BR112023022318A2 - Capsídeos de aav e seu uso - Google Patents
Capsídeos de aav e seu usoInfo
- Publication number
- BR112023022318A2 BR112023022318A2 BR112023022318A BR112023022318A BR112023022318A2 BR 112023022318 A2 BR112023022318 A2 BR 112023022318A2 BR 112023022318 A BR112023022318 A BR 112023022318A BR 112023022318 A BR112023022318 A BR 112023022318A BR 112023022318 A2 BR112023022318 A2 BR 112023022318A2
- Authority
- BR
- Brazil
- Prior art keywords
- aav
- aav capsids
- capsids
- pericytes
- mediator
- Prior art date
Links
- 210000000234 capsid Anatomy 0.000 abstract 2
- 230000002490 cerebral effect Effects 0.000 abstract 1
- 210000002889 endothelial cell Anatomy 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 210000003668 pericyte Anatomy 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 abstract 1
- 230000026683 transduction Effects 0.000 abstract 1
- 238000010361 transduction Methods 0.000 abstract 1
- 210000005166 vasculature Anatomy 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14145—Special targeting system for viral vectors
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Compounds Of Unknown Constitution (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Abstract
capsídeos de aav e seu uso. a presente invenção refere-se a peptídeos de capsídeo que atuaram como mediador da transdução eficiente de aav da vasculatura cerebral, principalmente células endoteliais e pericitos, assim como células musculares lisas, composições (incluindo aav) e métodos de uso dos mesmos.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US202163180320P | 2021-04-27 | 2021-04-27 | |
PCT/US2022/026608 WO2022232327A2 (en) | 2021-04-27 | 2022-04-27 | Aav capsids and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112023022318A2 true BR112023022318A2 (pt) | 2023-12-26 |
Family
ID=83847326
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112023022318A BR112023022318A2 (pt) | 2021-04-27 | 2022-04-27 | Capsídeos de aav e seu uso |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP4330414A2 (pt) |
JP (1) | JP2024515807A (pt) |
CN (1) | CN117980488A (pt) |
AU (1) | AU2022266615A1 (pt) |
BR (1) | BR112023022318A2 (pt) |
CA (1) | CA3218071A1 (pt) |
IL (1) | IL307957A (pt) |
MX (1) | MX2023012722A (pt) |
WO (1) | WO2022232327A2 (pt) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023196851A1 (en) | 2022-04-06 | 2023-10-12 | President And Fellows Of Harvard College | Reversing aging of the central nervous system |
CN117106825A (zh) * | 2023-08-28 | 2023-11-24 | 康霖生物科技(杭州)有限公司 | 用于治疗帕金森病的基因治疗载体及其用途 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6551795B1 (en) * | 1998-02-18 | 2003-04-22 | Genome Therapeutics Corporation | Nucleic acid and amino acid sequences relating to pseudomonas aeruginosa for diagnostics and therapeutics |
US20090087878A9 (en) * | 1999-05-06 | 2009-04-02 | La Rosa Thomas J | Nucleic acid molecules associated with plants |
CN112703198A (zh) * | 2018-07-11 | 2021-04-23 | 布里格姆妇女医院 | 用于跨血脑屏障递送试剂的方法和组合物 |
-
2022
- 2022-04-27 AU AU2022266615A patent/AU2022266615A1/en active Pending
- 2022-04-27 IL IL307957A patent/IL307957A/en unknown
- 2022-04-27 CN CN202280045122.5A patent/CN117980488A/zh active Pending
- 2022-04-27 EP EP22796682.7A patent/EP4330414A2/en active Pending
- 2022-04-27 JP JP2023565981A patent/JP2024515807A/ja active Pending
- 2022-04-27 WO PCT/US2022/026608 patent/WO2022232327A2/en active Application Filing
- 2022-04-27 MX MX2023012722A patent/MX2023012722A/es unknown
- 2022-04-27 BR BR112023022318A patent/BR112023022318A2/pt unknown
- 2022-04-27 CA CA3218071A patent/CA3218071A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2022266615A1 (en) | 2023-11-09 |
WO2022232327A3 (en) | 2022-11-24 |
CA3218071A1 (en) | 2022-11-03 |
WO2022232327A9 (en) | 2023-08-17 |
IL307957A (en) | 2023-12-01 |
EP4330414A2 (en) | 2024-03-06 |
MX2023012722A (es) | 2023-11-08 |
CN117980488A (zh) | 2024-05-03 |
WO2022232327A2 (en) | 2022-11-03 |
JP2024515807A (ja) | 2024-04-10 |
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