UY34565A - Ácidos 3-[4-(fenilaminooxalilamino)fenil]hex-4-inoicos, procedimiento para su preparación y uso de los mismos como un medicamento. - Google Patents

Ácidos 3-[4-(fenilaminooxalilamino)fenil]hex-4-inoicos, procedimiento para su preparación y uso de los mismos como un medicamento.

Info

Publication number
UY34565A
UY34565A UY0001034565A UY34565A UY34565A UY 34565 A UY34565 A UY 34565A UY 0001034565 A UY0001034565 A UY 0001034565A UY 34565 A UY34565 A UY 34565A UY 34565 A UY34565 A UY 34565A
Authority
UY
Uruguay
Prior art keywords
phenylaminooxylamino
inoic
hex
medicine
phenyl
Prior art date
Application number
UY0001034565A
Other languages
English (en)
Inventor
Dr Guenter Billen
Dr Elisabeth Defossa
Dr Viktoria Dietrich
Dr Thomas Klabunde
Dr Stefanie Keil
Dr Siegfried Stengelin
Dr Guido Haschke
Dr Andreas Herling
Dr Johanna Kuhlmann-Gottke
Dr Stefan Bartoschek
Dr Simon Gessler
Dr Angela Dudda
Dr Thomas Olpp
Dr Joerg Rieke-Zapp
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of UY34565A publication Critical patent/UY34565A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/56—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having carbon atoms of carboxamide groups bound to carbon atoms of carboxyl groups, e.g. oxamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines

Abstract

La invención se refiere a ácidos 3-[4-(fenilaminooxalilamino)fenil]hex-4-inoicos y a sales fisiológicamente compatibles de los mismos. La invención se refiere a compuestos de la fórmula Ien la que R1, R2, R3 y R4 se define cada uno según se especifica, y a sales fisiológicamente compatibles de los mismos. Los compuestos son adecuados, por ejemplo, para el tratamiento de diabetes.
UY0001034565A 2012-01-04 2013-01-04 Ácidos 3-[4-(fenilaminooxalilamino)fenil]hex-4-inoicos, procedimiento para su preparación y uso de los mismos como un medicamento. UY34565A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12305008 2012-01-04
US201261669440P 2012-07-09 2012-07-09
EP12306086 2012-09-10

Publications (1)

Publication Number Publication Date
UY34565A true UY34565A (es) 2013-09-02

Family

ID=48695298

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001034565A UY34565A (es) 2012-01-04 2013-01-04 Ácidos 3-[4-(fenilaminooxalilamino)fenil]hex-4-inoicos, procedimiento para su preparación y uso de los mismos como un medicamento.

Country Status (4)

Country Link
US (1) US20130172248A1 (es)
EP (1) EP2800736A1 (es)
UY (1) UY34565A (es)
WO (1) WO2013102626A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015084692A1 (en) 2013-12-04 2015-06-11 Merck Sharp & Dohme Corp. Antidiabetic bicyclic compounds
WO2015119899A1 (en) 2014-02-06 2015-08-13 Merck Sharp & Dohme Corp. Antidiabetic compounds
US10710986B2 (en) 2018-02-13 2020-07-14 Gilead Sciences, Inc. PD-1/PD-L1 inhibitors
JP7242702B2 (ja) 2018-04-19 2023-03-20 ギリアード サイエンシーズ， インコーポレイテッド Ｐｄ－１／ｐｄ－ｌ１阻害剤
UA126421C2 (uk) 2018-07-13 2022-09-28 Гіліад Сайєнсіз, Інк. Інгібітори pd-1/pd-l1
CN112955435A (zh) 2018-10-24 2021-06-11 吉利德科学公司 Pd-1/pd-l1抑制剂

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA011010B1 (ru) * 2004-02-27 2008-12-30 Эмджен, Инк. Соединения, модулирующие рецептор gpr40, фармацевтическая композиция, способ лечения заболеваний, чувствительных к модулированию рецептора gpr40 (варианты), способ модулирования функции gpr40 (варианты) и способ модулирования циркулирующей концентрации инсулина
EP2203416B1 (de) * 2007-09-21 2016-10-26 Sanofi (carboxylalkylen-phenyl)-phenyl-oxalamide, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Also Published As

Publication number Publication date
EP2800736A1 (en) 2014-11-12
US20130172248A1 (en) 2013-07-04
WO2013102626A1 (en) 2013-07-11

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