UY37863A - Virus adenoasociado (aav) con dominio de fosfolipasa modificado - Google Patents

Virus adenoasociado (aav) con dominio de fosfolipasa modificado

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Publication number
UY37863A
UY37863A UY0001037863A UY37863A UY37863A UY 37863 A UY37863 A UY 37863A UY 0001037863 A UY0001037863 A UY 0001037863A UY 37863 A UY37863 A UY 37863A UY 37863 A UY37863 A UY 37863A
Authority
UY
Uruguay
Prior art keywords
modified
aav
adenoasociated
virus
sequence
Prior art date
Application number
UY0001037863A
Other languages
English (en)
Inventor
STRINGS-UFOMBAH Vanessa
KAO Shih-Chu
W Roelvink Petrus
Original Assignee
Benitec Biopharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Benitec Biopharma Ltd filed Critical Benitec Biopharma Ltd
Publication of UY37863A publication Critical patent/UY37863A/es

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  • Health & Medical Sciences (AREA)
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  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
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  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
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  • Biochemistry (AREA)
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  • Virology (AREA)
  • Microbiology (AREA)
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  • Gastroenterology & Hepatology (AREA)
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  • Immunology (AREA)
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  • Peptides Or Proteins (AREA)
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Abstract

La presente descripción se refiere en términos generales a virus adenoasociados (AAV) modificados de serotipos distintos del serotipo 2, que tienen una proteína de la cápside vírica con una secuencia de una subunidad 1 (VP1) que está modificada en relación con la secuencia natural correspondiente. En particular, los AAV modificados de la descripción comprenden sustituciones de aminoácidos en sitios específicos dentro del dominio de la fosfolipasa A2 (PLA2) y la secuencia flanqueante en relación con la secuencia natural correspondiente, lo que mejora la funcionalidad de los AAV cuando se los produce en células de insecto.
UY0001037863A 2017-08-31 2018-08-30 Virus adenoasociado (aav) con dominio de fosfolipasa modificado UY37863A (es)

Applications Claiming Priority (1)

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US201762553028P 2017-08-31 2017-08-31

Publications (1)

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UY37863A true UY37863A (es) 2019-03-29

Family

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UY0001037863A UY37863A (es) 2017-08-31 2018-08-30 Virus adenoasociado (aav) con dominio de fosfolipasa modificado

Country Status (12)

Country Link
US (1) US11499141B2 (es)
EP (1) EP3676381A4 (es)
JP (1) JP7360382B2 (es)
KR (1) KR102612563B1 (es)
CN (1) CN111183224B (es)
AU (1) AU2018323049A1 (es)
BR (1) BR112020003976A8 (es)
CA (1) CA3074042A1 (es)
IL (1) IL272972A (es)
TW (1) TWI802584B (es)
UY (1) UY37863A (es)
WO (1) WO2019043630A1 (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018139634A1 (ja) * 2017-01-30 2018-08-02 学校法人日本医科大学 アデノ随伴ウイルス（ａａｖ）キャプシドタンパク質の変異体
US11499141B2 (en) 2017-08-31 2022-11-15 Benitec IP Holdings Inc. Adeno-associated virus (AAV) with modified phospholipase domain
JP7389040B2 (ja) * 2018-01-17 2023-11-29 メイラジーティーエックス・ユーケー・ザ・セカンド・リミテッド 遺伝子治療のための修飾ｒＡＡＶキャプシドタンパク質
CN113631706A (zh) 2019-02-28 2021-11-09 贝尼泰克知识产权控股股份有限公司 用于治疗眼咽肌营养不良(opmd)的组合物和方法
CN111349148A (zh) * 2020-03-13 2020-06-30 辉大(上海)生物科技有限公司 一种腺相关病毒载体及其用途
WO2021225921A1 (en) * 2020-05-04 2021-11-11 The University Of North Carolina At Chapel Hill Modified adeno-associated virus vectors that evade neutralizing antibodies and uses thereof
CN111825772B (zh) * 2020-07-30 2023-10-20 中国科学院精密测量科学与技术创新研究院 具有变异衣壳蛋白的腺相关病毒及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005072364A2 (en) 2004-01-27 2005-08-11 University Of Florida A modified baculovirus expression system for production of pseudotyped raav vector
WO2009137006A2 (en) * 2008-04-30 2009-11-12 The University Of North Carolina At Chapel Hill Directed evolution and in vivo panning of virus vectors
CN102071206A (zh) * 2010-10-22 2011-05-25 中山大学 一种腺相关病毒衣壳蛋白基因、相应的蛋白及其应用
US11499141B2 (en) 2017-08-31 2022-11-15 Benitec IP Holdings Inc. Adeno-associated virus (AAV) with modified phospholipase domain

Also Published As

Publication number Publication date
KR102612563B1 (ko) 2023-12-11
TWI802584B (zh) 2023-05-21
BR112020003976A8 (pt) 2023-02-28
EP3676381A1 (en) 2020-07-08
EP3676381A4 (en) 2021-06-02
TW201920676A (zh) 2019-06-01
US11499141B2 (en) 2022-11-15
JP7360382B2 (ja) 2023-10-12
BR112020003976A2 (pt) 2020-09-01
AU2018323049A1 (en) 2020-04-16
CN111183224A (zh) 2020-05-19
KR20200058427A (ko) 2020-05-27
JP2020533973A (ja) 2020-11-26
CN111183224B (zh) 2024-02-23
CA3074042A1 (en) 2019-03-07
US20200190481A1 (en) 2020-06-18
WO2019043630A1 (en) 2019-03-07
IL272972A (en) 2020-04-30

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