UY33428A - Derivados de 3,4-dihidropirrolo[1,2-a]pirazina-2,8(1h)-dicarboxamida su preparacion y su aplicacion en terapeutica - Google Patents
Derivados de 3,4-dihidropirrolo[1,2-a]pirazina-2,8(1h)-dicarboxamida su preparacion y su aplicacion en terapeuticaInfo
- Publication number
- UY33428A UY33428A UY0001033428A UY33428A UY33428A UY 33428 A UY33428 A UY 33428A UY 0001033428 A UY0001033428 A UY 0001033428A UY 33428 A UY33428 A UY 33428A UY 33428 A UY33428 A UY 33428A
- Authority
- UY
- Uruguay
- Prior art keywords
- cycloalkyl
- alkyl
- group
- dihydropirrolo
- pirazina
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Urology & Nephrology (AREA)
- Anesthesiology (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Compuestos que responden a la fórmula general (I)en la que R2 representa un grupo alquilo-C1-lo, cicloalquilo-C3-lo, cicloalquil-C3-,-alquilo-C1-6,al quilo-C1 - 6-cicloalquilo-C3-7, cicloalquil-C3--7-cicloalquilo-C3-,, alquiltio-C1-6-alquilo-C-1-lo, alcoxi-C1-6-alquilo-C1-1o, hidroxi-alquilo-C1-lo, hidroxi-alquil-C1-6-cicloalquil-C3-7-alquilo-C1-6, hidroxi-cicloalquilo-C3-10, fluoroalquilo-Cl-1o, fluorocicloalquilo-C3-10 ; un grupo heterocíclico sustituido opcionalmente ; un grupo alquilo -C1-10 sustituido con un grupo heterocíclico sustituido opcionalmente ; X6 representa un grupo elegido entre el átomo de hidrógeno, de flúor, de cloro o de bromo o un grupo alquilo-C1_6r cicloalquilo-C3-7, cicloalquil-C3-7-alquilo-C1-6, fluoroalquilo-C1-6 o ciano ; y R7 representa un grupo arilo tal como fenilo o naftilo, sustituidos opcionalmente con uno o varios sustituyentes .
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1054372A FR2960876B1 (fr) | 2010-06-03 | 2010-06-03 | Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY33428A true UY33428A (es) | 2011-12-30 |
Family
ID=42697541
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY0001033428A UY33428A (es) | 2010-06-03 | 2011-06-03 | Derivados de 3,4-dihidropirrolo[1,2-a]pirazina-2,8(1h)-dicarboxamida su preparacion y su aplicacion en terapeutica |
Country Status (38)
| Country | Link |
|---|---|
| US (2) | US8791119B2 (es) |
| EP (1) | EP2588480B1 (es) |
| JP (1) | JP5995841B2 (es) |
| KR (1) | KR20130113928A (es) |
| CN (1) | CN103168041B (es) |
| AR (1) | AR081832A1 (es) |
| AU (1) | AU2011268651B2 (es) |
| BR (1) | BR112012030697A2 (es) |
| CA (1) | CA2801154C (es) |
| CL (1) | CL2012003360A1 (es) |
| CO (1) | CO6602113A2 (es) |
| CR (1) | CR20120595A (es) |
| CY (1) | CY1118512T1 (es) |
| DK (1) | DK2588480T3 (es) |
| DO (1) | DOP2012000296A (es) |
| EA (1) | EA201291364A1 (es) |
| EC (1) | ECSP12012322A (es) |
| ES (1) | ES2603420T3 (es) |
| FR (1) | FR2960876B1 (es) |
| GT (1) | GT201200319A (es) |
| HR (1) | HRP20161494T1 (es) |
| HU (1) | HUE030650T2 (es) |
| IL (1) | IL223364A (es) |
| LT (1) | LT2588480T (es) |
| MA (1) | MA34360B1 (es) |
| MX (1) | MX2012014084A (es) |
| NI (1) | NI201200176A (es) |
| NZ (1) | NZ603947A (es) |
| PE (1) | PE20130259A1 (es) |
| PL (1) | PL2588480T3 (es) |
| PT (1) | PT2588480T (es) |
| SG (1) | SG186143A1 (es) |
| SI (1) | SI2588480T1 (es) |
| TN (1) | TN2012000520A1 (es) |
| TW (1) | TWI487707B (es) |
| UY (1) | UY33428A (es) |
| WO (1) | WO2011161537A2 (es) |
| ZA (1) | ZA201209071B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2960876B1 (fr) * | 2010-06-03 | 2012-07-27 | Sanofi Aventis | Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique. |
| AR098414A1 (es) * | 2013-11-14 | 2016-05-26 | Bristol Myers Squibb Co | PIPERAZINAS DE PIRAZOLO SUSTITUIDO COMO INHIBIDORES DE CASEÍNA QUINASA 1 d/e |
| JP6307989B2 (ja) * | 2014-04-02 | 2018-04-11 | 住友化学株式会社 | 塩、酸発生剤、レジスト組成物及びレジストパターンの製造方法 |
| BR112019018051A2 (pt) | 2017-04-12 | 2020-04-07 | Hoffmann La Roche | método para produzir um composto, composto e substância |
| CN109952305B (zh) * | 2017-07-27 | 2022-06-21 | 江苏恒瑞医药股份有限公司 | 哌嗪并杂芳基类衍生物、其制备方法及其在医药上的应用 |
| WO2024002157A1 (en) * | 2022-06-29 | 2024-01-04 | Insilico Medicine Ip Limited | Inhibitors of fgfr2 and fgfr3 and uses thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY129445A (en) | 1999-02-01 | 2007-04-30 | Univ Virginia Patent Found | Compositions for treating inflammatory response |
| NZ531378A (en) * | 2001-09-19 | 2006-11-30 | Aventis Pharma S | Indolizines as kinase protein inhibitors suitable for treating solid tumours |
| GB0202015D0 (en) * | 2002-01-29 | 2002-03-13 | Hoffmann La Roche | Piperazine Derivatives |
| RS50823B (sr) | 2003-12-11 | 2010-08-31 | Aventis Pharmaceuticals Inc. | Supstituisani 1h-pirolo[3,2-b, 3,2-c, i 2,3-c]piridin-2-karboksamidi i srodni analozi kao inhibitori kazein kinaze i epsilon |
| GB0328900D0 (en) | 2003-12-12 | 2004-01-14 | Glaxo Group Ltd | Novel compounds |
| US8304408B2 (en) * | 2007-05-24 | 2012-11-06 | The Regents Of The University Of California | Wnt signaling inhibitors, and methods for making and using them |
| JP2010534639A (ja) | 2007-07-27 | 2010-11-11 | サノフイ−アベンテイス | １，２，３，４−テトラヒドロピロロ［１，２−ａ］ピラジン−６−カルボキサミド誘導体および２，３，４，５−テトラヒドロピロロ［１，２−ａ］［１，４］−ジアゼピン−７−カルボキサミド誘導体、これらの調製および治療的使用 |
| EP2229395A1 (en) * | 2008-01-17 | 2010-09-22 | Grünenthal GmbH | Substituted sulfonamide derivatives |
| US20090192147A1 (en) * | 2008-01-30 | 2009-07-30 | Wyeth | [a]-FUSED INDOLE COMPOUNDS, THEIR USE AS mTOR KINASE AND PI3 KINASE INHIBITORS, AND THEIR SYNTHESES |
| FR2960876B1 (fr) * | 2010-06-03 | 2012-07-27 | Sanofi Aventis | Derives de 3,4-dihydropyrrolo[1,2-a]pyrazine-2,8(1h)-dicarboxamide leur preparation et leur application en therapeutique. |
-
2010
- 2010-06-03 FR FR1054372A patent/FR2960876B1/fr not_active Expired - Fee Related
-
2011
- 2011-06-01 LT LTEP11781590.2T patent/LT2588480T/lt unknown
- 2011-06-01 CA CA2801154A patent/CA2801154C/en not_active Expired - Fee Related
- 2011-06-01 SI SI201131022A patent/SI2588480T1/sl unknown
- 2011-06-01 DK DK11781590.2T patent/DK2588480T3/en active
- 2011-06-01 PT PT117815902T patent/PT2588480T/pt unknown
- 2011-06-01 KR KR1020127031424A patent/KR20130113928A/ko active Search and Examination
- 2011-06-01 ES ES11781590.2T patent/ES2603420T3/es active Active
- 2011-06-01 CN CN201180038277.8A patent/CN103168041B/zh not_active Expired - Fee Related
- 2011-06-01 BR BR112012030697A patent/BR112012030697A2/pt not_active IP Right Cessation
- 2011-06-01 EA EA201291364A patent/EA201291364A1/ru unknown
- 2011-06-01 PL PL11781590T patent/PL2588480T3/pl unknown
- 2011-06-01 MX MX2012014084A patent/MX2012014084A/es active IP Right Grant
- 2011-06-01 EP EP11781590.2A patent/EP2588480B1/en active Active
- 2011-06-01 NZ NZ603947A patent/NZ603947A/en not_active IP Right Cessation
- 2011-06-01 WO PCT/IB2011/001594 patent/WO2011161537A2/en active Application Filing
- 2011-06-01 MA MA35524A patent/MA34360B1/fr unknown
- 2011-06-01 HU HUE11781590A patent/HUE030650T2/en unknown
- 2011-06-01 PE PE2012002257A patent/PE20130259A1/es not_active Application Discontinuation
- 2011-06-01 AU AU2011268651A patent/AU2011268651B2/en not_active Ceased
- 2011-06-01 JP JP2013513006A patent/JP5995841B2/ja not_active Expired - Fee Related
- 2011-06-01 SG SG2012088795A patent/SG186143A1/en unknown
- 2011-06-02 AR ARP110101901A patent/AR081832A1/es not_active Application Discontinuation
- 2011-06-03 TW TW100119696A patent/TWI487707B/zh not_active IP Right Cessation
- 2011-06-03 UY UY0001033428A patent/UY33428A/es unknown
-
2012
- 2012-10-31 TN TNP2012000520A patent/TN2012000520A1/en unknown
- 2012-11-22 DO DO2012000296A patent/DOP2012000296A/es unknown
- 2012-11-26 CR CR20120595A patent/CR20120595A/es unknown
- 2012-11-27 GT GT201200319A patent/GT201200319A/es unknown
- 2012-11-29 US US13/688,916 patent/US8791119B2/en not_active Expired - Fee Related
- 2012-11-29 IL IL223364A patent/IL223364A/en not_active IP Right Cessation
- 2012-11-30 CL CL2012003360A patent/CL2012003360A1/es unknown
- 2012-11-30 ZA ZA2012/09071A patent/ZA201209071B/en unknown
- 2012-11-30 NI NI201200176A patent/NI201200176A/es unknown
- 2012-12-03 EC ECSP12012322 patent/ECSP12012322A/es unknown
- 2012-12-03 CO CO12218640A patent/CO6602113A2/es active IP Right Grant
-
2014
- 2014-07-23 US US14/339,112 patent/US9233965B2/en not_active Expired - Fee Related
-
2016
- 2016-11-11 HR HRP20161494TT patent/HRP20161494T1/hr unknown
- 2016-11-16 CY CY20161101179T patent/CY1118512T1/el unknown
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