Classifications

• • C—CHEMISTRY; METALLURGY
  • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
  • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
  • C08F20/00—Homopolymers and copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride, ester, amide, imide or nitrile thereof
  • C08F20/02—Monocarboxylic acids having less than ten carbon atoms, Derivatives thereof
• • A—HUMAN NECESSITIES
  • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
  • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
  • A61K6/00—Preparations for dentistry
  • A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
  • A61K6/884—Preparations for artificial teeth, for filling teeth or for capping teeth comprising natural or synthetic resins
  • A61K6/887—Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

Definitions

• the present invention relates to a (meth) acrylic acid fluoride component-containing polymer and its use, and more particularly, to a (meth) acrylic acid fluorinated phenololeide.
• (meth) acrylic acid referred to herein is either itself or part of a large group, even if it is part of a larger group. Includes acrylic acid and methacrylic acid.
• alkyl as used in the specification may or may not be a radical of any kind, even if it is one of the larger radicals.
• the polymer according to the present invention is a material having a high molecular weight / synthetic resin material, and has a material that gradually releases fluorine ion in water.
• _O PI _ — — Can be used for a variety of applications, but most
• non-fluorinated compounds such as sodium fluoride are combined.
• This fluorine compound has the drawback that it elutes in a short period of time, and thereafter the mechanical properties of the resin itself are significantly reduced.
• Another object of the present invention is to provide a material that releases fluorine ion gradually over a long period of time and that is used in the oral cavity; .
• ⁇ is also to provide a material containing the above-mentioned oblique.
• R represents H or CH 3 .
• R represents H or CH 3 ]
• R represents H or CH 3 , and R represents a C 8 -low alkyl group].
• Radical polymerization can be carried out in the presence of a solvent. In the absence or presence of an appropriate initiator, for example, peroxidized laurol, dementia benzoinole, etc. By adding a substance that easily produces free radicals such as lonitrile and adding polymerization conditions], the polymerization that can be easily performed is usually carried out under normal pressure. 40 to 80 "C” !! can be reacted for 48 hours, preferably 2 to 5 hours. b Control of the reaction and the acquisition of the product, which is a thermoplastic resin, were established in the production of (meta) acrylic polymer. Just follow the technician.
• Monomers for producing the above-mentioned homopolymers and copolymers include (meta) acrylic drums of the following formula.
• R represents H or CH 3 .
• the C the A Le key Le group [ ⁇ C 8 tables Wa 3 a are included.
• the ⁇ Honoré key Honoré group ⁇ c 8, main Ji Le, E Chinore, Buchinore, I This includes, but is not limited to, sobutinole, pentinole, n-hexinole, n-heminole, and n-octinole.
• the material of the invention emits fluorine in water
• OVPI-' ⁇ WiFO — Shows that the properties of the polymer represented by the above formula are — C (O) — The F portion is slowly hydrolyzed to — C (0) -OH. It is understood that HF is liberated
• the total amount of the released fluorine ion is, as the proportion of the monomer containing CC 0) -F in the formula of ⁇ is larger, the larger the proportion of the unit is, that is, -C
• the emission muck is higher when the m / n ratio is larger.
• the release rate may change temporally, and when the ratio of mn is maximum (100,000), the time is When the ratio of m ⁇ n is small (10 no 90), there is an annoyance. In the meantime, there should be a mono-to-quantity ratio with a nearly constant release rate.
• Units are at least 10 mol%, preferably between 20 and
• O PI a One. This is due to the fact that at less than 10%, the release of fluorine ions is slow and the total release is small.
• the molecular weight of the polymer is preferably from 1,500 to 250,000, and more preferably from 50,000 to 150,000.
• No. Copolymers are usually random copolymers in random form
• the rate of release of fluorine ions depends on the rate of formation of the material of the present invention (monomer ratio conditions, molecular weight, etc.).
• the state of use that is, whether the film is to be used or powdered, how thick the film is, what is the particle size of the powder), and more. It largely differs depending on the mode of combination with the components of the pond to be combined (the kind and composition ratio of other components). Of course, it depends on how sensitive it is to water. Therefore, in each case, we need to find the optimal writhing. That 's a little'
• the fluorine ion sustained-release material of the present invention is said to have been the end of the development], and it is suitable as a material that can be strengthened by fluoridation of the tooth.
• it has great application to various types of therapeutic agents and treatments in the dental field as described below.
• It may be irradiated with ultraviolet light or visible light, and polymerized.
• FIGS. 1, 2, 3 and 4 all show the results obtained by performing a fluorine dissolution test on an example of the fluorine ion sustained stopper material of the present invention. It is a graph. In the figure, the horizontal axis represents time, and the curve represents the amount of eluted fluorine (dots) and integral eluted fluorine per unit.
• Elemental analysis Direct (Actual measurement%) C: 59.19, ⁇ : 7.30,
• Example 41-methacrylic acid is obtained in the same manner as in Example 2. ⁇ Dissolve Fluoride 2.87 7 and Methacryl® 2.16 ⁇ ? In Benzene 5 and add azovisi sobutylonitrinole After adding 25 ⁇ and sealing, polymerization was carried out in a constant temperature water bath at 60 C for 150 minutes. After pouring the contents into an ether, a 0.84 ⁇ polymer was obtained. The total yield was 17.8% polymer. Light content 49.4% Elemental analysis Revision C: 57.03. ⁇ : 6.70, F: 9.9
• a methacrylic acid full-length guide 2.5 ⁇ and a methacrylonitrile methinolate 2.5 ⁇ are placed in a polymerization glass sealed tube having an inner volume of 1 and azovis. After dissolving with isobutyronitrile phosphorus 4 and substituting with nitrogen gas, the mixture was polymerized in a constant temperature water at 60 C for 4 ⁇ hours and further at 65 C for 6 hours.
• Example 6 using a mixture of methacryloyl phthalate 1.5 and methyl methacrylate 3,9- as monomer to be polymerized The same polymerization operation was performed. From the round bar of the piece, a rounded sample of 87 ⁇ and 17.7 in thickness was cut out and subjected to a dissolution test. Yugo is the first
• the fluorine ion sustained-release polymer obtained in Example 3 was mechanically pulverized to obtain a powder having a particle size of 2 ⁇ 0 to 350.
• the following composition was added to the base to produce a dental sealant.
• a paste obtained by mixing the above mixed powder 70 ⁇ and a comonomer solution 50 ' was used as a dental filler. After 8 minutes of curing, white cured 3 ⁇ 4 was obtained.
• a dental cement having a composition including the polymer of Example 3 was prototyped.
• Hardener hn Full boran ⁇ Dani3 ⁇ 4J9 In addition to the hardener solution, it was mixed with powder to form a solid, wrapped in cellophane, and cured at room temperature, with a curing time of 12 minutes. Colorless and transparent cured
• a 7 -lm film was prepared from the obtained polymer in the same manner as in Example 5, and a test piece of 30 x 14 N was immersed in 10 si of evaporating water. When the mixture was left standing, elution of fluorine ion at 0 to 18% / day was observed.

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• Health & Medical Sciences (AREA)
• Oral & Maxillofacial Surgery (AREA)
• Chemical & Material Sciences (AREA)
• Epidemiology (AREA)
• Animal Behavior & Ethology (AREA)
• Organic Chemistry (AREA)
• Medicinal Chemistry (AREA)
• Plastic & Reconstructive Surgery (AREA)
• Chemical Kinetics & Catalysis (AREA)
• Life Sciences & Earth Sciences (AREA)
• Polymers & Plastics (AREA)
• General Health & Medical Sciences (AREA)
• Public Health (AREA)
• Veterinary Medicine (AREA)
• Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
• Cosmetics (AREA)
• Dental Preparations (AREA)
• Medicinal Preparation (AREA)

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• 1980
  • 1980-11-19 JP JP55162782A patent/JPS5788106A/ja active Granted
• 1981
  • 1981-11-18 WO PCT/JP1981/000337 patent/WO1982001708A1/ja not_active Ceased

Non-Patent Citations (2)

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