UY35827A - Derivados de triazolopirazina como inhibidores de la proteína brd4 - Google Patents

Derivados de triazolopirazina como inhibidores de la proteína brd4

Info

Publication number
UY35827A
UY35827A UY0001035827A UY35827A UY35827A UY 35827 A UY35827 A UY 35827A UY 0001035827 A UY0001035827 A UY 0001035827A UY 35827 A UY35827 A UY 35827A UY 35827 A UY35827 A UY 35827A
Authority
UY
Uruguay
Prior art keywords
triazolopirazine
inhibitors
derivatives
compounds
brd4 protein
Prior art date
Application number
UY0001035827A
Other languages
English (en)
Spanish (es)
Inventor
Engelhardt Harald
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of UY35827A publication Critical patent/UY35827A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
UY0001035827A 2013-11-07 2014-11-07 Derivados de triazolopirazina como inhibidores de la proteína brd4 UY35827A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP13192002 2013-11-07

Publications (1)

Publication Number Publication Date
UY35827A true UY35827A (es) 2015-05-29

Family

ID=49518874

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001035827A UY35827A (es) 2013-11-07 2014-11-07 Derivados de triazolopirazina como inhibidores de la proteína brd4

Country Status (7)

Country Link
US (1) US9428513B2 (enExample)
EP (1) EP3066104B1 (enExample)
JP (1) JP6370376B2 (enExample)
AR (1) AR098337A1 (enExample)
TW (1) TW201609731A (enExample)
UY (1) UY35827A (enExample)
WO (1) WO2015067770A1 (enExample)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9266891B2 (en) 2012-11-16 2016-02-23 Boehringer Ingelheim International Gmbh Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors
GB201311888D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
GB201311891D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compound
US20180228907A1 (en) 2014-04-14 2018-08-16 Arvinas, Inc. Cereblon ligands and bifunctional compounds comprising the same
WO2016149668A1 (en) 2015-03-18 2016-09-22 Arvinas, Inc. Compounds and methods for the enhanced degradation of targeted proteins
WO2017024319A1 (en) 2015-08-06 2017-02-09 Dana-Farber Cancer Institute, Inc. Tunable endogenous protein degradation
EP3337476A4 (en) 2015-08-19 2019-09-04 Arvinas, Inc. Compounds and methods for the targeted degradation of bromodomain-containing proteins
EP3436006B1 (en) 2016-03-30 2025-07-30 Wisconsin Alumni Research Foundation Methods and compositions for modulating frataxin expression
CN109790143A (zh) 2016-05-10 2019-05-21 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
ES2989988T3 (es) 2016-05-10 2024-11-28 C4 Therapeutics Inc Degronímeros heterorocíclicos para la degradación de proteínas diana
WO2017197036A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
EP3577109A4 (en) 2017-01-31 2020-11-18 Arvinas Operations, Inc. CEREMONY LIGANDS AND BIFUNCTIONAL COMPOUNDS CONTAINING THEM
EP4119552A1 (en) 2017-02-08 2023-01-18 Dana-Farber Cancer Institute, Inc. Regulating chimeric antigen receptors
US11759533B2 (en) 2017-03-29 2023-09-19 Wisconsin Alumni Research Foundation Methods and compositions for modulating gene expression
CN118440096A (zh) 2017-06-20 2024-08-06 C4医药公司 用于蛋白降解的n/o-连接的降解决定子和降解决定子体
WO2019145410A1 (en) * 2018-01-25 2019-08-01 Boehringer Ingelheim International Gmbh Combination treatment of acute myeloid leukemia
US11220515B2 (en) 2018-01-26 2022-01-11 Yale University Imide-based modulators of proteolysis and associated methods of use
MX2020010571A (es) 2018-04-13 2021-01-08 Arvinas Operations Inc Ligandos de cereblon y compuestos bifuncionales que los comprenden.
CN113453679B (zh) 2018-12-20 2025-07-08 C4医药公司 靶向蛋白降解
AU2020405129A1 (en) 2019-12-19 2022-06-23 Arvinas Operations, Inc. Compounds and methods for the targeted degradation of androgen receptor
WO2021175432A1 (en) 2020-03-04 2021-09-10 Boehringer Ingelheim International Gmbh Method for administration of an anti cancer agent
WO2025049555A1 (en) 2023-08-31 2025-03-06 Oerth Bio Llc Compositions and methods for targeted inhibition and degradation of proteins in an insect cell

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20010031983A (ko) 1997-11-11 2001-04-16 우에노 도시오 축합 피라진 화합물
EP1598353A1 (en) * 2004-05-17 2005-11-23 Boehringer Ingelheim International GmbH Pyrrolobenzimidazolones and their use as antiproliferative agents
GB0919423D0 (en) 2009-11-05 2009-12-23 Glaxosmithkline Llc Novel compounds
HRP20140107T1 (hr) 2009-11-05 2014-04-25 Glaxosmithkline Llc Benzodiazepinski inhibitori bromodomene
WO2012174487A2 (en) 2011-06-17 2012-12-20 Constellation Pharmaceuticals, Inc. Bromodomain inhibitors and uses thereof
US9266891B2 (en) 2012-11-16 2016-02-23 Boehringer Ingelheim International Gmbh Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors

Also Published As

Publication number Publication date
US20150133447A1 (en) 2015-05-14
EP3066104B1 (en) 2017-12-06
JP2016540742A (ja) 2016-12-28
JP6370376B2 (ja) 2018-08-08
WO2015067770A1 (en) 2015-05-14
US9428513B2 (en) 2016-08-30
TW201609731A (zh) 2016-03-16
AR098337A1 (es) 2016-05-26
EP3066104A1 (en) 2016-09-14

Similar Documents

Publication Publication Date Title
UY35827A (es) Derivados de triazolopirazina como inhibidores de la proteína brd4
UY35142A (es) Derivados de triazolopirazinas como inhibidores de brd4
CO2020007218A2 (es) Nuevas piridopirimidinonas sustituidas con bencilamino y derivados como inhibidores de sos1
CO6670575A2 (es) Aminopirazoloqinazolinas sustituidas, útiles en el tratamiento de enfermedades proliferativas y composiciones farmaceúticas que las continen
GT201400063A (es) Benzilindazoles sustituidos para uso como inhibidores de la quinasa bub1 en el tratamiento de enfermedades hiperproliferativas
CL2018001569A1 (es) Compuestos heteroaromáticos como inhibidores de btk
CL2017001204A1 (es) Derivados de 6-amino-7-biciclo-7-deaza-purina como inhibidores de la proteína quinasa
CR20150610A (es) Compuestos de pirimidino sustituido y derivados para combatir plagas de animales
DOP2012000257A (es) Derivados del acido 1-amino-2-ciclopropiletilboronico
DOP2015000241A (es) Compuestos de biaril-amida como inhibidores de cinasa
UY33890A (es) Nuevas azaindolilfenil sulfonamidas como inhibidores de serina/ treonina cinasa
CU20160087A7 (es) Indazolcarboxamidas, procedimientos para su preparación, preparaciones farmacéuticas que las contienen
ECSP14013215A (es) Compuestos novedosos
CO6781507A2 (es) Novedosos derivados heterociclicos
MX2015012456A (es) Compuestos heterociclicos y usos de los mismos.
MX389256B (es) Compuestos heterociclicos y usos de los mismos.
PE20151982A1 (es) Derivados de bencimidazolona como inhibidores del bromodominio
ECSP15008851A (es) Compuestos heteroaromáticos como inhibidores de btk
UY33199A (es) 5-alquinil-pirimidinas.
UY33817A (es) ?nuevas oxindolpirimidinas bencílicas?.
UY35711A (es) Bis-amidopiridinas como moduladores de la actividad de iap y sus usos como miméticos de smac
UY35710A (es) 6-alquinilpiridinas como moduladores de la actividad de iap y sus usos como miméticos de smac
UY35922A (es) Derivados de sulfonamidas tricíclicas
CO2019009020A2 (es) Derivados de pirazol como inhibidores de bromodominio.
CR20150641U (es) Composiciones farmacéuticas