UY23540A1 - Procedimiento para la preparacion de pirrolilbenzodiazepinonas - Google Patents

Procedimiento para la preparacion de pirrolilbenzodiazepinonas

Info

Publication number
UY23540A1
UY23540A1 UY23540A UY23540A UY23540A1 UY 23540 A1 UY23540 A1 UY 23540A1 UY 23540 A UY23540 A UY 23540A UY 23540 A UY23540 A UY 23540A UY 23540 A1 UY23540 A1 UY 23540A1
Authority
UY
Uruguay
Prior art keywords
preparation
methyl
procedure
pyrrolylbenzodiazepinones
formula
Prior art date
Application number
UY23540A
Other languages
English (en)
Inventor
Hsu Ming-Chu
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of UY23540A1 publication Critical patent/UY23540A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Procedimiento para la preparación de compuestos de fórmula general (I) (figura 1), y sus sales farmacéuticamente aceptables donde: R es metilo, flúor o bromo, que comprende: hacer reaccionar una 2-bromo-2'-(1H-pirrol-2-ilcarbonil)-acetanilida 4'-sustituida de fórmula (II) (figura 2) con amoníaco y ciclizar la 2-aminoacetanilina obtenida. Ejemplo no limitante de un compuesto conforme al procedimiento descrito: 1,3-dihidro-7-metil-5-(1H-pirrol-2-il)-2H-1,4-benzodiacepin-2-ona. Estos productos son agentes terapéuticos activos, especialmente para el tratamiento de infecciones retrovirales, particularmente infecciones de HIV.
UY23540A 1992-01-24 1993-01-22 Procedimiento para la preparacion de pirrolilbenzodiazepinonas UY23540A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US82547592A 1992-01-24 1992-01-24

Publications (1)

Publication Number Publication Date
UY23540A1 true UY23540A1 (es) 1993-07-16

Family

ID=25244088

Family Applications (1)

Application Number Title Priority Date Filing Date
UY23540A UY23540A1 (es) 1992-01-24 1993-01-22 Procedimiento para la preparacion de pirrolilbenzodiazepinonas

Country Status (16)

Country Link
EP (1) EP0552665A1 (es)
JP (1) JPH069623A (es)
KR (1) KR930016417A (es)
CN (1) CN1074905A (es)
AU (1) AU3185693A (es)
BR (1) BR9300250A (es)
CA (1) CA2086368A1 (es)
CZ (1) CZ372792A3 (es)
FI (1) FI930244A (es)
HU (1) HUT63162A (es)
IL (1) IL104424A0 (es)
MX (1) MX9300260A (es)
NO (1) NO930224L (es)
TW (1) TW221687B (es)
UY (1) UY23540A1 (es)
ZA (1) ZA93285B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002098865A2 (fr) * 2001-06-07 2002-12-12 Neuro3D Inhibiteurs des phosphodiesterases des nucleotides cycliques, preparation et utilisations de ces inhibiteurs
JP4197965B2 (ja) 2003-01-31 2008-12-17 オリンパス株式会社 高周波スネアと医療器具
CN107056760A (zh) * 2017-01-22 2017-08-18 苏州楚凯药业有限公司 5,7位取代的1H‑苯并[e][1,4]二氮杂‑2(3H)‑酮衍生物的制备方法
CN106831726A (zh) * 2017-01-22 2017-06-13 苏州楚凯药业有限公司 抗病毒药物中间体苯并二氮杂酮衍生物的制备方法
KR20200144870A (ko) 2019-06-19 2020-12-30 김상은 항곰팡이 및 항균성이 우수한 수지 조성물

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUT61195A (en) * 1989-10-30 1992-12-28 Hoffmann La Roche Process for utilizing a benzodiazepine derivative and a phenylpyrrylketone derivative
EP0475231A1 (en) * 1990-09-10 1992-03-18 F. Hoffmann-La Roche Ag Benzodiazepines
EP0491218A1 (en) * 1990-12-17 1992-06-24 F. Hoffmann-La Roche Ag Benzodiazepinones

Also Published As

Publication number Publication date
AU3185693A (en) 1993-07-29
CZ372792A3 (en) 1993-12-15
EP0552665A1 (en) 1993-07-28
ZA93285B (en) 1993-08-19
FI930244A0 (fi) 1993-01-21
NO930224L (no) 1993-07-26
CN1074905A (zh) 1993-08-04
HU9300117D0 (en) 1993-04-28
JPH069623A (ja) 1994-01-18
BR9300250A (pt) 1993-07-27
NO930224D0 (no) 1993-01-22
CA2086368A1 (en) 1993-07-25
HUT63162A (en) 1993-07-28
IL104424A0 (en) 1993-05-13
MX9300260A (es) 1993-07-01
KR930016417A (ko) 1993-08-26
FI930244A (fi) 1993-07-25
TW221687B (es) 1994-03-11

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