAN, Bruce R. | Kernöle und krankheitsbekämpfung |
US5227403A (en) * | 1986-10-01 | 1993-07-13 | The Nisshin Oil Mills, Ltd. | Fats and oils having superior digestibility and absorptivity |
WO1999030740A1 (en) * | 1997-12-16 | 1999-06-24 | Abbott Laboratories | Method for enhancing the absorption and transport of lipid soluble compounds using structured glycerides |
FR2877577A1 (fr) * | 2004-11-09 | 2006-05-12 | Jean Pierre Maloisel | Extraits de fruits d'astrocaryum aculeatum a visee anti hypertrophie benigne de la prostate, anti inflammatoire et anti oxydante |
EP1981490A1 (de) * | 2005-12-24 | 2008-10-22 | DSMIP Assets B.V. | Langfristige gewichtskontrolle |
EP2548554A1 (de) * | 2010-03-18 | 2013-01-23 | The Nisshin OilliO Group, Ltd. | In-vivo-proteolyse-hemmer |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3268340A (en) * | 1965-08-30 | 1966-08-23 | Drew Chem Corp | Margarine oil and margarine made therefrom |
GB2067587A (en) * | 1980-01-14 | 1981-07-30 | Bristol Myers Co | Readily assimilable fat compositions |
US4329359A (en) * | 1979-12-28 | 1982-05-11 | University Of Kentucky Research Foundation | Method for improving the metabolic stability and survival of newborn pigs |
-
1985
- 1985-09-13 EP EP19850904733 patent/EP0193602A1/de not_active Withdrawn
- 1985-09-13 WO PCT/US1985/001747 patent/WO1986001715A1/en unknown
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3268340A (en) * | 1965-08-30 | 1966-08-23 | Drew Chem Corp | Margarine oil and margarine made therefrom |
US4329359A (en) * | 1979-12-28 | 1982-05-11 | University Of Kentucky Research Foundation | Method for improving the metabolic stability and survival of newborn pigs |
GB2067587A (en) * | 1980-01-14 | 1981-07-30 | Bristol Myers Co | Readily assimilable fat compositions |
Cited By (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5227403A (en) * | 1986-10-01 | 1993-07-13 | The Nisshin Oil Mills, Ltd. | Fats and oils having superior digestibility and absorptivity |
EP0271909A2 (de) * | 1986-12-17 | 1988-06-22 | Green Cross Corporation | Triglycerid enthaltende Zusammensetzung |
EP0271909A3 (de) * | 1986-12-17 | 1989-12-06 | Green Cross Corporation | Triglycerid enthaltende Zusammensetzung |
EP0365532A1 (de) * | 1987-04-01 | 1990-05-02 | BISTRIAN, Bruce R. | Kernöle und krankheitsbekämpfung |
EP0365532A4 (en) * | 1987-04-01 | 1990-09-05 | New England Deaconess Hospital Corporation | Kernel oils and disease treatment |
FR2618332A1 (fr) * | 1987-07-23 | 1989-01-27 | Synthelabo | Emulsion lipidique destinee a la nutrition parenterale ou enterale |
EP0302769A1 (de) * | 1987-07-23 | 1989-02-08 | Clintec Nutrition Company | Für die parenterale oder enterale Ernährung bestimmte Lipidemulsion |
US5840757A (en) * | 1987-07-23 | 1998-11-24 | Clintec Nutrition Company | Lipid emulsion intended for parenteral or enteral feeding |
WO1999030740A1 (en) * | 1997-12-16 | 1999-06-24 | Abbott Laboratories | Method for enhancing the absorption and transport of lipid soluble compounds using structured glycerides |
US6013665A (en) * | 1997-12-16 | 2000-01-11 | Abbott Laboratories | Method for enhancing the absorption and transport of lipid soluble compounds using structured glycerides |
US6160007A (en) * | 1997-12-16 | 2000-12-12 | Abbott Laboratories | Method for enhancing the absorption and transport of lipid soluble compounds using structured glycerides |
FR2877577A1 (fr) * | 2004-11-09 | 2006-05-12 | Jean Pierre Maloisel | Extraits de fruits d'astrocaryum aculeatum a visee anti hypertrophie benigne de la prostate, anti inflammatoire et anti oxydante |
EP1981490A1 (de) * | 2005-12-24 | 2008-10-22 | DSMIP Assets B.V. | Langfristige gewichtskontrolle |
CN102846589A (zh) * | 2005-12-24 | 2013-01-02 | 帝斯曼知识产权资产管理有限公司 | 长期体重维持 |
EP1981490A4 (de) * | 2005-12-24 | 2013-01-09 | Dsm Ip Assets Bv | Langfristige gewichtskontrolle |
EP2548554A1 (de) * | 2010-03-18 | 2013-01-23 | The Nisshin OilliO Group, Ltd. | In-vivo-proteolyse-hemmer |
JPWO2011115184A1 (ja) * | 2010-03-18 | 2013-07-04 | 日清オイリオグループ株式会社 | 生体内の蛋白質の分解抑制剤 |
EP2548554A4 (de) * | 2010-03-18 | 2013-08-07 | Nisshin Oillio Group Ltd | In-vivo-proteolyse-hemmer |
JP5860803B2 (ja) * | 2010-03-18 | 2016-02-16 | 日清オイリオグループ株式会社 | 生体内の蛋白質の分解抑制剤 |
Also Published As
Publication number | Publication date |
---|---|
EP0193602A1 (de) | 1986-09-10 |
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